trimethoprim has been researched along with brodimoprim in 66 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (22.73) | 18.7374 |
| 1990's | 47 (71.21) | 18.2507 |
| 2000's | 3 (4.55) | 29.6817 |
| 2010's | 1 (1.52) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Richards, WG; So, SS | 1 |
| Hansch, C; Li, RL; Poe, M; Selassie, CD | 1 |
| Debnath, G; Fang, ZX; Hansch, C; Kaufman, BT; Klein, TE; Langridge, R; Li, RL; Selassie, CD | 1 |
| Doweyko, AM | 1 |
| Fang, ZX; Hansch, C; Kaufman, BT; Klein, T; Langridge, R; Li, RL; Selassie, CD | 1 |
| Coats, EA; Genther, CS; Hansch, C; Selassie, CD; Strong, CD | 1 |
| Catana, C; Dunn, WJ; Duraiswami, C; Hopfinger, AJ | 1 |
| Papoulis, AT; Queener, SF; Rosowsky, A | 1 |
| Loukas, YL | 1 |
| Bera, S; Mondal, D | 1 |
| Gaspari, F; Pochobradsky, MG; Taiocchi, L | 1 |
| Braga, PC; Piatti, G; Reggio, S | 1 |
| Dhople, AM; Jagannathan, R; Mahadevan, PR; Rosenfeld, M; Seydel, JK; Wempe, EG | 1 |
| Hughes, WT | 1 |
| Kylmämaa, T; Lehtomäki, K; Salmi, HA | 1 |
| Gelber, RH | 1 |
| Caffrey, E; Climax, J; Darragh, A; Kenny, M; Lambe, R; Lenehan, TJ | 1 |
| Bergan, T; Digranes, A; Kalager, T; Salveson, A | 1 |
| Rosenfeld, M; Seydel, JK; Wempe, EG | 1 |
| Hermann, F; Then, RL | 1 |
| Birdsall, B; Feeney, J; Kompis, I; Kroehn, A; Müller, K; Pascual, C; Roberts, GC; Then, RL | 1 |
| Davies, BI; Maesen, FP; Salemans, T; van Noord, JA | 1 |
| Schwarzenbach, J; Wüst, J | 1 |
| Iversen, P; Madsen, PO | 1 |
| Birdsall, B; Feeney, J; Kompis, I; Morgan, WD; Polshakov, VI; Sali, D | 1 |
| Periti, P | 1 |
| Arndt, J; Maier, H; Riebenfeld, D; Weidauer, H | 1 |
| Stephan-Güldner, M | 1 |
| Amyes, SG | 1 |
| Seydel, JK | 1 |
| Nicoletti, P; Novelli, A; Periti, P | 1 |
| Benoit-Lemercier, C; Bergogne-Bérézin, E; Joly-Guillou, ML | 1 |
| Braga, PC; Gazzola, T; Limoli, A; Piatti, G; Santoro, M | 1 |
| Thomson, CJ | 1 |
| Weidekamm, E | 1 |
| Borzio, F; Deroubaix, X; Gaspari, F; Jeanbaptiste, B; Lebacq, E; Lins, R; Pavesio, D; Pelozi, GC; Rosillon, D; Stockis, A | 1 |
| Bergan, T | 1 |
| Cogo, R; Demartini, G; Dugnani, S; Fraschini, F; Maccarinelli, G; Pintucci, JP; Scaglione, F | 1 |
| Cassetta, MI; Fallani, S; Mazzei, T; Meli, E; Novelli, A; Periti, P | 1 |
| Coronnello, M; Fallani, S; Mini, E; Novelli, A; Periti, P; Pesciullesi, A | 1 |
| Braunsteiner, AR; Finsinger, F | 1 |
| Bandau, KH; Nouri, ME; Nyffenegger, R; Riebenfeld, D; Schirmböck, U; Streppel, M | 1 |
| Bisetti, A; Marchioni, CF; Moretti, M | 1 |
| Caroggio, A; Manzini, M | 1 |
| Münzel, MA | 1 |
| Camaioni, A; De Campora, E; Radici, M | 1 |
| Salmi, HA | 1 |
| Bellosta, C; Boccazzi, A; Careddu, P; Tonelli, P | 1 |
| Salzberg, R | 1 |
| Dallari, S; Galetti, G | 1 |
| Bergamini, G; Cantini, L; Dallari, S; Galetti, G; Ghidini, A; Martini, A; Mazzoli, M; Monici Preti, PA | 1 |
| Herz, G | 1 |
| Campora, U; Debbia, EA; Marchese, A; Massaro, S; Schito, G | 1 |
| Abate, F; Balsotti, G; Cantini, L; Carlomagno, G; Cirese, E; Cosmi, EV; Di Renzo, GC; Indraccolo, R; La Sala, GB; Mearini, L; Minozzi, M; Monici Preti, PA; Scarpello, F | 1 |
| Cocuzza, C; Cogo, R; Demartini, G; Raschi, S; Scaglione, F | 1 |
| Richards, RM; Xing, JZ | 1 |
| Braga, PC; Reggio, S | 1 |
| Bondiolotti, G; Braga, PC; Dal Sasso, M; Fonti, E; Maci, S; Reggio, S | 1 |
| Fresta, M; Furneri, PM; Mezzasalma, E; Nicolosi, VM; Puglisi, G | 1 |
| Cocci, A; Conforti, A; Gugliemo, L; Leone, R; Naldi, L; Venegoni, M | 1 |
| Birdsall, B; Feeney, J; Gargaro, AR; Morgan, WD; Nieto, PM | 1 |
| Dhople, AM | 1 |
| He, W; Kong, M; Si, Y; Xu, R; Zhang, S | 1 |
| Bettinetti, G; Caira, MR; Catenacci, L; Sorrenti, M | 1 |
| Li, Q; Liu, C; Song, N; Zhang, S | 1 |
7 review(s) available for trimethoprim and brodimoprim
| Article | Year |
|---|---|
Insights of synthetic analogues of anti-leprosy agents.
Topics: Humans; Leprostatic Agents; Leprosy; Structure-Activity Relationship | 2019 |
Brodimoprim, a new bacterial dihydrofolate reductase inhibitor: a minireview.
Topics: Anti-Bacterial Agents; Drug Evaluation; Folic Acid Antagonists; Humans; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1995 |
Preclinical toxicology and safety pharmacology of brodimoprim in comparison to trimethoprim and analogs.
Topics: Animals; Drug Evaluation, Preclinical; Mice; Mutagenicity Tests; Rabbits; Trimethoprim | 1993 |
Comparative antibacterial spectrum of trimethoprim and brodimoprim.
Topics: Animals; Gram-Negative Bacteria; Gram-Positive Bacteria; Mice; Microbial Sensitivity Tests; Trimethoprim | 1993 |
In vitro and in vivo results of brodimoprim and analogues alone and in combination against E. coli and mycobacteria.
Topics: Dapsone; Dihydropteroate Synthase; Escherichia coli; Escherichia coli Infections; Humans; Leprosy; Mycobacterium; Mycobacterium Infections; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1993 |
Trimethoprim and brodimoprim resistance of gram-positive and gram-negative bacteria.
Topics: Folic Acid Antagonists; Gram-Negative Bacteria; Gram-Positive Bacteria; Tetrahydrofolate Dehydrogenase; Trimethoprim; Trimethoprim Resistance | 1993 |
Pharmacokinetic profile of brodimoprim: oral bioavailability and penetration into interstitial fluid.
Topics: Administration, Oral; Biological Availability; Capillary Permeability; Extracellular Space; Humans; Trimethoprim | 1993 |
15 trial(s) available for trimethoprim and brodimoprim
| Article | Year |
|---|---|
Comparison of brodimoprim and doxycycline in acute respiratory tract infections. A double-blind clinical trial.
Topics: Adolescent; Adult; Clinical Trials as Topic; Double-Blind Method; Doxycycline; Drug Tolerance; Humans; Random Allocation; Respiratory Tract Infections; Trimethoprim | 1986 |
Therapeutic efficacy and tolerability of brodimoprim in comparison with doxycycline in acute sinusitis in adults.
Topics: Acute Disease; Adult; Bacteria; Doxycycline; Female; Humans; Male; Middle Aged; Sinusitis; Trimethoprim | 1994 |
Brodimoprim concentrations in bronchial mucosa, bronchial secretions and middle ear effusions.
Topics: Administration, Oral; Adult; Aged; Bronchi; Bronchitis; Chronic Disease; Exudates and Transudates; Female; Humans; Male; Middle Aged; Otitis Media with Effusion; Trimethoprim; Tympanic Membrane Perforation | 1993 |
Brodimoprim: therapeutic efficacy and safety in the treatment of bacterial infections.
Topics: Adult; Bacterial Infections; Child; Double-Blind Method; Female; Gastroenteritis; Humans; Male; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Respiratory Tract Infections; Trimethoprim; Typhoid Fever | 1993 |
A multicenter comparative study of brodimoprim and amoxicillin therapy in the treatment of tonsillopharyngitis in adults.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Amoxicillin; Bacterial Infections; Child; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Pharyngitis; Pneumococcal Infections; Staphylococcal Infections; Tonsillitis; Trimethoprim | 1993 |
Efficacy and tolerability of brodimoprim in respiratory tract infections.
Topics: Adult; Erythromycin; Female; Gram-Negative Bacterial Infections; Humans; Male; Middle Aged; Respiratory Tract Infections; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1993 |
Efficacy and tolerability of brodimoprim and roxithromycin in acute sinusitis of bacterial origin in adults.
Topics: Acute Disease; Adolescent; Adult; Aged; Bacterial Infections; Female; Frontal Sinusitis; Humans; Male; Maxillary Sinusitis; Middle Aged; Roxithromycin; Trimethoprim | 1993 |
Brodimoprim in maxillary sinusitis.
Topics: Administration, Oral; Bacterial Infections; Combined Modality Therapy; Doxycycline; Humans; Maxillary Sinus; Maxillary Sinusitis; Postoperative Care; Trimethoprim | 1993 |
Efficacy and tolerability of brodimoprim in otitis.
Topics: Acute Disease; Adolescent; Adult; Aged; Bacterial Infections; Drug Tolerance; Exudates and Transudates; Female; Humans; Josamycin; Male; Middle Aged; Otitis Media; Trimethoprim | 1993 |
Brodimoprim in acute respiratory tract infections.
Topics: Acute Disease; Adolescent; Adult; Body Temperature; Cough; Double-Blind Method; Doxycycline; Drug Tolerance; Humans; Length of Stay; Leukocyte Count; Leukocytes; Male; Mycoplasma Infections; Neutrophils; Respiration; Respiratory Tract Infections; Trimethoprim; Virus Diseases | 1993 |
Efficacy and tolerability of brodimoprim in pediatric infections.
Topics: Adolescent; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Child; Child, Preschool; Clavulanic Acids; Drug Therapy, Combination; Erythromycin; Humans; Otitis Media; Pharyngitis; Respiratory Tract Infections; Sinusitis; Tonsillitis; Trimethoprim | 1993 |
A randomized, open, comparative study of brodimoprim versus erythromycin in patients with acute tonsillitis or bronchitis.
Topics: Acute Disease; Bronchitis; Child; Child, Preschool; Erythromycin; Female; Humans; Infant; Male; Tonsillitis; Trimethoprim | 1993 |
Efficacy and tolerability of brodimoprim in bacterial otitis media in children. Controlled study versus cefaclor.
Topics: Acute Disease; Bacterial Infections; Cefaclor; Child; Child, Preschool; Female; Humans; Male; Otitis Media; Otitis Media with Effusion; Trimethoprim | 1993 |
Efficacy and tolerability of brodimoprim at two different dosage schedules in the treatment of acute uncomplicated bacterial cystitis: comparative study vs. pefloxacin.
Topics: Acute Disease; Adult; Aged; Anti-Infective Agents; Bacterial Infections; Cystitis; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Pefloxacin; Treatment Outcome; Trimethoprim | 1996 |
Efficacy and tolerability of brodimoprim od versus norfloxacin bid in the treatment of bacterial urinary tract infections.
Topics: Adult; Anti-Infective Agents; Clinical Trials, Phase III as Topic; Female; Folic Acid Antagonists; Humans; Male; Middle Aged; Norfloxacin; Trimethoprim; Urinary Tract Infections | 1995 |
44 other study(ies) available for trimethoprim and brodimoprim
| Article | Year |
|---|---|
Application of neural networks: quantitative structure-activity relationships of the derivatives of 2,4-diamino-5-(substituted-benzyl)pyrimidines as DHFR inhibitors.
Topics: Drug Design; Folic Acid Antagonists; Neural Networks, Computer; Pyrimidines; Regression Analysis; Structure-Activity Relationship | 1992 |
On the optimization of hydrophobic and hydrophilic substituent interactions of 2,4-diamino-5-(substituted-benzyl)pyrimidines with dihydrofolate reductase.
Topics: Diamines; Escherichia coli; Folic Acid Antagonists; Kinetics; Lacticaseibacillus casei; Molecular Structure; Protein Binding; Pyrimidines; Structure-Activity Relationship | 1991 |
On the structure selectivity problem in drug design. A comparative study of benzylpyrimidine inhibition of vertebrate and bacterial dihydrofolate reductase via molecular graphics and quantitative structure-activity relationships.
Topics: Animals; Chemical Phenomena; Chemistry; Chickens; Drug Design; Folic Acid Antagonists; Lacticaseibacillus casei; Liver; Pyrimidines; Structure-Activity Relationship; X-Ray Diffraction | 1989 |
The hypothetical active site lattice. An approach to modelling active sites from data on inhibitor molecules.
Topics: Binding Sites; Binding, Competitive; Chemical Phenomena; Chemistry; Enzyme Inhibitors; Escherichia coli; Folic Acid Antagonists; Lactoylglutathione Lyase; Lyases; Microcomputers; Models, Chemical; Models, Molecular; Molecular Conformation; Saccharomyces cerevisiae; Structure-Activity Relationship; Thermodynamics | 1988 |
Inhibition of chicken liver dihydrofolate reductase by 5-(substituted benzyl)-2,4-diaminopyrimidines. A quantitative structure-activity relationship and graphics analysis.
Topics: Animals; Chickens; Crystallography; Enzyme Inhibitors; Folic Acid Antagonists; Liver; Mathematics; Models, Molecular; Pyrimidines; Structure-Activity Relationship; Trimethoprim; X-Ray Diffraction | 1986 |
Quantitative structure-activity relationship of antifolate inhibition of bacteria cell cultures resistant and sensitive to methotrexate.
Topics: Biological Transport, Active; Chemical Phenomena; Chemistry; Drug Resistance, Microbial; Escherichia coli; Folic Acid Antagonists; Lacticaseibacillus casei; Mathematics; Methotrexate; Pyrimethamine; Pyrimidines; Structure-Activity Relationship; Triazines | 1985 |
Solution of the conformation and alignment tensors for the binding of trimethoprim and its analogs to dihydrofolate reductase: 3D-quantitative structure-activity relationship study using molecular shape analysis, 3-way partial least-squares regression, an
Topics: Chemical Phenomena; Chemistry; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Escherichia coli; Folic Acid Antagonists; Molecular Conformation; Molecular Structure; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1996 |
2,4-Diaminothieno[2,3-d]pyrimidine lipophilic antifolates as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.
Topics: Animals; Enzyme Inhibitors; Folic Acid Antagonists; Liver; Magnetic Resonance Spectroscopy; Pneumocystis; Pyrimidines; Rats; Tetrahydrofolate Dehydrogenase; Thiophenes; Toxoplasma | 1997 |
Adaptive neuro-fuzzy inference system: an instant and architecture-free predictor for improved QSAR studies.
Topics: Algorithms; Folic Acid Antagonists; Multivariate Analysis; Pyrimidines; Quantitative Structure-Activity Relationship; Regression Analysis; Tetrahydrofolate Dehydrogenase | 2001 |
Determination of brodimoprim and its hydroxy metabolite in human plasma, blood and urine by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Humans; Reproducibility of Results; Spectrometry, Fluorescence; Trimethoprim | 1992 |
Sub-inhibitory concentrations of brodimoprim inhibit adhesion of E. coli to human uroepithelial cells.
Topics: Bacterial Adhesion; Cells, Cultured; Epithelium; Escherichia coli; Humans; Trimethoprim | 1992 |
In vitro and in vivo experiments with the new inhibitor of mycobacterium leprae brodimoprim alone and in combination with dapsone.
Topics: Adenosine Triphosphate; Animals; Chromatography, High Pressure Liquid; Dapsone; Drug Interactions; Leprostatic Agents; Leprosy; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Mycobacterium leprae; Receptors, Fc; Thymidine; Trimethoprim | 1990 |
Comparison of dosages, intervals, and drugs in the prevention of Pneumocystis carinii pneumonia.
Topics: Amidines; Animals; Anti-Infective Agents; Dapsone; Drug Administration Schedule; Drug Combinations; Immunosuppression Therapy; Male; Pentamidine; Pneumonia, Pneumocystis; Rats; Rats, Inbred Strains; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1988 |
The use of rodent models in assessing antimicrobial activity against Mycobacterium leprae.
Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Drug Evaluation, Preclinical; Mice; Microbial Sensitivity Tests; Minocycline; Mycobacterium leprae; Rats; Trimethoprim | 1986 |
Interaction of antimicrobial agents with human peripheral blood leucocytes: uptake and intracellular localization of certain sulphonamides and trimethoprims.
Topics: Chromatography, High Pressure Liquid; Humans; In Vitro Techniques; Leukocytes; Neutrophils; Phagocytosis; Subcellular Fractions; Sulfonamides; Trimethoprim; Zymosan | 1986 |
Pharmacokinetics of brodimoprim in serum and skin blister fluid.
Topics: Administration, Oral; Adult; Blister; Female; Humans; Kinetics; Male; Trimethoprim | 1985 |
Bacterial growth kinetics of Escherichia coli and mycobacteria in the presence of brodimoprim and metioprim alone and in combination with sulfamerazine and dapsone (VI).
Topics: Anti-Bacterial Agents; Dapsone; Drug Synergism; Escherichia coli; Kinetics; Microbial Sensitivity Tests; Mycobacterium; Sulfamerazine; Trimethoprim | 1983 |
Properties of brodimoprim as an inhibitor of dihydrofolate reductases.
Topics: Animals; Bacteria; Cattle; Chickens; Columbidae; Dogs; Folic Acid Antagonists; In Vitro Techniques; Kinetics; Liver; Papio; Rats; Species Specificity; Trimethoprim; Trypanosoma cruzi | 1984 |
A 1H NMR study of the interactions and conformations of rationally designed brodimoprim analogues in complexes with Lactobacillus casei dihydrofolate reductase.
Topics: Binding Sites; Folic Acid Antagonists; Indicators and Reagents; Lacticaseibacillus casei; Magnetic Resonance Spectroscopy; Methotrexate; Models, Molecular; Molecular Conformation; Protein Binding; Structure-Activity Relationship; Trimethoprim | 1984 |
Brodimoprim in acute exacerbations of chronic bronchitis: a clinical and bacteriological pilot study.
Topics: Acute Disease; Bacterial Infections; Bronchitis; Humans; Pilot Projects; Sputum; Trimethoprim | 1984 |
Activity of brodimoprim and metioprim alone and in combination with sulfonamides against anaerobic bacteria.
Topics: Anaerobiosis; Anti-Bacterial Agents; Bacteria; Drug Combinations; Microbial Sensitivity Tests; Sulfonamides; Trimethoprim | 1983 |
Trimethoprim, metioprim, tetroxoprim, and RO 10-5970 in canine bone.
Topics: Animals; Bone and Bones; Dogs; Male; Pyrimidines; Trimethoprim | 1982 |
Solution structure of a brodimoprim analogue in its complex with Lactobacillus casei dihydrofolate reductase.
Topics: Amino Acid Sequence; Binding Sites; Lacticaseibacillus casei; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Molecular Structure; Solutions; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1995 |
Seminar on Bacterial Dihydrofolate Reductase Inhibitors in Antimicrobial Chemotherapy. Proceedings. Florence, Italy, September 9-10, 1993.
Topics: Animals; Anti-Infective Agents; Folic Acid Antagonists; Humans; Trimethoprim | 1993 |
In vitro brodimoprim activity on nosocomial bacterial strains.
Topics: Cross Infection; Enterobacter; Gram-Negative Bacteria; Gram-Positive Cocci; Humans; Microbial Sensitivity Tests; Regression Analysis; Staphylococcus; Trimethoprim | 1993 |
In vitro brodimoprim activity on bacterial strains.
Topics: Anti-Bacterial Agents; Erythromycin; Gram-Negative Bacteria; Gram-Positive Bacteria; Gram-Positive Cocci; Lactams; Microbial Sensitivity Tests; Respiratory Tract Infections; Trimethoprim | 1993 |
Inhibition of bacterial adhesion by sub-inhibitory concentrations: brodimoprim vs trimethoprim.
Topics: Bacterial Adhesion; Cells, Cultured; Epithelial Cells; Epithelium; Escherichia coli; Folic Acid Antagonists; Humans; Kinetics; Microbial Sensitivity Tests; Microscopy, Electron, Scanning; Mouth Mucosa; Staphylococcus aureus; Trimethoprim | 1993 |
Pharmacokinetics of brodimoprim.
Topics: Administration, Oral; Adult; Blood Proteins; Drug Administration Schedule; Female; Half-Life; Humans; Male; Middle Aged; Protein Binding; Trimethoprim | 1993 |
Pharmacokinetics of brodimoprim in special populations.
Topics: Adult; Aged; Aged, 80 and over; Aging; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Liver Diseases; Male; Middle Aged; Renal Insufficiency; Trimethoprim | 1993 |
Pharmacokinetics and blister fluid penetration of brodimoprim in adults.
Topics: Adult; Aged; Blister; Exudates and Transudates; Humans; Male; Middle Aged; Trimethoprim | 1993 |
In vitro effects of brodimoprim on human polymorphonuclear leukocyte functions. Preliminary results.
Topics: Cells, Cultured; Chemotaxis, Leukocyte; Humans; Neutrophils; Phagocytosis; Superoxides; Time Factors; Trimethoprim | 1993 |
Efficacy and tolerability of brodimoprim in pharyngotonsillitis in children.
Topics: Adolescent; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Child; Child, Preschool; Clavulanic Acids; Drug Therapy, Combination; Humans; Pharyngitis; Suspensions; Tonsillitis; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1993 |
Respiratory infections in children: when is brodimoprim indicated?
Topics: Bacterial Infections; Child; Child, Preschool; Erythromycin; Female; Humans; Infant; Infant, Newborn; Male; Respiratory Tract Infections; Trimethoprim; Virus Diseases | 1993 |
Brodimoprim: effects of subminimal inhibitory concentrations on virulence traits of respiratory and urinary tract pathogens, and on plasmid transfer and stability.
Topics: Bacterial Adhesion; beta-Lactamases; Cell Adhesion; Cells, Cultured; Cheek; Endopeptidases; Epithelial Cells; Epithelium; Folic Acid Antagonists; Haemophilus influenzae; Hemolysin Proteins; Klebsiella pneumoniae; Moraxella catarrhalis; Plasmids; Respiratory Tract Infections; Streptococcus pneumoniae; Streptolysins; Trachea; Trimethoprim; Urinary Tract Infections | 1996 |
Brodimoprim synergy against Enterococcus faecalis evaluated in vitro.
Topics: Anti-Bacterial Agents; Carbenicillin; Ciprofloxacin; Drug Synergism; Drug Therapy, Combination; Enterococcus faecalis; Enzyme Inhibitors; Evaluation Studies as Topic; Folic Acid Antagonists; Gentamicins; Microbial Sensitivity Tests; Rifampin; Trimethoprim | 1996 |
Correlation between reduction of surface hydrophobicity of S. aureus and the decrease in its adhesiveness induced by subinhibitory concentrations of brodimoprim.
Topics: Bacterial Adhesion; Cells, Cultured; Chemical Phenomena; Chemistry, Physical; Epithelium; Folic Acid Antagonists; Humans; Microbial Sensitivity Tests; Mouth Mucosa; Staphylococcus aureus; Surface Properties; Trimethoprim | 1995 |
Penetration of brodimoprim into human neutrophils and intracellular activity.
Topics: Anti-Infective Agents; Antimetabolites; Cell Survival; Chromatography, High Pressure Liquid; Folic Acid Antagonists; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Microbial Sensitivity Tests; Neutrophils; Phagocytosis; Respiratory Burst; Temperature; Trimethoprim | 1996 |
Correlation of trimethoprim and brodimoprim physicochemical and lipid membrane interaction properties with their accumulation in human neutrophils.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Anti-Infective Agents; Biological Transport; Calorimetry, Differential Scanning; Humans; Hydrogen-Ion Concentration; Lipid Bilayers; Neutrophils; Octanols; Permeability; Solubility; Trimethoprim | 1996 |
Brodimoprim: adverse drug reactions from spontaneous reporting.
Topics: Adverse Drug Reaction Reporting Systems; Anti-Infective Agents; Central Nervous System Diseases; Gastrointestinal Diseases; Humans; Italy; Skin Diseases; Trimethoprim | 1997 |
1H/15N HSQC NMR studies of ligand carboxylate group interactions with arginine residues in complexes of brodimoprim analogues and Lactobacillus casei dihydrofolate reductase.
Topics: Arginine; Carboxylic Acids; Crystallography, X-Ray; Enzyme Inhibitors; Folic Acid Antagonists; Lacticaseibacillus casei; Ligands; Macromolecular Substances; Nitrogen Isotopes; Nuclear Magnetic Resonance, Biomolecular; Protons; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1999 |
In vitro activity of epiroprim, a dihydrofolate reductase inhibitor, singly and in combination with brodimoprim and dapsone, against Mycobacterium leprae.
Topics: Cell-Free System; Dapsone; Folic Acid Antagonists; Leprostatic Agents; Microbial Sensitivity Tests; Mycobacterium leprae; Trimethoprim | 1999 |
[Solid-phase extraction coupled with high-field proton nuclear magnetic resonance spectroscopy: application to the analysis of brodimoprim metabolites in rat urine].
Topics: Animals; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Wistar; Trimethoprim | 1998 |
Relationships between structural and thermal properties of anhydrous and solvated crystalline forms of brodimoprim.
Topics: 2-Propanol; Anti-Infective Agents; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Crystallization; Crystallography, X-Ray; Formates; Hydrogen Bonding; Microscopy, Polarization; Models, Chemical; Models, Molecular; Molecular Conformation; Powder Diffraction; Powders; Solvents; Thermogravimetry; Transition Temperature; Trimethoprim; Water | 2007 |
Establishment of a liquid chromatographic/mass spectrometry method for quantification of tetrandrine in rat plasma and its application to pharmacokinetic study.
Topics: Animals; Area Under Curve; Benzylisoquinolines; Calibration; Chromatography, Liquid; Drug Stability; Fasting; Female; Half-Life; Immunosuppressive Agents; Male; Mass Spectrometry; Molecular Structure; Quality Control; Rats; Rats, Sprague-Dawley; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Time Factors; Trimethoprim | 2008 |