Page last updated: 2024-08-16

trimethoprim and cimetidine

trimethoprim has been researched along with cimetidine in 54 studies

Research

Studies (54)

Timeframe	Studies, this research(%)	All Research%
pre-1990	6 (11.11)	18.7374
1990's	3 (5.56)	18.2507
2000's	25 (46.30)	29.6817
2010's	19 (35.19)	24.3611
2020's	1 (1.85)	2.80

Authors

Authors	Studies
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	2
Chieli, E; Romiti, N; Tramonti, G	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Alimuddin, M; Bulloch, D; Dahl, R; Grant, D; Lee, N; Peacock, M	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Campillo, NE; Guerra, A; Páez, JA	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Avdeef, A; Tam, KY	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, X; Lin, X; Skolnik, S; Wang, J	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Chen, EC; Chien, HC; Giacomini, KM; Huang, Y; Khuri, N; Liang, X; Sali, A; Stecula, A; Yee, SW	1
Coleman, MD; Park, BK; Russell, RM; Tingle, MD	1
McCormack, JJ; Tong, WP; Webster, LK	1
Debreczeni, LA; Herjavecz, I; Szeitz, A	1
Durupinar, B	1
Janknegt, R; Koks, CH	1
Muther, RS	1
Bradbrook, ID; James, CA; Morrison, PJ; Rogers, HJ	1
Lehmann, DF; Morse, PD; Newman, N	1
Andreev, E; Arisz, L; Koopman, M	1
Hanada, K; Kato, T; Kinami, J; Ogata, H; Takubo, T	2
Barendt, WM; Wright, SH	1
Inui, K; Kimura, N; Okuda, M; Urakami, Y	1
Inui, K; Katsura, T; Kimura, N; Masuda, S; Okuda, M; Urakami, Y	1
Bloomer, JR; McGuire, BM	1
KuKanich, B; KuKanich, K	1
Dallmann, R; Fromm, MF; Lehr, T; Müller, F; Selzer, D; Türk, D	1

Reviews

3 review(s) available for trimethoprim and cimetidine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Pharmacokinetic aspects during continuous ambulatory peritoneal dialysis: a literature review. Pharmaceutisch weekblad. Scientific edition, 1984, Dec-14, Volume: 6, Issue:6 Topics: Aminoglycosides; Anti-Bacterial Agents; Antifungal Agents; Cephalosporins; Cimetidine; Drug Combinations; Half-Life; Humans; Kinetics; Penicillins; Peritoneal Dialysis; Peritoneal Dialysis, Continuous Ambulatory; Pharmaceutical Preparations; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination; Vancomycin	1984
A rise in plasma creatinine that is not a sign of renal failure: which drugs can be responsible? Journal of internal medicine, 1999, Volume: 246, Issue:3 Topics: Adrenal Cortex Hormones; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Benzeneacetamides; Cimetidine; Creatinine; Drug-Related Side Effects and Adverse Reactions; Glomerular Filtration Rate; Histamine H2 Antagonists; Humans; Pyrimethamine; Renal Insufficiency; Salicylates; Trimethoprim; Urea; Vitamin D	1999

Trials

1 trial(s) available for trimethoprim and cimetidine

Article	Year
The effect of cimetidine on the formation of sulfamethoxazole hydroxylamine in patients with human immunodeficiency virus. Journal of clinical pharmacology, 1998, Volume: 38, Issue:5 Topics: Adult; Anti-Infective Agents; Anti-Ulcer Agents; Antibiotic Prophylaxis; Cimetidine; Double-Blind Method; Drug Interactions; Female; HIV Infections; Humans; Male; Pilot Projects; Sulfamethoxazole; Trimethoprim	1998

Article

Year

The effect of cimetidine on the formation of sulfamethoxazole hydroxylamine in patients with human immunodeficiency virus.

Journal of clinical pharmacology, 1998, Volume: 38, Issue:5

Topics: Adult; Anti-Infective Agents; Anti-Ulcer Agents; Antibiotic Prophylaxis; Cimetidine; Double-Blind Method; Drug Interactions; Female; HIV Infections; Humans; Male; Pilot Projects; Sulfamethoxazole; Trimethoprim

1998

Other Studies

50 other study(ies) available for trimethoprim and cimetidine

Article	Year
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Rational use of in vitro P-glycoprotein assays in drug discovery. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera	2001
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
Influence of different chemicals on MDR-1 P-glycoprotein expression and activity in the HK-2 proximal tubular cell line. Toxicology and applied pharmacology, 2002, Sep-01, Volume: 183, Issue:2 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Blotting, Western; Cell Line, Transformed; DNA Primers; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation; Humans; Kidney Tubules, Proximal; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger	2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Determination of log D via automated microfluidic liquid-liquid extraction. Journal of medicinal chemistry, 2008, Aug-28, Volume: 51, Issue:16 Topics: Automation; Biopharmaceutics; Microfluidic Analytical Techniques; Pharmacokinetics	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nature chemical biology, 2009, Volume: 5, Issue:10 Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9 Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2 Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1 Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1). Journal of medicinal chemistry, 2017, 04-13, Volume: 60, Issue:7 Topics: Drug Discovery; HEK293 Cells; Humans; Ligands; Molecular Docking Simulation; Organic Cation Transporter 1; Small Molecule Libraries	2017
Inhibition of dapsone-induced methaemoglobinaemia by cimetidine in the presence of trimethoprim in the rat. The Journal of pharmacy and pharmacology, 1992, Volume: 44, Issue:2 Topics: Acetylation; Animals; Cimetidine; Dapsone; Drug Interactions; Half-Life; Male; Methemoglobin; Methemoglobinemia; Rats; Rats, Inbred Strains; Trimethoprim	1992
Effect of trimethoprim, paracetamol and cimetidine on trimetrexate metabolism by rat perfused isolated livers. The Journal of pharmacy and pharmacology, 1987, Volume: 39, Issue:11 Topics: Acetaminophen; Animals; Cimetidine; Drug Interactions; Folic Acid Antagonists; In Vitro Techniques; Liver; Male; Quinazolines; Rats; Rats, Inbred Strains; Trimethoprim; Trimetrexate	1987
Effects of drugs on aminophylline elimination in rats. Arzneimittel-Forschung, 1988, Volume: 38, Issue:12 Topics: Aminophylline; Animals; Behavior, Animal; Carbamazepine; Cimetidine; Drug Combinations; Drug Interactions; Erythromycin; Female; Half-Life; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Rifampin; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination	1988
[The effect of drugs on the immune response]. Mikrobiyoloji bulteni, 1987, Volume: 21, Issue:2 Topics: Animals; Antibody Formation; BCG Vaccine; Chloramphenicol; Cimetidine; Drug Combinations; Immunity, Cellular; Rabbits; Rifampin; Salmonella typhi; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination; Tuberculin Test	1987
Drug interference with renal function tests. American journal of kidney diseases : the official journal of the National Kidney Foundation, 1983, Volume: 3, Issue:2 Topics: Anti-Bacterial Agents; Cefoxitin; Cimetidine; Creatinine; Drug Combinations; False Positive Reactions; Glomerular Filtration Rate; Humans; Kidney Function Tests; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination	1983
Effect of cimetidine on oral absorption of ampicillin and cotrimoxazole. The Journal of antimicrobial chemotherapy, 1980, Volume: 6, Issue:2 Topics: Adult; Ampicillin; Cimetidine; Drug Combinations; Drug Interactions; Female; Food; Guanidines; Half-Life; Humans; Intestinal Absorption; Kinetics; Male; Middle Aged; Sulfamethoxazole; Trimethoprim	1980
Effect of trimethoprim on the renal clearance of lamivudine in rats. The Journal of pharmacy and pharmacology, 2000, Volume: 52, Issue:3 Topics: Animals; Anti-HIV Agents; Cimetidine; Drug Interactions; Glomerular Filtration Rate; Kidney; Lamivudine; Male; Metabolic Clearance Rate; Probenecid; Quinidine; Rats; Rats, Wistar; Time Factors; Trimethoprim	2000
Dofetilide for atrial fibrillation. The Medical letter on drugs and therapeutics, 2000, May-15, Volume: 42, Issue:1078 Topics: Anti-Arrhythmia Agents; Anti-Infective Agents; Anti-Infective Agents, Urinary; Anti-Ulcer Agents; Antifungal Agents; Atrial Fibrillation; Cimetidine; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Interactions; Humans; Ketoconazole; Phenethylamines; Potassium Channel Blockers; Sulfamethoxazole; Sulfonamides; Torsades de Pointes; Trimethoprim	2000
Uptake of lamivudine by rat renal brush border membrane vesicles. The Journal of pharmacy and pharmacology, 2002, Volume: 54, Issue:1 Topics: Animals; Anti-HIV Agents; Antimalarials; Biological Transport; Cimetidine; Drug Interactions; Ion Transport; Kidney Cortex; Lamivudine; Metabolic Clearance Rate; Microvilli; Rats; Trimethoprim	2002
The human organic cation transporter (hOCT2) recognizes the degree of substrate ionization. The Journal of biological chemistry, 2002, Jun-21, Volume: 277, Issue:25 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Binding, Competitive; Biological Transport; CHO Cells; Cimetidine; Corticosterone; Cricetinae; Dose-Response Relationship, Drug; Enzyme Inhibitors; Folic Acid Antagonists; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Ions; Kinetics; Organic Cation Transport Proteins; Organic Cation Transporter 2; Protein Binding; Pyridines; Substrate Specificity; Time Factors; Transfection; Trimethoprim	2002
Creatinine transport by basolateral organic cation transporter hOCT2 in the human kidney. Pharmaceutical research, 2004, Volume: 21, Issue:6 Topics: 1-Methyl-4-phenylpyridinium; Anions; Carbon Radioisotopes; Cations; Cell Line; Cimetidine; Creatinine; Dose-Response Relationship, Drug; Estrone; Humans; Japan; Kidney Tubules; Membrane Potentials; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Transfection; Trimethoprim; Tritium	2004
Transcellular transport of creatinine in renal tubular epithelial cell line LLC-PK1. Drug metabolism and pharmacokinetics, 2005, Volume: 20, Issue:3 Topics: Animals; Anions; Biological Transport; Cations; Cimetidine; Creatinine; Kidney Tubules; LLC-PK1 Cells; Membrane Potentials; Swine; Tetraethylammonium; Trimethoprim	2005
Intermittent unexplained abdominal pain: is it porphyria? Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2007, Volume: 5, Issue:11 Topics: Abdominal Pain; Acute Disease; Adult; Aminolevulinic Acid; Anti-Infective Agents; Cimetidine; Contraceptives, Oral; Diet, Reducing; Enzyme Inhibitors; Female; Heme; Hemin; Humans; Liver; Liver Transplantation; Porphobilinogen; Porphyrias, Hepatic; Sulfamethoxazole; Trimethoprim; Urinary Tract Infections	2007
Chloramphenicol significantly affects the pharmacokinetics of oral methadone in Greyhound dogs. Veterinary anaesthesia and analgesia, 2015, Volume: 42, Issue:6 Topics: Administration, Oral; Analgesics, Opioid; Animals; Chloramphenicol; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Dogs; Drug Interactions; Female; Fluoxetine; Ketoconazole; Male; Medetomidine; Methadone; Trimethoprim	2015
Renal Transporter-Mediated Drug-Biomarker Interactions of the Endogenous Substrates Creatinine and N Clinical pharmacology and therapeutics, 2022, Volume: 112, Issue:3 Topics: Biomarkers; Cimetidine; Creatinine; Drug Interactions; Humans; Organic Cation Transport Proteins; Pharmaceutical Preparations; Pyrimethamine; Trimethoprim	2022