Page last updated: 2024-08-16

trimethadione and primidone

trimethadione has been researched along with primidone in 38 studies

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-199031 (81.58)18.7374
1990's0 (0.00)18.2507
2000's3 (7.89)29.6817
2010's4 (10.53)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bruno-Blanch, L; Gálvez, J; García-Domenech, R1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Bohlen, N; Hertl, M1
Göbel, W; Löscher, W1
Goodman, RM; Hertz, M; Katznelson, D; Katznelson, MB; Rotem, Y1
Knotts, GR; Thomas, JA1
Aderet, NB; Biale, Y; Lewenthal, H1
Frey, HH; Löscher, W1
Lossing, JH; Saper, JR1
Millichap, JG2
Hooshmand, H1
Sayers, A; Stille, G1
Rümke, CL1
Jannasch, R1
Mandel, HG; Riis, M1
Kutt, H; Louis, S1
Beam, RE1
Zellweger, H1
Kutt, H1
DeVivo, DC; Pagliara, AS; Prensky, AL1
Cremers, HM; Verheesen, PE1
Nuhn, P; Woitkowitz, P; Zschunke, A1
Perchalski, RJ; Wilder, BJ1
Booker, HE; Chun, RW; Sanguino, M1
Borgstedt, AD; Bryson, MF; Forbes, GB; Young, LW1
Danielsson, B1
Endröczi, E; Fekete, T1
Spilker, B; Yeager, CL1
Bruni, J; Wilder, BJ1
Friis, ML1
Albright, PS; Bruni, J1

Reviews

8 review(s) available for trimethadione and primidone

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Pharmacokinetics of anti-epileptic drugs in the dog: a review.
    Journal of veterinary pharmacology and therapeutics, 1985, Volume: 8, Issue:3

    Topics: Animals; Anticonvulsants; Blood Proteins; Carbamazepine; Clonazepam; Diazepam; Dog Diseases; Dogs; Epilepsy; Ethosuximide; Kinetics; Phenobarbital; Phenytoin; Primidone; Species Specificity; Trimethadione; Valproic Acid

1985
Relation of laboratory evaluation to clinical effectiveness of antiepileptic drugs.
    Epilepsia, 1969, Volume: 10, Issue:2

    Topics: Acetazolamide; Adrenocorticotropic Hormone; Animals; Anticonvulsants; Benzazepines; Clinical Trials as Topic; Drug Tolerance; Electroencephalography; Electroshock; Epilepsy; Ethosuximide; Humans; Pentylenetetrazole; Phenobarbital; Phenytoin; Primidone; Seizures; Trimethadione; Urea

1969
Toxic effects of anticonvulsants: general principles.
    Pediatrics, 1974, Volume: 53, Issue:4

    Topics: Adrenocorticotropic Hormone; Adult; Anticonvulsants; Benzodiazepinones; Body Surface Area; Body Weight; Carbamazepine; Child; Chlorobenzenes; Diagnosis, Differential; Diazepam; Drug Interactions; Drug Therapy, Combination; Epilepsy; Half-Life; Humans; Nitro Compounds; Phenobarbital; Phenytoin; Primidone; Succinimides; Tranquilizing Agents; Trimethadione

1974
[Antiepileptics. 39].
    Pharmazeutische Praxis, 1969, Volume: 10

    Topics: Acetazolamide; Adrenocorticotropic Hormone; Aminoglutethimide; Anticonvulsants; Barbiturates; Carbamates; Carbamazepine; Dibenzazepines; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Glutethimide; Humans; Hydantoins; Methaqualone; Primidone; Succinimides; Thiazines; Thiazoles; Thioridazine; Trimethadione

1969
Anticonvulsants during pregnancy: a danger to the developing fetus?
    Clinical pediatrics, 1974, Volume: 13, Issue:4

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Barbiturates; Blood Coagulation Disorders; Chromosome Aberrations; Chromosome Disorders; Female; Fetus; Folic Acid; Humans; Infant, Newborn; Phenytoin; Pregnancy; Pregnancy Complications; Primidone; Succinimides; Trimethadione; Vitamin K; Vitamin K Deficiency Bleeding

1974
Pharmacodynamic and pharmacokinetic measurements of antiepileptic drugs.
    Clinical pharmacology and therapeutics, 1974, Volume: 16, Issue:1

    Topics: Anticonvulsants; Chromatography, Gas; Dose-Response Relationship, Drug; Ethosuximide; Humans; Phenobarbital; Phenytoin; Primidone; Trimethadione

1974
The clinical pharmacology of antiepileptic drugs.
    Clinical neuropharmacology, 1984, Volume: 7, Issue:1

    Topics: Adult; Anticonvulsants; Benzodiazepines; Carbamazepine; Drug Interactions; Ethosuximide; Female; Half-Life; Humans; Intestinal Absorption; Kidney; Kidney Diseases; Kinetics; Liver Diseases; Phenobarbital; Phenytoin; Pregnancy; Primidone; Protein Binding; Tissue Distribution; Trimethadione; Valproic Acid

1984

Trials

1 trial(s) available for trimethadione and primidone

ArticleYear
Relation of laboratory evaluation to clinical effectiveness of antiepileptic drugs.
    Epilepsia, 1969, Volume: 10, Issue:2

    Topics: Acetazolamide; Adrenocorticotropic Hormone; Animals; Anticonvulsants; Benzazepines; Clinical Trials as Topic; Drug Tolerance; Electroencephalography; Electroshock; Epilepsy; Ethosuximide; Humans; Pentylenetetrazole; Phenobarbital; Phenytoin; Primidone; Seizures; Trimethadione; Urea

1969

Other Studies

30 other study(ies) available for trimethadione and primidone

ArticleYear
Topological virtual screening: a way to find new anticonvulsant drugs from chemical diversity.
    Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16

    Topics: Anticonvulsants; Computer Simulation; Databases, Factual; Discriminant Analysis; Drug Design; Molecular Structure; Quantitative Structure-Activity Relationship

2003
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
[Adverse effects of anti-epileptic drugs].
    Deutsche medizinische Wochenschrift (1946), 1975, Sep-19, Volume: 100, Issue:38

    Topics: Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Carbamazepine; Diazepam; Epilepsy; Ethosuximide; Humans; Mephenytoin; Nitrazepam; Phenytoin; Primidone; Succinimides; Thiazines; Trimethadione; Valproic Acid

1975
Consecutive gas chromatographic determination of phenytoin, phenobarbital, primidone, phenylethylmalondiamide, carbamazepine, trimethadione, dimethadione, ethosuximide, and valproate from the same serum specimen.
    Epilepsia, 1978, Volume: 19, Issue:5

    Topics: Anticonvulsants; Carbamazepine; Chromatography, Gas; Dimethadione; Ethosuximide; Phenobarbital; Phenylethylmalonamide; Phenytoin; Primidone; Trimethadione; Valproic Acid

1978
Congenital malformations in four siblings of a mother taking anticonvulsant drugs.
    American journal of diseases of children (1960), 1976, Volume: 130, Issue:8

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Child; Child, Preschool; Epilepsy, Tonic-Clonic; Female; Humans; Infant; Male; Phenobarbital; Phenytoin; Pregnancy; Primidone; Trimethadione

1976
Epilepsy and other seizure disorders in children: drug management.
    The Journal of school health, 1976, Volume: 46, Issue:8

    Topics: Acetazolamide; Anticonvulsants; Child; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Clonic; Humans; Phenobarbital; Phenytoin; Primidone; Succinimides; Trimethadione

1976
Congenital malformations due to anticonvulsive drugs.
    Obstetrics and gynecology, 1975, Volume: 45, Issue:4

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anencephaly; Anticonvulsants; Birth Order; Cleft Lip; Cleft Palate; Epilepsy; Female; Fetal Death; Folic Acid; Folic Acid Antagonists; Hemorrhage; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications; Primidone; Trimethadione

1975
Drugs for epilepsy.
    The Medical letter on drugs and therapeutics, 1976, Mar-12, Volume: 18, Issue:6

    Topics: Anticonvulsants; Carbamazepine; Clonazepam; Diazepam; Epilepsy; Ethosuximide; Humans; Phenobarbital; Phenytoin; Primidone; Trimethadione

1976
Prolonged trance-like stupor in epilepsy. Petit mal status-wave stupor, spaced-out status.
    Archives of internal medicine, 1974, Volume: 134, Issue:6

    Topics: Adult; Behavior; Diagnosis, Differential; Diazepam; Electroencephalography; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Female; Humans; Intelligence; Male; Middle Aged; Phenytoin; Primidone; Trimethadione; Unconsciousness

1974
Drug treatment of convulsive disorders.
    The New England journal of medicine, 1972, Mar-02, Volume: 286, Issue:9

    Topics: Acetazolamide; Adrenocorticotropic Hormone; Adult; Anticonvulsants; Barbiturates; Child; Diazepam; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Ethosuximide; Humans; Infant; Myoclonus; Oxazoles; Phenobarbital; Phenytoin; Primidone; Pyrrolidinones; Seizures; Trimethadione

1972
Motor convulsions and EEG during maximal electroshock in the rat.
    International journal of neuropharmacology, 1967, Volume: 6, Issue:3

    Topics: Animals; Anticonvulsants; Cerebral Cortex; Cornea; Electric Stimulation; Electroencephalography; Electroshock; Muscles; Phenobarbital; Phenytoin; Primidone; Rats; Seizures; Stress, Physiological; Succinimides; Thiazines; Trimethadione

1967
Increased susceptibility of mice to seizures after some anticonvulsant drugs.
    European journal of pharmacology, 1967, Volume: 1, Issue:5

    Topics: Animals; Anticonvulsants; Bemegride; Central Nervous System Stimulants; Drug Synergism; Electroshock; Ethionine; Female; Hydantoins; Male; Methods; Mice; Oxazines; Pentylenetetrazole; Phenobarbital; Phenytoin; Primidone; Rats; Seizures; Trimethadione

1967
Interference of barbiturates with pyrimidine incorporation. II. Structural specificity of the inhibition of orotate uptake in Bacillus cereus.
    Biochemical pharmacology, 1970, Volume: 19, Issue:6

    Topics: Amobarbital; Bacillus cereus; Barbiturates; Bemegride; Biological Transport; Carbon Isotopes; Carboxylic Acids; Central Nervous System Stimulants; Chemical Phenomena; Chemistry; Chemistry, Physical; Chlorine; Chlorpromazine; Glutethimide; Hexobarbital; Hydantoins; Hydrocarbons, Halogenated; Hydrogen-Ion Concentration; Orotic Acid; Pentobarbital; Phenobarbital; Phenytoin; Primidone; Solubility; Succinimides; Thiopental; Thymine; Trimethadione; Tromethamine; Uracil; Urea

1970
Anticonvulsant drugs. I. Patho-physiological and pharmacological aspects.
    Drugs, 1972, Volume: 4, Issue:3

    Topics: Acetates; Acetazolamide; Anticonvulsants; Carbamazepine; Diazepam; Dibenzazepines; Electroencephalography; Epilepsies, Partial; Epilepsy; Ethosuximide; Humans; Phenobarbital; Phenytoin; Primidone; Seizures; Succinimides; Thiazines; Trimethadione

1972
Broad-spectrum simultaneous GLC assay of nonderivatized antiepileptic drugs.
    The American journal of medical technology, 1974, Volume: 40, Issue:5

    Topics: Anticonvulsants; Barbiturates; Carbamazepine; Chromatography, Gas; Ethosuximide; Humans; Phenobarbital; Phenytoin; Primidone; Quality Control; Trimethadione

1974
Ketotic hypoglycemia and the ketogenic diet.
    Neurology, 1973, Volume: 23, Issue:6

    Topics: Acetazolamide; Acetone; Acidosis; Blood Glucose; Child, Preschool; Diet Therapy; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Electroencephalography; Epilepsy; Ethosuximide; Female; Glucagon; Gluconeogenesis; Humans; Hydroxybutyrates; Hypoglycemia; Insulin; Ketones; Primidone; Trimethadione

1973
A rapid method for the estimation of anti-epileptic drugs in blood serum by gas-liquid chromatography.
    Clinica chimica acta; international journal of clinical chemistry, 1973, Nov-15, Volume: 48, Issue:4

    Topics: Anticonvulsants; Carbamazepine; Chromatography, Gas; Epilepsy; Ethosuximide; Evaluation Studies as Topic; Humans; Mephobarbital; Methods; Methylation; Microchemistry; Phenobarbital; Phenytoin; Primidone; Succinimides; Temperature; Time Factors; Trimethadione

1973
[1H-NMR-Spectroscopic study of various anticonvulsants. 4. NMR-spectroscopy of drugs].
    Die Pharmazie, 1973, Volume: 28, Issue:7

    Topics: Anticonvulsants; Ethosuximide; Magnetic Resonance Spectroscopy; Primidone; Succinimides; Trimethadione

1973
Letter: GLC microdetermination of plasma anticonvulsant levels.
    Journal of pharmaceutical sciences, 1974, Volume: 63, Issue:5

    Topics: Anticonvulsants; Chromatography, Gas; Ethosuximide; Humans; Methods; Phenobarbital; Phenytoin; Primidone; Trimethadione

1974
Myasthenia gravis syndrome associated with trimethadione.
    JAMA, 1970, Jun-29, Volume: 212, Issue:13

    Topics: Anticonvulsants; Autoimmune Diseases; Child; Drug Hypersensitivity; Epilepsy, Absence; Female; Humans; Mephobarbital; Myasthenia Gravis; Neostigmine; Oxazoles; Primidone; Trimethadione

1970
Long-term administration of antiepileptic drugs and the development of rickets.
    The Journal of pediatrics, 1972, Volume: 81, Issue:1

    Topics: Alkaline Phosphatase; Anticonvulsants; Calcium; Diazepam; Ethosuximide; Female; Gluconates; Humans; Infant; Mephobarbital; Osteomalacia; Phenobarbital; Phenytoin; Phosphorus; Primidone; Radiography; Rickets; Seizures; Time Factors; Trimethadione; Vitamin D

1972
[Anticonvulsants. 1. Chemical survey].
    Lakartidningen, 1971, Oct-18, Volume: 68

    Topics: Anticonvulsants; Barbiturates; Carbamazepine; Chemical Phenomena; Chemistry; Diazepam; Hydantoins; Phenobarbital; Primidone; Pyrrolidines; Trimethadione

1971
Amino acid composition of the Ammon's horn and the effect of anticonvulsant drugs.
    Acta physiologica Academiae Scientiarum Hungaricae, 1967, Volume: 32, Issue:4

    Topics: Amino Acids; Animals; Anticonvulsants; Body Weight; Brain Chemistry; Chromatography, Paper; DNA; Hippocampus; Injections, Intraperitoneal; Male; Phenytoin; Primidone; Rats; Trimethadione

1967
Ten years EEG studies in epileptic children (two cases).
    Diseases of the nervous system, 1969, Volume: 30, Issue:3

    Topics: Adolescent; Child; Child, Preschool; Electroencephalography; Emotions; Epilepsy; Humans; Mephobarbital; Phenytoin; Primidone; Trimethadione

1969
Mechanisms of action of antiepileptic drugs.
    Clinical neuropharmacology, 1982, Volume: 5, Issue:1

    Topics: Acetazolamide; Animals; Anti-Anxiety Agents; Anticonvulsants; Barbiturates; Benzodiazepines; Carbamazepine; Chemical Phenomena; Chemistry; Humans; Paraldehyde; Phenytoin; Primidone; Seizures; Succinimides; Trimethadione; Valproic Acid

1982
Antiepileptic drugs and teratogenesis. How should patients, doctors and health authorities be counselled?
    Acta neurologica Scandinavica. Supplementum, 1983, Volume: 94

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Infant, Newborn; Oxazoles; Phenytoin; Pregnancy; Pregnancy Complications; Primidone; Risk; Trimethadione; Valproic Acid

1983
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