trimethoprim has been researched along with 2,4-diamino-5-benzylpyrimidine in 24 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (70.83) | 18.7374 |
| 1990's | 5 (20.83) | 18.2507 |
| 2000's | 2 (8.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fukunaga, JY; Hansch, C; Jow, PY | 1 |
| Blaney, JM; Dietrich, SW; Hansch, C; Reynolds, MA | 1 |
| Richards, WG; So, SS | 1 |
| Hansch, C; Li, RL; Poe, M; Selassie, CD | 1 |
| Debnath, G; Fang, ZX; Hansch, C; Kaufman, BT; Klein, TE; Langridge, R; Li, RL; Selassie, CD | 1 |
| Li, RL; Poe, M | 1 |
| Doweyko, AM | 1 |
| Fang, ZX; Hansch, C; Kaufman, BT; Klein, T; Langridge, R; Li, RL; Selassie, CD | 1 |
| Crippen, GM; Ghose, AK | 2 |
| Coats, EA; Genther, CS; Hansch, C; Selassie, CD; Strong, CD | 1 |
| Hopfinger, AJ | 1 |
| Blaney, JM; Hansch, C; Langridge, R; Li, R | 1 |
| Blaney, JM; Dietrich, SW; Hansch, C; Jow, PY; Reynolds, MA | 1 |
| Dietrich, SW; Hansch, C; Li, RL | 1 |
| Hansch, C; Kaufman, BT; Li, R | 1 |
| Dias, CB; Hansch, C; Khwaja, TA; Li, R; Selassie, CD | 1 |
| Battershell, C; Hopfinger, AJ; Malhotra, D | 1 |
| Catana, C; Dunn, WJ; Duraiswami, C; Hopfinger, AJ | 1 |
| Crippen, GM | 1 |
| Gan, WX; Kallander, LS; Klein, TE; Selassie, CD | 1 |
| Loukas, YL | 1 |
| Bartels, R; Hänsel, W; Kunz, B; Lehwark-Yvetot, G; Otzen, T; Schaper, KJ; Seydel, JK; Wempe, EG | 1 |
| Averett, DR; Baccanari, DP; Paterson, SJ; Roth, B; Stone, D; Tansik, RL | 1 |
24 other study(ies) available for trimethoprim and 2,4-diamino-5-benzylpyrimidine
| Article | Year |
|---|---|
Quantitative structure-activity relationships of antimalarial and dihydrofolate reductase inhibition by quinazolines and 5-substituted benzyl-2,4-diaminopyrimidines.
Topics: Animals; Antimalarials; Escherichia coli; Folic Acid Antagonists; Mathematics; Mice; Microbial Sensitivity Tests; Pyrimidines; Quinazolines; Streptococcus; Structure-Activity Relationship | 1977 |
Quantitative structure-activity relationship of 5-(X-benzyl)-2,4-diaminopyrimidines inhibiting bovine liver dihydrofolate reductase.
Topics: Animals; Cattle; Folic Acid Antagonists; In Vitro Techniques; Liver; Models, Biological; Pyrimidines; Structure-Activity Relationship | 1979 |
Application of neural networks: quantitative structure-activity relationships of the derivatives of 2,4-diamino-5-(substituted-benzyl)pyrimidines as DHFR inhibitors.
Topics: Drug Design; Folic Acid Antagonists; Neural Networks, Computer; Pyrimidines; Regression Analysis; Structure-Activity Relationship | 1992 |
On the optimization of hydrophobic and hydrophilic substituent interactions of 2,4-diamino-5-(substituted-benzyl)pyrimidines with dihydrofolate reductase.
Topics: Diamines; Escherichia coli; Folic Acid Antagonists; Kinetics; Lacticaseibacillus casei; Molecular Structure; Protein Binding; Pyrimidines; Structure-Activity Relationship | 1991 |
On the structure selectivity problem in drug design. A comparative study of benzylpyrimidine inhibition of vertebrate and bacterial dihydrofolate reductase via molecular graphics and quantitative structure-activity relationships.
Topics: Animals; Chemical Phenomena; Chemistry; Chickens; Drug Design; Folic Acid Antagonists; Lacticaseibacillus casei; Liver; Pyrimidines; Structure-Activity Relationship; X-Ray Diffraction | 1989 |
Quantitative structure-activity relationships for the inhibition of Escherichia coli dihydrofolate reductase by 5-(substituted benzyl)-2,4-diaminopyrimidines.
Topics: Binding Sites; Escherichia coli; Folic Acid Antagonists; Pyrimidines; Structure-Activity Relationship; Trimethoprim | 1988 |
The hypothetical active site lattice. An approach to modelling active sites from data on inhibitor molecules.
Topics: Binding Sites; Binding, Competitive; Chemical Phenomena; Chemistry; Enzyme Inhibitors; Escherichia coli; Folic Acid Antagonists; Lactoylglutathione Lyase; Lyases; Microcomputers; Models, Chemical; Models, Molecular; Molecular Conformation; Saccharomyces cerevisiae; Structure-Activity Relationship; Thermodynamics | 1988 |
Inhibition of chicken liver dihydrofolate reductase by 5-(substituted benzyl)-2,4-diaminopyrimidines. A quantitative structure-activity relationship and graphics analysis.
Topics: Animals; Chickens; Crystallography; Enzyme Inhibitors; Folic Acid Antagonists; Liver; Mathematics; Models, Molecular; Pyrimidines; Structure-Activity Relationship; Trimethoprim; X-Ray Diffraction | 1986 |
Use of physicochemical parameters in distance geometry and related three-dimensional quantitative structure-activity relationships: a demonstration using Escherichia coli dihydrofolate reductase inhibitors.
Topics: Binding Sites; Escherichia coli; Folic Acid Antagonists; Models, Molecular; Protein Conformation; Structure-Activity Relationship | 1985 |
Quantitative structure-activity relationship of antifolate inhibition of bacteria cell cultures resistant and sensitive to methotrexate.
Topics: Biological Transport, Active; Chemical Phenomena; Chemistry; Drug Resistance, Microbial; Escherichia coli; Folic Acid Antagonists; Lacticaseibacillus casei; Mathematics; Methotrexate; Pyrimethamine; Pyrimidines; Structure-Activity Relationship; Triazines | 1985 |
Theory and application of molecular potential energy fields in molecular shape analysis: a quantitative structure--activity relationship study of 2,4-diamino-5-benzylpyrimidines as dihydrofolate reductase inhibitors.
Topics: Escherichia coli; Folic Acid Antagonists; Models, Molecular; Pyrimidines; Structure-Activity Relationship; Thermodynamics; Trimethoprim | 1983 |
General distance geometry three-dimensional receptor model for diverse dihydrofolate reductase inhibitors.
Topics: Animals; Binding Sites; Chemical Phenomena; Chemistry, Physical; Crystallography; Folic Acid Antagonists; Liver; Models, Chemical; Pyridines; Pyrimidines; Pyrroles; Quinazolines; Rats; Structure-Activity Relationship; Triazines | 1984 |
Comparison of the inhibition of Escherichia coli and Lactobacillus casei dihydrofolate reductase by 2,4-diamino-5-(substituted-benzyl)pyrimidines: quantitative structure-activity relationships, X-ray crystallography, and computer graphics in structure-act
Topics: Binding Sites; Computers; Escherichia coli; Folic Acid Antagonists; Lacticaseibacillus casei; Models, Molecular; Pyrimidines; Structure-Activity Relationship; X-Ray Diffraction | 1982 |
Quantitative structure-selectivity relationships. Comparison of the inhibition of Escherichia coli and bovine liver dihydrofolate reductase by 5-(substituted-benzyl)-2,4-diaminopyrimidines.
Topics: Animals; Cattle; Escherichia coli; Folic Acid Antagonists; Kinetics; Liver; Models, Theoretical; Pyrimidines; Structure-Activity Relationship | 1980 |
Quantitative structure-selectivity relationships. Comparison of the inhibition of Escherichia coli and bovine liver dihydrofolate reductase by 5-(substituted-benzyl)-2,4-diaminopyrimidines.
Topics: Animals; Cattle; Escherichia coli; Folic Acid Antagonists; In Vitro Techniques; Kinetics; Liver; Pyrimidines; Structure-Activity Relationship | 1981 |
A comparison of the inhibitory action of 5-(substituted-benzyl)-2,4-diaminopyrimidines on dihydrofolate reductase from chicken liver with that from bovine liver.
Topics: Animals; Cattle; Chickens; Folic Acid Antagonists; In Vitro Techniques; Kinetics; Liver; Pyrimidines; Species Specificity | 1982 |
Inhibition by 5-(substituted-benzyl)-2,4-diaminopyrimidines of murine tumor (L5178Y) cell cultures sensitive to and resistant to methotrexate. Further evidence for the sensitivity of resistant cells to hydrophobic drugs.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Chemical Phenomena; Chemistry; Chemistry, Pharmaceutical; Drug Resistance; Leukemia L5178; Leukemia, Experimental; Methotrexate; Mice; Pyrimidines; Solubility | 1982 |
Inhibition of dihydrofolate reductase: structure-activity correlations of quinazolines based upon molecular shape analysis.
Topics: Chemical Phenomena; Chemistry, Physical; Folic Acid Antagonists; Models, Molecular; Molecular Conformation; Quinazolines; Structure-Activity Relationship | 1981 |
Solution of the conformation and alignment tensors for the binding of trimethoprim and its analogs to dihydrofolate reductase: 3D-quantitative structure-activity relationship study using molecular shape analysis, 3-way partial least-squares regression, an
Topics: Chemical Phenomena; Chemistry; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Escherichia coli; Folic Acid Antagonists; Molecular Conformation; Molecular Structure; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1996 |
Validation of EGSITE2, a mixed integer program for deducing objective site models for experimental binding data.
Topics: Algorithms; Animals; Binding Sites; Computer Simulation; Folic Acid Antagonists; Models, Molecular; Peptidyl-Dipeptidase A; Protein Binding; Receptors, Cell Surface; Sex Hormone-Binding Globulin; Steroids; Testosterone; Tetrahydrofolate Dehydrogenase; Transcortin | 1997 |
Quantitative structure-activity relationships of 2, 4-diamino-5-(2-X-benzyl)pyrimidines versus bacterial and avian dihydrofolate reductase.
Topics: Animals; Anti-Bacterial Agents; Chickens; Folic Acid Antagonists; Lacticaseibacillus casei; Liver; Models, Molecular; Protein Binding; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 1998 |
Adaptive neuro-fuzzy inference system: an instant and architecture-free predictor for improved QSAR studies.
Topics: Algorithms; Folic Acid Antagonists; Multivariate Analysis; Pyrimidines; Quantitative Structure-Activity Relationship; Regression Analysis; Tetrahydrofolate Dehydrogenase | 2001 |
Folate-synthesizing enzyme system as target for development of inhibitors and inhibitor combinations against Candida albicans-synthesis and biological activity of new 2,4-diaminopyrimidines and 4'-substituted 4-aminodiphenyl sulfones.
Topics: Aminopyridines; Animals; Antifungal Agents; Candida albicans; Dihydropteroate Synthase; Drug Combinations; Drug Resistance, Multiple, Fungal; Folic Acid Antagonists; Microbial Sensitivity Tests; Mutation; Quantitative Structure-Activity Relationship; Rats; Sulfones; Tetrahydrofolate Dehydrogenase | 2004 |
Species-specific irreversible inhibition of Neisseria gonorrhoeae dihydrofolate reductase by a substituted 2,4-diamino-5-benzylpyrimidine.
Topics: Folic Acid Antagonists; Kinetics; Mathematics; Neisseria gonorrhoeae; Pyrimidines; Species Specificity; Trimethoprim; X-Ray Diffraction | 1984 |