trimethoprim has been researched along with aminopterin in 22 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (54.55) | 18.7374 |
| 1990's | 3 (13.64) | 18.2507 |
| 2000's | 6 (27.27) | 29.6817 |
| 2010's | 1 (4.55) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gangjee, A; Mavandadi, F; McGuire, JJ; Queener, SF | 1 |
| Bertino, JR; Ercikan-Abali, E; Mota, CE; Queener, SF; Rosowsky, A; Waltham, M | 1 |
| Elzein, E; Gangjee, A; McGuire, JJ; Queener, SF | 1 |
| Gangjee, A; Kisliuk, RL; McGuire, JJ; Zeng, Y | 1 |
| Gangjee, A; Haile, WH; Kisliuk, RL; McGuire, JJ; Sobrero, G; Yu, J | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Bera, S; Mondal, D | 1 |
| Danchin, A; Joseph, E; Ullmann, A | 1 |
| Birdsall, B; Burgen, AS; Feeney, J; Roberts, GC; Way, JL | 1 |
| Arnold, HH | 1 |
| Girdwood, RH | 1 |
| Andrews, PR; Sadek, M; Spark, MJ; Winkler, DA | 1 |
| Sirotnak, FM | 1 |
| McCullough, JL; Weinstein, GD | 1 |
| Brown, VH; Colwell, WT; DeGraw, JI; Morrison, NE | 1 |
| Kelln, RA; Warren, RA | 1 |
| Deering, RA; Michrina, CA | 1 |
| Bush, K; Freudenberger, JS; Meyers, E; Slusarchyk, DS; Sykes, RB | 1 |
| Hermann, F; Then, RL | 1 |
1 review(s) available for trimethoprim and aminopterin
| Article | Year |
|---|---|
Insights of synthetic analogues of anti-leprosy agents.
Topics: Humans; Leprostatic Agents; Leprosy; Structure-Activity Relationship | 2019 |
21 other study(ies) available for trimethoprim and aminopterin
| Article | Year |
|---|---|
Novel 2,4-diamino-5-substituted-pyrrolo[2,3-d]pyrimidines as classical and nonclassical antifolate inhibitors of dihydrofolate reductases.
Topics: Folic Acid Antagonists; Humans; Peptide Synthases; Pyrimidines; Tumor Cells, Cultured | 1995 |
2,4-Diamino-5-substituted-quinazolines as inhibitors of a human dihydrofolate reductase with a site-directed mutation at position 22 and of the dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii.
Topics: Animals; Folic Acid Antagonists; Humans; In Vitro Techniques; Liver; Mutagenesis, Site-Directed; Pneumocystis; Quinazolines; Rats; Structure-Activity Relationship; Toxoplasma | 1995 |
Synthesis and biological activities of tricyclic conformationally restricted tetrahydropyrido annulated furo[2,3-d]pyrimidines as inhibitors of dihydrofolate reductases.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antimetabolites, Antineoplastic; Cell Division; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Glutamic Acid; Humans; Liver; Methotrexate; Mycobacterium avium; Pneumocystis; Pyrimidines; Rats; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Toxoplasma; Tumor Cells, Cultured | 1998 |
Synthesis of classical and nonclassical, partially restricted, linear, tricyclic 5-deaza antifolates.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; Drug Resistance, Neoplasm; Escherichia coli; Folic Acid Antagonists; Heterocyclic Compounds, 3-Ring; Humans; Methotrexate; Molecular Conformation; Peptide Synthases; Pneumocystis; Recombinant Proteins; Species Specificity; Structure-Activity Relationship; Substrate Specificity; Tetrahydrofolate Dehydrogenase; Toxoplasma; Tumor Cells, Cultured | 2002 |
Design, synthesis, and biological activities of classical N-[4-[2-(2-amino-4-ethylpyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid and its 6-methyl derivative as potential dual inhibitors of thymidylate synthase and dihydrofolate reductase and
Topics: Antineoplastic Agents; Cell Division; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Escherichia coli; Folic Acid Antagonists; Glutamic Acid; Humans; Lacticaseibacillus casei; Peptide Synthases; Pyrimidines; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Tumor Cells, Cultured | 2003 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection | 2009 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Modulation of the lactose operon mRNA turnover by inhibitors of dihydrofolate reductase.
Topics: Aminoglycosides; Aminopterin; Anti-Bacterial Agents; beta-Galactosidase; Chloramphenicol; Enzyme Induction; Escherichia coli; Folic Acid Antagonists; Kinetics; Lac Operon; RNA, Messenger; Trimethoprim | 1978 |
A nuclear magnetic resonance study of nicotinamide adenine dinucleotide phosphate binding to Lactobacillus casei dihydrofolate reductase.
Topics: Amides; Aminopterin; Binding Sites; Carbon Isotopes; Carboxylic Acids; Folic Acid; Kinetics; Lacticaseibacillus casei; Magnetic Resonance Spectroscopy; Mathematics; Methotrexate; NADP; Protein Binding; Protein Conformation; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1975 |
Initiation of protein synthesis in bacillus subtilis in the presence of trimethoprim or aminopterin.
Topics: Aminopterin; Bacillus subtilis; Bacterial Proteins; Methionine; N-Formylmethionine; Peptide Chain Initiation, Translational; Phenylalanine; RNA, Bacterial; RNA, Transfer; Trimethoprim; Uridine | 1977 |
The nature of possible adverse reactions to co-trimoxazole.
Topics: Aminopterin; Anemia, Megaloblastic; Chemical Phenomena; Chemistry; Drug Combinations; Folic Acid; Humans; Methotrexate; Pyrimethamine; Sulfamethoxazole; Thrombocytopenia; Trimethoprim; Vitamin B 12 | 1976 |
Conformational energy calculations and electrostatic potentials of dihydrofolate reductase ligands: relevance to mode of binding and species specificity.
Topics: Aminopterin; Chemical Phenomena; Chemistry, Physical; Crystallization; Escherichia coli; Lactobacillus; Ligands; Methotrexate; Models, Molecular; Protein Conformation; Species Specificity; Stereoisomerism; Substrate Specificity; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1986 |
Two different effects of mutation on the binding of folate antagonists by a microbial dihydrofolate reductase.
Topics: Amines; Amino Acids; Aminopterin; Binding Sites; Cell-Free System; Folic Acid; Folic Acid Antagonists; Genes; Hydrogen-Ion Concentration; Kinetics; Methotrexate; Mutation; NADP; Pteridines; Pyrimethamine; Pyrimidines; Species Specificity; Streptococcus pneumoniae; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1973 |
Effect of lipid-soluble esters of methotrexate on DNA synthesis in human skin.
Topics: Aminopterin; Depression, Chemical; DNA; Esters; Humans; Lipids; Methotrexate; Pyrimethamine; Skin; Solubility; Temperature; Time Factors; Trimethoprim; Tritium; Uridine | 1974 |
Potential antileprotic agents. 2. Inhibition of mycobacterial dihydrofolic reductase.
Topics: Aminopterin; Folic Acid Antagonists; Kinetics; Leprosy; Methotrexate; Mycobacterium leprae; Protein Binding; Pteridines; Pyrimethamine; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1974 |
Obligate thymidine auxotrophs of Pseudomonas acidovorans.
Topics: Aminopterin; Culture Media; Mutation; Phosphotransferases; Pseudomonas; Thymidine; Thymine; Trimethoprim | 1973 |
Inhibitors of DNA precursor metabolism in Dictyostelium discoideum.
Topics: Aminopterin; Antimetabolites; Dictyostelium; DNA; Floxuridine; Folic Acid; Hydroxyurea; Methotrexate; Time Factors; Trimethoprim | 1982 |
Activity of sulfa drugs and dihydrofolate reductase inhibitors against Candida albicans.
Topics: Aminopterin; Animals; Candida albicans; Cattle; Folic Acid Antagonists; Kinetics; Liver; Methotrexate; NADP; Trimethoprim | 1982 |
Mechanisms of trimethoprim resistance in enterobacteria isolated in Finland.
Topics: Aminopterin; Drug Resistance, Microbial; Enterobacteriaceae; Enterobacteriaceae Infections; Finland; Folic Acid Antagonists; Humans; Microbial Sensitivity Tests; Trimethoprim | 1981 |