trimebutine has been researched along with n-desmethyltrimebutine in 10 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (20.00) | 18.7374 |
| 1990's | 3 (30.00) | 18.2507 |
| 2000's | 4 (40.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Junien, JL; Pascaud, X; Roman, F; Taylor, JE | 1 |
| Buéno, L; Hondé, C; Junien, JL; Pascaud, X | 1 |
| Buéno, L; Coelho, AM; Fioramonti, J; Lacheze, C | 1 |
| Chang, WI; Joo, EH; Lee, YB; Na, HK; Oh, I; Shin, SC | 1 |
| Alessandri, N; Brunelle, G; Champeroux, P; Gola, M; Hamon, J; Lanet, S; Maurin, A; Richard, S; Roman, FJ | 1 |
| Christensen, D; Guilbaud, G; Kayser, V; Roman, F | 1 |
| Boudra, H; Cahiez, G; Chomard, JM; Houin, G; Labaune, JP; Lavit, M; Martin, A; Michel, F; Saivin, S | 1 |
| Cahiez, G; Chomard, JM; Donazzolo, C; Houin, G; Labaune, JP; Lavit, M; Martin, A; Michel, F; Saivin, S | 1 |
| Chevalier, E; Chovet, M; Langlois, A; Pétoux, F | 1 |
| Colin, P; Furtado, M; Garofolo, F; Montpetit, H; Ranger, M | 1 |
2 trial(s) available for trimebutine and n-desmethyltrimebutine
| Article | Year |
|---|---|
Determination of trimebutine and desmethyl-trimebutine in human plasma by HPLC.
Topics: Calibration; Chromatography, High Pressure Liquid; Drug Stability; Gastrointestinal Agents; Humans; Indicators and Reagents; Quality Control; Reproducibility of Results; Spectrophotometry, Ultraviolet; Therapeutic Equivalency; Trimebutine | 2000 |
Pharmacokinetics and bioequivalence of two trimebutine formulations in healthy volunteers using desmethyl-trimebutine levels.
Topics: Adult; Area Under Curve; Chromatography, High Pressure Liquid; Cross-Over Studies; Female; Gastrointestinal Agents; Humans; Male; Spectrophotometry, Ultraviolet; Tablets; Therapeutic Equivalency; Trimebutine | 2000 |
8 other study(ies) available for trimebutine and n-desmethyltrimebutine
| Article | Year |
|---|---|
Interactions of trimebutine with guinea-pig opioid receptors.
Topics: Animals; Benzoates; Binding, Competitive; Brain; Guinea Pigs; In Vitro Techniques; Kinetics; Male; Radioligand Assay; Receptors, Opioid; Trimebutine | 1987 |
Effects of orally vs. parenterally administrated trimebutine on gastrointestinal and colonic motility in dogs.
Topics: Administration, Oral; Animals; Benzoates; Colon; Dogs; Duodenum; Gastrointestinal Motility; Infusions, Intravenous; Time Factors; Trimebutine | 1987 |
Influence of trimebutine on inflammation- and stress-induced hyperalgesia to rectal distension in rats.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Gastrointestinal Agents; Hyperalgesia; Male; Peritoneal Cavity; Proctitis; Rats; Rats, Wistar; Receptors, Opioid; Rectum; Restraint, Physical; Trimebutine; Trinitrobenzenesulfonic Acid | 1998 |
High-performance liquid chromatographic determination of trimebutine and its major metabolite, N-monodesmethyl trimebutine, in rat and human plasma.
Topics: Animals; Chromatography, High Pressure Liquid; Gastrointestinal Agents; Humans; Male; Rats; Rats, Sprague-Dawley; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Trimebutine | 1999 |
Pharmacological properties of trimebutine and N-monodesmethyltrimebutine.
Topics: Animals; Batrachotoxins; Binding, Competitive; Cell Line; Cells, Cultured; Cerebral Cortex; Cornea; Embryo, Mammalian; Embryo, Nonmammalian; Female; Ganglia, Spinal; Glutamic Acid; Humans; In Vitro Techniques; Intracellular Membranes; Kv1.1 Potassium Channel; Kv1.2 Potassium Channel; Lidocaine; Male; Membrane Potentials; Neurons; Oocytes; Potassium Channels; Potassium Channels, Voltage-Gated; Rabbits; Rats; Rats, Sprague-Dawley; Spinal Cord; Stereoisomerism; Synaptosomes; Trimebutine; Xenopus laevis | 1999 |
Antinociceptive effect of (S)-N-desmethyl trimebutine against a mechanical stimulus in a rat model of peripheral neuropathy.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Hindlimb; Male; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Pressure; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Stereoisomerism; Trimebutine | 2000 |
Beneficial effect of trimebutine and N-monodesmethyl trimebutine on trinitrobenzene sulfonic acid-induced colitis in rats.
Topics: Administration, Rectal; Anesthetics, Local; Animals; Bupivacaine; Colitis; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Gastrointestinal Agents; Injections, Subcutaneous; Lidocaine; Male; Organ Size; Rats; Rats, Sprague-Dawley; Trimebutine; Trinitrobenzenesulfonic Acid | 2004 |
Discovery of a novel trimebutine metabolite and its impact on N-desmethyltrimebutine quantification by LC-MS/MS.
Topics: Chromatography, Liquid; Clinical Trials, Phase I as Topic; Drug Discovery; Glucuronides; Healthy Volunteers; Humans; Hydrolysis; Tandem Mass Spectrometry; Trimebutine | 2015 |