triiodothyronine--reverse and 3-3--5-triiodothyronamine

triiodothyronine--reverse has been researched along with 3-3--5-triiodothyronamine* in 1 studies

Other Studies

1 other study(ies) available for triiodothyronine--reverse and 3-3--5-triiodothyronamine

Article	Year
Triiodothyronamine--a beta-adrenergic metabolite of triiodothyronine? Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1983, Volume: 15, Issue:12 Triiodothyronamine (Triam) is a potential metabolite of triidothyronine (T3), resulting from decarboxylation of the side-chain. In an attempt to elucidate the physiological properties of Triam we have investigated the binding of Triam to beta-adrenergic receptors, using turkey-erythrocytes and performing binding studies with ( (-)(3H)-dihydroalprenolol) ( (-)(3H)-DHA) as a specific beta-adrenergic ligand. The inhibition constant Ki for Triam was determined as 5 X 10(-6) M, compared to dopamine (Ki = 1,3 X 10(-2) M), norepinephrine (Ki = 3 X 10(-4) M), epinephrine (Ki = 5 X 10(-5) M) and isoproterenol (Ki = 3 X 10(-6) M). The inhibition of ( (-)(3H)-DHA)-binding by Triam was further compared with other iodothyronines thyroxine (T4), T3, 3,3',5'-triiodothyronine (rT3) and 3,3'-diiodothyronine (3,3'-T2). It is concluded that Triam binds to beta-adrenergic receptors like naturally occurring amines but different from typical circulating iodothyronines. Topics: Animals; Decarboxylation; Dihydroalprenolol; Diiodothyronines; Dopamine; Epinephrine; Erythrocytes; In Vitro Techniques; Isoproterenol; Norepinephrine; Receptors, Adrenergic, beta; Thyroxine; Triiodothyronine; Triiodothyronine, Reverse; Turkeys	1983

Article

Year

Triiodothyronamine--a beta-adrenergic metabolite of triiodothyronine?

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1983, Volume: 15, Issue:12

Triiodothyronamine (Triam) is a potential metabolite of triidothyronine (T3), resulting from decarboxylation of the side-chain. In an attempt to elucidate the physiological properties of Triam we have investigated the binding of Triam to beta-adrenergic receptors, using turkey-erythrocytes and performing binding studies with ( (-)(3H)-dihydroalprenolol) ( (-)(3H)-DHA) as a specific beta-adrenergic ligand. The inhibition constant Ki for Triam was determined as 5 X 10(-6) M, compared to dopamine (Ki = 1,3 X 10(-2) M), norepinephrine (Ki = 3 X 10(-4) M), epinephrine (Ki = 5 X 10(-5) M) and isoproterenol (Ki = 3 X 10(-6) M). The inhibition of ( (-)(3H)-DHA)-binding by Triam was further compared with other iodothyronines thyroxine (T4), T3, 3,3',5'-triiodothyronine (rT3) and 3,3'-diiodothyronine (3,3'-T2). It is concluded that Triam binds to beta-adrenergic receptors like naturally occurring amines but different from typical circulating iodothyronines.

Topics: Animals; Decarboxylation; Dihydroalprenolol; Diiodothyronines; Dopamine; Epinephrine; Erythrocytes; In Vitro Techniques; Isoproterenol; Norepinephrine; Receptors, Adrenergic, beta; Thyroxine; Triiodothyronine; Triiodothyronine, Reverse; Turkeys

1983