trilostane has been researched along with dehydroepiandrosterone in 28 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (25.00) | 18.7374 |
| 1990's | 10 (35.71) | 18.2507 |
| 2000's | 7 (25.00) | 29.6817 |
| 2010's | 4 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Komanicky, P; Melby, JC; Spark, RF | 1 |
| Benahmed, M; Chauvin, MA; de Peretti, E; Morera, AM; Sordoillet, C | 1 |
| Benahmed, M; Chauvin, MA; de Peretti, E; Mauduit, C; Morera, AM | 1 |
| de Launoit, Y; Dumont, M; Labrie, F; Lachance, Y; Luu-The, V; Takahashi, M | 1 |
| Labrie, F; Luu-The, V; Takahashi, M | 1 |
| Nowotny, P; Vierhapper, H; Waldhäusl, W | 1 |
| Ishikawa, S; Katayama, T; Kazama, T; Koike, H; Nakada, T; Yoshikawa, M | 1 |
| Fukuchi, S; Haruyama, K; Shigetomi, S; Yamazaki, M | 1 |
| Jacobs, HS; James, VH; Jones, DL; Paintin, DB; Piura, B; van der Spuy, ZM; Wright, CS | 1 |
| Auzeby, A; Bogdan, A; Galan, P; Luton, JP; Touitou, Y | 1 |
| Carlström, K; Döberl, A; Pousette, A; Rannevik, G; Wilking, N | 1 |
| Baulieu, EE; Corpéchot, C; Haug, M; Mayo, W; Perché, F; Robel, P; Simon, H; Young, J | 1 |
| Steffensen, SC | 1 |
| Cooke, GM | 1 |
| Baulieu, EE; Corpéchot, C; Eychenne, B; Haug, M; Perché, F; Robel, P; Young, J | 1 |
| Attal-Khémis, S; Dalmeyda, V; Morfin, R | 1 |
| Furster, C | 1 |
| Chang, LL; Ho, LL; Wang, PS; Wun, WS | 1 |
| Debonnel, G; Robichaud, M | 1 |
| Childs, GV; Iruthayanathan, M; Zhou, YH | 1 |
| Boretti, FS; Maser-Gluth, C; Reusch, CE; Sieber-Ruckstuhl, NS; Wenger, M | 1 |
| Dubnau, E; Sampson, NS; Smith, I; Yang, X | 1 |
| Pradhan, DS; Soma, KK; Yu, Y | 1 |
| Bucholtz, KM; Kacsoh, B; Mack, VL; Sun, J; Thomas, JL | 1 |
| Bucholtz, KM; Mack, VL; Sun, J; Terrell, JR; Thomas, JL | 1 |
| Auchus, RJ; Evaul, K; Li, R; Papari-Zareei, M; Sharifi, N | 1 |
| Hara, N; Hoshii, T; Ishizaki, F; Miyashiro, Y; Nishiyama, T; Takahashi, K; Takizawa, I | 1 |
| Lepschy, M; Möstl, E; Ouschan, C; Zeugswetter, F | 1 |
1 review(s) available for trilostane and dehydroepiandrosterone
| Article | Year |
|---|---|
Biosynthesis and assay of neurosteroids in rats and mice: functional correlates.
Topics: Adrenalectomy; Aggression; Aging; Animals; Behavior, Animal; Dehydroepiandrosterone; Dihydrotestosterone; Female; gamma-Aminobutyric Acid; Humans; Infant, Newborn; Lactation; Male; Memory; Mice; Orchiectomy; Pregnenolone; Progesterone; Radioimmunoassay; Rats; Rats, Sprague-Dawley | 1995 |
27 other study(ies) available for trilostane and dehydroepiandrosterone
| Article | Year |
|---|---|
Treatment of Cushing's syndrome with trilostane (WIN 24,540), an inhibitor of adrenal steroid biosynthesis.
Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Adult; Blood Pressure; Carcinoma; Cushing Syndrome; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dihydrotestosterone; Female; Humans; Hydrocortisone; Kinetics; Male; Middle Aged; Mineralocorticoids; Potassium; Renin | 1978 |
Epidermal growth factor directly stimulates steroidogenesis in primary cultures of porcine Leydig cells: actions and sites of action.
Topics: 3-Hydroxysteroid Dehydrogenases; 8-Bromo Cyclic Adenosine Monophosphate; Androgens; Androstenedione; Animals; Cells, Cultured; Chorionic Gonadotropin; Dehydroepiandrosterone; Dihydrotestosterone; Epidermal Growth Factor; ErbB Receptors; Leydig Cells; Male; Swine; Testosterone | 1991 |
Effect of activin A on dehydroepiandrosterone and testosterone secretion by primary immature porcine Leydig cells.
Topics: 3-Hydroxysteroid Dehydrogenases; Activins; Animals; Cells, Cultured; Chorionic Gonadotropin; Cytochrome P-450 Enzyme System; Dehydroepiandrosterone; Dihydrotestosterone; Hydroxycholesterols; Inhibins; Leydig Cells; Male; Pregnenolone; Swine; Testosterone | 1991 |
Evidence for distinct dehydrogenase and isomerase sites within a single 3 beta-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase protein.
Topics: Androgen Antagonists; Androstane-3,17-diol; Azasteroids; Binding Sites; Binding, Competitive; Cell Line; Dehydroepiandrosterone; Dihydrotestosterone; Humans; Kinetics; Multienzyme Complexes; Placenta; Progesterone Reductase; Protein Conformation; Steroid Isomerases; Substrate Specificity; Tumor Cells, Cultured | 1991 |
Differential inhibition of dehydrogenase and 5-ene----4-ene isomerase activities of purified 3 beta-hydroxysteroid dehydrogenase. Evidence for two distinct sites.
Topics: 3-Hydroxysteroid Dehydrogenases; Androstenedione; Azasteroids; Binding Sites; Dehydroepiandrosterone; Dihydrotestosterone; Humans; In Vitro Techniques; Kinetics | 1991 |
Effect of trilostan on steroid excretion in man: compensated inhibition of 3 beta-hydroxysteroid dehydrogenase.
Topics: 3-Hydroxysteroid Dehydrogenases; Adult; Aldosterone; Androstenediol; Chromatography, Gas; Dehydroepiandrosterone; Dexamethasone; Dihydrotestosterone; Glucocorticoids; Humans; Hydrocortisone; Male; Pregnenolone; Renin; Steroids | 1986 |
Primary aldosteronism treated by trilostane (3 beta-hydroxysteroid dehydrogenase inhibitor).
Topics: 17-Hydroxycorticosteroids; Adenoma; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Adult; Androstenedione; Dehydroepiandrosterone; Desoxycorticosterone; Dihydrotestosterone; Estradiol; Female; Humans; Hydroxysteroid Dehydrogenases; Hyperaldosteronism; Male; Middle Aged; Oxidative Phosphorylation Coupling Factors; Progesterone; Radioimmunoassay; Renin-Angiotensin System; Testosterone | 1985 |
[The effect of trilostane, a new inhibitor of adrenal steroid biosynthesis, on blood pressure, plasma aldosterone and other steroid hormones, serum potassium and plasma renin activity in primary aldosteronism (author's transl)].
Topics: Adult; Aldosterone; Blood Pressure; Dehydroepiandrosterone; Dihydrotestosterone; Female; Humans; Hyperaldosteronism; Male; Middle Aged; Oxidative Phosphorylation; Potassium; Renin | 1982 |
Inhibition of 3-beta-hydroxy steroid dehydrogenase activity in first trimester human pregnancy with trilostane and WIN 32729.
Topics: 3-Hydroxysteroid Dehydrogenases; Abortifacient Agents; Abortifacient Agents, Steroidal; Dehydroepiandrosterone; Dihydrotestosterone; Dose-Response Relationship, Drug; Female; Humans; Hydrocortisone; Pregnancy; Pregnancy Trimester, First; Pregnenolone; Progesterone | 1983 |
11 beta-Hydroxy-11-ketosteroids equilibrium, a source of misinterpretation in steroid synthesis: evidence through the effects of trilostane on 11 beta-hydroxysteroid dehydrogenase in sheep and human adrenals in vitro.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; 3-Hydroxysteroid Dehydrogenases; Adrenal Glands; Androgens; Androstenedione; Animals; Dehydroepiandrosterone; Dihydrotestosterone; Humans; Hydroxysteroid Dehydrogenases; Hydroxysteroids; Ketosteroids; Sheep; Species Specificity | 1984 |
Inhibition of steroid sulfatase activity by danazol.
Topics: Aminoglutethimide; Breast Neoplasms; Carcinoma; Culture Techniques; Danazol; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dihydrotestosterone; Estrogen Antagonists; Estrone; Female; Humans; Medroxyprogesterone; Medroxyprogesterone Acetate; Pregnadienes; Tamoxifen | 1984 |
Dehydroepiandrosterone sulfate suppresses hippocampal recurrent inhibition and synchronizes neuronal activity to theta rhythm.
Topics: 3-Hydroxysteroid Dehydrogenases; Androstenedione; Animals; Dehydroepiandrosterone; Dentate Gyrus; Dihydrotestosterone; Enzyme Inhibitors; Evoked Potentials; Extracellular Space; gamma-Aminobutyric Acid; Hippocampus; Iontophoresis; Male; Neural Inhibition; Neurons; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Theta Rhythm | 1995 |
Differential effects of trilostane and cyanoketone on the 3 beta-hydroxysteroid dehydrogenase-isomerase reactions in androgen and 16-androstene biosynthetic pathways in the pig testis.
Topics: Androstadienes; Androstenedione; Androstenes; Androstenols; Animals; Cyanoketone; Dehydroepiandrosterone; Dihydrotestosterone; Kinetics; Male; Microsomes; Multienzyme Complexes; Progesterone Reductase; Steroid Isomerases; Swine; Testis | 1996 |
Neurosteroids in the mouse brain: behavioral and pharmacological effects of a 3 beta-hydroxysteroid dehydrogenase inhibitor.
Topics: 3-Hydroxysteroid Dehydrogenases; Animals; Brain; Dehydroepiandrosterone; Dihydrotestosterone; Enzyme Inhibitors; Female; Humans; Mice; Pregnanolone; Pregnenolone; Progesterone; Sexual Behavior, Animal | 1996 |
Change of 7alpha-hydroxy-dehydroepiandrosterone levels in serum of mice treated by cytochrome P450-modifying agents.
Topics: Animals; Brain; Cytochrome P-450 Enzyme System; Dehydroepiandrosterone; Dexamethasone; Dihydrotestosterone; Gas Chromatography-Mass Spectrometry; Male; Melatonin; Metyrapone; Mice; Mice, Inbred C57BL; Microsomes, Liver; Phenobarbital | 1998 |
Hepatic and extrahepatic dehydrogenation/isomerization of 5-cholestene-3 beta,7 alpha-diol: localization of 3 beta-hydroxy-delta 5-C27-steroid dehydrogenase in pig tissues and subcellular fractions.
Topics: 3-Hydroxysteroid Dehydrogenases; Animals; Antibodies, Monoclonal; Bile Acids and Salts; Bile Ducts; Dehydroepiandrosterone; Dihydrotestosterone; Enzyme Inhibitors; Female; Hydroxycholesterols; Immunohistochemistry; Liver; Male; Microsomes; Microsomes, Liver; Pregnenolone; Subcellular Fractions; Swine; Tissue Distribution | 1999 |
Effects of dehydroepiandrosterone on corticosterone release in rat zona fasciculata-reticularis cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adrenocorticotropic Hormone; Animals; Cells, Cultured; Cholesterol Side-Chain Cleavage Enzyme; Corticosterone; Cyclic AMP; Dehydroepiandrosterone; Desoxycorticosterone; Dihydrotestosterone; Enzyme Inhibitors; Female; Gene Expression; Hydroxycholesterols; Phosphoproteins; Pregnenolone; Progesterone; Rats; Rats, Sprague-Dawley; RNA, Messenger; Steroid 11-beta-Hydroxylase; Zona Fasciculata; Zona Reticularis | 2003 |
Modulation of the firing activity of female dorsal raphe nucleus serotonergic neurons by neuroactive steroids.
Topics: 5-alpha-Dihydroprogesterone; Animals; Anisoles; Antipsychotic Agents; Dehydroepiandrosterone; Dihydrotestosterone; Female; Finasteride; Gender Identity; Gonadal Steroid Hormones; Neurons; Ovariectomy; Pregnenolone; Progesterone; Propylamines; Protein Isoforms; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, sigma; Serotonin; Synaptic Transmission; Time Factors | 2004 |
Dehydroepiandrosterone restoration of growth hormone gene expression in aging female rats, in vivo and in vitro: evidence for actions via estrogen receptors.
Topics: Aging; Aminoglutethimide; Animals; Aromatase Inhibitors; Cells, Cultured; Dehydroepiandrosterone; Dihydrotestosterone; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Female; Fulvestrant; Gene Expression; Growth Hormone; Pituitary Gland; Rats; Receptors, Estrogen; Receptors, Neuropeptide; Receptors, Pituitary Hormone-Regulating Hormone; RNA, Messenger | 2005 |
Cortisol, aldosterone, cortisol precursor, androgen and endogenous ACTH concentrations in dogs with pituitary-dependant hyperadrenocorticism treated with trilostane.
Topics: 17-alpha-Hydroxypregnenolone; 3-Hydroxysteroid Dehydrogenases; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Aldosterone; Androstenedione; Animals; Cortodoxone; Dehydroepiandrosterone; Dihydrotestosterone; Dog Diseases; Dogs; Enzyme Inhibitors; Female; Hydrocortisone; Male; Prospective Studies; Statistics, Nonparametric | 2006 |
Rv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenase.
Topics: 3-Hydroxysteroid Dehydrogenases; Bacterial Proteins; Catalysis; Cholesterol; Computational Biology; Dehydroepiandrosterone; Detergents; Dihydrotestosterone; Enzyme Inhibitors; Hydrogen-Ion Concentration; Kinetics; Mutation; Mycobacterium tuberculosis; NAD; Osmolar Concentration; Phylogeny; Pregnenolone; Recombinant Proteins; Sterols; Substrate Specificity | 2007 |
Rapid estrogen regulation of DHEA metabolism in the male and female songbird brain.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Dehydroepiandrosterone; Dihydrotestosterone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estradiol; Estrogens; Female; Finches; Male; Multienzyme Complexes; Progesterone Reductase; Sex Characteristics; Steroid Isomerases; Time Factors | 2008 |
Structural basis for the selective inhibition of human 3beta-hydroxysteroid dehydrogenase 1 in human breast tumor MCF-7 cells.
Topics: 3-Hydroxysteroid Dehydrogenases; Arginine; Aromatase Inhibitors; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Coenzymes; Dehydroepiandrosterone; Dihydrotestosterone; Enzyme Inhibitors; Estradiol; Estrone; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Kinetics; Mutant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substrate Specificity | 2009 |
The functions of key residues in the inhibitor, substrate and cofactor sites of human 3beta-hydroxysteroid dehydrogenase type 1 are validated by mutagenesis.
Topics: 3-Hydroxysteroid Dehydrogenases; Amino Acids; Binding Sites; Breast Neoplasms; Dehydroepiandrosterone; Dihydrotestosterone; Female; Humans; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Substrate Specificity | 2010 |
3beta-hydroxysteroid dehydrogenase is a possible pharmacological target in the treatment of castration-resistant prostate cancer.
Topics: 17-Hydroxysteroid Dehydrogenases; Antineoplastic Agents; Carcinoma; Cell Line, Tumor; Cell Nucleus; Dehydroepiandrosterone; Dihydrotestosterone; Dose-Response Relationship, Drug; Drug Delivery Systems; Drug Evaluation, Preclinical; Enzyme Inhibitors; Humans; Male; Models, Biological; Orchiectomy; Prostatic Neoplasms; Receptors, Androgen; Treatment Failure | 2010 |
Trilostane, an inhibitor of 3β-hydroxysteroid dehydrogenase, has an agonistic activity on androgen receptor in human prostate cancer cells.
Topics: 3-Hydroxysteroid Dehydrogenases; Androgens; Cell Line, Tumor; Chromatography, Liquid; Dehydroepiandrosterone; Dihydrotestosterone; Enzyme Inhibitors; Humans; Male; Mass Spectrometry; Prostatic Neoplasms; Receptors, Androgen; Testosterone | 2010 |
The influence of trilostane on steroid hormone metabolism in canine adrenal glands and corpora lutea-an in vitro study.
Topics: 3-Hydroxysteroid Dehydrogenases; Adrenal Glands; Animals; Autoradiography; Corpus Luteum; Dehydroepiandrosterone; Dihydrotestosterone; Dogs; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Male; Pregnenolone | 2012 |