Page last updated: 2024-08-17

triiodothyronine and gc 1 compound

triiodothyronine has been researched along with gc 1 compound in 41 studies

Research

Studies (41)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (2.44)	18.2507
2000's	20 (48.78)	29.6817
2010's	18 (43.90)	24.3611
2020's	2 (4.88)	2.80

Authors

Authors	Studies
Apriletti, JW; Baxter, JD; Chiellini, G; Ribeiro, RC; Scanlan, TS; Yoshihara, HA	1
Apriletti, JW; Baxter, JD; Cunha Lima, ST; Nguyen, NH; Scanlan, TS; Webb, P	1
Apriletti, JW; Baxter, JD; Scanlan, TS; Yoshihara, HA	1
Boyer, SH; Cable, EE; Erion, MD; Fujitaki, JM; Godwin, JL; Hecker, SJ; Hou, J; Jacintho, JD; Jiang, H; Li, H; Li, W; Reddy, MV; Schulz, WG; Wu, R	1
Asano, Y; Maeda, K; Takahashi, N; Watanabe, N	2
Banner, B; Conde-Knape, K; Danzi, S; Dvorozniak, M; Haynes, NE; Huang, KS; Kelly, MJ; Klein, I; Larigan, JD; Mennona, F; Pietranico-Cole, S; Qian, Y; Reynolds, CH; Scott, N; So, SS; Taub, R; Thakkar, K; Tilley, J; Vermeulen, J	1
Banerji, T; Bourdette, D; Ferrara, SJ; Hartley, MD; McTigue, P; Meinig, JM; Placzek, AT; Sanford-Crane, HS; Scanlan, TS	1
Banerji, T; Bourdette, D; Ferrara, SJ; Meinig, JM; Sanford-Crane, HS; Scanlan, TS	1
Baxter, JD; Chiellini, G; Dillmann, WH; Gloss, B; Grover, GJ; Scanlan, TS; Swanson, E; Trost, SU; Volodarsky, T; Wang-Iverson, DB; Zhang, H	1
Apriletti, JW; Baxter, JD; Cunha Lima, ST; Fletterick, RJ; Huber, BR; Kelly, A; Scanlan, TS; Shiau, AK; Wagner, RL; West, BL	1
Bianco, AC; Brent, GA; Carvalho, SD; Chiellini, G; Ribeiro, MO; Scanlan, TS; Schultz, JJ	1
Bernal, J; Manzano, J; Morte, B; Scanlan, TS	1
Baxter, JD; Beehler, BC; Chiellini, G; Egan, DM; Grover, GJ; Nguyen, NH; Scanlan, TS; Sleph, PG	1
Chiellini, G; Ermio, DJ; Furlow, JD; Hsu, M; Lim, W; Scanlan, TS; Yang, HY	1
Dowdell, S; Hubner, I; Koh, JT; Link, KH; Putnam, MC; Shi, Y; Ye, H	1
Angelin, B; Baxter, J; Johansson, L; Lundåsen, T; Parini, P; Rudling, M; Scanlan, TS; Webb, P	1
Baxter, JD; Chiellini, G; Dillmann, WH; Giannocco, G; Gloss, B; Moriscot, AS; Scanlan, T; Swanson, EA	1
Aoki, MS; Bianco, AC; Freitas, FR; Gouveia, CH; Moriscot, AS; Ribeiro, MO; Scanlan, TS; Taffarel, C; Villicev, CM	1
Scanlan, TS	1
Cocco, MT; Columbano, A; Kowalik, MA; Ledda-Columbano, GM; Perra, A; Pibiri, M; Simbula, G; Simbula, M; Sulas, P	1
Josseaume, C; Lorcy, Y	1
Denver, RJ; Furlow, JD; Hu, F; Scanlan, TS	1
Beber, EH; Capelo, LP; Costa, CC; Fonseca, TL; Gouveia, CH; Lotfi, CF; Scanlan, TS	1
Bari, A; Chiellini, G; Columbano, A; Di Meo, S; Di Stefano, L; Scanlan, TS; Venditti, P; Zucchi, R	1
Genin, EC; Gondcaille, C; Savary, S; Trompier, D	1
Davis, FB; Davis, PJ; Mousa, SA; Mousa, SS	1
Chiellini, G; Columbano, A; Di Meo, S; Di Stefano, L; Napolitano, G; Scanlan, TS; Venditti, P; Zucchi, R	1
Martinez de Mena, R; Obregon, MJ; Scanlan, TS	1
Foguel, D; Lima, LM; Polikarpov, I; Sairre, MI; Trivella, DB	1
Ayers, SD; Baxter, JD; Denoto-Reynolds, F; Lin, JZ; Sieglaff, DH; Webb, P; Yuan, C	1
Baxter, JD; Gustafsson, JÅ; Hsueh, WA; Lin, JZ; Martagón, AJ; Phillips, KJ; Webb, P	1
Cubelo, A; Fischer, JD; Guyenet, SJ; Kaiyala, KJ; Matsen, ME; Meek, TH; Morton, GJ; Ogimoto, K; Schwartz, MW; Thaler, JP; Wisse, BE	1
Noszál, B; Tóth, G	1
Furlanetto Júnior, R; Gonçalves, A; Huss, JC; Lopes, LT; Neves, Fde A; Souza, FR; Tolentino, CC; Zinato, Kde L	1
Brent, GA; Cervantes, V; Cheng, SY; Kahng, A; Kim, NH; Lee, JW; Liu, YY; Milanesi, A; Perin, L; Sedrakyan, S; Tripuraneni, N; Yang, A	1
Alvarado, TF; Columbano, A; Monga, SP; Nejak-Bowen, K; Poddar, M; Preziosi, M; Puliga, E; Singh, S	1
Bárez-López, S; Grijota-Martínez, C; Guadaño-Ferraz, A; Hartley, MD; Scanlan, TS	1
Bourdette, D; Ferrara, SJ; Scanlan, TS	1
Zucchi, R	1
Bensen, AL; Bourdette, DN; Calkins, E; Chaudhary, P; Emery, B; Marracci, GH; Pocius, E; Scanlan, TS	1

Reviews

3 review(s) available for triiodothyronine and gc 1 compound

Article	Year
Thyroid hormone analogues: useful biological probes and potential therapeutic agents. Annales d'endocrinologie, 2008, Volume: 69, Issue:2 Topics: Acetates; Humans; Phenols; Thyroid Hormones; Thyroxine; Triiodothyronine	2008
[Thyroid hormones and their precursors I. Biochemical properties]. Acta pharmaceutica Hungarica, 2013, Volume: 83, Issue:2 Topics: Acetates; Biological Transport; Diiodothyronines; Diiodotyrosine; Humans; Hydrogen-Ion Concentration; Membrane Transport Proteins; Monoiodotyrosine; Phenols; Phenyl Ethers; Phenylacetates; Protein Isoforms; Receptors, Thyroid Hormone; Structure-Activity Relationship; Thyroid Hormones; Thyroxine; Thyroxine-Binding Globulin; Triiodothyronine; Triiodothyronine, Reverse	2013
Thyroid Hormone Analogues: An Update. Thyroid : official journal of the American Thyroid Association, 2020, Volume: 30, Issue:8 Topics: Acetates; Anilides; Animals; Central Nervous System Diseases; Clinical Trials as Topic; Diiodothyronines; Drug Design; Dyslipidemias; Humans; Liver Diseases; Male; Mice; Mutation; Non-alcoholic Fatty Liver Disease; Phenols; Pyridazines; Rats; Signal Transduction; Thyroid Hormone Receptors alpha; Thyroid Hormone Receptors beta; Thyroid Hormones; Thyronines; Triiodothyronine; Uracil	2020

Other Studies

38 other study(ies) available for triiodothyronine and gc 1 compound

Article	Year
A high-affinity subtype-selective agonist ligand for the thyroid hormone receptor. Chemistry & biology, 1998, Volume: 5, Issue:6 Topics: Animals; Cell Line; Drug Design; HeLa Cells; Humans; Ligands; Phenols; Rats; Receptors, Thyroid Hormone; Structure-Activity Relationship; Substrate Specificity; Transcription, Genetic; Triiodothyronine	1998
Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment. Journal of medicinal chemistry, 2002, Jul-18, Volume: 45, Issue:15 Topics: Acetates; Binding, Competitive; DNA-Binding Proteins; Drug Design; HeLa Cells; Humans; Nuclear Proteins; Nuclear Receptor Co-Repressor 1; Nuclear Receptor Coactivator 2; Phenoxyacetates; Radioligand Assay; Receptors, Cytoplasmic and Nuclear; Receptors, Thyroid Hormone; Repressor Proteins; Structure-Activity Relationship; Transcription Factors; Transcriptional Activation; Triiodothyronine	2002
Structural determinants of selective thyromimetics. Journal of medicinal chemistry, 2003, Jul-03, Volume: 46, Issue:14 Topics: Acetates; Binding, Competitive; Humans; Ligands; Phenols; Structure-Activity Relationship; Thyroid Hormone Receptors beta	2003
Synthesis and biological evaluation of a series of liver-selective phosphonic acid thyroid hormone receptor agonists and their prodrugs. Journal of medicinal chemistry, 2008, Nov-27, Volume: 51, Issue:22 Topics: Animals; Cholesterol; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Drug Evaluation, Preclinical; Glycerolphosphate Dehydrogenase; Hypercholesterolemia; Ligands; Liver; Molecular Structure; Organophosphonates; Prodrugs; Rats; Rats, Sprague-Dawley; Receptors, Thyroid Hormone; Stereoisomerism; Structure-Activity Relationship	2008
Synthesis and pharmacological characterization of 1-benzyl-4-aminoindole-based thyroid hormone receptor β agonists. Bioorganic & medicinal chemistry, 2014, Jan-01, Volume: 22, Issue:1 Topics: Animals; Indoles; Rats; Thyroid Hormone Receptors beta	2014
Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β agonist in clinical trials for the treatment of dys Journal of medicinal chemistry, 2014, May-22, Volume: 57, Issue:10 Topics: Animals; Bone Density; Clinical Trials as Topic; Drug Discovery; Dyslipidemias; Humans; Male; Mice; Mice, Inbred C57BL; Pyridazines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thyroid Hormone Receptors beta; Uracil	2014
Ester-to-amide rearrangement of ethanolamine-derived prodrugs of sobetirome with increased blood-brain barrier penetration. Bioorganic & medicinal chemistry, 2017, 05-15, Volume: 25, Issue:10 Topics: Acetates; Administration, Oral; Amides; Animals; Area Under Curve; Blood-Brain Barrier; Brain; Esters; Ethanolamine; Half-Life; Male; Mice; Mice, Inbred C57BL; Phenols; Prodrugs; ROC Curve	2017
Structure-Activity Relationships of Central Nervous System Penetration by Fatty Acid Amide Hydrolase (FAAH)-Targeted Thyromimetic Prodrugs. ACS medicinal chemistry letters, 2019, Jan-10, Volume: 10, Issue:1 Topics:	2019
The thyroid hormone receptor-beta-selective agonist GC-1 differentially affects plasma lipids and cardiac activity. Endocrinology, 2000, Volume: 141, Issue:9 Topics: Acetates; Animals; Blotting, Northern; Body Weight; Dose-Response Relationship, Drug; Heart; Hemodynamics; Hypercholesterolemia; Hypolipidemic Agents; Hypothyroidism; Lipids; Male; Mice; Organ Size; Phenols; Rats; Rats, Sprague-Dawley; Receptors, Thyroid Hormone; RNA, Messenger; Thyroxine; Triiodothyronine	2000
Hormone selectivity in thyroid hormone receptors. Molecular endocrinology (Baltimore, Md.), 2001, Volume: 15, Issue:3 Topics: Acetates; Amino Acid Sequence; Asparagine; Binding Sites; Crystallography, X-Ray; Humans; Molecular Sequence Data; Mutation; Phenols; Protein Conformation; Receptors, Thyroid Hormone; Sequence Homology, Amino Acid; Thyroid Hormones; Triiodothyronine	2001
Thyroid hormone--sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform--specific. The Journal of clinical investigation, 2001, Volume: 108, Issue:1 Topics: Acetates; Adaptation, Physiological; Adipocytes; Adipose Tissue, Brown; Animals; Carrier Proteins; Cold Temperature; Cyclic AMP; Gene Expression Regulation; Glycerolphosphate Dehydrogenase; Heart Rate; Humans; Hypothyroidism; Ion Channels; Liver; Malate Dehydrogenase; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondrial Proteins; Norepinephrine; Phenols; Protein Isoforms; Rats; Receptors, Thyroid Hormone; Sympathetic Nervous System; Thermogenesis; Thyroid Hormones; Triiodothyronine; Uncoupling Protein 1	2001
Differential effects of triiodothyronine and the thyroid hormone receptor beta-specific agonist GC-1 on thyroid hormone target genes in the b ain. Endocrinology, 2003, Volume: 144, Issue:12 Topics: Acetates; Animals; Brain; Calmodulin-Binding Proteins; Caudate Nucleus; Cerebellum; Female; Gene Expression; GTP-Binding Proteins; Male; Mice; Mice, Mutant Strains; Neocortex; Nerve Tissue Proteins; Neurogranin; Phenols; Pregnancy; Rats; Rats, Wistar; Receptors, Thyroid Hormone; Reelin Protein; Thyroid Hormone Receptors beta; Thyroxine; Triiodothyronine	2003
Effects of the thyroid hormone receptor agonist GC-1 on metabolic rate and cholesterol in rats and primates: selective actions relative to 3,5,3'-triiodo-L-thyronine. Endocrinology, 2004, Volume: 145, Issue:4 Topics: Acetates; Animals; Body Weight; Cholesterol; Cholesterol, Dietary; Dose-Response Relationship, Drug; Female; Heart Rate; Lipoprotein(a); Macaca fascicularis; Male; Phenols; Rats; Rats, Sprague-Dawley; Receptors, Thyroid Hormone; Triiodothyronine	2004
Induction of larval tissue resorption in Xenopus laevis tadpoles by the thyroid hormone receptor agonist GC-1. The Journal of biological chemistry, 2004, Jun-18, Volume: 279, Issue:25 Topics: Acetates; Animals; Blotting, Northern; Cell Nucleus; DNA Mutational Analysis; Dose-Response Relationship, Drug; Ligands; Metamorphosis, Biological; Models, Chemical; Phenols; Protein Binding; Transcriptional Activation; Triiodothyronine; Xenopus laevis	2004
Mutant-selective thyromimetics for the chemical rescue of thyroid hormone receptor mutants associated with resistance to thyroid hormone. Biochemistry, 2005, Mar-29, Volume: 44, Issue:12 Topics: Acetates; Arginine; Carboxylic Acids; Cell Line; Cysteine; Drug Resistance; Glycine; Histidine; Humans; Ligands; Molecular Mimicry; Mutagenesis, Site-Directed; Phenols; Promoter Regions, Genetic; Protein Binding; Receptors, Thyroid Hormone; Repetitive Sequences, Nucleic Acid; Response Elements; Thyroid Hormone Receptors beta; Thyrotropin; Triiodothyronine	2005
Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice. Proceedings of the National Academy of Sciences of the United States of America, 2005, Jul-19, Volume: 102, Issue:29 Topics: Acetates; Analysis of Variance; Animals; Bile Acids and Salts; Cardiovascular Diseases; CD36 Antigens; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Feces; Gene Expression Regulation; Hypercholesterolemia; Immunoblotting; Liver; Male; Mice; Mice, Inbred C57BL; Phenols; Phenyl Ethers; Phenylacetates; Receptors, Immunologic; Receptors, Scavenger; Reverse Transcriptase Polymerase Chain Reaction; Thyroid Hormone Receptors beta; Triglycerides; Triiodothyronine	2005
Different configurations of specific thyroid hormone response elements mediate opposite effects of thyroid hormone and GC-1 on gene expression. Endocrinology, 2005, Volume: 146, Issue:11 Topics: Acetates; Animals; Base Sequence; Calcium-Transporting ATPases; Cells, Cultured; Chromatin Immunoprecipitation; DNA; Gene Expression; Histone Acetyltransferases; Histone Deacetylases; Molecular Sequence Data; Mutation; Nuclear Proteins; Nuclear Receptor Co-Repressor 1; Nuclear Receptor Coactivator 1; Phenols; Promoter Regions, Genetic; Rats; Receptors, Thyroid Hormone; Repressor Proteins; Response Elements; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Transcription Factors; Triiodothyronine	2005
Thyroid hormone receptor beta-specific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats. The Journal of endocrinology, 2007, Volume: 193, Issue:1 Topics: Absorptiometry, Photon; Acetates; Adipose Tissue; Animals; Body Composition; Energy Metabolism; Female; Heart; Muscle, Skeletal; Obesity; Organ Size; Oxygen Consumption; Phenols; Random Allocation; Rats; Rats, Wistar; Thyroid Hormone Receptors beta; Triiodothyronine	2007
Thyroid hormone (T3) and TRbeta agonist GC-1 inhibit/reverse nonalcoholic fatty liver in rats. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2008, Volume: 22, Issue:8 Topics: Acetates; Animals; Base Sequence; Diet; Disease Models, Animal; DNA Primers; Fatty Liver; Lipid Peroxidation; Liver; Male; Phenols; Rats; Rats, Inbred F344; Thyroid Hormone Receptors beta; Triglycerides; Triiodothyronine	2008
[Thyroid hormone analogs: an important biological supply and new therapeutic possibilities]. Annales d'endocrinologie, 2008, Volume: 69 Suppl 1 Topics: Acetates; Anilides; Anticholesteremic Agents; Humans; Hypolipidemic Agents; Phenols; Phenyl Ethers; Phenylacetates; Receptors, Thyroid Hormone; Signal Transduction; Thyroid Hormones; Triiodothyronine	2008
Thyroid hormone receptor subtype specificity for hormone-dependent neurogenesis in Xenopus laevis. Developmental biology, 2009, Feb-01, Volume: 326, Issue:1 Topics: Acetates; Animals; Benzhydryl Compounds; Brain; Cell Proliferation; Green Fluorescent Proteins; Hydantoins; Larva; Metamorphosis, Biological; Neurogenesis; Phenols; Thyroid Hormone Receptors alpha; Thyroid Hormone Receptors beta; Triiodothyronine; Xenopus laevis	2009
The thyroid hormone receptor (TR) beta-selective agonist GC-1 inhibits proliferation but induces differentiation and TR beta mRNA expression in mouse and rat osteoblast-like cells. Calcified tissue international, 2009, Volume: 84, Issue:4 Topics: Acetates; Alkaline Phosphatase; Animals; Cell Differentiation; Cell Line; Cell Proliferation; Gene Expression; Mice; Osteoblasts; Osteocalcin; Phenols; Polymerase Chain Reaction; Rats; RNA, Messenger; Thyroid Hormone Receptors beta; Triiodothyronine	2009
T3 and the thyroid hormone beta-receptor agonist GC-1 differentially affect metabolic capacity and oxidative damage in rat tissues. The Journal of experimental biology, 2009, Volume: 212, Issue:Pt 7 Topics: Acetates; Analysis of Variance; Animals; Calorimetry; Electrocardiography; Electron Transport Complex IV; Energy Metabolism; Heart; Heart Rate; Liver; Male; Muscle, Skeletal; Oxidative Stress; Oxygen Consumption; Phenols; Rats; Rats, Wistar; Thyroid Hormone Receptors beta; Triiodothyronine	2009
Induction of the adrenoleukodystrophy-related gene (ABCD2) by thyromimetics. The Journal of steroid biochemistry and molecular biology, 2009, Volume: 116, Issue:1-2 Topics: Acetates; Adrenoleukodystrophy; Animals; ATP Binding Cassette Transporter, Subfamily D; ATP-Binding Cassette Transporters; Chlorocebus aethiops; COS Cells; Glyoxylates; Humans; Phenols; Rats; Thyroid Hormones; Transfection; Triiodothyronine; Up-Regulation	2009
Human platelet aggregation and degranulation is induced in vitro by L-thyroxine, but not by 3,5,3'-triiodo-L-thyronine or diiodothyropropionic acid (DITPA). Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2010, Volume: 16, Issue:3 Topics: Acetates; Adenosine Triphosphate; Adolescent; Blood Platelets; Collagen; Cytoplasmic Granules; Diiodothyronines; Female; Humans; Imidazoles; Male; Phenols; Platelet Activation; Platelet Aggregation; Propionates; Receptors, Thyroid Hormone; Substrate Specificity; Thyroxine; Triiodothyronine; Young Adult	2010
The TRbeta-selective agonist, GC-1, stimulates mitochondrial oxidative processes to a lesser extent than triiodothyronine. The Journal of endocrinology, 2010, Volume: 205, Issue:3 Topics: Acetates; Animals; GA-Binding Protein Transcription Factor; Hydrogen Peroxide; Male; Mitochondria; Models, Animal; Nuclear Respiratory Factor 1; Oxidation-Reduction; Oxygen Consumption; Phenols; PPAR gamma; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; Triiodothyronine	2010
The T3 receptor beta1 isoform regulates UCP1 and D2 deiodinase in rat brown adipocytes. Endocrinology, 2010, Volume: 151, Issue:10 Topics: Acetates; Adipose Tissue, Brown; Adrenergic Agents; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Hydantoins; Iodide Peroxidase; Iodothyronine Deiodinase Type II; Ion Channels; Mitochondrial Proteins; Norepinephrine; Phenols; Protein Isoforms; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Thyroid Hormone Receptors beta; Triiodothyronine; Uncoupling Protein 1	2010
The binding of synthetic triiodo l-thyronine analogs to human transthyretin: molecular basis of cooperative and non-cooperative ligand recognition. Journal of structural biology, 2011, Volume: 173, Issue:2 Topics: Acetates; Benzhydryl Compounds; Calorimetry; Humans; Phenols; Prealbumin; Thyroid Hormone Receptors beta; Triiodothyronine; X-Ray Diffraction	2011
Identical gene regulation patterns of T3 and selective thyroid hormone receptor modulator GC-1. Endocrinology, 2012, Volume: 153, Issue:1 Topics: Acetates; Angiopoietin-Like Protein 4; Angiopoietins; Animals; Binding Sites; Gene Expression Regulation; Hep G2 Cells; Humans; Liver; Male; Mice; Mice, Inbred C57BL; Phenols; Receptors, Thyroid Hormone; RNA, Small Interfering; Thyroid Hormone Receptors alpha; Thyroid Hormone Receptors beta; Triiodothyronine	2012
Thyroid hormone receptor agonists reduce serum cholesterol independent of the LDL receptor. Endocrinology, 2012, Volume: 153, Issue:12 Topics: Acetates; Anilides; Animals; Apolipoproteins B; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Feces; Lipoproteins; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phenols; Receptors, LDL; Receptors, Thyroid Hormone; Thyroid Hormone Receptors beta; Triglycerides; Triiodothyronine	2012
In uncontrolled diabetes, thyroid hormone and sympathetic activators induce thermogenesis without increasing glucose uptake in brown adipose tissue. American journal of physiology. Endocrinology and metabolism, 2013, Apr-01, Volume: 304, Issue:7 Topics: Acetates; Adipose Tissue, Brown; Adrenergic beta-3 Receptor Agonists; Animals; Body Composition; Diabetes Mellitus, Experimental; Eating; Glucose; Hyperglycemia; Ion Channels; Male; Mitochondrial Proteins; Phenols; Rats; Rats, Wistar; Receptors, Adrenergic, beta-3; Streptozocin; Sympathetic Nervous System; Thermogenesis; Thyroid Hormone Receptors beta; Triiodothyronine; Uncoupling Protein 1	2013
In vivo evaluation of 1-benzyl-4-aminoindole-based thyroid hormone receptor β agonists: importance of liver selectivity in drug discovery. Biological & pharmaceutical bulletin, 2014, Volume: 37, Issue:7 Topics: Acetates; Administration, Oral; Animals; Blood Glucose; Dose-Response Relationship, Drug; Drug Discovery; Heart Rate; Hypertriglyceridemia; Indoles; Injections, Intravenous; Lipids; Liver; Male; Malonates; Molecular Structure; Phenols; Rats, Sprague-Dawley; Structure-Activity Relationship; Thyroid Hormone Receptors beta; Thyroxine; Tissue Distribution; Triiodothyronine	2014
The thyroid hormone receptor β-selective agonist GC-1 does not affect tolerance to exercise in hypothyroid rats. Archives of endocrinology and metabolism, 2015, Volume: 59, Issue:2 Topics: Acetates; Animals; Exercise Tolerance; Hypothyroidism; Methimazole; Muscle, Skeletal; Myocytes, Cardiac; Perchlorates; Phenols; Rats, Wistar; Sodium Compounds; Swimming; Thyroid Hormone Receptors beta; Thyrotropin; Thyroxine; Triiodothyronine	2015
Thyroid Hormone Receptor α Plays an Essential Role in Male Skeletal Muscle Myoblast Proliferation, Differentiation, and Response to Injury. Endocrinology, 2016, Volume: 157, Issue:1 Topics: Acetates; Animals; Cell Line; Cell Proliferation; Cells, Cultured; Drug Resistance; Frameshift Mutation; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Muscle Development; Muscle, Skeletal; Myoblasts, Skeletal; Phenols; Regeneration; RNA Interference; Thyroid Hormone Receptors alpha; Thyroid Hormone Receptors beta; Triiodothyronine; Wnt Signaling Pathway	2016
Thyroid Hormone Receptor β Agonist Induces β-Catenin-Dependent Hepatocyte Proliferation in Mice: Implications in Hepatic Regeneration. Gene expression, 2016, Volume: 17, Issue:1 Topics: Acetates; Animals; beta Catenin; Cell Proliferation; Cyclic AMP-Dependent Protein Kinases; Hepatectomy; Hepatocytes; Liver; Liver Regeneration; Male; Mice; Mice, Inbred C57BL; Phenols; Thyroid Hormone Receptors beta; Triiodothyronine; Wnt Signaling Pathway	2016
Sobetirome and its Amide Prodrug Sob-AM2 Exert Thyromimetic Actions in Mct8-Deficient Brain. Thyroid : official journal of the American Thyroid Association, 2018, Volume: 28, Issue:9 Topics: Acetates; Animals; Brain; Membrane Transport Proteins; Mice; Mice, Knockout; Monocarboxylic Acid Transporters; Phenols; Prodrugs; Symporters; Thyroxine; Triiodothyronine; Uncoupling Protein 2	2018
Hypothalamic-Pituitary-Thyroid Axis Perturbations in Male Mice by CNS-Penetrating Thyromimetics. Endocrinology, 2018, 07-01, Volume: 159, Issue:7 Topics: Acetates; Animals; Central Nervous System; Hypothalamo-Hypophyseal System; Hypothyroidism; Male; Mice; Mice, Inbred C57BL; Phenols; Pituitary Gland; Radioimmunoassay; Thyroid Gland; Thyroid Hormones; Thyroxine; Triiodothyronine	2018
Thyroid hormone and thyromimetics inhibit myelin and axonal degeneration and oligodendrocyte loss in EAE. Journal of neuroimmunology, 2021, 03-15, Volume: 352 Topics: Acetates; Animals; Demyelinating Diseases; Encephalomyelitis, Autoimmune, Experimental; Female; Mice; Mice, Inbred C57BL; Myelin Sheath; Nerve Degeneration; Oligodendroglia; Phenols; Prodrugs; Triiodothyronine	2021