trilobolide and 2-5-di-tert-butylbenzoquinone

trilobolide has been researched along with 2-5-di-tert-butylbenzoquinone* in 1 studies

Other Studies

1 other study(ies) available for trilobolide and 2-5-di-tert-butylbenzoquinone

Article	Year
The importance of the hydroxyl moieties for inhibition of the Ca(2+)-ATPase by trilobolide and 2,5-di(tert-butyl)-1,4-benzohydroquinone. Biochemical and biophysical research communications, 1994, Mar-15, Volume: 199, Issue:2 Trilobolide and 2,5-di(tert-butyl)-1,4-benzohydroquinone (BHQ) are potent inhibitors of the Ca(2+)-ATPase of skeletal muscle sarcoplasmic reticulum. Desoxytrilobolide and 2,5-di(tert-butyl)-1,4-diacetylphenol (acetyl-BHQ) have much lower potencies than their parent compounds and 2,5-di(tert-butyl)-1,4-benzoquinone (BQ) has no effect on ATPase activity. Studies using the ATPase labelled with 4-nitrobenzo-2-oxa-1,3-diazole (NBD) suggest that both trilobolide and BHQ bind more strongly to the E2 conformation of the ATPase than to the E1 conformation. Desoxytrilobolide, acetyl-BHQ and BQ have little effect on the E1/E2 equilibrium. Studies with mixtures of trilobolide and desoxytrilobolide suggest that the inactive derivatives are unable to bind to the ATPase. Topics: Adenosine Triphosphatases; Animals; Antioxidants; Benzoquinones; Butyrates; Calcium-Transporting ATPases; Furans; Hydroxyl Radical; Kinetics; Muscles; Protein Conformation; Rabbits; Sarcoplasmic Reticulum; Spectrometry, Fluorescence; Structure-Activity Relationship	1994

Article

Year

The importance of the hydroxyl moieties for inhibition of the Ca(2+)-ATPase by trilobolide and 2,5-di(tert-butyl)-1,4-benzohydroquinone.

Biochemical and biophysical research communications, 1994, Mar-15, Volume: 199, Issue:2

Trilobolide and 2,5-di(tert-butyl)-1,4-benzohydroquinone (BHQ) are potent inhibitors of the Ca(2+)-ATPase of skeletal muscle sarcoplasmic reticulum. Desoxytrilobolide and 2,5-di(tert-butyl)-1,4-diacetylphenol (acetyl-BHQ) have much lower potencies than their parent compounds and 2,5-di(tert-butyl)-1,4-benzoquinone (BQ) has no effect on ATPase activity. Studies using the ATPase labelled with 4-nitrobenzo-2-oxa-1,3-diazole (NBD) suggest that both trilobolide and BHQ bind more strongly to the E2 conformation of the ATPase than to the E1 conformation. Desoxytrilobolide, acetyl-BHQ and BQ have little effect on the E1/E2 equilibrium. Studies with mixtures of trilobolide and desoxytrilobolide suggest that the inactive derivatives are unable to bind to the ATPase.

Topics: Adenosine Triphosphatases; Animals; Antioxidants; Benzoquinones; Butyrates; Calcium-Transporting ATPases; Furans; Hydroxyl Radical; Kinetics; Muscles; Protein Conformation; Rabbits; Sarcoplasmic Reticulum; Spectrometry, Fluorescence; Structure-Activity Relationship

1994