trifluridine has been researched along with floxuridine in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (55.17) | 18.7374 |
| 1990's | 2 (6.90) | 18.2507 |
| 2000's | 6 (20.69) | 29.6817 |
| 2010's | 4 (13.79) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Bhooshan, B; Torrence, PF | 1 |
| Matsumoto, H; Takeda, S; Unemi, N; Yamashita, J; Yasumoto, M | 1 |
| Balzarini, J; Bentrude, WG; Béres, J; De Clercq, E; Otvös, L; Sági, G | 1 |
| Meyer, RB; Nakayama, C; Saneyoshi, M; Santi, DV; Ueda, T; Wataya, Y | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Cordeiro, MN; Fernández, F; García-Mera, X; Helguera, AM; Rodríguez-Borges, JE | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Agrawal, B; Kumar, R; Mak, M; Shakya, N; Srivastav, NC; Tyrrell, DL | 1 |
| Agrawal, B; Kumar, R; Mak, M; Srivastav, NC; Tyrrell, DL | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Baker, MS; Benedict, WF; Heidelberger, C; Jones, PA; Mondal, S; Rapp, U | 1 |
| Armstrong, DK; Davidson, NE; Isaacs, JT; Ottaviano, YL | 1 |
| Berry, JP; Boumati, P; Cavellier, JF; Escaig, F; Lespinats, G; Tlouzeau, S | 1 |
| Isaacs, JT; Kyprianou, N | 1 |
| Berry, JP; Boumati, P; Cavellier, JF; Escaig, F; Galle, P; Lespinats, G; Tlouzeau, S | 1 |
| Boothman, DA; Greer, SB; Mekras, JA | 1 |
| De Clercq, E; Huyghe, P; Maudgal, PC | 1 |
| Wawra, E | 1 |
| Benedict, WF; Heidelberger, C; Peterson, AR | 1 |
| Busi, C; Fiume, L; Mattioli, A | 1 |
| Jacky, PB; Sutherland, GR | 1 |
| Danenberg, PV; Lockshin, A | 1 |
| Emura, T; Fukushima, M; Kazuno, H; Murakami, Y; Suzuki, N; Tsujimoto, H | 1 |
| GOTTSCHLING, H; HEIDELBERGER, C | 1 |
| BIRNIE, GD; BOOHAR, J; HEIDELBERGER, C; WENTLAND, D | 1 |
| Emura, T; Fukushima, M; Ohshimo, H; Suzuki, N; Yamaguchi, M | 1 |
| Peters, GJ; Prins, HJ; Temmink, OH; van Gelderop, E | 1 |
| Fukada, M; Futamura, M; Imai, H; Imai, T; Iwata, Y; Matsuhashi, N; Mori, R; Okumura, N; Sato, Y; Suetsugu, T; Takahashi, T; Tanaka, H; Tanaka, Y; Yasufuku, I; Yoshida, K | 1 |
| Ando, K; Iimori, M; Kiniwa, M; Kitao, H; Kiyonari, S; Maehara, Y; Matsuoka, K; Niimi, S; Oki, E; Saeki, H; Tokunaga, E; Tsukihara, H; Watanabe, S | 1 |
3 review(s) available for trifluridine and floxuridine
| Article | Year |
|---|---|
Oncogenic transformation of C3H/10T1/2 Cl 8 mouse embryo fibroblasts by inhibitors of nucleotide metabolism.
Topics: Animals; Bromodeoxyuridine; Cell Line; Cell Transformation, Neoplastic; Cytidine; Deoxycytidine; Deoxyribonucleotides; DNA; Embryo, Mammalian; Fibroblasts; Floxuridine; Fluorouracil; Idoxuridine; Methotrexate; Mice; Mice, Inbred C3H; Mutation; Thymidine; Trifluridine | 1985 |
Targeting of antiviral drugs by coupling with protein carriers.
Topics: Albumins; alpha-Fetoproteins; Amanitins; Amino Sugars; Animals; Antiviral Agents; Asialoglycoproteins; Chemical Phenomena; Chemistry; Cytarabine; DNA Replication; Ectromelia virus; Fetuins; Floxuridine; Glycoproteins; Hepatitis B; Hepatitis B virus; Humans; Liver; Macrophages; Serum Albumin; Trifluridine; Vidarabine; Virus Replication | 1983 |
Fluorinated pyrimidines as tight-binding inhibitors of thymidylate synthetase.
Topics: Amino Acid Sequence; Amino Acids; Animals; Chemical Phenomena; Chemistry; Deoxyuracil Nucleotides; Floxuridine; Fluorodeoxyuridylate; Kinetics; Methyltransferases; Thymidylate Synthase; Thymine Nucleotides; Trifluridine | 1981 |
26 other study(ies) available for trifluridine and floxuridine
| Article | Year |
|---|---|
Improved synthesis and in vitro antiviral activities of 5-cyanouridine and 5-cyano-2'-deoxyuridine.
Topics: Animals; Antiviral Agents; Cell Line; Cytopathogenic Effect, Viral; Deoxyuridine; Humans; Rabbits; Simplexvirus; Uridine; Vaccinia virus | 1977 |
Studies on antitumor agents. 8. Antitumor activities of O-alkyl derivatives of 2'-deoxy-5-(trifluoromethyl)uridine and 2'-deoxy-5-fluorouridine.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Floxuridine; Male; Mice; Mice, Inbred ICR; Sarcoma 180; Structure-Activity Relationship | 1989 |
Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Cell Line; Deoxyuracil Nucleotides; Drug Evaluation, Preclinical; Humans; Hydrocarbons, Halogenated; Indicators and Reagents; Leukemia L1210; Magnetic Resonance Spectroscopy; Mice; Simplexvirus; Structure-Activity Relationship; Vaccinia virus; Vesicular stomatitis Indiana virus | 1986 |
Thymidine phosphorylase. Substrate specificity for 5-substituted 2'-deoxyuridines.
Topics: Animals; Deoxyuridine; Horses; In Vitro Techniques; Models, Biological; Pentosyltransferases; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Substrate Specificity; Thymidine Phosphorylase | 1980 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Probing the anticancer activity of nucleoside analogues: a QSAR model approach using an internally consistent training set.
Topics: Algorithms; Antineoplastic Agents; Databases, Factual; Discriminant Analysis; Models, Molecular; Nucleosides; Quantitative Structure-Activity Relationship | 2007 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Antiviral activity of various 1-(2'-deoxy-β-D-lyxofuranosyl), 1-(2'-fluoro-β-D-xylofuranosyl), 1-(3'-fluoro-β-D-arabinofuranosyl), and 2'-fluoro-2',3'-didehydro-2',3'-dideoxyribose pyrimidine nucleoside analogues against duck hepatitis B virus (DHBV) and
Topics: Animals; Antiviral Agents; Cell Line, Tumor; Drug Resistance, Viral; Ducks; Hepatitis B virus; Hepatitis B Virus, Duck; Hepatocytes; Humans; Lamivudine; Mutation; Pyrimidine Nucleosides; Stereoisomerism; Structure-Activity Relationship; Virus Replication | 2010 |
Antiviral activity of 2,3'-anhydro and related pyrimidine nucleosides against hepatitis B virus.
Topics: Antiviral Agents; Hepatitis B virus; Pyrimidine Nucleosides | 2010 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
Oncogenic transformation of C3H/10T1/2 clone 8 mouse embryo cells by halogenated pyrimidine nucleosides.
Topics: Animals; Antigens, Viral; Bromodeoxyuridine; Cell Division; Cell Line; Cell Transformation, Neoplastic; Clone Cells; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Idoxuridine; Mice; Oncogenic Viruses; Sarcoma, Experimental; Thymidine; Time Factors; Trifluridine | 1976 |
Programmed cell death in an estrogen-independent human breast cancer cell line, MDA-MB-468.
Topics: Breast Neoplasms; Cell Death; Cell Division; Cell Membrane; DNA Damage; DNA, Neoplasm; Female; Floxuridine; Humans; Microscopy, Electron, Scanning; RNA, Messenger; Thymidine; Transforming Growth Factor beta; Trifluridine; Tumor Cells, Cultured | 1992 |
Intracellular localization of drugs in cultured tumor cells by ion microscopy and image processing.
Topics: Bromodeoxyuridine; Cyanides; Floxuridine; Halogens; Humans; Image Processing, Computer-Assisted; Ions; Microscopy; Thymidine; Trifluridine; Tumor Cells, Cultured | 1990 |
"Thymineless" death in androgen-independent prostatic cancer cells.
Topics: Animals; Blotting, Northern; Cell Line; Cell Survival; DNA, Neoplasm; Drug Screening Assays, Antitumor; Floxuridine; Iodoacetates; Iodoacetic Acid; Male; Nucleic Acid Hybridization; Ouabain; Prostatic Neoplasms; Rats; Thymidine; Thymine; Trifluridine | 1989 |
[Intracellular localization of halogenated drugs or molecules in cultured tumor cells. A study using ionic microscopy associated with an imaging processing system].
Topics: Breast Neoplasms; Bromodeoxyuridine; Cells, Cultured; Female; Floxuridine; Humans; Image Processing, Computer-Assisted; Thymidine; Trifluridine | 1989 |
Use of 5-trifluoromethyldeoxycytidine and tetrahydrouridine to circumvent catabolism and exploit high levels of cytidine deaminase in tumors to achieve DNA- and target-directed therapies.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cells, Cultured; Cytidine Deaminase; Deoxycytidine; DNA; Female; Floxuridine; Fluorouracil; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasms, Experimental; Nucleoside Deaminases; Tetrahydrouridine; Thymidylate Synthase; Trifluridine; Uridine | 1985 |
Experimental thymidine kinase-deficient HSV-1 keratitis: therapeutic attempts.
Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Drug Evaluation, Preclinical; Floxuridine; Keratitis, Dendritic; Rabbits; Thymidine; Thymidine Kinase; Trifluridine | 1987 |
Microinjected deoxynucleotides for the study of chemical inhibition of DNA synthesis.
Topics: Animals; Aphidicolin; Autoradiography; Cell Nucleus; Cells, Cultured; Cytarabine; Deoxyribonucleotides; Diterpenes; DNA Replication; Floxuridine; Hydroxyurea; Kinetics; Methotrexate; Trifluridine; Tritium | 1988 |
Thymidylate synthetase inhibitors and fragile site expression in lymphocytes.
Topics: Adolescent; Adult; Cells, Cultured; Child; Child, Preschool; Culture Media; Deoxycytidine; Female; Floxuridine; Folic Acid; Fragile X Syndrome; Gene Expression Regulation; Humans; Male; Methyltransferases; Middle Aged; Sex Chromosome Aberrations; Thymidylate Synthase; Trifluridine | 1983 |
Different mechanisms of acquired resistance to fluorinated pyrimidines in human colorectal cancer cells.
Topics: Antimetabolites, Antineoplastic; Cell Division; Colorectal Neoplasms; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Floxuridine; Fluorouracil; Humans; Neoplasm Proteins; Thymidylate Synthase; Trifluridine; Tumor Cells, Cultured | 2000 |
FLUORINATED PYRIMIDINES. XIX. SOME BIOLOGICAL EFFECTS OF 5-TRIFLUOROMETHYLURACIL AND 5-TRIFLUOROMETHYL-2'-DEOXYURIDINE ON ESCHERICHIA COLI AND BACTERIOPHAGE T4B.
Topics: Antimetabolites; Carbon Isotopes; Chromatography; Coliphages; Escherichia coli; Floxuridine; Fluorouracil; Metabolism; Mutation; Pharmacology; Pyrimidines; Research; Thymine; Trifluridine; Virus Cultivation | 1963 |
FLUORINATED PYRIMIDINES. XX. INHIBITION OF THE NUCLEOSIDE PHOSPHORYLASE CLEAVAGE OF 5-FLUORO-2'-DEOXYURIDINE BY 5-TRIFLUOROMETHYL-2'-DEOXYURIDINE.
Topics: Animals; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Deoxyuridine; Enzyme Inhibitors; Floxuridine; Fluorine; Glucosyltransferases; Nucleosides; Pentosyltransferases; Pyrimidines; Research; Tissue Extracts; Trifluridine | 1963 |
A novel combination antimetabolite, TAS-102, exhibits antitumor activity in FU-resistant human cancer cells through a mechanism involving FTD incorporation in DNA.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Colonic Neoplasms; DNA Damage; DNA, Neoplasm; Drug Combinations; Drug Resistance, Neoplasm; Floxuridine; Fluorouracil; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Pyrrolidines; Rats; Rats, Nude; Stomach Neoplasms; Thymine; Trifluridine; Uracil; Xenograft Model Antitumor Assays | 2004 |
The Hollow Fibre Assay as a model for in vivo pharmacodynamics of fluoropyrimidines in colon cancer cells.
Topics: Administration, Oral; Animals; Apoptosis; Capecitabine; Cell Cycle; Cell Line, Tumor; Colonic Neoplasms; Deoxycytidine; Drug Combinations; Drug Synergism; Enzyme Inhibitors; Flow Cytometry; Floxuridine; Fluorouracil; Humans; Mice; Mice, Inbred BALB C; Pyrrolidines; Sensitivity and Specificity; Thymidine Phosphorylase; Thymine; Treatment Outcome; Trifluridine; Tumor Cells, Cultured; Uracil; Xenograft Model Antitumor Assays | 2007 |
Mechanism of acquired 5FU resistance and strategy for overcoming 5FU resistance focusing on 5FU metabolism in colon cancer cell lines.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Colonic Neoplasms; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Floxuridine; Fluorouracil; Humans; Hydroxyurea; Metabolic Networks and Pathways; Pyrrolidines; Ribonucleotide Reductases; Thymidine Phosphorylase; Thymine; Trifluridine | 2021 |
Trifluridine Induces p53-Dependent Sustained G2 Phase Arrest with Its Massive Misincorporation into DNA and Few DNA Strand Breaks.
Topics: Antineoplastic Agents; CDC2 Protein Kinase; Cell Line, Tumor; Cyclin B1; Deoxyuridine; DNA Breaks; DNA Replication; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Gene Knockout Techniques; Humans; Inhibitory Concentration 50; Oncogene Protein p21(ras); Proteasome Endopeptidase Complex; Transcription, Genetic; Trifluridine; Tumor Suppressor Protein p53 | 2015 |