Page last updated: 2024-08-21

triflusal and salicylates

triflusal has been researched along with salicylates in 137 studies

Research

Studies (137)

TimeframeStudies, this research(%)All Research%
pre-199023 (16.79)18.7374
1990's25 (18.25)18.2507
2000's55 (40.15)29.6817
2010's31 (22.63)24.3611
2020's3 (2.19)2.80

Authors

AuthorsStudies
Garcia Rafanell, J; Planas, JM; Puig-Parellada, P1
Bellés, L; Forn, J; García Rafanell, J1
Conte, L; Forn, J; Mis, R; Ramis, J2
de la Cruz, JP; Mata, JM; Sanchez de la Cuesta, F1
Campos, A; Cervós-Navarro, J; Heye, N; Kannuki, S1
Conget, JI; Esmatjes, E; Fernandez, MR; Ferrer, JP; Gaya, J; Rivera, F; Vilardell, E1
Barbanoj, MJ; Conte, L; Forn, J; Jané, J; Mis, R; Ramis, J; Torrent, J1
Alvarez, L; Castillo-Olivares, JL; de Haro, J; Escudero, MC; Millán, I; Rodríguez, V1
Altimiras, J; Arís, A; Augé, JM; Bassons, T; Bonal, J; Caralps, JM; Castellarnau, C; Crexells, C; Guiteras, P; Masotti, M1
Conget, I; Coves, MJ; Esmatjes, E; Gállego, M; Maseras, M1
Alvarez, L; Castillo-Olivares, JL; del Moral, JH; Escudero-Vela, MC; Millán, I; Rodríguez, V1
De la Cruz, JP; Garcia-Arnes, J; Pavia, J; Sanchez de la Cuesta, F1
Forn, J; García-Rafanell, J; Gomez, L; Ramis, J1
Forn, J; García Rafanell, J; Gómez, L1
Albors, M; De Castellarnau, C; Rutllant, ML; Sancho, MJ; Vila, L1
Coves, MJ; Esmatjes, E; Figuerola, D; Gallego, M; Maseras, M; Ríos, M1
Bellido, I; de la Cruz, JP; González, MC; Pavia, J; Sánchez de la Cuesta, F1
Bellido, I; de la Cruz, JP; Pavia, J; Sánchez de la Cuesta, F1
Aliaga, A; Planells, I; Serrano, G1
Dominguez, MJ; Forn, J; Iriarte, JA; Olabarría, I; Sáez, Y; Vacas, M; Velasco, A1
Forn, J; García Rafanell, J; Ramis, J; Sánchez, MS3
Azanza, JR; Honorato, J1
Forn, J; Rimbau, V; Torralba, A1
Fernández, A; Forn, J; López, R; Rimbau, V1
Forn, J; García Rafanell, J; Sánchez, MS1
Aranza Perea, J; Arcas, R; Herreros, J; Honorato, J; Rocha, E1
Bergqvist, D; Granero, X; Lafoz, E; Monreal, M; Olazabal, A; Roca, J; Salazar, X; Soler, J1
De La Cruz, JP; García, PJ; Sánchez de la Cuesta, F; Smith-Agreda, JM; Villalobos, MA1
Cruz, JM; García-Rubira, JC; López, V; Navas, JC; Plaza, L1
Auteri, A; Di Perri, T; Franchi, M; Messa, GL1
Alegría, E; Artal, A; Cabadés, A; Cruz-Fernández, JM; López-Bescós, L; Malpartida, F; Martín-Jadraque, L; Plaza, L; Ruipérez, JA; Velasco, J1
Campos, A; Cervos-Navarro, J; Heye, N; Sampaolo, S1
Ambrosoli, L; Angaroni, A; Auteri, A; Borgatti, E; Catalano, M; De Vizzi, GB; Forconi, S; Fossati, L; Girardello, R; Poli, A1
Calpe Climent, AV; Horrach Pérez, M; Llobera C-anaves, J; Peña Díaz, JJ; Rodríguez Moreno, C; Thomàs Mulet, V; Tomàs Arbona, FJ1
Alvarez-Sabín, J; Martín, R; Matías-Guiu, J; Molina, C1
López-Pousa, S; Lozano-Gallego, M; Martí-Cuadros, AM; Mercadal-Dalmau, J; Vilalta-Franch, J1
Alvarez-Sabín, J; Codina, A; Matías-Guiu, J1
Bellver, T; Casado, S; Esteban, A; Farré, J; García-Durán, M; Guerra, JI; López-Farré, A; Mata, P; Montón, M; Rico, LA; Romero, J; Sánchez de Miguel, L; Sierra, MP1
Goa, KL; McNeely, W1
Arjona, A; Bartolomé, MT; Millán, I; Zabala, JA1
Alvarez Sabín, J; Codina Puiggrós, A; Galiano, L; Matías-Guiu, J1
Alonso, A; Bayón, Y; Cavalcanti, F; Fernández de Arriba, A; Forn, J; García-Rafanell, J; Merlos, M; Miralles, A1
Alonso, A; Bayón, Y; Sánchez Crespo, M1
Lee, AY; Lee, KH; Yoo, SH1
Ambrosoli, L; Belcaro, G; Cesarone, MR; DeSanctis, MT; Fugazza, L; Girardello, R; Incandela, L; Laurora, G; Peracino, L; Poli, A1
Bayés de Luna, A1
Cabadés, A; Castro-Beiras, A; Cruz-Fernández, JM; García-Dorado, D; López García-Aranda, V; López-Bescós, L; Marfil, F; Martín-Jadraque, L; Navarro, E; Torres, F; Velasco, JA1
Ayala, R; Bellver, T; Casado, S; Farré, J; García-Durán, M; Gómez, J; González-Fernández, F; Guerra, JI; Jiménez, A; López-Farré, A; Mar Arriero, M; Marcos, P; Montón, M; Núñez, A; Rico, L; Romero, J; Sánchez de Miguel, L1
De La Cruz, JP; Del Prado, MF; Prieto, MA; Sánchez de la Cuesta, F1
Segade Buceta, XM1
Acarin, L; Castellano, B; González, B3
Casado, S; De Miguel, LS; Del Mar Arriero, M; Farré, AL; Farré, J; García-Cañete, J; Gómez, J; Jiménez, A; Montón, M; Núñez, A; Rico, L; Rodríguez-Feo, JA1
Aliaga, A; Nagore, E; Pérez-Ferriols, A; Sánchez-Motilla, JM; Serrano, G1
Berdié, J; Galindo, G; Morató, J; Navarro, MA; Peiró, R; Plana, A1
Crespo, MS; de Arriba, AF; Fuentes, L; Hernández, M; Merlos, M; Nieto, ML1
Boscá, F; Cuquerella, MC; Marín, ML; Miranda, MA1
Darbà, J; Izquierdo, I; Navas, C; Pontes, C; Rovira, J1
Apostolou, D; Comelli, S; Maselli, M; Moniaci, D; Ortensio, M; Scovazzi, P; Varetto, G; Zan, S1
Companion, J; Escriba, A; Guillén, M; Lourenzo, PI; Perez Gomez, F; Perez Saldaña, D; S-Harguindey, L; Vargas, E1
Alvarez-Sabín, J; Ferro, JM; Jiménez, MD; Lago, A; Matías-Guiu, J; Melo, T; Torres, F1
Tong, DC1
Cho, HY; Jeong, TJ; Lee, YB1
Garcia-Porrua, C; Gonzalez-Gay, MA; Gonzalez-Juanatey, C; Testa, A1
Del Valle, C; Ferrit, M; López, M; Luque, R; Martínez, F1
Anderson, DC; Goldstein, LB1
Abiusi, G; Bauso-Tosselli, L; Culebras, A; Domínguez, R; Famulari, A; Ferrari, J; Gori, H; Reich, E; Rey, R; Rotta-Escalante, R; Vila, J1
Arrebola, MM; De La Cruz, JP; González-Correa, JA; Guerrero, A; Muñoz-Marín, J; Ruiz-Villafranca, D; Sánchez De La Cuesta, F; Ureña, IM2
García Robaina, JC; Sánchez-Machín, I; Torre Morin, F1
Aguilar, MR; Fernández, M; Gallardo, A; Rodríguez, G; San Román, J1
Alegría, E; Berjón, J; Iriarte, JA; Mataix, L; Pérez-Gómez, F; Salvador, A; Zumalde, J1
Falk, RH1
Barbanoj, MJ; Brunner, M; Donner, A; Eichler, HG; Herranz, U; Izquierdo, I; Klein, N; Müller, M; Valle, M1
Borja, J1
Weinberger, J1
Aramendi, JI; Campos, V; Martinez-León, J; Mestres, CA; Muñoz, G; Navas, C1
Alvarez-Sabin, J; Costa, J; Ferro, JM; Matias-Guiu, J; Torres, F1
Cechetto, DF; Cheng, G; Hachinski, V; Whitehead, S1
Ezekowitz, MD; Jamieson, DG; Parekh, A1
Avellone, G; Ballone, E; Ciabattoni, G; Davì, G; Di Febbo, C; Di Nicola, M; Falco, A; Pinto, A; Salvati, F; Vitacolonna, E1
de Arriba, AF; Laguna, JC; Merlos, M; Planavila, A; Rodríguez-Calvo, R; Sánchez, RM; Vazquez-Carrera, M1
Murdoch, D; Plosker, GL1
Borja, J; García, O; Izquierdo, I1
Bereznicki, LR; Jackson, SL; Jeffrey, EC; Peterson, GM1
De La Cruz, JP; González-Correa, JA1
Allen, GV; Bayona, NA; Cechetto, DF; Cheng, G; Hachinski, VC; Whitehead, SN1
del Valle, C; Ferrit, M; Martínez, F1
Borja, J; Fraj, J; Izquierdo, I; Pérez, I; Picado, C; Valero, A; Vives, R1
Argemí, A; Domingo, C; López-Periago, A; Saurina, J1
Arnaiz, E; Bassols, J; Casamitjana, R; Fernández-Real, JM; Gomis, R; López-Bermejo, A; Nadal, A; Pérez, I; Piquer, S; Ricart, W; Ropero, AB1
Badimon, L; Duran, X; Sánchez, S; Vilahur, G1
Azanza, JR; Campanero, MA; Escolar, M; Quetglas, EG; Sádaba, B1
González, B; Montero Domínguez, M; Zimmer, J1
Blanca, M; Jiménez, MC; Lhiaubet-Vallet, V; Miranda, MA; Montanaro, S1
Arumugam, S; Boey, FY; Huang, Y; Mohanty, M; Umashankar, PR; Venkatraman, SS1
Alvarez-Sabín, J; García-Bonilla, L; Krupinski, J; Montaner, J; Penalba, A; Quintana, M1
Asenjo, S; Bover, R; Coleto, D; Fernández, C; Igea, A; Maluenda, MP; Pérez-Gómez, F; Pérez-Saldaña, R; Suárez, M1
Kang, HJ; Kim, HS; Kim, SY; Kim, YS; Koo, BK; Park, JS; Suh, JW1
Agulló, J; Bacskai, BJ; Borrelli, LA; Clarimón, J; Coma, M; Da Rocha-Souto, B; España, J; Garcia-Alloza, M; Gómez-Isla, T; Guardia-Laguarta, C; Hyman, BT; Lleó, A; Rodríguez, M; Sánchez, MB; Saura, CA; Scotton, TC; Serenó, L1
Borja, J; Cebrecos, J; García-Rafanell, J; Izquierdo, I; Pelagio, P; Rovira, S; Torres, F1
Arumugam, S; Boey, FY; Huang, Y; Khanolkar, L; Lahti, EM; Mohanty, M; Umashankar, PR; Vaishnav, S; Venkatraman, SS1
Frautschy, SA1
Enache, TA; Fatibello-Filho, O; Oliveira-Brett, AM1
Buján, J; Duocastella, L; Fernández-Gutiérrez, M; Honduvilla, NG; López-Bravo, A; Molina, M; Parra, J; Rodríguez, G; San Román, J1
Balduini, W; Cechetto, DF; Cheng, G; Cimino, M; Hachinski, VC; Massoni, E; Whitehead, SN1
Antonijoan, RM; Azaro, A; Balanzó, J; Barbanoj, MJ; Blanch, I; Borja, J; Donado, E; Gich, I; Izquierdo, I; Sainz, S1
Borja, J; García-Rafanell, J1
Baek, IH; Kwon, KI; Lee, HW; Lee, J; Lim, MS; Park, J; Seo, JJ; Seong, SJ; Yoon, YR; Yun, HY1
Alarcón-Galván, G; Cámara-Lemarroy, CR; Cordero-Pérez, P; Fernández-Garza, NE; Guzmán-de la Garza, FJ; Muñoz-Espinosa, LE; Torres-Gonzalez, L1
Acciarresi, M; Caso, V; Paciaroni, M; Pezzella, FR; Santalucia, P1
García, E; Guarinos, J; Ioannidis, K; Larman, M; Moreu, J; Ortas, MR; Piqué, N; Puigfel, B; Rincón, A; Rumoroso, JR; Serra, A; Zueco, JJ1
Hua, W; Huang, M; Wang, M; Zhang, Q; Zhou, W; Zong, S1
Alvarez-Sabín, J; Maisterra, O; Quintana, M; Santamarina, E1
Kang, W; Kwon, KI; Lee, BY; Park, S; Yeul Ma, J; Yoon, YR; Yun, HY1
Blasco, A; Del Pozo, MD; Escudero, R; Gonzalez, I; Lobera, T; Sánchez, M1
Gwon, MR; Han, S; Kwon, KI; Lee, HW; Lee, J; Lim, MS; Park, JG; Park, SM; Seong, SJ; Yang, DH; Yoon, YR1
Ding, LK; Ding, Y; Ge, J; Jia, YY; Lu, CT; Song, W; Song, Y; Wen, AD; Yang, J1
Chang, HJ; Cho, IJ; Chung, N; Hong, GR; Jang, Y; Kim, KJ; Rah, YM; Shin, S1
Domingo, C; Salerno, A; Saurina, J1
Espasandín-Arias, M; García-Rodiño, S; Rodríguez-Granados, MT; Vázquez-Osorio, I1
Ahn, SH; Han, SW; Kim, YJ; Kim, YN; Lee, KY; Oh, SH; Seo, WK; Yu, S1
Cubells Sánchez, L; Martínez Leboráns, L; Pérez Ferriols, A; Zaragoza Ninet, V1
Choi, KJ; Kim, SW; Lee, JK; Park, JY; Yoon, SH1
Colás, C; Cubero, JL; Millán, P; Simó Sánchez, B1
Fuertes Ferre, G; Galache Osuna, JG; Laita Monreal, S; Ortas Nadal, MDR; Sánchez Insa, E; Sánchez Rubio-Lezcano, J1
Amtul, Z; Cechetto, DF; Haque, W1
Adamopoulos, D; Asimakopoulos, C; Bourdakis, A; Chantzichristos, VG; Darmanis, P; Dimitriadou, A; Gkiokas, S; Goudevenos, JA; Ipeirotis, K; Kalantzi, KI; Kitikidou, K; Klonaris, I; Kostaki, A; Logothetis, D; Mainas, K; Mais, T; Maragiannis, A; Martiadou, K; Mavronasos, K; Michelongonas, I; Mitropoulos, D; Ntalas, IV; Panagiotakos, DB; Papadimitriou, G; Papadopoulos, A; Papaioakeim, M; Sofillas, K; Stabola, S; Stefanakis, E; Stergiou, D; Thoma, M; Tselepis, AD; Tsoumani, ME; Zenetos, A; Zisekas, S1
de Abajo, FJ; García-Rodríguez, LA; Gil, M; Montoya, H; Rodríguez-Martín, S; Rodríguez-Miguel, A1
Doherty, P; Duty, S; Fletcher, EJR; Jamieson, AD; Williams, G1
Barrutia, L; Garabito Solovera, E; Garayar Cantero, M; Ruiz-Sanchez, D; Santamarina Albertos, A; Valtueña, J; Volo, V1
Berenguer, A; de la Torre Hernandez, JM; Diaz, JF; Garcia Del Blanco, B; Gomez-Lara, J; Gomez-Menchero, A; Moreno, R; Muñoz-Garcia, E; Otaegui, I; Rondan, J; Rumoroso, JR; Sainz-Laso, F; Subinas, A; Zueco, J1
Alonso-Ventura, V; Andrés Esteban, EM; Casasnovas Lenguas, JA; Cubero Saldaña, JL; Diarte de Miguel, JA; Fuertes Ferre, G; Galache Osuna, JG; Jimeno Sánchez, J; Linares Vicente, JA; Ortas Nadal, MDR; Pérez Guerrero, A1

Reviews

8 review(s) available for triflusal and salicylates

ArticleYear
Triflusal.
    Drugs, 1998, Volume: 55, Issue:6

    Topics: Adult; Angina Pectoris; Animals; Aspirin; Carotid Stenosis; Humans; In Vitro Techniques; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Postoperative Complications; Pulmonary Embolism; Randomized Controlled Trials as Topic; Salicylates; Thrombophlebitis

1998
[The risk of hemorrhage in long-term use of aspirin and triflusal].
    Revista de neurologia, 1998, Volume: 27, Issue:160

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cerebral Infarction; Female; Follow-Up Studies; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Salicylates; Sex Factors; Time Factors

1998
Adverse effects and drug interactions of antithrombotic agents used in prevention of ischaemic stroke.
    Drugs, 2005, Volume: 65, Issue:4

    Topics: Anticoagulants; Aspirin; Clopidogrel; Dipyridamole; Drug Interactions; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Salicylates; Stroke; Ticlopidine; Warfarin

2005
Triflusal for preventing serious vascular events in people at high risk.
    The Cochrane database of systematic reviews, 2005, Jul-20, Issue:3

    Topics: Aspirin; Humans; Ischemic Attack, Transient; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk Factors; Salicylates; Stroke

2005
Review of antiplatelet therapy in secondary prevention of cerebrovascular events: a need for direct comparisons between antiplatelet agents.
    Journal of cardiovascular pharmacology and therapeutics, 2005, Volume: 10, Issue:3

    Topics: Aspirin; Clopidogrel; Dipyridamole; Humans; Platelet Aggregation Inhibitors; Recurrence; Salicylates; Stroke; Ticlopidine

2005
Triflusal: a review of its use in cerebral infarction and myocardial infarction, and as thromboprophylaxis in atrial fibrillation.
    Drugs, 2006, Volume: 66, Issue:5

    Topics: Atrial Fibrillation; Cardiovascular Diseases; Cerebral Infarction; Drug Interactions; Humans; Meta-Analysis as Topic; Myocardial Infarction; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Salicylates; Thromboembolism

2006
Triflusal: an antiplatelet drug with a neuroprotective effect?
    Cardiovascular drug reviews, 2006,Spring, Volume: 24, Issue:1

    Topics: Animals; Biological Availability; Clinical Trials as Topic; Female; Humans; Male; Neuroprotective Agents; Platelet Aggregation Inhibitors; Salicylates; Stroke; Tissue Distribution

2006
Antiplatelet treatment in primary and secondary stroke prevention in women.
    European journal of internal medicine, 2012, Volume: 23, Issue:7

    Topics: Aspirin; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Female; Humans; Naphthalenes; Platelet Aggregation Inhibitors; Primary Prevention; Propionates; Salicylates; Secondary Prevention; Sex Factors; Stroke; Ticlopidine

2012

Trials

37 trial(s) available for triflusal and salicylates

ArticleYear
Prevention of aortocoronary vein-graft attrition with low-dose aspirin and triflusal, both associated with dipyridamole: a randomized, double-blind, placebo-controlled trial.
    European heart journal, 1989, Volume: 10, Issue:2

    Topics: Adult; Aged; Aspirin; Clinical Trials as Topic; Coronary Artery Bypass; Dipyridamole; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Patient Compliance; Prospective Studies; Random Allocation; Salicylates; Vascular Patency

1989
Effect of treatment with an inhibitor of platelet aggregation on the evolution of background retinopathy: 2 years of follow-up.
    Diabetes research and clinical practice, 1989, Nov-06, Volume: 7, Issue:4

    Topics: Adult; Clinical Trials as Topic; Diabetes Mellitus, Type 1; Diabetic Retinopathy; Female; Humans; Male; Platelet Aggregation Inhibitors; Salicylates; Visual Acuity

1989
Platelet count, antiplatelet therapy and pulmonary embolism--a prospective study in patients with hip surgery.
    Thrombosis and haemostasis, 1995, Volume: 73, Issue:3

    Topics: Aged; Aged, 80 and over; Aspirin; Double-Blind Method; Drug Therapy, Combination; Female; Hemorrhage; Heparin; Hip Fractures; Hip Prosthesis; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Count; Postoperative Complications; Prospective Studies; Pulmonary Embolism; Radionuclide Imaging; Salicylates; Thrombophlebitis; Treatment Outcome; Ultrasonography; Vomiting

1995
Outcome of patients with diabetes and unstable angina. A subgroup analysis in the Spanish Multicentre Trial of trifusal in unstable angina. Grupo de Estudio del Trifusal en la Angina Inestable.
    International journal of cardiology, 1994, Volume: 46, Issue:2

    Topics: Aged; Angina, Unstable; Diabetes Complications; Female; Follow-Up Studies; Humans; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Myocardial Revascularization; Platelet Aggregation Inhibitors; Prognosis; Salicylates; Spain; Treatment Outcome

1994
Action of 2-acetoxy-trifluoromethylbenzoic acid (Triflusal) on platelet function after repeated oral administration in man: a pharmacological clinical study.
    International journal of clinical pharmacology research, 1993, Volume: 13, Issue:5

    Topics: 6-Ketoprostaglandin F1 alpha; Administration, Oral; Aged; beta-Thromboglobulin; Blood Platelet Disorders; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Factor 3; Platelet Factor 4; Salicylates; Thromboxane B2

1993
Protective effect of triflusal against acute myocardial infarction in patients with unstable angina: results of a Spanish multicenter trial. Grupo de Estudio del Triflusal en la Angina Inestable.
    Cardiology, 1993, Volume: 82, Issue:6

    Topics: Administration, Oral; Aged; Angina, Unstable; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Salicylates; Spain; Survival Rate

1993
Triflusal in the treatment of patients with chronic peripheral arteriopathy: multicentre double-blind clinical study vs placebo.
    International journal of clinical pharmacology research, 1995, Volume: 15, Issue:2

    Topics: Adult; Aged; Chronic Disease; Double-Blind Method; Female; Humans; Male; Middle Aged; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Salicylates

1995
[Triflusal in the prevention of vascular dementia].
    Revista de neurologia, 1997, Volume: 25, Issue:146

    Topics: Aged; Cerebrovascular Disorders; Dementia, Vascular; Female; Humans; Male; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Salicylates

1997
[Comparative study of the effect of low-dosage acetylsalicylic acid and triflusal in the prevention of cardiovascular events among young adults with ischemic cerebrovascular disease].
    Revista de neurologia, 1997, Volume: 25, Issue:147

    Topics: Adult; Aspirin; Brain Ischemia; Cardiovascular Diseases; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Salicylates; Survival Rate

1997
Effects of triflusal on arteriosclerosis progression assessed with high-resolution arterial ultrasound.
    Angiology, 1999, Volume: 50, Issue:6

    Topics: Administration, Oral; Adult; Aged; Analysis of Variance; Arteriosclerosis; Aspirin; Carotid Artery Diseases; Chi-Square Distribution; Disease Progression; Double-Blind Method; Female; Femoral Artery; Humans; Male; Middle Aged; Pilot Projects; Placebos; Platelet Aggregation Inhibitors; Salicylates; Stomach; Tunica Intima; Tunica Media; Ultrasonography

1999
Randomized comparative trial of triflusal and aspirin following acute myocardial infarction.
    European heart journal, 2000, Volume: 21, Issue:6

    Topics: Aged; Aspirin; Cerebrovascular Disorders; Double-Blind Method; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Recurrence; Salicylates; Spain; Treatment Outcome

2000
Influence of triflusal on platelet activation after coronary artery bypass graft.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2000, Volume: 11, Issue:2

    Topics: Adenosine Diphosphate; Adult; Aged; beta-Thromboglobulin; Collagen; Coronary Artery Bypass; Erythrocyte Count; Female; Hematocrit; Hemoglobins; Humans; Leukocyte Count; Male; Middle Aged; Myocardial Ischemia; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Salicylates; Thromboxane B2; Time Factors

2000
A 4-trifluoromethyl derivative of salicylate, triflusal, stimulates nitric oxide production by human neutrophils: role in platelet function.
    European journal of clinical investigation, 2000, Volume: 30, Issue:9

    Topics: Administration, Oral; Adult; Humans; Male; Neutrophils; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Salicylates

2000
Economic evaluation of triflusal and aspirin in the treatment of acute myocardial infarction.
    PharmacoEconomics, 2002, Volume: 20, Issue:3

    Topics: Acute Disease; Aspirin; Double-Blind Method; Drug Costs; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Recurrence; Salicylates; Spain

2002
Platelet aggregation in different antithrombotic regimens. Possible proaggregant effect of low level oral anticoagulation.
    Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology, 2002, Volume: 21, Issue:5

    Topics: Acenocoumarol; Adenosine Diphosphate; Aged; Analysis of Variance; Anticoagulants; Arachidonic Acid; Atrial Fibrillation; Blood Platelets; Collagen; Embolism; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Salicylates; Time Factors

2002
Comparison of triflusal and aspirin for prevention of vascular events in patients after cerebral infarction: the TACIP Study: a randomized, double-blind, multicenter trial.
    Stroke, 2003, Volume: 34, Issue:4

    Topics: Aspirin; Cardiovascular Diseases; Cerebral Infarction; Double-Blind Method; Female; Hemorrhage; Humans; Incidence; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Salicylates; Secondary Prevention; Stroke; Survival Analysis

2003
Triflusal vs aspirin for prevention of cerebral infarction: a randomized stroke study.
    Neurology, 2004, Apr-13, Volume: 62, Issue:7

    Topics: Aged; Aspirin; Cerebral Infarction; Double-Blind Method; Female; Follow-Up Studies; Humans; Ischemic Attack, Transient; Male; Middle Aged; Odds Ratio; Pilot Projects; Platelet Aggregation Inhibitors; Salicylates; Secondary Prevention; Stroke; Survival Analysis; Treatment Outcome

2004
Comparative effects of antiplatelet, anticoagulant, or combined therapy in patients with valvular and nonvalvular atrial fibrillation: a randomized multicenter study.
    Journal of the American College of Cardiology, 2004, Oct-19, Volume: 44, Issue:8

    Topics: Acenocoumarol; Aged; Anticoagulants; Atrial Fibrillation; Cause of Death; Dose-Response Relationship, Drug; Drug Therapy, Combination; Embolism; Female; Follow-Up Studies; Hemorrhage; Humans; International Normalized Ratio; Intracranial Embolism; Male; Middle Aged; Mitral Valve Stenosis; Platelet Aggregation Inhibitors; Proportional Hazards Models; Salicylates; Survival Analysis; Treatment Outcome

2004
Access of HTB, main metabolite of triflusal, to cerebrospinal fluid in healthy volunteers.
    European journal of clinical pharmacology, 2005, Volume: 61, Issue:2

    Topics: Adult; Blood-Brain Barrier; Chromatography, High Pressure Liquid; Clinical Trials as Topic; Female; Humans; Male; Metabolic Clearance Rate; Models, Biological; Neuroprotective Agents; Salicylates

2005
Triflusal versus oral anticoagulation for primary prevention of thromboembolism after bioprosthetic valve replacement (trac): prospective, randomized, co-operative trial.
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2005, Volume: 27, Issue:5

    Topics: Acenocoumarol; Aged; Anticoagulants; Bioprosthesis; Epidemiologic Methods; Female; Heart Valve Diseases; Heart Valve Prosthesis Implantation; Humans; Male; Platelet Aggregation Inhibitors; Postoperative Complications; Postoperative Hemorrhage; Salicylates; Thromboembolism

2005
Inhibition of thromboxane biosynthesis by triflusal in type 2 diabetes mellitus.
    Atherosclerosis, 2005, Volume: 183, Issue:2

    Topics: Adult; Aged; Aspirin; Biomarkers; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Middle Aged; P-Selectin; Platelet Activation; Platelet Aggregation Inhibitors; Radioimmunoassay; Retrospective Studies; Salicylates; Thromboxane B2; von Willebrand Factor

2005
Safety of triflusal (antiplatelet drug) in patients with aspirin-exacerbated respiratory diseases.
    Allergy, 2008, Volume: 63, Issue:1

    Topics: Administration, Oral; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Hypersensitivity; Female; Follow-Up Studies; Humans; Male; Middle Aged; Multivariate Analysis; Probability; Reference Values; Respiratory Function Tests; Risk Assessment; Salicylates; Severity of Illness Index; Single-Blind Method; Treatment Outcome

2008
Salicylates increase insulin secretion in healthy obese subjects.
    The Journal of clinical endocrinology and metabolism, 2008, Volume: 93, Issue:7

    Topics: Aged; C-Reactive Protein; Calcium; Cross-Over Studies; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Humans; Insulin; Insulin Secretion; Male; Middle Aged; Obesity; Salicylates

2008
Bioequivalence of two oral formulations of triflusal capsules in healthy volunteers.
    Arzneimittel-Forschung, 2008, Volume: 58, Issue:6

    Topics: Adolescent; Adult; Area Under Curve; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Platelet Aggregation Inhibitors; Reference Standards; Salicylates; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Therapeutic Equivalency

2008
Triflusal and aspirin have different effects on inflammatory biomarkers measured in patients with acute ischemic stroke.
    Cerebrovascular diseases (Basel, Switzerland), 2009, Volume: 28, Issue:4

    Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents; Aspirin; Biomarkers; Brain Ischemia; Female; Humans; Inflammation Mediators; Logistic Models; Male; Middle Aged; Neuroprotective Agents; Pilot Projects; Platelet Aggregation Inhibitors; Prospective Studies; Salicylates; Stroke; Time Factors; Treatment Outcome

2009
Comparison of triple antiplatelet therapy including triflusal and conventional dual therapy in patients who underwent drug-eluting stent implantation.
    International heart journal, 2009, Volume: 50, Issue:6

    Topics: Drug Combinations; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Penile Implantation; Platelet Aggregation Inhibitors; Prospective Studies; Salicylates

2009
Comparative bioavailability study of triflusal oral solution vs. triflusal capsules in healthy subjects. A single, randomized, two-way cross-over, open-label phase I study.
    Arzneimittel-Forschung, 2010, Volume: 60, Issue:1

    Topics: Adult; Area Under Curve; Biological Availability; Capsules; Chemistry, Pharmaceutical; Cross-Over Studies; Double-Blind Method; Female; Half-Life; Humans; Male; Pharmaceutical Solutions; Platelet Aggregation Inhibitors; Salicylates; Young Adult

2010
Gastrointestinal safety of triflusal solution in healthy volunteers: a proof of concept endoscopic study.
    European journal of clinical pharmacology, 2011, Volume: 67, Issue:7

    Topics: Administration, Oral; Adult; Capsules; Double-Blind Method; Endoscopy, Gastrointestinal; Female; Gastric Mucosa; Gastrointestinal Tract; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Salicylates; Spain; Statistics as Topic; Therapeutic Equivalency; Young Adult

2011
A phase I study to characterize the multiple-dose pharmacokinetics, pharmacodynamics and safety of new enteric-coated triflusal formulations in healthy male volunteers.
    Expert opinion on drug metabolism & toxicology, 2011, Volume: 7, Issue:12

    Topics: Administration, Oral; Adult; Arachidonic Acid; Asian People; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Cross-Over Studies; Dose-Response Relationship, Drug; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Salicylates; Tandem Mass Spectrometry; Therapeutic Equivalency; Young Adult

2011
Long-term clinical performance of paclitaxel-eluting stents coated with a bioactive polymer (P-5) containing a triflusal derivative: results of the REWAC registry.
    The Journal of invasive cardiology, 2013, Volume: 25, Issue:8

    Topics: Aged; Coronary Artery Disease; Coronary Restenosis; Drug-Eluting Stents; Female; Humans; Incidence; Male; Middle Aged; Paclitaxel; Percutaneous Coronary Intervention; Polymers; Prospective Studies; Registries; Salicylates; Thrombosis; Treatment Outcome

2013
Pharmacokinetics, safety and tolerability of triflusal and its main active metabolite HTB in healthy Chinese subjects.
    Drug research, 2014, Volume: 64, Issue:5

    Topics: Adult; Area Under Curve; Asian People; Female; Healthy Volunteers; Humans; Male; Salicylates; Young Adult

2014
Triflusal and aspirin in the secondary prevention of atherothrombotic ischemic stroke: a very long-term follow-up.
    Cerebrovascular diseases (Basel, Switzerland), 2014, Volume: 37, Issue:3

    Topics: Aged; Aspirin; Brain Ischemia; Dyspepsia; Female; Follow-Up Studies; Hemorrhage; Humans; Incidence; Intracranial Arteriosclerosis; Ischemic Attack, Transient; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation Inhibitors; Recurrence; Salicylates; Secondary Prevention; Vascular Diseases

2014
Population pharmacokinetic and pharmacodynamic modeling of transformed binary effect data of triflusal in healthy Korean male volunteers: a randomized, open-label, multiple dose, crossover study.
    BMC pharmacology & toxicology, 2014, Dec-23, Volume: 15

    Topics: Adult; Cross-Over Studies; Healthy Volunteers; Humans; Male; Middle Aged; Models, Theoretical; Platelet Aggregation Inhibitors; Republic of Korea; Salicylates; Young Adult

2014
Effect of food on the pharmacokinetics of triflusal and its major active metabolite, 2-hydroxy-4-trifluoromethyl benzoic acid, in healthy subjects.
    International journal of clinical pharmacology and therapeutics, 2015, Volume: 53, Issue:3

    Topics: Administration, Oral; Adolescent; Adult; Area Under Curve; Biotransformation; Capsules; China; Cross-Over Studies; Dietary Fats; Fasting; Female; Food-Drug Interactions; Healthy Volunteers; Humans; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Platelet Aggregation Inhibitors; Postprandial Period; Salicylates; Therapeutic Equivalency; Young Adult

2015
Effect of Triflusal on Primary Vascular Dysregulation Compared with Aspirin: A Double-Blind, Randomized, Crossover Trial.
    Yonsei medical journal, 2015, Volume: 56, Issue:5

    Topics: Adult; Aspirin; Cardiovascular Diseases; Cross-Over Studies; Double-Blind Method; Female; Humans; Indocyanine Green; Male; Middle Aged; Perfusion Imaging; Platelet Aggregation Inhibitors; Recurrence; Salicylates; Treatment Outcome

2015
Protocol for the comparison of triflusal and clopidogrel in secondary prevention of stroke based on cytochrome P450 2C19 genotyping (MASETRO study): A multicenter, randomized, open-label, parallel-group trial.
    International journal of stroke : official journal of the International Stroke Society, 2016, Volume: 11, Issue:4

    Topics: Brain Ischemia; Cerebral Hemorrhage; Chemoprevention; Clopidogrel; Cytochrome P-450 CYP2C19; Follow-Up Studies; Genotype; Humans; Pharmacogenomic Variants; Platelet Aggregation Inhibitors; Recurrence; Salicylates; Secondary Prevention; Single-Blind Method; Stroke; Ticlopidine; Treatment Outcome

2016
Comparison of Triflusal with Aspirin in the Secondary Prevention of Atherothrombotic Events; Α Randomised Clinical Trial.
    Current vascular pharmacology, 2019, Volume: 17, Issue:6

    Topics: Aged; Aspirin; Brain Ischemia; Coronary Artery Disease; Cyclooxygenase Inhibitors; Female; Greece; Hemorrhage; Humans; Intracranial Embolism; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Recurrence; Risk Factors; Salicylates; Secondary Prevention; Stroke; Time Factors; Treatment Outcome

2019

Other Studies

92 other study(ies) available for triflusal and salicylates

ArticleYear
Comparison of the inhibitory effects of acetylsalicylic acid and trifusal on enzymes related to thrombosis.
    Archives internationales de pharmacodynamie et de therapie, 1979, Volume: 237, Issue:2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Aspirin; Cattle; Cyclooxygenase Inhibitors; Fibrinolytic Agents; Horses; In Vitro Techniques; Microsomes; Myocardial Contraction; Oxidoreductases; Salicylates; Sheep; Thrombosis; Thromboxane-A Synthase

1979
[Induction of pulmonary thrombosis in mice, rabbits and hamsters by intravenous injection of arachidonic acid. Comparative study of 3 experimental models in vivo and the antithrombotic activity of triflusal].
    Archivos de farmacologia y toxicologia, 1979, Volume: 5, Issue:3

    Topics: Animals; Arachidonic Acids; Cricetinae; Disease Models, Animal; Fibrinolytic Agents; Injections, Intravenous; Lung Diseases; Mice; Rabbits; Respiration Disorders; Salicylates; Thrombosis

1979
In-vitro protein binding interaction between a metabolite of triflusal, 2-hydroxy-4-trifluoromethylbenzoic acid and other drugs.
    The Journal of pharmacy and pharmacology, 1992, Volume: 44, Issue:11

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Binding, Competitive; Drug Interactions; Humans; Platelet Aggregation Inhibitors; Protein Binding; Salicylates; Serum Albumin

1992
Binding of a metabolite of triflusal (2-hydroxy-4-trifluoromethylbenzoic acid) to serum proteins in rat and man.
    European journal of clinical pharmacology, 1992, Volume: 42, Issue:2

    Topics: Administration, Oral; Animals; Blood Proteins; Female; Humans; Orosomucoid; Platelet Aggregation Inhibitors; Protein Binding; Rats; Rats, Inbred Strains; Salicylates; Serum Albumin

1992
Triflusal vs aspirin on the inhibition of human platelet and vascular cyclooxygenase.
    General pharmacology, 1992, Volume: 23, Issue:2

    Topics: 6-Ketoprostaglandin F1 alpha; Arachidonic Acid; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Humans; In Vitro Techniques; Mesenteric Arteries; Muscle, Smooth, Vascular; Platelet Aggregation Inhibitors; Salicylates; Thromboxane B2

1992
Effects of triflusal and acetylsalicylic acid on microthrombi formation in experimental brain ischemia.
    Experimental pathology, 1991, Volume: 41, Issue:1

    Topics: Animals; Aspirin; Brain Ischemia; Cerebral Arteries; Intracranial Embolism and Thrombosis; Male; Platelet Aggregation Inhibitors; Rats; Rats, Inbred Strains; Salicylates

1991
Effects of thromboxane synthesis inhibitor triflusal on renal hemodynamics in microalbuminuric diabetic patients.
    Diabetes care, 1990, Volume: 13, Issue:11

    Topics: 6-Ketoprostaglandin F1 alpha; Adult; Albuminuria; Blood Glucose; Diabetes Mellitus, Type 1; Dinoprostone; Female; Glomerular Filtration Rate; Humans; Male; Platelet Aggregation Inhibitors; Renal Circulation; Renin; Salicylates; Thromboxane B2

1990
Pharmacokinetics of triflusal after single and repeated doses in man.
    International journal of clinical pharmacology, therapy, and toxicology, 1990, Volume: 28, Issue:8

    Topics: Adult; Chromatography, High Pressure Liquid; Half-Life; Humans; Male; Platelet Aggregation Inhibitors; Random Allocation; Salicylates

1990
[Use of aspirin in the primary prevention of vascular thrombi. A comparative study with other anti-aggregant drugs].
    Revista espanola de cardiologia, 1989, Volume: 42, Issue:8

    Topics: Animals; Aspirin; Dipyridamole; Dogs; Drug Evaluation; Drug Therapy, Combination; Platelet Aggregation Inhibitors; Salicylates; Thrombosis

1989
Prevention of the formation of arterial thrombi using different antiplatelet drugs: experimental study in dogs.
    Thrombosis research, 1989, May-01, Volume: 54, Issue:3

    Topics: Animals; Aspirin; Dipyridamole; Dogs; Indium Radioisotopes; Platelet Aggregation Inhibitors; Salicylates; Scintillation Counting; Thrombosis

1989
Effects of triflusal and acetylsalicylic acid on platelet aggregation in whole blood of diabetic patients.
    European journal of haematology, 1988, Volume: 40, Issue:3

    Topics: Adult; Aspirin; beta-Thromboglobulin; Diabetes Mellitus, Type 1; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandins F; Salicylates; Thromboxane B2

1988
Effect of triflusal and other salicylic acid derivatives on cyclic AMP levels in rat platelets.
    Archives internationales de pharmacodynamie et de therapie, 1986, Volume: 284, Issue:1

    Topics: Alprostadil; Animals; Aspirin; Blood Platelets; Cyclic AMP; Dipyridamole; Drug Interactions; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Salicylates; Salicylic Acid

1986
Protective effect of triflusal and acetylsalicylic acid against arachidonic acid induced cerebrovascular occlusion in anesthetized rats.
    Methods and findings in experimental and clinical pharmacology, 1987, Volume: 9, Issue:1

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Cerebrovascular Disorders; Electroencephalography; Male; Platelet Aggregation; Rats; Rats, Inbred Strains; Salicylates

1987
Effects and interaction studies of triflusal and other salicylic derivatives on cyclooxygenase in rats.
    Prostaglandins, leukotrienes, and essential fatty acids, 1988, Volume: 31, Issue:2

    Topics: Alprostadil; Animals; Aorta, Thoracic; Aspirin; Blood Platelets; Drug Interactions; In Vitro Techniques; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Strains; Salicylates; Salicylic Acid; Vasodilator Agents

1988
[Effect of platelet antiaggregant treatment on the evolution of simple diabetic retinopathy. Preliminary results].
    Medicina clinica, 1988, Feb-20, Volume: 90, Issue:7

    Topics: Adolescent; Adult; Diabetic Retinopathy; Drug Evaluation; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Salicylates

1988
Platelet antiaggregatory effect of triflusal in human whole blood.
    Methods and findings in experimental and clinical pharmacology, 1988, Volume: 10, Issue:4

    Topics: Adenosine Diphosphate; Adult; Collagen; Epinephrine; Humans; In Vitro Techniques; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Salicylates; Thromboxane B2

1988
Effect of triflusal and acetylsalicylic acid on platelet aggregation in human whole blood: influence of red blood cells and leukocytes.
    Methods and findings in experimental and clinical pharmacology, 1988, Volume: 10, Issue:6

    Topics: Adult; Aspirin; Erythrocytes; Humans; In Vitro Techniques; Leukocytes; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Salicylates; Salicylic Acid

1988
Photosensitivity associated with triflusal (Disgren).
    Photo-dermatology, 1987, Volume: 4, Issue:2

    Topics: Female; Humans; Middle Aged; Photosensitivity Disorders; Salicylates

1987
Effects of triflusal in patients with prosthetic heart valves.
    Clinical therapeutics, 1985, Volume: 7, Issue:3

    Topics: 6-Ketoprostaglandin F1 alpha; Adult; Female; Heart Valve Prosthesis; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Count; Salicylates

1985
[Effect of chronic administration of triflusal on pulmonary thrombosis induced by arachidonic acid].
    Archivos de farmacologia y toxicologia, 1982, Volume: 8, Issue:3

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Female; Fibrinolytic Agents; Male; Rats; Rats, Inbred Strains; Salicylates; Thrombosis

1982
[Inhibition of platelet cyclo-oxygenase by triflusal].
    Archivos de farmacologia y toxicologia, 1982, Volume: 8, Issue:3

    Topics: Animals; Blood Platelets; Cyclooxygenase Inhibitors; Female; Humans; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Salicylates

1982
[Triflusal].
    Revista de medicina de la Universidad de Navarra, 1982, Volume: 26, Issue:1

    Topics: Humans; Platelet Aggregation; Salicylates; Thromboembolism; Vascular Diseases

1982
[Induction of pulmonary thrombosis in the rat by i.v. injections of ADP and the antithrombotic activity of triflusal].
    Archivos de farmacologia y toxicologia, 1982, Volume: 8, Issue:3

    Topics: Adenosine Diphosphate; Animals; Female; Fibrinolytic Agents; Injections, Intravenous; Lung Diseases; Male; Rats; Rats, Inbred Strains; Salicylates; Thrombosis

1982
[Distribution and metabolism of triflusal].
    Archivos de farmacologia y toxicologia, 1982, Volume: 8, Issue:3

    Topics: Animals; Male; Rats; Rats, Inbred Strains; Salicylates; Tissue Distribution

1982
[Pharmacokinetic study of triflusal (UR-1501)].
    Archivos de farmacologia y toxicologia, 1981, Volume: 7, Issue:1

    Topics: Administration, Oral; Animals; Dogs; Injections, Intravenous; Kinetics; Salicylates

1981
[Comparative study of the in vitro anti-aggregating action of various salicylic derivatives].
    Archivos de farmacologia y toxicologia, 1981, Volume: 7, Issue:1

    Topics: Animals; Aspirin; Chemical Phenomena; Chemistry; Organophosphates; Platelet Aggregation; Rats; Salicylates

1981
[Clinico-biological effectiveness of triflusal during the postoperative period of patients with chronic ischemic syndrome of the extremities].
    Revista de medicina de la Universidad de Navarra, 1981, Volume: 25, Issue:2

    Topics: Adult; Aged; Blood Vessel Prosthesis; Drug Evaluation; Endarterectomy; Female; Fibrinolytic Agents; Humans; Ischemia; Leg; Male; Middle Aged; Postoperative Complications; Salicylates; Thrombosis

1981
Effects of triflusal and its main metabolite HTB on platelet interaction with subendothelium in healthy volunteers.
    European journal of clinical pharmacology, 1995, Volume: 47, Issue:6

    Topics: Adult; Animals; Aspirin; Blood Platelets; Endothelium, Vascular; Humans; Male; Perfusion; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Salicylates

1995
Morphometrical evaluation of triflusal in brain infarction.
    Acta neurochirurgica. Supplementum, 1993, Volume: 57

    Topics: Animals; Brain; Brain Damage, Chronic; Capillaries; Cerebral Infarction; Dose-Response Relationship, Drug; Intracranial Embolism and Thrombosis; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Salicylates

1993
[Prescription of platelet antiaggregants in secondary prevention of ischemic heart disease].
    Atencion primaria, 1996, Mar-15, Volume: 17, Issue:4

    Topics: Age Factors; Aged; Aged, 80 and over; Aspirin; Dipyridamole; Drug Prescriptions; Family Practice; Female; Humans; Male; Medical Audit; Medicine; Myocardial Ischemia; Platelet Aggregation Inhibitors; Prevalence; Primary Health Care; Salicylates; Spain; Specialization; Ticlopidine; Urban Population

1996
[The tolerance of two therapeutic uses of triflusal in patients with ischemic stroke. Letter].
    Revista de neurologia, 1996, Volume: 24, Issue:134

    Topics: Brain Ischemia; Cerebral Hemorrhage; Female; Humans; Male; Platelet Aggregation Inhibitors; Salicylates

1996
Comparison of in vitro effects of triflusal and acetysalicylic acid on nitric oxide synthesis by human neutrophils.
    European journal of pharmacology, 1998, Feb-05, Volume: 343, Issue:1

    Topics: Aspirin; Cyclic GMP; Cyclooxygenase Inhibitors; Humans; Neutrophils; Nitric Oxide; Platelet Aggregation Inhibitors; Salicylates

1998
[Intracerebral hemorrhage and treatment with platelet aggregation inhibitors: study of 21 cases].
    Revista de neurologia, 1998, Volume: 27, Issue:158

    Topics: Aged; Aged, 80 and over; Aspirin; Cerebral Hemorrhage; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prognosis; Retrospective Studies; Risk Factors; Salicylates

1998
Inhibition of cyclooxygenase-2 expression by 4-trifluoromethyl derivatives of salicylate, triflusal, and its deacetylated metabolite, 2-hydroxy-4-trifluoromethylbenzoic acid.
    Molecular pharmacology, 1999, Volume: 55, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Humans; Inflammation; Isoenzymes; Leukocytes, Mononuclear; Lipopolysaccharides; Male; Membrane Proteins; NF-kappa B; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Lew; Salicylates

1999
4-trifluoromethyl derivatives of salicylate, triflusal and its main metabolite 2-hydroxy-4-trifluoromethylbenzoic acid, are potent inhibitors of nuclear factor kappaB activation.
    British journal of pharmacology, 1999, Volume: 126, Issue:6

    Topics: Animals; Aspirin; Cell Line; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Macrophages, Peritoneal; NF-kappa B; Nitric Oxide; Platelet Aggregation Inhibitors; Rats; RNA, Messenger; Salicylates; Thrombin; Tumor Necrosis Factor-alpha; Umbilical Veins; Vascular Cell Adhesion Molecule-1

1999
A case of photoallergic drug eruption caused by triflusal (Disgren).
    Photodermatology, photoimmunology & photomedicine, 1999, Volume: 15, Issue:2

    Topics: Aged; Cerebrovascular Disorders; Drug Eruptions; Humans; Male; Platelet Aggregation Inhibitors; Salicylates; Skin Tests

1999
May aspirin be replaced in the treatment of myocardial infarction?
    European heart journal, 2000, Volume: 21, Issue:6

    Topics: Aspirin; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Salicylates

2000
[The effect of triflusal on human platelet aggregation and secretion: the role of nitric oxide].
    Revista espanola de cardiologia, 2000, Volume: 53, Issue:2

    Topics: Adult; Blood Platelets; Citrulline; Cyclic GMP; Guanosine Monophosphate; Humans; Neutrophils; Nitric Oxide; Platelet Aggregation; Platelet Aggregation Inhibitors; Salicylates; Transforming Growth Factor beta

2000
[Impact of various objectives related to the rational use of medication in a primary care area].
    Atencion primaria, 2000, Mar-15, Volume: 25, Issue:4

    Topics: Antihypertensive Agents; Costs and Cost Analysis; Drug Prescriptions; Drug Utilization; Humans; Platelet Aggregation Inhibitors; Primary Health Care; Quinolones; Retirement; Salicylates; Spain; Urban Population

2000
Oral administration of the anti-inflammatory substance triflusal results in the downregulation of constitutive transcription factor NF-kappaB in the postnatal rat brain.
    Neuroscience letters, 2000, Jul-07, Volume: 288, Issue:1

    Topics: Administration, Oral; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Brain Chemistry; Immunohistochemistry; Neuroglia; Neurons; NF-kappa B; Rats; Rats, Long-Evans; Salicylates

2000
Photosensitivity associated with treatment with triflusal.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2000, Volume: 14, Issue:3

    Topics: Aged; Aged, 80 and over; Female; Humans; Ischemic Attack, Transient; Photosensitivity Disorders; Platelet Aggregation Inhibitors; Salicylates

2000
[Prevention of thromboembolic disease in patients with heart disease].
    Atencion primaria, 2000, Sep-30, Volume: 26, Issue:5

    Topics: Age Factors; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Cross-Sectional Studies; Dipyridamole; Female; Heart Diseases; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Salicylates; Sex Factors; Thromboembolism; Ticlopidine

2000
Effect of 4-trifluoromethyl derivatives of salicylate on nuclear factor kappaB-dependent transcription in human astrocytoma cells.
    British journal of pharmacology, 2001, Volume: 132, Issue:2

    Topics: Astrocytoma; Blotting, Western; Brain Neoplasms; Cyclooxygenase 2; DNA, Complementary; Electrophoresis; Humans; Indicators and Reagents; Isoenzymes; Membrane Proteins; Neoplasm Proteins; Neurons; NF-kappa B; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction; Salicylates; Tumor Cells, Cultured; Vascular Cell Adhesion Molecule-1

2001
Photochemistry of 2-hydroxy-4-trifluoromethylbenzoic acid, major metabolite of the photosensitizing platelet antiaggregant drug triflusal.
    Photochemistry and photobiology, 2001, Volume: 73, Issue:5

    Topics: Dermatitis, Photoallergic; Photochemistry; Platelet Aggregation Inhibitors; Protein Binding; Salicylates; Serum Albumin, Bovine; Spectrometry, Fluorescence

2001
Triflusal posttreatment inhibits glial nuclear factor-kappaB, downregulates the glial response, and is neuroprotective in an excitotoxic injury model in postnatal brain.
    Stroke, 2001, Volume: 32, Issue:10

    Topics: Administration, Oral; Animals; Astrocytes; Brain; DNA-Binding Proteins; Down-Regulation; Drug Administration Schedule; Glial Fibrillary Acidic Protein; Microglia; Microinjections; N-Methylaspartate; Neuroglia; Neuroprotective Agents; NF-kappa B; Platelet Aggregation Inhibitors; Rats; Rats, Long-Evans; Salicylates; STAT3 Transcription Factor; Trans-Activators

2001
Compliance of geriatric patients subjected to antiplatelet agents with Triflusal in peripheral arteriopathy. Preliminary data.
    Minerva cardioangiologica, 2002, Volume: 50, Issue:3

    Topics: Age Factors; Aged; Aged, 80 and over; Arterial Occlusive Diseases; Female; Follow-Up Studies; Humans; Male; Patient Compliance; Platelet Aggregation Inhibitors; Risk Factors; Salicylates; Time Factors

2002
Decrease of proinflammatory molecules correlates with neuroprotective effect of the fluorinated salicylate triflusal after postnatal excitotoxic damage.
    Stroke, 2002, Volume: 33, Issue:10

    Topics: Administration, Oral; Animals; Astrocytes; Cyclooxygenase 2; Disease Models, Animal; Inflammation Mediators; Interleukin-1; Isoenzymes; Microglia; Microinjections; N-Methylaspartate; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Neurotoxins; Neutrophil Infiltration; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Long-Evans; Salicylates; Somatosensory Cortex; Tumor Necrosis Factor-alpha

2002
Can aspirin ever be surpassed for stroke prevention?
    Stroke, 2003, Volume: 34, Issue:4

    Topics: Aspirin; Clinical Trials as Topic; Drug Therapy, Combination; Fibrinolytic Agents; Forecasting; Humans; Platelet Aggregation Inhibitors; Salicylates; Stroke

2003
Simultaneous determination of triflusal and its major active metabolite, 2-hydroxy-4-trifluoromethyl benzoic acid, in rat and human plasma by high-performance liquid chromatography.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2003, Dec-25, Volume: 798, Issue:2

    Topics: Animals; Area Under Curve; Chromatography, High Pressure Liquid; Humans; Male; Rats; Reproducibility of Results; Salicylates; Sensitivity and Specificity; Spectrophotometry, Ultraviolet

2003
Potential role of mitral valve strands on stroke recurrence in rheumatoid arthritis.
    Arthritis and rheumatism, 2003, Dec-15, Volume: 49, Issue:6

    Topics: Arthritis, Rheumatoid; Echocardiography, Transesophageal; Female; Humans; Middle Aged; Mitral Valve; Mitral Valve Prolapse; Platelet Aggregation Inhibitors; Recurrence; Salicylates; Stroke; Treatment Outcome

2003
The stability of 2-acetoxy-4-trifluoromethylbenzoic acid (Triflusal) in micellar pseudophase.
    Journal of pharmaceutical sciences, 2004, Volume: 93, Issue:2

    Topics: Algorithms; Alkalies; Bromides; Chemical Phenomena; Chemistry, Physical; Drug Stability; Electric Conductivity; Hydrolysis; Indicators and Reagents; Kinetics; Micelles; Platelet Aggregation Inhibitors; Potassium Compounds; Salicylates; Surface-Active Agents; Temperature

2004
Aspirin: it's hard to beat.
    Neurology, 2004, Apr-13, Volume: 62, Issue:7

    Topics: Aspirin; Cerebral Infarction; Humans; Pilot Projects; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Salicylates; Stroke; Treatment Outcome

2004
Effects of triflusal on oxidative stress, prostaglandin production and nitric oxide pathway in a model of anoxia-reoxygenation in rat brain slices.
    Brain research, 2004, Jun-18, Volume: 1011, Issue:2

    Topics: Analysis of Variance; Animals; Aspirin; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Hypoxia; In Vitro Techniques; L-Lactate Dehydrogenase; Lipid Peroxidation; Male; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidative Stress; Oxygen; Platelet Aggregation Inhibitors; Prostaglandins; Rats; Rats, Wistar; Salicylates

2004
Widespread eczema from triflusal confirmed by patch testing.
    Contact dermatitis, 2004, Volume: 50, Issue:4

    Topics: Diabetes Mellitus, Type 2; Diagnosis, Differential; Drug Eruptions; Eczema; Humans; Hypercholesterolemia; Hypertension; Male; Middle Aged; Myocardial Infarction; Patch Tests; Platelet Aggregation Inhibitors; Salicylates

2004
Polymeric drugs with prolonged sustained delivery of specific anti-aggregant agents for platelets: kinetic analysis of the release mechanism.
    Journal of biomaterials science. Polymer edition, 2004, Volume: 15, Issue:7

    Topics: Acrylamides; Biocompatible Materials; Blood Platelets; Drug Design; Free Radicals; Humans; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Magnetic Resonance Spectroscopy; Models, Chemical; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymers; Salicylates; Thrombin; Time Factors; Toluene; Water

2004
Reconsidering combined antiplatelet and anticoagulant therapy in atrial fibrillation.
    Journal of the American College of Cardiology, 2004, Oct-19, Volume: 44, Issue:8

    Topics: Acenocoumarol; Aged; Anticoagulants; Aspirin; Atrial Fibrillation; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; International Normalized Ratio; Male; Middle Aged; Mitral Valve Stenosis; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Salicylates; Warfarin

2004
Protective effect of triflusal and its main metabolite HTB in an in vitro model of anoxia-reoxygenation in rat brain slices: comparison with acetylsalicylic and salicylic acids.
    Naunyn-Schmiedeberg's archives of pharmacology, 2005, Volume: 371, Issue:1

    Topics: Animals; Aspirin; Brain Chemistry; Dinoprostone; Glutathione; Hypoxia, Brain; In Vitro Techniques; L-Lactate Dehydrogenase; Lipid Peroxidation; Male; Nerve Tissue Proteins; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Reperfusion Injury; Salicylates; Thiobarbituric Acid Reactive Substances

2005
Oral antiplatelet therapy.
    JAMA, 2005, Feb-16, Volume: 293, Issue:7

    Topics: Cerebrovascular Disorders; Clinical Trials as Topic; Clopidogrel; Coronary Artery Disease; Humans; Platelet Aggregation Inhibitors; Salicylates; Ticlopidine

2005
Interaction between a rat model of cerebral ischemia and beta-amyloid toxicity: II. Effects of triflusal.
    Stroke, 2005, Volume: 36, Issue:8

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Astrocytes; Behavior, Animal; Brain; Brain Ischemia; Corpus Striatum; Cytokines; Disease Models, Animal; Endothelins; Glial Fibrillary Acidic Protein; Hippocampus; Immunohistochemistry; Inflammation; Microglia; Neurons; Peptides; Rats; Rats, Wistar; Salicylates; Temperature

2005
Inhibition of cardiac hypertrophy by triflusal (4-trifluoromethyl derivative of salicylate) and its active metabolite.
    Molecular pharmacology, 2006, Volume: 69, Issue:4

    Topics: Animals; Aspirin; Base Sequence; Cardiomegaly; DNA Primers; Electrophoretic Mobility Shift Assay; Immunoprecipitation; Male; NF-kappa B; Rats; Rats, Sprague-Dawley; RNA Processing, Post-Transcriptional; Salicylates; Signal Transduction

2006
Antithrombotic treatment in atrial fibrillation. Response to: Bereznicki LR, Peterson GM, Jackson SL, Jeffrey EC: the risks of warfarin use in the elderly. Expert Opin. Drug Saf. (2006) 5(3):417-431.
    Expert opinion on drug safety, 2006, Volume: 5, Issue:4

    Topics: Acenocoumarol; Aged; Anticoagulants; Atrial Fibrillation; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Salicylates; Thromboembolism; Treatment Outcome; Warfarin

2006
Antithrombotic treatment in atrial fibrillation.
    Expert opinion on drug safety, 2006, Volume: 5, Issue:5

    Topics: Aged; Atrial Fibrillation; Death, Sudden, Cardiac; Geriatrics; Humans; Platelet Aggregation Inhibitors; Salicylates

2006
Effects of triflusal and aspirin in a rat model of cerebral ischemia.
    Stroke, 2007, Volume: 38, Issue:2

    Topics: Animals; Aspirin; Brain Ischemia; Disease Models, Animal; Drug Therapy, Combination; Male; Rats; Rats, Wistar; Salicylates

2007
The study of the influence of surfactant charge on alkaline hydrolysis reactions of acetylsalicylic acid (ASA) and triflusal (TFL) using spectrophotometric methods.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2007, Volume: 31, Issue:3-4

    Topics: Algorithms; Alkalies; Aspirin; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Platelet Aggregation Inhibitors; Polyethylene Glycols; Quaternary Ammonium Compounds; Salicylates; Salicylic Acid; Sodium Dodecyl Sulfate; Sodium Hydroxide; Spectrophotometry, Ultraviolet; Static Electricity; Surface-Active Agents; Water

2007
Spectroscopic and chromatographic characterization of triflusal delivery systems prepared by using supercritical impregnation technologies.
    Journal of pharmaceutical and biomedical analysis, 2008, Feb-13, Volume: 46, Issue:3

    Topics: Chromatography, Supercritical Fluid; Delayed-Action Preparations; Hydrogen-Ion Concentration; Salicylates; Solubility; Spectrophotometry; Technology, Pharmaceutical

2008
Protective effects of triflusal on secondary thrombus growth and vascular cyclooxygenase-2.
    Journal of thrombosis and haemostasis : JTH, 2008, Volume: 6, Issue:8

    Topics: Animals; Aspirin; Base Sequence; Blood Vessels; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Disease Models, Animal; DNA Primers; Endothelium, Vascular; Fibrinolytic Agents; In Vitro Techniques; Male; Perfusion; Rabbits; Recurrence; RNA, Messenger; Salicylates; Thrombosis

2008
Neuroprotective effects of the anti-inflammatory compound triflusal on ischemia-like neurodegeneration in mouse hippocampal slice cultures occur independent of microglia.
    Experimental neurology, 2009, Volume: 218, Issue:1

    Topics: Analysis of Variance; Animals; Animals, Newborn; Cell Count; Cell Death; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Glucose; Hippocampus; Ischemia; Mice; Mice, Inbred C57BL; Microglia; Nerve Degeneration; Neurons; Neuroprotective Agents; NF-kappa B; Plant Lectins; Propidium; Salicylates; Tissue Culture Techniques

2009
Photonucleophilic addition of the epsilon-amino group of lysine to a triflusal metabolite as a mechanistic key to photoallergy mediated by the parent drug.
    ChemMedChem, 2009, Volume: 4, Issue:7

    Topics: Binding Sites; Dermatitis, Photoallergic; Humans; Lysine; Photolysis; Protein Binding; Salicylates; Serum Albumin; Spectrometry, Fluorescence

2009
The short-term effect on restenosis and thrombosis of a cobalt-chromium stent eluting two drugs in a porcine coronary artery model.
    Journal of interventional cardiology, 2009, Volume: 22, Issue:5

    Topics: Animals; Blood Vessel Prosthesis; Blood Vessel Prosthesis Implantation; Chromium Alloys; Coronary Restenosis; Coronary Vessels; Disease Models, Animal; Drug Therapy, Combination; Drug-Eluting Stents; Immunosuppressive Agents; Platelet Aggregation Inhibitors; Prosthesis Design; Salicylates; Sirolimus; Swine; Thrombosis; Treatment Outcome

2009
Long-term follow-up of atrial fibrillation patients in the NASPEAF study. Prospective evaluation of different antiplatelet treatments.
    Revista espanola de cardiologia, 2009, Volume: 62, Issue:9

    Topics: Aged; Aspirin; Atrial Fibrillation; Female; Follow-Up Studies; Humans; Male; Platelet Aggregation Inhibitors; Prospective Studies; Salicylates; Time Factors

2009
Triflusal reduces dense-core plaque load, associated axonal alterations and inflammatory changes, and rescues cognition in a transgenic mouse model of Alzheimer's disease.
    Neurobiology of disease, 2010, Volume: 38, Issue:3

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Axons; Brain; Brain-Derived Neurotrophic Factor; Central Nervous System Agents; Cognition Disorders; Cytokines; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuroglia; Plaque, Amyloid; Proto-Oncogene Proteins c-fos; Salicylates

2010
In vitro and in vivo performance of a dual drug-eluting stent (DDES).
    Biomaterials, 2010, Volume: 31, Issue:15

    Topics: Animals; Antibiotics, Antineoplastic; Coated Materials, Biocompatible; Drug Delivery Systems; Drug-Eluting Stents; Humans; Hyperplasia; Materials Testing; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Salicylates; Sirolimus; Surface Properties; Swine; Thrombosis

2010
Thinking outside the box about COX-1 in Alzheimer's disease.
    Neurobiology of disease, 2010, Volume: 38, Issue:3

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Central Nervous System Agents; Cognition Disorders; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Humans; Membrane Proteins; Mice; Salicylates

2010
Electrochemical behavior of triflusal, aspirin and their metabolites at glassy carbon and boron doped diamond electrodes.
    Combinatorial chemistry & high throughput screening, 2010, Volume: 13, Issue:7

    Topics: Alkalies; Aspirin; Boron; Carbon; Diamond; Electrochemistry; Electrodes; Glass; High-Throughput Screening Assays; Hydrogen-Ion Concentration; Hydrolysis; Molecular Structure; Particle Size; Salicylates; Salicylic Acid; Surface Properties; Water

2010
Bioactive polymeric systems with platelet antiaggregating activity for the coating of vascular devices.
    Biomacromolecules, 2010, Oct-11, Volume: 11, Issue:10

    Topics: Acrylic Resins; Blood Platelets; Blood Vessel Prosthesis; Cell Adhesion; Cell Line; Cell Survival; Coated Materials, Biocompatible; Endothelial Cells; Humans; Microscopy, Electron, Scanning; Platelet Aggregation; Platelet Aggregation Inhibitors; Salicylates; Surface Properties

2010
Triflusal reduces cerebral ischemia induced inflammation in a combined mouse model of Alzheimer's disease and stroke.
    Brain research, 2010, Dec-17, Volume: 1366

    Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Antigens, CD; Brain Ischemia; Disease Models, Animal; Endothelin-1; Humans; Inflammation; Mice; Mice, Inbred C57BL; Mice, Transgenic; NF-kappa B; Platelet Aggregation Inhibitors; Salicylates; Stroke; tau Proteins; Tumor Necrosis Factor-alpha

2010
Letter by Borja and Garcia-Rafanell regarding article, "Guidelines for the prevention of stroke in patients with stroke or transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association"
    Stroke, 2011, Volume: 42, Issue:6

    Topics: Aspirin; Carotid Arteries; Clinical Trials as Topic; Endarterectomy, Carotid; Guidelines as Topic; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Salicylates; Stents; Stroke

2011
Comparative effects of triflusal, S-adenosylmethionine, and dextromethorphan over intestinal ischemia/reperfusion injury.
    TheScientificWorldJournal, 2011, Volume: 11

    Topics: Animals; Antioxidants; Dextromethorphan; Intestines; Male; Malondialdehyde; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Reperfusion Injury; S-Adenosylmethionine; Salicylates; Tumor Necrosis Factor-alpha

2011
Semi-mechanistic modelling and simulation of inhibition of platelet aggregation by antiplatelet agents.
    Basic & clinical pharmacology & toxicology, 2014, Volume: 115, Issue:4

    Topics: Adult; Blood Platelets; Cilostazol; Clopidogrel; Half-Life; Humans; Models, Theoretical; Platelet Aggregation; Platelet Aggregation Inhibitors; Retrospective Studies; Salicylates; Tetrazoles; Ticlopidine; Young Adult

2014
Tolerance of triflusal in patients with immediate cutaneous hypersensitivity to nonsteroidal anti-inflammatory drugs.
    Journal of investigational allergology & clinical immunology, 2014, Volume: 24, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Drug Hypersensitivity; Drug Tolerance; Female; Humans; Hypersensitivity, Immediate; Male; Middle Aged; Platelet Aggregation Inhibitors; Salicylates; Skin Diseases

2014
Supercritical CO2 foamed polycaprolactone scaffolds for controlled delivery of 5-fluorouracil, nicotinamide and triflusal.
    International journal of pharmaceutics, 2015, Dec-30, Volume: 496, Issue:2

    Topics: Carbon Dioxide; Drug Delivery Systems; Fluorouracil; HeLa Cells; Humans; Niacinamide; Polyesters; Salicylates; Tissue Scaffolds

2015
Photosensitivity associated with systemic triflusal therapy.
    Photodermatology, photoimmunology & photomedicine, 2016, Volume: 32, Issue:2

    Topics: Aged; Humans; Male; Photosensitivity Disorders; Salicylates; Thromboembolism; Urticaria

2016
Atypical photosensitivity associated with triflusal.
    Contact dermatitis, 2016, Volume: 75, Issue:4

    Topics: Aged, 80 and over; Facial Dermatoses; Humans; Male; Photosensitivity Disorders; Platelet Aggregation Inhibitors; Salicylates; Skin Tests

2016
Neuroprotective effect of triflusal and its main metabolite, 2-hydroxy-4-trifluoromethylbenzoic acid (HTB), in the postischemic brain.
    Neuroscience letters, 2017, 03-16, Volume: 643

    Topics: Animals; Anti-Inflammatory Agents; Aspirin; Brain; Brain Ischemia; Cytokines; Infarction, Middle Cerebral Artery; Male; Neurons; Neuroprotective Agents; Rats, Sprague-Dawley; Salicylates

2017
Aspirin desensitization in patients with coronary artery disease: Cost savings.
    Medicina intensiva, 2017, Volume: 41, Issue:7

    Topics: Aspirin; Clopidogrel; Coronary Disease; Cost Savings; Desensitization, Immunologic; Drug Hypersensitivity; Drug Substitution; Humans; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Salicylates; Ticlopidine

2017
Triflusal in Patients With Aspirin Hypersensitivity Treated With Coronary Stent Implantation.
    Revista espanola de cardiologia (English ed.), 2018, Volume: 71, Issue:7

    Topics: Aged; Aspirin; Drug Hypersensitivity; Female; Fibrinolytic Agents; Graft Occlusion, Vascular; Humans; Male; Myocardial Ischemia; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Salicylates; Stents

2018
Dipyridamole plus Triflusal versus Triflusal Alone in Infarct Reduction after Middle Cerebral Artery Occlusion.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2018, Volume: 27, Issue:5

    Topics: Animals; Brain; Cytoprotection; Dipyridamole; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; Rats, Wistar; Salicylates

2018
Clopidogrel and Low-Dose Aspirin, Alone or Together, Reduce Risk of Colorectal Cancer.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2019, Volume: 17, Issue:10

    Topics: Aged; Aged, 80 and over; Aspirin; Case-Control Studies; Clopidogrel; Colorectal Neoplasms; Dual Anti-Platelet Therapy; Female; Humans; Logistic Models; Male; Middle Aged; Platelet Aggregation Inhibitors; Protective Factors; Risk Reduction Behavior; Salicylates; Spain

2019
Targeted repositioning identifies drugs that increase fibroblast growth factor 20 production and protect against 6-hydroxydopamine-induced nigral cell loss in rats.
    Scientific reports, 2019, 06-06, Volume: 9, Issue:1

    Topics: Albuterol; Animals; Brain; Computer Simulation; Corpus Striatum; Dimethadione; Dopaminergic Neurons; Drug Repositioning; Female; Fibroblast Growth Factors; Humans; MCF-7 Cells; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Salicylates; Substantia Nigra; Trazodone; Treatment Outcome

2019
Photosensitivity to Triflusal.
    The journal of allergy and clinical immunology. In practice, 2021, Volume: 9, Issue:4

    Topics: Humans; Photosensitivity Disorders; Salicylates

2021
First-in-Man Evaluation of a Sirolimus-Eluting Stent With Abluminal Fluoropolymeric/Triflusal Coating With Ultrathin Struts by OCT at 9 Months' Follow-Up: The PROMETHEUS Study.
    Cardiovascular revascularization medicine : including molecular interventions, 2021, Volume: 32

    Topics: Coronary Vessels; Drug-Eluting Stents; Humans; Neointima; Percutaneous Coronary Intervention; Prospective Studies; Salicylates; Sirolimus; Stents; Tomography, Optical Coherence; Treatment Outcome

2021
Triflusal in Patients with Acute Coronary Syndrome and Acetylsalicylic Acid Hypersensitivity.
    Cardiology, 2021, Volume: 146, Issue:4

    Topics: Acute Coronary Syndrome; Aspirin; Drug Therapy, Combination; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Retrospective Studies; Salicylates; Treatment Outcome

2021