Page last updated: 2024-08-16

trihexyphenidyl and procyclidine

trihexyphenidyl has been researched along with procyclidine in 45 studies

Research

Studies (45)

TimeframeStudies, this research(%)All Research%
pre-199036 (80.00)18.7374
1990's2 (4.44)18.2507
2000's5 (11.11)29.6817
2010's2 (4.44)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Taylor, J1
Butzer, JF; Sahs, AL; Silver, DE1
Crow, TJ; Johnstone, EC; McClelleand, HA1
Parkenberg, H1
di Costanzo, E; Schifano, F1
Delva, N; Lawson, JS; Letemendia, FJ; Owen, JA; Sribney, M1
Götestam, KG; Vågen, R1
Aasen, AJ; Groth, P; Harbitz, O; Schjelderup, L1
Bowers, MB; Roth, RH1
Mano, T1
Birket-Smith, E1
Chatten, LG; Racz, WJ1
Denber, HC; Goldner, F; Seeman, MV1
Barlow, RB1
Caffey, E; Klett, CJ1
Benesová, O1
McCulloch, JA; Ursillo, RC1
Villeneuve, A1
Garattini, S; Giovannucci, M; Montanini, R; Morselli, PL; Muscettola, GB1
Ananth, JV; Ban, TA; Lehmann, HE; Pecknold, JC1
Kline, NS1
Millichap, JG; Millichap, MG; Pitchford, GL1
Chatten, LG; Doan, LA1
Warnes, H1
Feaver, BD; MacEwan, DW; Usher, M1
Camerman, A; Camerman, N1
Bennie, EH1
Caviglia, A; Cellitti, M; Di Bianco, V; Di Castro, A; Pavoncello, S1
Adlersberg, S; Averbuch, E; Gonen, N; Mester, R; Spivak, B; Weizman, A1
Buhrich, N; Kevans, P; Weller, A1
DUFFIN, WM; GREEN, AF1
DOSHAY, LJ; ZIER, A1
KONCHEGUL, L1
MILCH, LJ; RENZI, AA1
KASICH, AM; RAFSKY, JC2
SHAY, H; SUN, DC1
ALPHIN, RS; CHEN, KK; LIN, TM1
SHAY, H; SUN, DC; WOLOSHIN, HJ1
Hadidi, KA1
Liu, J; Sun, X; Wang, E; Yan, J; Yang, X; You, T; Zhao, X1
Aas, P; Enger, S; Myhrer, T1
Al-Amri, A; Ali, HS; El-Haj, B1

Reviews

2 review(s) available for trihexyphenidyl and procyclidine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
[Review of current pharmacotherapy of Parkinsonism. Comprehensive review].
    Ceskoslovenska neurologie, 1973, Volume: 36, Issue:3

    Topics: 5-Hydroxytryptophan; Amantadine; Anticonvulsants; Apomorphine; Benztropine; Carboxy-Lyases; Chemical Phenomena; Chemistry; Dihydroxyphenylalanine; Humans; Parasympatholytics; Parkinson Disease; Procyclidine; Trihexyphenidyl

1973

Trials

3 trial(s) available for trihexyphenidyl and procyclidine

ArticleYear
Amantadine in Parkinson's disease. A double-blind, placebo-controlled, crossover study with long-term follow-up.
    Neurology, 1975, Volume: 25, Issue:7

    Topics: Activities of Daily Living; Aged; Amantadine; Benztropine; Clinical Trials as Topic; Diphenhydramine; Drug Evaluation; Female; Follow-Up Studies; Humans; Locomotion; Long-Term Care; Male; Middle Aged; Muscle Rigidity; Parkinson Disease; Procyclidine; Time Factors; Tremor; Trihexyphenidyl

1975
An experimental evaluation of the euphoric properties of antiparkinson drugs on psychotic patients.
    Acta psychiatrica Scandinavica, 1986, Volume: 74, Issue:5

    Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Double-Blind Method; Euphoria; Female; Humans; Male; Middle Aged; Orphenadrine; Parkinson Disease, Secondary; Procyclidine; Psychotic Disorders; Pyrrolidines; Trihexyphenidyl

1986
Evaluating the long-term need for antiparkinson drugs by chronic schizophrenics.
    Archives of general psychiatry, 1972, Volume: 26, Issue:4

    Topics: 1-Propanol; Adult; Antiparkinson Agents; Basal Ganglia Diseases; Benztropine; Biperiden; Chronic Disease; Clinical Trials as Topic; Drug Combinations; Evaluation Studies as Topic; Humans; Male; Middle Aged; Movement Disorders; Parasympatholytics; Piperidines; Procyclidine; Pyrrolidines; Schizophrenia; Tranquilizing Agents; Trihexyphenidyl; Tropanes

1972

Other Studies

40 other study(ies) available for trihexyphenidyl and procyclidine

ArticleYear
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
    Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2

    Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase

2008
Parkinson's disease.
    The Australian nurses' journal. Royal Australian Nursing Federation, 1977, Volume: 7, Issue:5

    Topics: Amantadine; Benztropine; Humans; Levodopa; Parkinson Disease; Procyclidine; Trihexyphenidyl

1977
The coincidence of schizophrenia and Parkinsonism: some neurochemical implications.
    Psychological medicine, 1976, Volume: 6, Issue:2

    Topics: Aged; Delusions; Dopamine; Female; Hallucinations; Humans; Middle Aged; Parkinson Disease, Postencephalitic; Parkinson Disease, Secondary; Procyclidine; Receptors, Dopamine; Schizophrenia; Schizophrenic Psychology; Trihexyphenidyl

1976
[Treatment of parkinsonism].
    Ugeskrift for laeger, 1976, Apr-26, Volume: 138, Issue:18

    Topics: Amantadine; Benztropine; Biperiden; Humans; Levodopa; Orphenadrine; Parkinson Disease; Procyclidine; Trihexyphenidyl

1976
Excessive use of anticholinergic drugs in a sub-sample of Italian schizophrenics.
    International journal of clinical pharmacology, therapy, and toxicology, 1991, Volume: 29, Issue:5

    Topics: Adult; Biperiden; Female; Humans; Italy; Male; Middle Aged; Orphenadrine; Parasympatholytics; Patient Compliance; Procyclidine; Retrospective Studies; Sampling Studies; Schizophrenia; Trihexyphenidyl

1991
Capillary gas chromatography of trihexyphenidyl, procyclidine and cycrimine in biological fluids.
    Journal of chromatography, 1989, Sep-29, Volume: 494

    Topics: Antipsychotic Agents; Chromatography, Gas; False Positive Reactions; Flame Ionization; Humans; Parasympatholytics; Piperidines; Procyclidine; Pyrrolidines; Trihexyphenidyl

1989
Syntheses of (S)-(+)-trihexyphenidyl hydrochloride and (S)-(+)-procyclidine hydrochloride, two anticholinergics, using (S)-(-)-3-cyclohexyl-3-hydroxy-3-phenylpropanoic acid as chiral synthon.
    Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry, 1987, Volume: 41, Issue:5

    Topics: Circular Dichroism; Indicators and Reagents; Magnetic Resonance Spectroscopy; Molecular Conformation; Optical Rotation; Phenylpropionates; Procyclidine; Pyrrolidines; Spectrophotometry, Infrared; Stereoisomerism; Trihexyphenidyl

1987
Interaction of atropine-like drugs with dopamine-containing neurones in rat brain.
    British journal of pharmacology, 1972, Volume: 44, Issue:2

    Topics: Animals; Atropine; Benztropine; Brain; Chlorpromazine; Dopamine; Homovanillic Acid; Male; Methyltyrosines; Neurons; Orphenadrine; Phenothiazines; Procyclidine; Rats; Time Factors; Trihexyphenidyl

1972
[Dyskinesia induced by anticholinergic drugs--electrophysiological analysis].
    Rinsho shinkeigaku = Clinical neurology, 1974, Volume: 14, Issue:3

    Topics: Aged; Benztropine; Biperiden; Electromyography; Female; Humans; Male; Middle Aged; Movement Disorders; Parasympatholytics; Parkinson Disease; Phenothiazines; Procyclidine; Trihexyphenidyl

1974
Abnormal involuntary movements induced by anticholinergic therapy.
    Acta neurologica Scandinavica, 1974, Volume: 50, Issue:6

    Topics: Aged; Biperiden; Dibenzazepines; Female; Humans; Mastication; Middle Aged; Movement Disorders; Orphenadrine; Parasympatholytics; Parkinson Disease; Phenothiazines; Procyclidine; Tremor; Trihexyphenidyl

1974
Quantitative determination of some synthetic antiparkinsonism agents.
    Journal of pharmaceutical sciences, 1968, Volume: 57, Issue:1

    Topics: Amines; Biperiden; Borates; Chemistry Techniques, Analytical; Chemistry, Pharmaceutical; Chloroform; Colorimetry; Indicators and Reagents; Methods; Parasympatholytics; Perchlorates; Phenethylamines; Phenols; Procyclidine; Trihexyphenidyl

1968
Paradoxical effects of phenothiazines.
    The Psychiatric quarterly, 1968, Volume: 42, Issue:1

    Topics: Adult; Amitriptyline; Chlorpromazine; Diazepam; Female; Humans; Meclofenoxate; Meprobamate; Phenothiazines; Prochlorperazine; Procyclidine; Schizophrenia; Thioridazine; Trifluoperazine; Trihexyphenidyl

1968
Differences in the stereospecificity of closely related compounds; a reinvestigation of the enantiomers of procyclidine, benzhexol and their metho- and etho-salts.
    The Journal of pharmacy and pharmacology, 1971, Volume: 23, Issue:2

    Topics: 1-Propanol; Acetylcholine; Animals; Atropine; Biological Assay; Guinea Pigs; Ileum; In Vitro Techniques; Parasympatholytics; Polarography; Procyclidine; Pyrrolidines; Receptors, Drug; Stereoisomerism; Trihexyphenidyl

1971
The effect of elantrine, a new anti-Parkinsonism agent, on drug-induced tremor in mice.
    Archives internationales de pharmacodynamie et de therapie, 1972, Volume: 197, Issue:1

    Topics: Alkaloids; Animals; Antiparkinson Agents; Atropine; Benztropine; Body Temperature; Central Nervous System; Dibenzazepines; Drug Antagonism; Indoles; Male; Methylamines; Mice; Nicotine; Oxotremorine; Parasympatholytics; Procyclidine; Pupil; Pyridines; Seizures; Tremor; Trihexyphenidyl

1972
The rabbit syndrome. A peculiar extrapyramidal reaction.
    Canadian Psychiatric Association journal, 1972, Volume: 17, Issue:2

    Topics: Aged; Anxiety; Basal Ganglia Diseases; Benztropine; Chlorpromazine; Fatigue; Female; Humans; Male; Masticatory Muscles; Middle Aged; Mouth; Movement Disorders; Perphenazine; Procyclidine; Reserpine; Schizophrenia; Syndrome; Tranquilizing Agents; Trifluoperazine; Trihexyphenidyl

1972
Relationship between desipramine plasma levels and the effect in Parkinson's syndrome.
    Revue europeenne d'etudes cliniques et biologiques. European journal of clinical and biological research, 1972, Volume: 17, Issue:4

    Topics: Adult; Aged; Contracture; Desipramine; Drug Synergism; Female; Humans; Male; Middle Aged; Paralysis; Parkinson Disease; Procyclidine; Trihexyphenidyl

1972
Lack of indication for use of antiparkinson medication. A follow-up study.
    Diseases of the nervous system, 1971, Volume: 32, Issue:8

    Topics: Adolescent; Adult; Female; Follow-Up Studies; Humans; Intellectual Disability; Male; Mental Disorders; Middle Aged; Nortropanes; Parasympatholytics; Parkinson Disease; Parkinson Disease, Secondary; Procyclidine; Schizophrenia; Substance Withdrawal Syndrome; Sulfonic Acids; Time Factors; Tranquilizing Agents; Trihexyphenidyl

1971
Greater than recommended drug dosages--some effects.
    The American journal of psychiatry, 1970, Volume: 126, Issue:12

    Topics: Adult; Extrapyramidal Tracts; Female; Fluphenazine; Humans; Male; Movement Disorders; Procyclidine; Schizophrenia; Trihexyphenidyl

1970
Anticonvulsant activity of antiparkinsonism agents.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1968, Volume: 127, Issue:4

    Topics: Animals; Anticonvulsants; Child; Child, Preschool; Electroshock; Female; Glaucoma; Humans; Infant; Male; Mice; Myoclonus; Nervous System Diseases; Parasympatholytics; Pentylenetetrazole; Procyclidine; Pyrrolidines; Seizures; Trihexyphenidyl; Urethral Stricture

1968
Identification and differentiation of organic medicinal agents. 3. Amine-containing antiparkinson agents and newer muscle relaxants.
    Journal of pharmaceutical sciences, 1966, Volume: 55, Issue:4

    Topics: Amines; Crystallography; Infrared Rays; Muscles; Parasympatholytics; Phenethylamines; Procyclidine; Spectrophotometry; Spectrum Analysis; Trihexyphenidyl

1966
Toxic psychosis due to antiparkinsonian drugs.
    Canadian Psychiatric Association journal, 1967, Volume: 12, Issue:3

    Topics: Adolescent; Adult; Bipolar Disorder; Female; Humans; Male; Middle Aged; Paranoid Disorders; Parasympatholytics; Procyclidine; Psychoses, Substance-Induced; Schizophrenia; Trihexyphenidyl

1967
The effect of antidepressant drugs on the urinary tract. Clinical and animal studies.
    Journal of the Canadian Association of Radiologists, 1967, Volume: 18, Issue:4

    Topics: 1-Propanol; Adult; Amitriptyline; Animals; Antidepressive Agents; Diagnosis, Differential; Female; Humans; Imipramine; Male; Middle Aged; Parasympatholytics; Procyclidine; Propantheline; Pyrrolidines; Quaternary Ammonium Compounds; Rabbits; Trihexyphenidyl; Urination Disorders; Urography; Urologic Diseases; Xanthenes

1967
Stereochemical similarities in chemically different antiepileptic drugs.
    Advances in neurology, 1980, Volume: 27

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzeneacetamides; Diazepam; Molecular Conformation; Phenobarbital; Phenylacetates; Phenylbutyrates; Phenytoin; Procyclidine; Stereoisomerism; Structure-Activity Relationship; Trihexyphenidyl; Urea

1980
Antiparkinsonian medication in depressed schizophrenics on depot neuroleptics.
    The British journal of psychiatry : the journal of mental science, 1982, Volume: 140

    Topics: Antipsychotic Agents; Humans; Procyclidine; Pyrrolidines; Schizophrenia; Trihexyphenidyl

1982
[Neurological aspects and modern trends in therapy of Parkinson's disease].
    La Clinica terapeutica, 1980, Feb-29, Volume: 92, Issue:4

    Topics: Atropine; Biperiden; Humans; Levodopa; Parasympatholytics; Parkinson Disease; Procyclidine; Trihexyphenidyl

1980
Neuroleptic malignant syndrome associated with abrupt withdrawal of anticholinergic agents.
    International clinical psychopharmacology, 1996, Volume: 11, Issue:3

    Topics: Adult; Antipsychotic Agents; Delayed-Action Preparations; Fluphenazine; Humans; Male; Muscarinic Antagonists; Neuroleptic Malignant Syndrome; Penfluridol; Procyclidine; Schizophrenia; Substance Withdrawal Syndrome; Trihexyphenidyl

1996
Misuse of anticholinergic drugs by people with serious mental illness.
    Psychiatric services (Washington, D.C.), 2000, Volume: 51, Issue:7

    Topics: Adult; Benztropine; Female; Humans; Illicit Drugs; Male; Mental Disorders; Muscarinic Antagonists; New South Wales; Orphenadrine; Prevalence; Procyclidine; Substance-Related Disorders; Trihexyphenidyl

2000
The pharmacological properties of the optical isomers of benzhexol, procyclidine, tricyclamol and related compounds.
    British journal of pharmacology and chemotherapy, 1955, Volume: 10, Issue:3

    Topics: Ethanol; Isomerism; Parasympatholytics; Procyclidine; Propanols; Trihexyphenidyl

1955
Procyclidine hydrochloride (kemadrin) treatment of parkinsonism; result in 108 patients.
    Neurology, 1957, Volume: 7, Issue:7

    Topics: Parkinson Disease; Parkinsonian Disorders; Procyclidine; Trihexyphenidyl

1957
The use of kemadrin in the treatment of drug-induced parkinsonism; preliminary report.
    The Medical annals of the District of Columbia, 1958, Volume: 27, Issue:8

    Topics: Parkinson Disease; Parkinsonian Disorders; Procyclidine; Trihexyphenidyl

1958
Effectiveness of procyclidine hydrochloride (kemadrin) and cycrimine hydrochloride (pagitane) in the prevention of airsickness.
    The Journal of aviation medicine, 1958, Volume: 29, Issue:8

    Topics: Biomedical Research; Humans; Motion Sickness; Muscarinic Antagonists; Piperidines; Procyclidine; Trihexyphenidyl

1958
A balloonkymographic study of the effects of tricyclamol on colonic motility in irritable colon.
    The American journal of gastroenterology, 1959, Volume: 31, Issue:1

    Topics: Colon; Colonic Diseases; Disease; Humans; Irritable Bowel Syndrome; Procyclidine; Trihexyphenidyl

1959
Clinical evaluation of an anticholinergic in the irritable colon syndrome; a double blind study of tricyclamol.
    The American journal of gastroenterology, 1959, Volume: 31, Issue:1

    Topics: Cholinergic Antagonists; Colon; Colonic Diseases; Disease; Double-Blind Method; Humans; Irritable Bowel Syndrome; Procyclidine; Trihexyphenidyl

1959
Synergistic action of chlorpromazine and tricyclamol on basal gastric secretion in duodenal ulcer patients.
    Gastroenterology, 1959, Volume: 36, Issue:2

    Topics: Chlorpromazine; Digestion; Duodenal Ulcer; Gastric Juice; Peptic Ulcer; Procyclidine; Trihexyphenidyl

1959
Action of tricyclamol sulfate on gastric secretion of rats and dogs.
    The Journal of pharmacology and experimental therapeutics, 1959, Volume: 125, Issue:1

    Topics: Animals; Dogs; Gastric Juice; Ions; Procyclidine; Rats; Sulfates; Trihexyphenidyl

1959
Effect of tricyclamol on gastric emptying and intestinal transit; comparative studies with placebos, single dose, and optimal effective dose.
    The American journal of digestive diseases, 1959, Volume: 4, Issue:4

    Topics: Gastric Emptying; Humans; Intestines; Peptic Ulcer; Procyclidine; Stomach; Trihexyphenidyl

1959
Development of a screening method for the most commonly abused anticholinergic drugs in Jordan; trihexyphenidyl, procyclidine and biperiden.
    Legal medicine (Tokyo, Japan), 2004, Volume: 6, Issue:4

    Topics: Adolescent; Adult; Biperiden; Forensic Medicine; Gas Chromatography-Mass Spectrometry; Humans; Jordan; Male; Muscarinic Antagonists; Procyclidine; Substance Abuse Detection; Substance-Related Disorders; Trihexyphenidyl

2004
Drug-human serum albumin binding studied by capillary electrophoresis with electrochemiluminescence detection.
    Electrophoresis, 2004, Volume: 25, Issue:20

    Topics: Antiparkinson Agents; Binding, Competitive; Electrophoresis, Capillary; Humans; Luminescent Measurements; Organometallic Compounds; Piperidines; Procyclidine; Protein Binding; Serum Albumin; Trihexyphenidyl

2004
Antiparkinson drugs used as prophylactics for nerve agents: studies of cognitive side effects in rats.
    Pharmacology, biochemistry, and behavior, 2008, Volume: 89, Issue:4

    Topics: Animals; Antiparkinson Agents; Behavior, Animal; Benactyzine; Biperiden; Cholinergic Antagonists; Cholinesterase Inhibitors; Cognition; Cyclopentanes; Exploratory Behavior; Male; Motor Activity; Neurotoxins; Organophosphorus Compounds; Physostigmine; Procyclidine; Rats; Rats, Wistar; Trihexyphenidyl

2008
Target urinary analytes for the gas chromatographic- mass spectrometric detection of procyclidine and benzhexol in drug abuse cases.
    Journal of analytical toxicology, 2011, Volume: 35, Issue:2

    Topics: Antiparkinson Agents; Gas Chromatography-Mass Spectrometry; Humans; Procyclidine; Substance Abuse Detection; Trihexyphenidyl

2011