trimethoprim--sulfamethoxazole-drug-combination and trimerazine

Patients with normal and decreased kidney function were treated with an initial dose of 4 tablets Berlocombin and following with a dose of 2 tablets for 10 d in a 12 h period. The dialysis patients got only once the initial dose. The kinetic parameters were calculated by means of a one compartment model. Independend on the kidney function the minimum therapeutic serum concentrations of 1 microgram/ml at trimethoprime and of 20 micrograms/ml at the sulphonamides were reached during the first hours after medicament application. At all patients the urine concentration of trimethoprime were some times over the minimum therapeutic concentration. The individually found maintenance doses fluctuate between 2 tablets each 12 h and 1 tablet each 24 h. At patients with serum creatinine levels greater than 3 mg/100 ml (greater than 265 mumol/l) 1 tablet each 12 h is sufficient as maintenance dose. At a higher degree of kidney function decreasing (serum creatinine greater than 6 mg/100 ml (greater than 530 mumol/l] cumulating of the sulphonamide metabolites in the serum is found. The evaluated elimination velocity of the investigated sulphonamides during the hemodialysis was higher than that at patients with normal kidney function. The elimination rate of trimethoprime during the dialysis is in the same region as at patients without any kidney diseases.

Topics: Drug Combinations; Humans; Kidney Diseases; Kinetics; Renal Dialysis; Sulfamerazine; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination