Page last updated: 2024-08-22

trimetazidine and ranolazine

trimetazidine has been researched along with ranolazine in 39 studies

Research

Studies (39)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (7.69)	18.2507
2000's	20 (51.28)	29.6817
2010's	13 (33.33)	24.3611
2020's	3 (7.69)	2.80

Authors

Authors	Studies
Arrhenius, T; Barr, R; Brown, S; Chen, M; Cheng, JF; Dyck, JR; Haramura, M; Harmon, C; Liu, B; Lopaschuk, GD; Mak, CC; Nadzan, AM; Reily, S; Thorn, V; Tith, S; Wallace, D	1
Arrhenius, T; Barbosa, M; Barr, R; Chen, M; Cheng, JF; Chu, D; Dyck, JR; Huang, Y; Lopaschuk, GD; Mak, CC; Nadzan, AM; Nishimoto, M; Penuliar, R; Wallace, D; Yang, G; Zhang, L	1
Ribeiro, C	1
Chierchia, SL; Fragasso, G	1
Iliceto, S; Marangelli, V; Rizzon, P	1
Hauet, T; Morin, D; Spedding, M; Tillement, J	1
Stanley, WC	1
Maisch, B; Rupp, H; Zarain-Herzberg, A	1
Andreadou, I; Cicchitelli, G; Ferrari, R; Guardigli, G; Merli, E	1
Binding, P; Fairman, DA; Haddock, PS; Karran, EH; MacInnes, A; Phelan, A; Rhodes, Ja; Wyatt, MJ	1
Hill, JA; Schofield, RS	1
Frenneaux, M; Horowitz, J; Lee, L	1
Pauly, DF; Pepine, CJ	1
McCullough, PA	1
Arora, R; Parang, P; Singh, B	1
Inglis, S; Stewart, S	1
Abozguia, K; Clarke, K; Frenneaux, M; Lee, L	1
Marazzi, G; Rosano, GM; Volterrani, M	1
Chaitman, BR; Sano, J	1
Arora, R; Jawad, E	1
César, LA; Gowdak, LH; Mansur, AP	1
Barone, L; Crea, F; Di Monaco, A; Lamendola, P; Lanza, GA; Pisanello, C	1
Mellana, WM; Mohan, D; Palaniswamy, C; Selvaraj, DR	1
Lango, R	1
Chirkov, YY; Horowitz, JD; Kennedy, JA; Sverdlov, AL	1
Archer, SL; Bache-Wiig, P; Fang, YH; Hong, Z; Marsboom, G; Piao, L; Rehman, J; Toth, PT	1
Jones, DA; Timmis, A; Wragg, A	1
Castriota, F; Cremonesi, A; De Luca, G; Fattori, R; Lupi, A; Marino, PN; Mirabella, F; Parisi, R; Rognoni, A; Secco, GG	1
Amaral, N; Okonko, DO	1
Rehberger-Likozar, A; Šebeštjen, M	1
Blum, A	1
Ambrosio, G; Grant, PJ; Tamargo, J	1
Colombo, A; Fragasso, G; Fumero, A; Giannini, F; Godino, C; Maranta, F; Margonato, A; Oppizzi, M; Slavich, M	1
Heggermont, WA; Heymans, S; Papageorgiou, AP; van Bilsen, M	1
Balla, C; Ferrari, R; Pavasini, R	1
Barchukov, VV; Gudasheva, TA; Kryzhanovskii, SA; Likhosherstov, AM; Mokrov, GV; Tsorin, IB; Vititnova, MB	1
Devarakonda, T; Fang, X; Ma, Y; Salloum, FN; Spiegel, S; Wang, W; Wang, XY; Zhou, H	1
Tolunay, H	1
Cesar, LAM; Dourado, LOC; Gowdak, LHW; Grobe, SF; Moreno, CPD	1

Reviews

26 review(s) available for trimetazidine and ranolazine

Article	Year
Metabolic management of ischaemic heart disease. European heart journal, 1993, Volume: 14 Suppl G Topics: Acetanilides; Adrenergic beta-Antagonists; Angina Pectoris; Calcium Channel Blockers; Carnitine; Energy Metabolism; Humans; Myocardium; Nitroglycerin; Piperazines; Ranolazine; Trimetazidine	1993
Metabolic approach to myocardial ischemia: a novel therapeutic strategy for patients with coronary artery disease? Cardiologia (Rome, Italy), 1995, Volume: 40, Issue:10 Topics: Acetanilides; Carnitine; Clinical Trials as Topic; Coenzymes; Coronary Disease; Enzyme Inhibitors; Humans; Myocardial Ischemia; Piperazines; Ranolazine; Superoxide Dismutase; Trimetazidine; Ubiquinone; Vasodilator Agents	1995
Mitochondria as target for antiischemic drugs. Advanced drug delivery reviews, 2001, Jul-02, Volume: 49, Issue:1-2 Topics: Acetanilides; Animals; Antioxidants; Coenzymes; Drug Delivery Systems; Enzyme Inhibitors; Humans; Ion Channels; Membrane Proteins; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Piperazines; Potassium Channels; Ranolazine; Reperfusion Injury; Sodium-Calcium Exchanger; Trimetazidine; Ubiquinone; Vasodilator Agents	2001
Partial fatty acid oxidation inhibitors for stable angina. Expert opinion on investigational drugs, 2002, Volume: 11, Issue:5 Topics: Acetanilides; Adenosine Triphosphate; Angina Pectoris; Chronic Disease; Energy Metabolism; Fatty Acids; Humans; Myocardium; Oxidation-Reduction; Oxygen Consumption; Piperazines; Ranolazine; Trimetazidine	2002
The use of partial fatty acid oxidation inhibitors for metabolic therapy of angina pectoris and heart failure. Herz, 2002, Volume: 27, Issue:7 Topics: Acetanilides; Angina Pectoris; Animals; Calcium; Cardiovascular Agents; Clinical Trials as Topic; Enzyme Inhibitors; Epoxy Compounds; Fatty Acids; Gene Expression; Glucose; Heart Failure; Humans; Hypoglycemic Agents; Methylhydrazines; Myocytes, Cardiac; Oxidation-Reduction; Piperazines; Ranolazine; Rats; Rats, Wistar; Sarcoplasmic Reticulum; Trimetazidine; Up-Regulation; Vasodilator Agents	2002
Metabolic modulation and optimization of energy consumption in heart failure. The Medical clinics of North America, 2003, Volume: 87, Issue:2 Topics: Acetanilides; Cardiac Pacing, Artificial; Cardiotonic Agents; Carnitine; Energy Metabolism; Heart Failure; Humans; Piperazines; Ranolazine; Trimetazidine	2003
Role of metabolically active drugs in the management of ischemic heart disease. American journal of cardiovascular drugs : drugs, devices, and other interventions, 2001, Volume: 1, Issue:1 Topics: Acetanilides; Animals; Cardiovascular Agents; Carnitine; Clinical Trials as Topic; Dichloroacetic Acid; Energy Metabolism; Fatty Acids; Glucose; Humans; Insulin; Myocardial Ischemia; Myocardium; Piperazines; Potassium; Ranolazine; Trimetazidine	2001
Metabolic manipulation in ischaemic heart disease, a novel approach to treatment. European heart journal, 2004, Volume: 25, Issue:8 Topics: Acetanilides; Adrenergic beta-Antagonists; Angina Pectoris; Cardiovascular Agents; Drug Therapy, Combination; Enzyme Inhibitors; Epoxy Compounds; Glucose; Humans; Hypoglycemic Agents; Insulin; Myocardial Ischemia; Myocardium; Perhexiline; Piperazines; Potassium; Ranolazine; Trimetazidine	2004
Ischemic heart disease: metabolic approaches to management. Clinical cardiology, 2004, Volume: 27, Issue:8 Topics: Acetanilides; Cardiovascular Agents; Carnitine; Dichloroacetic Acid; Energy Metabolism; Humans; Myocardial Ischemia; Oxidation-Reduction; Piperazines; Ranolazine; Ribose; Trimetazidine	2004
Chronic angina: new medical options for treatment. Reviews in cardiovascular medicine, 2005,Summer, Volume: 6, Issue:3 Topics: Acetanilides; Angina Pectoris; Cardiovascular Agents; Chronic Disease; Enzyme Inhibitors; Humans; Piperazines; Ranolazine; Trimetazidine; Vasodilator Agents	2005
Metabolic modulators for chronic cardiac ischemia. Journal of cardiovascular pharmacology and therapeutics, 2005, Volume: 10, Issue:4 Topics: Acetanilides; Animals; Carnitine; Chronic Disease; Drug Evaluation, Preclinical; Enzyme Inhibitors; Heart; Humans; Lipid Metabolism; Myocardial Ischemia; Myocardium; Piperazines; Randomized Controlled Trials as Topic; Ranolazine; Trimetazidine; Vasodilator Agents; Vitamin B Complex	2005
Metabolic therapeutics in angina pectoris: history revisited with perhexiline. European journal of cardiovascular nursing, 2006, Volume: 5, Issue:2 Topics: Acetanilides; Angina Pectoris; Calcium Channel Blockers; Cardiovascular Agents; Carnitine O-Palmitoyltransferase; Drug Monitoring; Epoxy Compounds; Fatty Acids; Half-Life; Humans; Metabolic Clearance Rate; Nurse's Role; Nursing Assessment; Patient Education as Topic; Patient Selection; Perhexiline; Piperazines; Randomized Controlled Trials as Topic; Ranolazine; Treatment Outcome; Trimetazidine; Vasodilator Agents	2006
Modification of myocardial substrate use as a therapy for heart failure. Nature clinical practice. Cardiovascular medicine, 2006, Volume: 3, Issue:9 Topics: Acetanilides; Adrenergic beta-Antagonists; Animals; Cardiac Output, Low; Cardiovascular Agents; Energy Metabolism; Epoxy Compounds; Fatty Acids, Nonesterified; Glycine; Heart; Humans; Myocardium; Oxygen; Perhexiline; Piperazines; Ranolazine; Trimetazidine	2006
Novel therapeutic approaches to treating chronic angina in the setting of chronic ischemic heart disease. Clinical cardiology, 2007, Volume: 30, Issue:2 Suppl 1 Topics: Acetanilides; Adrenergic beta-Antagonists; Angina Pectoris; Angiotensin-Converting Enzyme Inhibitors; Benzazepines; Calcium Channel Blockers; Chronic Disease; Enzyme Inhibitors; Humans; Ivabradine; Myocardial Ischemia; Nicorandil; Nitro Compounds; Piperazines; Ranolazine; rho-Associated Kinases; Sinoatrial Node; Trimetazidine; Vasodilator Agents	2007
Chronic stable angina pectoris. Disease-a-month : DM, 2008, Volume: 54, Issue:9 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetanilides; Angina Pectoris; Antihypertensive Agents; Benzazepines; Bosentan; Chronic Disease; Counterpulsation; Cyclic Nucleotide-Gated Cation Channels; Exercise Test; Heart Murmurs; Humans; Ivabradine; Myocardial Contraction; Myocardial Ischemia; Myocardial Revascularization; Myocardium; Nicorandil; Oxygen Consumption; Perhexiline; Piperazines; Protein Kinase Inhibitors; Ranolazine; Sulfonamides; Trimetazidine; Vasodilator Agents	2008
The metabolic treatment of patients with coronary artery disease: effects on quality of life and effort angina. Current pharmaceutical design, 2009, Volume: 15, Issue:8 Topics: Acetanilides; Angina Pectoris; Animals; Carnitine; Clinical Trials as Topic; Coronary Artery Disease; Dichloroacetic Acid; Humans; Piperazines; Quality of Life; Ranolazine; Ribose; Surveys and Questionnaires; Trimetazidine; Vasodilator Agents	2009
[Mechanisms of myocardial cell protection from ischemia/reperfusion injury and potential clinical implications]. Giornale italiano di cardiologia (2006), 2009, Volume: 10, Issue:1 Topics: Acetanilides; Acute Coronary Syndrome; Angina Pectoris; Animals; Apoptosis; Cell Death; Collateral Circulation; Disease Models, Animal; Humans; Ischemic Preconditioning, Myocardial; Meta-Analysis as Topic; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Oxygen Consumption; Piperazines; Randomized Controlled Trials as Topic; Ranolazine; Trimetazidine; Vasodilator Agents	2009
Metabolic modulation: a new therapeutic target in treatment of heart failure. American journal of therapeutics, 2011, Volume: 18, Issue:6 Topics: Acetanilides; Carnitine O-Palmitoyltransferase; Enzyme Inhibitors; Epoxy Compounds; Fatty Acids; Glucose; Heart Failure; Humans; Mitochondria, Heart; Myocytes, Cardiac; Perhexiline; Piperazines; Ranolazine; Trimetazidine; Vasodilator Agents	2011
[Regulation of myocardial metabolism: possibilities and application in cardiac surgery]. Kardiologia polska, 2003, Volume: 59 Suppl 2 Topics: Acetanilides; Animals; Cardiac Surgical Procedures; Cardiotonic Agents; Carnitine; Drug Therapy, Combination; Glucose; Glutamine; Humans; Insulin; Intraoperative Care; Myocardial Stunning; Myocardium; Myocytes, Cardiac; Piperazines; Potassium; Ranolazine; Trimetazidine; Vasodilator Agents	2003
Modulation of myocardial metabolism: an emerging therapeutic principle. Current opinion in cardiology, 2010, Volume: 25, Issue:4 Topics: Acetanilides; Amiodarone; Cardiovascular Agents; Heart Failure; Humans; Hypertrophy, Left Ventricular; Myocardial Ischemia; Myocardial Perfusion Imaging; Myocardial Reperfusion; Myocardium; Perhexiline; Piperazines; Ranolazine; Trimetazidine; Vasodilator Agents	2010
Novel drugs for treating angina. BMJ (Clinical research ed.), 2013, Sep-09, Volume: 347 Topics: Acetanilides; Angina Pectoris; Benzazepines; Enzyme Inhibitors; Heart Rate; Humans; Ivabradine; Nicorandil; Piperazines; Ranolazine; Trimetazidine; Vasodilator Agents	2013
Old and New Drugs for Treatment of Stable Angina: New Anti-Anginal Drugs and Coronary Revascularization. Cardiovascular & hematological agents in medicinal chemistry, 2015, Volume: 13, Issue:1 Topics: Angina, Stable; Animals; Benzazepines; Cardiovascular Agents; Humans; Ivabradine; Nicorandil; Percutaneous Coronary Intervention; Ranolazine; Trimetazidine	2015
Metabolic abnormalities of the heart in type II diabetes. Diabetes & vascular disease research, 2015, Volume: 12, Issue:4 Topics: Antioxidants; Cardiovascular Agents; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Energy Metabolism; Fatty Acids; Glucose; Humans; Mitochondria, Heart; Myocardium; Organophosphorus Compounds; Oxidative Phosphorylation; Oxidative Stress; Perhexiline; Ranolazine; Trimetazidine; Ubiquinone	2015
Non-haemodynamic anti-anginal agents in the management of patients with stable coronary artery disease and diabetes: A review of the evidence. Diabetes & vascular disease research, 2016, Volume: 13, Issue:2 Topics: Animals; Cardiovascular Agents; Coronary Artery Disease; Diabetes Mellitus; Humans; Ranolazine; Trimetazidine; Vasodilator Agents	2016
Metabolic support for the heart: complementary therapy for heart failure? European journal of heart failure, 2016, Volume: 18, Issue:12 Topics: Acetyl-CoA C-Acyltransferase; Cardiovascular Agents; Carnitine; Carnitine O-Palmitoyltransferase; Dichloroacetic Acid; Energy Metabolism; Enzyme Inhibitors; Epoxy Compounds; Fatty Acids; Glucose; Heart Failure; Humans; Myocardium; Myocytes, Cardiac; Oxidation-Reduction; Perhexiline; Ranolazine; Stroke Volume; Trimetazidine	2016
Treatment of Angina: Where Are We? Cardiology, 2018, Volume: 140, Issue:1 Topics: Adrenergic beta-Antagonists; Angina, Stable; Calcium Channel Blockers; Cardiovascular Agents; Chest Pain; Humans; Ivabradine; Nicorandil; Patient Selection; Practice Guidelines as Topic; Ranolazine; Treatment Outcome; Trimetazidine	2018

Trials

2 trial(s) available for trimetazidine and ranolazine

Article	Year
Influence of trimetazidine and ranolazine on endothelial function in patients with ischemic heart disease. Coronary artery disease, 2015, Volume: 26, Issue:8 Topics: Adult; Aged; Blood Flow Velocity; Brachial Artery; Double-Blind Method; Endothelium, Vascular; Humans; Male; Middle Aged; Myocardial Ischemia; Nitroglycerin; Ranolazine; Sodium Channel Blockers; Treatment Outcome; Trimetazidine; Ultrasonography, Doppler; Vasodilation; Vasodilator Agents	2015
Antinociceptive effect of ranolazine and trimetazidine. Expert review of cardiovascular therapy, 2021, Volume: 19, Issue:5 Topics: Aged; Aged, 80 and over; Analgesics; Cardiovascular Agents; Female; Humans; Male; Middle Aged; Prospective Studies; Quality of Life; Ranolazine; Treatment Outcome; Trimetazidine; Vasodilator Agents	2021

Article

Year

Influence of trimetazidine and ranolazine on endothelial function in patients with ischemic heart disease.

Coronary artery disease, 2015, Volume: 26, Issue:8

Topics: Adult; Aged; Blood Flow Velocity; Brachial Artery; Double-Blind Method; Endothelium, Vascular; Humans; Male; Middle Aged; Myocardial Ischemia; Nitroglycerin; Ranolazine; Sodium Channel Blockers; Treatment Outcome; Trimetazidine; Ultrasonography, Doppler; Vasodilation; Vasodilator Agents

2015

Antinociceptive effect of ranolazine and trimetazidine.

Expert review of cardiovascular therapy, 2021, Volume: 19, Issue:5

Topics: Aged; Aged, 80 and over; Analgesics; Cardiovascular Agents; Female; Humans; Male; Middle Aged; Prospective Studies; Quality of Life; Ranolazine; Treatment Outcome; Trimetazidine; Vasodilator Agents

2021

Other Studies

11 other study(ies) available for trimetazidine and ranolazine

Article	Year
Synthesis and structure-activity relationship of small-molecule malonyl coenzyme A decarboxylase inhibitors. Journal of medicinal chemistry, 2006, Mar-09, Volume: 49, Issue:5 Topics: Animals; Carboxy-Lyases; Energy Metabolism; Fatty Acids; Glucose; In Vitro Techniques; Male; Malonyl Coenzyme A; Morpholines; Myocardial Ischemia; Myocardium; Oxidation-Reduction; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Swine	2006
Heteroaryl substituted bis-trifluoromethyl carbinols as malonyl-CoA decarboxylase inhibitors. Bioorganic & medicinal chemistry letters, 2006, Jul-01, Volume: 16, Issue:13 Topics: Animals; Carboxy-Lyases; Drug Evaluation, Preclinical; Enzyme Activation; Enzyme Inhibitors; Glucose; Heart; Heterocyclic Compounds; In Vitro Techniques; Methanol; Molecular Structure; Oxidation-Reduction; Rats; Stereoisomerism; Structure-Activity Relationship	2006
[Therapeutic application of myocardial cytoprotection]. Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology, 1994, Volume: 13, Issue:9 Topics: Acetanilides; Adrenergic beta-Antagonists; Angina Pectoris; Calcium Channel Blockers; Carnitine; Humans; Myocardial Ischemia; Niacinamide; Nicorandil; Piperazines; Ranolazine; Trimetazidine; Vasodilator Agents	1994
The antianginal agent trimetazidine does not exert its functional benefit via inhibition of mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Circulation research, 2003, Aug-08, Volume: 93, Issue:3 Topics: Acetanilides; Acetyl-CoA C-Acyltransferase; Animals; Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Heart; Humans; In Vitro Techniques; Male; Mitochondria, Heart; Myocardial Ischemia; Myocardium; Myocytes, Cardiac; Oxidation-Reduction; Piperazines; Ranolazine; Rats; Recombinant Proteins; Trimetazidine; Vasodilator Agents	2003
Metabolic agents in the management of diabetic coronary patients: a new era. International journal of cardiology, 2008, Jun-23, Volume: 127, Issue:1 Topics: Acetanilides; Citric Acid Cycle; Coronary Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Dichloroacetic Acid; Enzyme Inhibitors; Epoxy Compounds; Humans; Insulin Resistance; Perhexiline; Piperazines; Ranolazine; Trimetazidine; Vasodilator Agents	2008
Therapeutic inhibition of fatty acid oxidation in right ventricular hypertrophy: exploiting Randle's cycle. Journal of molecular medicine (Berlin, Germany), 2012, Volume: 90, Issue:1 Topics: Acetanilides; Animals; Enzyme Inhibitors; Fatty Acids; Glucose Transporter Type 1; Glycogen; Glycolysis; Hexokinase; Hypertrophy, Right Ventricular; Male; Myocytes, Cardiac; Oxidation-Reduction; Piperazines; Ranolazine; Rats; Rats, Sprague-Dawley; Trimetazidine; Vasodilator Agents; Ventricular Function, Right	2012
New oral nitric oxide-dependent medications for patients with coronary artery disease who have persistent angina pectoris. Coronary artery disease, 2015, Volume: 26, Issue:8 Topics: Administration, Oral; Angina, Stable; Coronary Artery Disease; Humans; Nitric Oxide; Ranolazine; Sodium Channel Blockers; Trimetazidine; Vasodilator Agents	2015
Long-Term Preservation of Left Ventricular Systolic Function in Patients With Refractory Angina Pectoris and Inducible Myocardial Ischemia on Optimal Medical Therapy. The American journal of cardiology, 2016, 05-15, Volume: 117, Issue:10 Topics: Aged; Angina Pectoris; Benzazepines; Cardiovascular Agents; Echocardiography; Exercise Test; Female; Follow-Up Studies; Humans; Ivabradine; Male; Myocardial Ischemia; Ranolazine; Retrospective Studies; Sodium Channel Blockers; Stroke Volume; Systole; Time Factors; Tomography, Emission-Computed, Single-Photon; Trimetazidine; Vasodilator Agents; Ventricular Function, Left	2016
Anti-Ischemic Activity of Triamine ALM-802 under Conditions of Endothelial Dysfunction. Bulletin of experimental biology and medicine, 2019, Volume: 167, Issue:4 Topics: Animals; Electrophysiology; Hyperhomocysteinemia; Isoproterenol; Male; Myocardial Infarction; Ranolazine; Rats; Trimetazidine	2019
Functional analysis of molecular and pharmacological modulators of mitochondrial fatty acid oxidation. Scientific reports, 2020, 01-29, Volume: 10, Issue:1 Topics: Animals; Energy Metabolism; Epoxy Compounds; Fatty Acids; Female; Glycine; Humans; MCF-7 Cells; Mice; Mice, Inbred C57BL; Mitochondria; Oxidation-Reduction; PPAR alpha; Ranolazine; Trimetazidine	2020
Concomitant Use of Ranolazine and Trimetazidine in Patients with Refractory Angina: An Initial Experience. Arquivos brasileiros de cardiologia, 2022, Volume: 119, Issue:4 Topics: Angina Pectoris; Angina, Stable; Cardiovascular Agents; Humans; Ranolazine; Treatment Outcome; Trimetazidine; Vasodilator Agents	2022