trimethadione has been researched along with pentylenetetrazole in 46 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 44 (95.65) | 18.7374 |
| 1990's | 1 (2.17) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (2.17) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Anhut, H; Hertting, G; Steinhauer, HB | 1 |
| Banerjee, U; Yeoh, PN | 1 |
| Novack, GD; Peterson, SL; Stark, LG | 1 |
| Isaac, L; McMillen, BA | 1 |
| Faugier-Grimaud, S | 1 |
| Frey, HH; Löscher, W | 1 |
| Bigler, ED; Fleming, DE; Shearer, DE | 1 |
| Gardner, CR; Webster, RA | 2 |
| Hudda, MM; Kim, CK; Pinel, JP; Wong, DJ; Yung, A | 1 |
| Bender, AS; Hertz, L | 1 |
| Gogerty, JH; Iorio, LC; Ryan, EA | 1 |
| Killam, EK; Killam, KF; Naquet, R | 1 |
| Diaz, PM | 1 |
| Millichap, JG | 1 |
| Laycock, GM; Shulman, A | 1 |
| Rümke, CL | 1 |
| Buchanan, AS; Laycock, GM; Shulman, A | 1 |
| Izquierdo, I | 1 |
| Kirsten, EB; Schoener, EP | 1 |
| Gross, GJ; Woodbury, DM | 1 |
| Berry, CA; Faingold, CL | 1 |
| Izquierdo, I; Tannhauser, M | 1 |
| Swinyard, EA | 1 |
| Halpern, LM; Ward, AA | 1 |
| Fromm, GH; Killian, JM; Sanchez, F | 1 |
| Frey, HH; Kretschmer, BH | 1 |
| Kästner, I; Müller, M; Wenzel, J | 1 |
| Ahmad, A; Dhawan, BN | 1 |
| Frey, HH | 1 |
| Blackburn, WH; Napoli, MD; Wallin, RF | 1 |
| Southgate, PJ | 1 |
| Carrillo, L; de Bonnevaux, SC | 1 |
| Burba, JV | 1 |
| Ferngren, H | 1 |
| Castellion, AW; Swinyard, EA | 1 |
| Bartels, E; Rosenberg, P | 1 |
| Bennett, DA; Brugger, S; Dutta, P; Fielding, S; Geyer, H; Lal, H | 1 |
| Angel, A; Clarke, KA | 1 |
| Passarelli, F; Sagratella, S; Scotti de Carolis, A | 1 |
| Czuczwar, SJ; Kleinrok, Z; Turski, L; Turski, W | 1 |
| Noack, G; Portig, J; Stein, K | 1 |
| Freeman, JJ; Kosh, JW; Powers, DL; Sowell, JW | 1 |
| CURTO, EM; ESPLIN, DW | 1 |
| ALDOUS, RA; FOX, SR; JOHNSON, DG; LOEWE, S; PERKINS, W | 1 |
| Bruno-Blanch, LE; Higgs, J; Mangialavori, IC; Marder, M; Pastore, V; Wasowski, C | 1 |
2 review(s) available for trimethadione and pentylenetetrazole
| Article | Year |
|---|---|
Relation of laboratory evaluation to clinical effectiveness of antiepileptic drugs.
Topics: Acetazolamide; Adrenocorticotropic Hormone; Animals; Anticonvulsants; Benzazepines; Clinical Trials as Topic; Drug Tolerance; Electroencephalography; Electroshock; Epilepsy; Ethosuximide; Humans; Pentylenetetrazole; Phenobarbital; Phenytoin; Primidone; Seizures; Trimethadione; Urea | 1969 |
Laboratory evaluation of antiepileptic drugs. Review of laboratory methods.
Topics: Animals; Anticonvulsants; Biological Assay; Brain Injuries; Diagnosis; Electroconvulsive Therapy; Electroshock; Humans; Methionine Sulfoximine; Methods; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Seizures; Strychnine; Thiosemicarbazones; Trimethadione; Urea | 1969 |
2 trial(s) available for trimethadione and pentylenetetrazole
| Article | Year |
|---|---|
Relation of laboratory evaluation to clinical effectiveness of antiepileptic drugs.
Topics: Acetazolamide; Adrenocorticotropic Hormone; Animals; Anticonvulsants; Benzazepines; Clinical Trials as Topic; Drug Tolerance; Electroencephalography; Electroshock; Epilepsy; Ethosuximide; Humans; Pentylenetetrazole; Phenobarbital; Phenytoin; Primidone; Seizures; Trimethadione; Urea | 1969 |
Observations on the discrepancy between the clinical and the laboratory effects of anti-petit mal drugs.
Topics: Action Potentials; Anticonvulsants; Chloralose; Clinical Trials as Topic; Diazepam; Epilepsy, Absence; Humans; Oxazoles; Pentylenetetrazole; Trigeminal Nerve; Trimethadione | 1967 |
43 other study(ies) available for trimethadione and pentylenetetrazole
| Article | Year |
|---|---|
The synthesis of prostaglandins and thromboxane in the mouse brain in vivo. Influence of drug induced convulsions, hypoxia and the anticonvulsants trimethadione and diazepam.
Topics: Animals; Brain; Diazepam; In Vitro Techniques; Male; Mice; Oxazoles; Oxygen; Pentylenetetrazole; Picrotoxin; Prostaglandins; Seizures; Thromboxanes; Time Factors; Trimethadione | 1979 |
The temporal dimensions of anticonvulsant action of some newer benzodiazepines against metrazol induced seizures in mice and rats.
Topics: Animals; Benzodiazepines; Clonazepam; Diazepam; Drug Evaluation, Preclinical; Ethosuximide; Female; Flurazepam; Male; Mice; Nitrazepam; Pentylenetetrazole; Phenobarbital; Seizures; Trimethadione | 1977 |
Anticonvulsant effects of benzhydryl piperazines on pentylenetetrazol-induced seizures in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Benzhydryl Compounds; Male; Mice; Pentylenetetrazole; Piperazines; Seizures; Time Factors; Trimethadione | 1978 |
Effects of pentylenetetrazol and trimethadione on feline brain monoamine metabolism.
Topics: Animals; Biogenic Amines; Body Temperature; Brain; Cats; Half-Life; Oxazoles; Pentylenetetrazole; Time Factors; Trimethadione; Tryptophan | 1978 |
Action of anticonvulsants on pentylenetetrazol-induced epileptiform activity on invertebrate neurones (Helix aspersa).
Topics: Action Potentials; Amobarbital; Animals; Anticonvulsants; Diazepam; Epilepsy; Helix, Snails; In Vitro Techniques; Neurons; Pentylenetetrazole; Phenytoin; Trimethadione | 1978 |
Di-n-propylacetic acid--profile of anticonvulsant activity in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Dose-Response Relationship, Drug; Electroshock; Ethosuximide; Female; Male; Mice; Pentylenetetrazole; Phenobarbital; Picrotoxin; Seizures; Strychnine; Trimethadione; Valerates; Valproic Acid | 1976 |
The photically evoked afterdischarge: a model for the study of drugs useful in the treatment of petit mal epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Absence; Evoked Potentials; Female; Pentylenetetrazole; Phenytoin; Rats; Sodium Chloride; Trimethadione; Valproic Acid | 1976 |
Convulsant-anticonvulsant interactions on seizure activity and cortical acetylcholine release.
Topics: Acetylcholine; Animals; Anticonvulsants; Bicuculline; Blood Pressure; Cerebral Cortex; Convulsants; Drug Interactions; Electroencephalography; Male; Pentylenetetrazole; Phenobarbital; Phenytoin; Rats; Seizures; Time Factors; Trimethadione | 1977 |
Tolerance to the anticonvulsant effects of phenobarbital, trimethadione, and clonazepam in kindled rats: cross tolerance to carbamazepine.
Topics: Amygdala; Animals; Anticonvulsants; Brain; Carbamazepine; Clonazepam; Drug Tolerance; Electrodes, Implanted; Electroshock; Kindling, Neurologic; Male; Pentylenetetrazole; Phenobarbital; Rats; Seizures; Stereotaxic Techniques; Trimethadione | 1992 |
Evidence for involvement of the astrocytic benzodiazepine receptor in the mechanism of action of convulsant and anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Astrocytes; Barbiturates; Benzodiazepinones; Brain; Carbamazepine; Cells, Cultured; Convulsants; Diazepam; Ethosuximide; Mice; Neurons; Pentylenetetrazole; Phenobarbital; Picrotoxin; Receptors, GABA-A; Sesterterpenes; Trimethadione; Valproic Acid | 1988 |
Anticonvulsant testing with a new analeptic convulsant: N-sulfamoyl-hexahydro-azepine (Sah 41-178).
Topics: Acetamides; Animals; Anticonvulsants; Azepines; Central Nervous System Stimulants; Chlordiazepoxide; Chlorpromazine; Diazepam; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electroshock; Glutethimide; Haloperidol; Male; Mice; Pentylenetetrazole; Phenobarbital; Phenytoin; Strychnine; Sulfonamides; Trimethadione | 1973 |
An animal model of light sensitive epilepsy.
Topics: Adaptation, Physiological; Animals; Anticonvulsants; Cerebral Cortex; Chlorpromazine; Diazepam; Electroencephalography; Electromyography; Electrophysiology; Evoked Potentials; Eye Movements; Female; Haplorhini; Light; Male; Noise; Pentylenetetrazole; Phenobarbital; Photosensitivity Disorders; Seizures; Sleep; Trimethadione | 1967 |
Interaction of pentylenetetrazol and trimethadione on the metabolism of serotonin in brain and its relation to the anticonvulsant action of trimethadione.
Topics: 5-Hydroxytryptophan; Animals; Anticonvulsants; Brain; Brain Chemistry; Dose-Response Relationship, Drug; Drug Interactions; Fenclonine; Fluorometry; Germ-Free Life; Hydroxyindoleacetic Acid; Injections, Intraperitoneal; Kinetics; Male; Methyltyrosines; Motor Activity; Pargyline; Pentylenetetrazole; Rats; Reserpine; Seizures; Serotonin; Time Factors; Trimethadione | 1974 |
Action of central nervous system stimulant and depressant drugs in the intact animal. 3. Dual action of 5-ethyl-5-(1,3-dimethylbutyl)barbiturate, dilantin and beta-methyl-beta-eta-propylglutarimide.
Topics: Animals; Anticonvulsants; Barbiturates; Bemegride; Central Nervous System; Central Nervous System Stimulants; Depression, Chemical; Drug Antagonism; Hypnotics and Sedatives; Mice; Pentobarbital; Pentylenetetrazole; Phenytoin; Piperidines; Sensory Receptor Cells; Stimulation, Chemical; Trimethadione | 1967 |
Increased susceptibility of mice to seizures after some anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Bemegride; Central Nervous System Stimulants; Drug Synergism; Electroshock; Ethionine; Female; Hydantoins; Male; Methods; Mice; Oxazines; Pentylenetetrazole; Phenobarbital; Phenytoin; Primidone; Rats; Seizures; Trimethadione | 1967 |
Action of central nervous system stimulant and depressant drugs in the intact animal. 4. Surface activity of drugs with central stimulant depressant, or dual stimulant-depressant action.
Topics: Air; Amobarbital; Barbiturates; Central Nervous System Stimulants; Chemical Phenomena; Chemistry; Depression, Chemical; Glutarates; Hypnotics and Sedatives; Oxazines; Pentobarbital; Pentylenetetrazole; Phenytoin; Picrotoxin; Pregnanediones; Solutions; Stimulation, Chemical; Surface Properties; Surface Tension; Trimethadione | 1969 |
Effect on pseudoconditioning of drugs with known central nervous activity.
Topics: Amobarbital; Animals; Avoidance Learning; Behavior, Animal; Caffeine; Cannabis; Chlorpromazine; Conditioning, Psychological; Depression, Chemical; Diazepam; Dibenzylchlorethamine; Female; Meprobamate; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Rats; Stimulation, Chemical; Strychnine; Trimethadione | 1974 |
Antagonism of pentylenetetrazol excitation by anticonvulsants on single brain stem neurons.
Topics: Animals; Anticonvulsants; Brain Stem; Cats; Decerebrate State; Diazepam; Drug Antagonism; In Vitro Techniques; Microelectrodes; Neurons; Pentobarbital; Pentylenetetrazole; Phenytoin; Stereotaxic Techniques; Time Factors; Trimethadione | 1972 |
Effects of pentylenetetrazol on ion transport in the isolated toad bladder.
Topics: Amphotericin B; Animals; Biological Transport; Bufo marinus; Cell Membrane Permeability; Chlorides; Drug Interactions; In Vitro Techniques; Membrane Potentials; Osmolar Concentration; Pentylenetetrazole; Potassium; Potassium Isotopes; Sodium; Sodium Isotopes; Structure-Activity Relationship; Trimethadione; Urinary Bladder; Vasopressins | 1972 |
The effect of some anticonvulsant drugs on leptazol and bicuculline induced acetylcholine efflux from rat cerebral cortex.
Topics: Acetylcholine; Alkaloids; Animals; Anticonvulsants; Cerebral Cortex; Dioxoles; Dose-Response Relationship, Drug; Electroencephalography; Isoquinolines; Pentylenetetrazole; Phenobarbital; Phenytoin; Rats; Seizures; Trimethadione | 1973 |
Quantitative evaluation of the pentylenetetrazol-anticonvulsant interaction on the EEG of the cat.
Topics: Animals; Anticonvulsants; Cats; Cerebral Cortex; Computers; Drug Interactions; Electroencephalography; Hippocampus; Pentylenetetrazole; Phenobarbital; Phenytoin; Reticular Formation; Thalamus; Time Factors; Trimethadione | 1973 |
Effect of seizures and anticonvulsant agents on hippocampal RNA concentration.
Topics: Anesthesia, General; Animals; Anticonvulsants; Cannabis; Cerebral Cortex; Depression, Chemical; Electric Stimulation; Electroshock; Glucose; Hippocampus; Hyponatremia; Male; Pentylenetetrazole; Phenobarbital; Phenytoin; Rats; RNA; Seizures; Time Factors; Trimethadione; Urethane | 1974 |
The hyperexcitable neuron as a model for the laboratory analysis of anticonvulsant drugs.
Topics: Acetazolamide; Action Potentials; Aluminum; Animals; Behavior, Animal; Cats; Cerebral Cortex; Electroencephalography; Haplorhini; Hydroxides; Models, Biological; Neurons; Pentylenetetrazole; Phenobarbital; Phenytoin; Seizures; Time Factors; Trimethadione | 1969 |
Anticonvulsant effect of trimethadione in mice during continued treatment via the drinking water.
Topics: Animals; Anticonvulsants; Female; Male; Mice; Osmolar Concentration; Oxazoles; Pentylenetetrazole; Seizures; Trimethadione; Water | 1971 |
[Experimental animal studies on the effect of trimethadione on acute and chronic epileptiform activity].
Topics: Animals; Anticonvulsants; Arousal; Behavior, Animal; Cerebral Cortex; Cobalt; Electroencephalography; Evoked Potentials; Male; Pentylenetetrazole; Rats; Reflex, Startle; Seizures; Sleep; Trimethadione; Visual Cortex | 1971 |
Metrazol test for rapid screening of anticonvulsants.
Topics: Animals; Anticonvulsants; Electroshock; Injections, Subcutaneous; Mice; Pentylenetetrazole; Phenytoin; Seizures; Trimethadione | 1969 |
Determination of the anticonvulsant potency of unmetabolized trimethadione.
Topics: Animals; Anticonvulsants; Female; Male; Mice; Pentylenetetrazole; Seizures; Trimethadione | 1969 |
Pharmacologic interactions of albutoin with other anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Drug Synergism; Electroshock; Hydantoins; Male; Mice; Pentylenetetrazole; Phenobarbital; Phenytoin; Seizures; Trimethadione | 1970 |
A comparison of the anticonvulsant properties of 2-diethylaminopento-4-ynoyl-2',6'-xylidide (WY 21745) with lignocaine, phenytoin, phenobarbitone and trimethadione.
Topics: Anesthetics, Local; Animals; Anticonvulsants; Drug Antagonism; Electroshock; Lethal Dose 50; Lidocaine; Mice; Oxazoles; Pentylenetetrazole; Phenobarbital; Phenytoin; Seizures; Trimethadione | 1971 |
Autonomic response to pentamethylenetetrazol following trimetadione and benzodiazepines administration.
Topics: Animals; Anticonvulsants; Autonomic Nervous System; Blood Glucose; Blood Pressure; Chlordiazepoxide; Curare; Diazepam; Drug Antagonism; Female; Hyperglycemia; Male; Oxazoles; Pentylenetetrazole; Pupil; Rabbits; Trimethadione | 1968 |
Influence of several drugs on the in vivo and in vitro activity of mammalian hepatic azo-reductase.
Topics: Animals; Caffeine; Guanethidine; Guinea Pigs; In Vitro Techniques; Iproniazid; Isoniazid; Liver; Nitrofurantoin; Oxidoreductases; Pentylenetetrazole; Phenobarbital; Phenylbutazone; Phenytoin; Rabbits; Rats; Sulfinpyrazone; Sulfonic Acids; Trimethadione | 1968 |
Further studies on chemically induced siezures and their antagonism by anticonvulsants during postnatal development in the mouse.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Mice; Pentylenetetrazole; Phenobarbital; Picrotoxin; Seizures; Trimethadione | 1968 |
Anticonvulsant properties of some benzodiazepines.
Topics: Animals; Anticonvulsants; Azepines; Cats; Chlordiazepoxide; Diazepam; Electric Stimulation; Electroconvulsive Therapy; Male; Mice; Neural Conduction; Pentylenetetrazole; Trimethadione | 1966 |
Drug effects on the spontaneous electrical activity of the squid giant axon.
Topics: Acetylcholine; Action Potentials; Animals; Anticonvulsants; Atropine; Axons; Barbiturates; Bromides; Chloroform; Chlorpheniramine; Chlorpromazine; Curare; Dopamine; Electrophysiology; Ethanol; Ethers; Evoked Potentials; Hydantoins; Mollusca; Muscles; Nortropanes; Parasympatholytics; Pentylenetetrazole; Phenobarbital; Phenytoin; Picrotoxin; Procaine; Serotonin; Strychnine; Tetracaine; Tremorine; Trihexyphenidyl; Trimethadione | 1967 |
Comparison of the actions of trimethadione and chlordiazepoxide in animal models of anxiety and benzodiazepine receptor binding.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Chlordiazepoxide; Conflict, Psychological; Discrimination Learning; Disease Models, Animal; Humans; Male; Oxazoles; Pentylenetetrazole; Rats; Receptors, Cell Surface; Receptors, GABA-A; Trimethadione | 1982 |
The effects of trimethadione on pentetrazol-induced discharges of primary muscle spindle afferents from the hind limb of the rat.
Topics: Afferent Pathways; Animals; Female; Hindlimb; In Vitro Techniques; Muscle Spindles; Oxazoles; Pentylenetetrazole; Rats; Spinal Nerve Roots; Trimethadione | 1981 |
An EEG investigation on the effects of phencyclidine on pentylentetrazol convulsions in rats and rabbits.
Topics: Animals; Electroencephalography; Male; Pentylenetetrazole; Phencyclidine; Phenobarbital; Rabbits; Rats; Rats, Inbred Strains; Seizures; Species Specificity; Trimethadione | 1983 |
Effects of some antiepileptic drugs in pentetrazol-induced convulsions in mice lesioned with kainic acid.
Topics: Acetazolamide; Animals; Anticonvulsants; Carbamazepine; Diazepam; Dose-Response Relationship, Drug; Hippocampus; Injections, Intraventricular; Kainic Acid; Male; Mice; Pentylenetetrazole; Phenobarbital; Pyrrolidines; Seizures; Succinimides; Trimethadione; Valproic Acid | 1981 |
Neuropharmacological effects of isomers of hexachlorocyclohexane--3. An account of the convulsant activity of the gamma-isomer in rats.
Topics: Age Factors; Animals; Convulsants; Cyclohexanes; Female; Hydrocarbons, Chlorinated; Injections, Intraventricular; Isomerism; Male; Motor Activity; Pentylenetetrazole; Rats; Rats, Inbred Strains; Reserpine; Trimethadione | 1981 |
Anticonvulsant properties of selected pyrrolo[2,3-d]pyrimidine-2,4-diones and intermediates.
Topics: Animals; Anticonvulsants; Electroshock; Male; Mice; Pentylenetetrazole; Phenytoin; Pyrimidinones; Pyrroles; Seizures; Solubility; Structure-Activity Relationship; Trimethadione | 1980 |
Effects of trimethadione on synaptic transmission in the spinal cord; antagonism of trimethadione and pentylenetetrazol.
Topics: Anticonvulsants; Humans; Pentylenetetrazole; Spinal Cord; Synapses; Synaptic Transmission; Trimethadione | 1957 |
Isobols of dose-effect relations in the combination of pentylenetetrazole and trimethadione.
Topics: Anticonvulsants; Humans; Pentylenetetrazole; Trimethadione | 1955 |
A synthetic bioisoster of trimethadione and phenytoin elicits anticonvulsant effect, protects the brain oxidative damage produced by seizures and exerts antidepressant action in mice.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Brain Injuries; Disease Models, Animal; Flunitrazepam; Glutathione; Hindlimb Suspension; Lipid Peroxidation; Male; Maze Learning; Mice; Motor Activity; Pentylenetetrazole; Phenytoin; Seizures; Sodium-Potassium-Exchanging ATPase; Time Factors; Trimethadione; Veratrine | 2014 |