Page last updated: 2024-08-17

trifluoroacetic acid and halothane

trifluoroacetic acid has been researched along with halothane in 84 studies

Research

Studies (84)

Timeframe	Studies, this research(%)	All Research%
pre-1990	42 (50.00)	18.7374
1990's	33 (39.29)	18.2507
2000's	7 (8.33)	29.6817
2010's	2 (2.38)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Furukawa, T; Karashima, D; Kuhara, T; Shigematsu, A; Takahashi, S	1
Hirokata, Y; Karashima, D; Mikuriya, K; Shigematsu, A	1
Di Padua, D; Kahan, BD; Mathieu, A; Mills, J	1
Larsen, ER; Malek, RS; McCarty, LP	1
Doenicke, A; Fuhrhop, JH; Grote, B; Nau, H; Witte, L	1
Furukawa, T; Hirokata, Y; Karashima, D; Shigematsu, A	1
Cohen, EN; Edmunds, HN; Trudell, JR; Watson, E	1
Van Dyke, RA	1
Dumonde, DC; Hamblin, A; Simpson, R; Walton, B	1
McCracken, LE; Reves, JG	1
Gut, J; Huwyler, J; Jedlitschky, G; Keppler, D	1
Bürgin, M; Christen, U; Gut, J; Huwyler, J; Kenna, JG	1
Kenna, JG; Martin, JL; Pohl, LR	1
Gandolfi, AJ; Hubbard, AK; Levy, JP; Roth, TP	1
Bürgin, M; Christen, U; Gut, J	1
Gandolfi, AJ; Hastings, KL; Hubbard, AK; Thomas, C	1
Aguilera, L; Calvo, R; Martínez-Jorda, R; Rodríguez-Sasiaín, JM; Suárez, E	1
Fujii, K; Kinoshita, H; Morio, M; Nakao, M; Yuge, O	1
Hayden, PJ; Ichimura, T; McCann, DJ; Pohl, LR; Stevens, JL	1
Anderson, WR; Ardies, CM; Trudell, JR	1
Butler, LE; Ferrans, VJ; Martin, BM; Martin, JL; Perrone, A; Pohl, LR; Pumford, NR; Satoh, H; Thomassen, D	1
Brown, AP; Gandolfi, AJ; Hastings, KL; Schuman, S; Thomas, C	1
Chau, D; Earl, J; Overton, J; Wark, H	1
Chau, DD; Cheung, HT; Earl, J; Overton, J; Wark, H	1
Chau, DD; Earl, J; Overton, J; Wark, H	1
Christ, D; Kenna, JG; Martin, JL; Pohl, LR; Satoh, H	1
Gandolfi, AJ; Hubbard, AK; Roth, TP; Schuman, S	1
Biermann, JS; Fish, KJ; Rice, SA; Serra, MT	1
Aguilera, L; Calvo, R; Rodriguez-Sasiaín, JM; Suárez, E	1
Christ, DD; Kenna, JG; Martin, BM; Pohl, LR; Satoh, H; Schulick, AH	1
Büch, HP; Eckes, L	1
Gruenke, LD; Waskell, LA	1
Brendel, K; Dale, O; Gandolfi, AJ; Schuman, S	1
Berman, LM; Harbison, RD; James, RC; Roberts, SM; Smith, AC	1
Gruenke, LD; Konopka, K; Koop, DR; Waskell, LA	1
Brown, BR; Gandolfi, AJ; Hubbard, AK; Roth, TP	1
Erb, C; Erb, F; Goldstein, P; Imbenotte, M; Scherpereel, P	1
Brooks, SD; Brown, BR; Callis, AH; Gandolfi, AJ; Roth, TP	1
Baden, JM; Fujinaga, M; Mazze, RI; Serra, M	1
Gandolfi, AJ; Hubbard, AK; Roth, TP; Siadat-Pajouh, M	1
Fujii, K; Kikuchi, H; Okida, M	1
Clark, DL; Gallagher, JD; Gandolfi, AJ; Kerns, D; McNicholas, KW; Moore, RA; Sipes, IG	1
Danielsson, BR; Dencker, L; Ghantous, H; Parnerud, I	1
Chikasue, F; Fujii, K; Jordanov, JG; Kikuchi, H; Morio, M; Taira, Y; Takiyama, R; Yuge, O	1
Anderson, DK; Ferrans, VJ; Fukuda, Y; Gillette, JR; Pohl, LR; Satoh, H	1
Dale, O; Nilsen, OG	2
Dale, O	1
Brown, BR; Gandolfi, AJ; Lind, RC; Sipes, IG	1
Geddes, IC	1
Coyle, DE; Ford, DJ; Harrington, JF	1
Fujii, K; Hirokawa, T; Kikuchi, H; Kiso, Y; Morio, M; Takemi, H; Takiyama, R	1
Bentley, JB; Cork, RC; Gandolfi, AJ; Vaughan, RW	1
Gandolfi, AJ; Soltis, JJ	1
Chikasue, F; Fujii, K; Kikuchi, H; Morio, M; Ribarić, L; Takiyama, R	1
Dallmeier, E; Henschler, D	1
Lin, WQ; Marsh, HM; Trudell, JR; van Dyke, RA	1
Amouzadeh, HR; Pohl, LR	1
Christen, U; Frey, N; Gut, J; Koch, V; Stoffler, D	1
Brown, AP; Gandolfi, AJ; Hastings, KL; Thomas, C	1
Inaba, S; Irita, K; Nawata, H; Sakaguchi, Y; Sakai, H; Takahashi, S	1
Guillouzo, A; Ilyin, GP; Malledant, Y; Rissel, M; Tanguy, M	1
Niederstadt, M; Stier, A; Trudell, JR	1
Kenna, JG; Knight, TL; van Pelt, FN	1
Kenna, JG; Martin, BM; Martin, JL; Pohl, LR; Reed, GF; Thomassen, D	1
Fujii, K	1
Hankins, D; Kharasch, ED; Mautz, D; Thummel, KE	1
Fisher, JW; Jarabek, AM; McDougal, JN; Vinegar, A; Williams, RJ	1
Anders, MW; Loizou, GD; Tran, CL	1
Amouzadeh, HR; Bourdi, M; Martin, BM; Martin, JL; Pohl, LR	1
Furst, SM; Gandolfi, AJ; Gaw, HH; Luedke, D; Reich, R	1
Furst, SM; Gandolfi, AJ; Luedke, D	1
Hankins, DC; Kharasch, ED	1
Feierman, DE; Melnikov, Z	1
Ansari, A; Bach, JF; Coppel, RL; Gershwin, ME; Humphries, KM; Leung, PS; Nakanuma, Y; Pumford, N; Roche, TE; Sasaki, M; Szweda, LI; van de Water, J	1
Amouzadeh, HR; Bourdi, M; Martin, JL; Pohl, LR; Rushmore, TH	1
Emery, ME; Kharasch, ED; Spracklin, DK; Thummel, KE	1
Bortolato, S; Brotto, M; Gervasi, PG; Manno, M; Marini, S; Rugge, M; Zanovello, A	1
Albores, A; Dekant, W; García-Latorre, EA; Manno, M; Oropeza-Hernández, LF; Quintanilla-Vega, B; Reyes-Mejía, RA; Serrano, CJ	1
STIER, A	1
Cheng, L; Ju, C; Reilly, TP; Wegmann, D; You, Q	1
Nguyen, C; Njoku, DB; Rose, NR	1
Cheng, L; Ju, C; You, Q	1
Iyer, SV; John Mihic, S; Tipps, ME	1

Reviews

4 review(s) available for trifluoroacetic acid and halothane

Article	Year
Hapten carrier conjugates associated with halothane hepatitis. Advances in experimental medicine and biology, 1991, Volume: 283 Topics: Animals; Carrier Proteins; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Halothane; Haptens; Humans; Microsomes, Liver; Rats; Trifluoroacetic Acid	1991
Neoantigens associated with halothane hepatitis. Drug metabolism reviews, 1989, Volume: 20, Issue:2-4 Topics: Animals; Antigens; Carrier Proteins; Chemical and Drug Induced Liver Injury; Halothane; Humans; Trifluoroacetic Acid	1989
Metabolism of volatile anesthetics. International anesthesiology clinics, 1971,Fall, Volume: 9, Issue:3 Topics: Anesthetics; Animals; Carbon Tetrachloride; Chloroform; Cyclopropanes; Enzyme Induction; Ether; Ethers; Ethylenes; Free Radicals; Halothane; Humans; Methoxyflurane; Mice; Trichloroethylene; Trifluoroacetic Acid	1971
Molecular mimicry in halothane hepatitis: biochemical and structural characterization of lipoylated autoantigens. Toxicology, 1995, Mar-31, Volume: 97, Issue:1-3 Topics: Autoantigens; Chemical and Drug Induced Liver Injury; Cross Reactions; Halothane; Humans; Liver Cirrhosis, Biliary; Thioctic Acid; Trifluoroacetic Acid	1995

Trials

2 trial(s) available for trifluoroacetic acid and halothane

Article	Year
Halothane and enflurane metabolite elimination during anaesthesia in man. European journal of anaesthesiology, 1987, Volume: 4, Issue:3 Topics: Adult; Anesthesia, Inhalation; Chromatography, Gas; Chromatography, High Pressure Liquid; Enflurane; Fluorides; Halothane; Humans; Middle Aged; Oxalates; Time Factors; Trifluoroacetic Acid	1987
Identification of the enzyme responsible for oxidative halothane metabolism: implications for prevention of halothane hepatitis. Lancet (London, England), 1996, May-18, Volume: 347, Issue:9012 Topics: Adult; Alanine Transaminase; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Disulfiram; Halothane; Hepatic Encephalopathy; Humans; Male; Oxidoreductases, N-Demethylating; Preoperative Care; Trifluoroacetic Acid	1996

Article

Year

Halothane and enflurane metabolite elimination during anaesthesia in man.

European journal of anaesthesiology, 1987, Volume: 4, Issue:3

Topics: Adult; Anesthesia, Inhalation; Chromatography, Gas; Chromatography, High Pressure Liquid; Enflurane; Fluorides; Halothane; Humans; Middle Aged; Oxalates; Time Factors; Trifluoroacetic Acid

1987

Identification of the enzyme responsible for oxidative halothane metabolism: implications for prevention of halothane hepatitis.

Lancet (London, England), 1996, May-18, Volume: 347, Issue:9012

Topics: Adult; Alanine Transaminase; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Disulfiram; Halothane; Hepatic Encephalopathy; Humans; Male; Oxidoreductases, N-Demethylating; Preoperative Care; Trifluoroacetic Acid

1996

Other Studies

78 other study(ies) available for trifluoroacetic acid and halothane

Article	Year
The gas chromatographic mass spectrometric determination of trifluoroacetic acid in biological fluid. Application to halothane metabolism. Biomedical mass spectrometry, 1976, Volume: 3, Issue:1 Topics: Animals; Chromatography, Gas; Esters; Fluoroacetates; Gas Chromatography-Mass Spectrometry; Halothane; Hydrogen-Ion Concentration; Microsomes, Liver; NAD; Oxygen; Rabbits; Trifluoroacetic Acid	1976
Species and individual differences in the rate of halothane metabolism to trifluoroacetic acid. Fukuoka igaku zasshi = Hukuoka acta medica, 1979, Volume: 70, Issue:1 Topics: Animals; Biotransformation; Fluoroacetates; Halothane; Haplorhini; In Vitro Techniques; Macaca; Male; Microsomes, Liver; Rabbits; Rats; Species Specificity; Trifluoroacetic Acid	1979
Humoral immunity to a metabolite of halothane, fluroxene, and enflurane. Anesthesiology, 1975, Volume: 42, Issue:5 Topics: Animals; Antibody Formation; Complement Fixation Tests; Enflurane; Ethers; Fluoroacetates; Freund's Adjuvant; Guinea Pigs; Halothane; Hemolysis; Humans; Hypersensitivity, Delayed; Immunity; Immunoglobulin M; Injections, Intradermal; Injections, Intravenous; Male; Mercaptoethanol; Methyl Ethers; Passive Cutaneous Anaphylaxis; Serum Albumin; Skin Tests; Trifluoroacetic Acid	1975
The effects of deuteration on the metabolism of halogenated anesthetics in the rat. Anesthesiology, 1979, Volume: 51, Issue:2 Topics: Alanine Transaminase; Anesthetics; Animals; Bromides; Chemical Phenomena; Chemistry, Physical; Chloroform; Deuterium; Enflurane; Fluorides; Halothane; Male; Methoxyflurane; Oxidation-Reduction; Rats; Trifluoroacetic Acid	1979
Quantitative analysis of trifluoroacetic acid in body fluids of patients treated with halothane. Journal of chromatography, 1977, Jul-01, Volume: 143, Issue:4 Topics: Anesthesia; Chromatography, Gas; Fluoroacetates; Halothane; Humans; Mass Spectrometry; Methods; Time Factors; Trifluoroacetic Acid	1977
The in vitro metabolism of halothane (2-bromo-2-chloro-1,1,1-trifluoroethane) by hepatic microsomal cytochrome P-450. The Journal of pharmacology and experimental therapeutics, 1977, Volume: 203, Issue:2 Topics: Animals; Chromatography, Gas; Cytochrome P-450 Enzyme System; Halothane; In Vitro Techniques; Male; Microsomes, Liver; Phenobarbital; Rabbits; Trifluoroacetic Acid	1977
Urinary metabolites of halothane in man. Anesthesiology, 1975, Volume: 43, Issue:4 Topics: Binding Sites; Carbon Radioisotopes; Chemical and Drug Induced Liver Injury; Cysteine; Ethanolamines; Fluoroacetates; Glutathione; Halothane; Heart Transplantation; Humans; Liver; Tissue Donors; Transplantation, Homologous; Trifluoroacetic Acid	1975
Metabolism of halothane. Anesthesiology, 1975, Volume: 43, Issue:4 Topics: Glutathione; Halothane; Humans; Hydrocarbons, Halogenated; Oxidation-Reduction; Sulfhydryl Compounds; Trifluoroacetic Acid	1975
Absence of cellular hypersensitivity in patients with unexplained hepatitis following halothane. Anesthesiology, 1976, Volume: 44, Issue:5 Topics: Anesthesia, Inhalation; Cell Migration Inhibition; Chemical and Drug Induced Liver Injury; Halothane; Humans; Hypersensitivity, Delayed; Immunity, Cellular; Leukocytes; Liver; Lymphocyte Activation; Lymphocytes; Proteins; Serum Albumin; Trifluoroacetic Acid	1976
Hepatic pathology and skin test reactions to trifluoro-acetylated autologous protein after repeated halothane anaesthesia in the guineapig. British journal of anaesthesia, 1976, Volume: 48, Issue:5 Topics: Anesthesia, General; Animals; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Fluoroacetates; Guinea Pigs; Halothane; Liver; Serum Albumin; Skin Tests; Trifluoroacetic Acid	1976
Halothane metabolism. Impairment of hepatic omega-oxidation of leukotrienes in vivo and in vitro. European journal of biochemistry, 1992, Jun-15, Volume: 206, Issue:3 Topics: Animals; Cytochrome P-450 Enzyme System; Halothane; Isoenzymes; Kinetics; Leukotriene B4; Leukotriene E4; Leukotrienes; Liver; Male; Microsomes, Liver; Oxidation-Reduction; Rats; Rats, Inbred Strains; SRS-A; Trifluoroacetic Acid	1992
Molecular mimicry of trifluoroacetylated human liver protein adducts by constitutive proteins and immunochemical evidence for its impairment in halothane hepatitis. European journal of biochemistry, 1992, Dec-01, Volume: 210, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Animals; Biopsy; Chemical and Drug Induced Liver Injury; Child, Preschool; Female; Fluoroacetates; Halothane; Humans; Immunoblotting; Immunohistochemistry; Liver; Male; Middle Aged; Molecular Weight; Proteins; Rats; Rats, Sprague-Dawley; Trifluoroacetic Acid	1992
The topography of trifluoroacetylated protein antigens in liver microsomal fractions from halothane treated rats. Biochemical pharmacology, 1992, Aug-18, Volume: 44, Issue:4 Topics: Animals; Antigens; Deoxycholic Acid; Detergents; Endoplasmic Reticulum; Fluoroacetates; Halothane; Immunoblotting; Intracellular Membranes; Male; Membrane Proteins; Microsomes, Liver; Rats; Rats, Inbred Strains; Trifluoroacetic Acid; Trypsin	1992
Use of structural alterations in the synthesis of halothane metabolite antigens to mimic halothane-induced immunogen. Drug and chemical toxicology, 1990, Volume: 13, Issue:2-3 Topics: Acetates; Acetylation; Aminocaproates; Animals; Antibodies; Chemical and Drug Induced Liver Injury; Epitopes; Female; Fluorine; Fluoroacetates; Halothane; Haptens; Humans; Immunoblotting; Rabbits; Serum Albumin; Trifluoroacetic Acid; Vaccines, Synthetic	1990
Halothane metabolism: immunochemical evidence for molecular mimicry of trifluoroacetylated liver protein adducts by constitutive polypeptides. Molecular pharmacology, 1991, Volume: 40, Issue:3 Topics: Animals; Blotting, Western; Cross Reactions; Epitopes; Halothane; Humans; Immunohistochemistry; Liver; Male; Organ Specificity; Peptides; Proteins; Rabbits; Rats; Rats, Inbred Strains; Serum Albumin; Trifluoroacetic Acid	1991
Screening for antibodies associated with halothane hepatitis. British journal of anaesthesia, 1991, Volume: 67, Issue:6 Topics: Animals; Chemical and Drug Induced Liver Injury; Enzyme-Linked Immunosorbent Assay; Fluoroacetates; Halothane; Hepatitis Antibodies; Humans; Infant; Lysine; Male; Microsomes, Liver; Rabbits; Serum Albumin; Trifluoroacetic Acid	1991
Effect of halothane anesthesia and trifluoroacetic acid on protein binding of benzodiazepines. Methods and findings in experimental and clinical pharmacology, 1991, Volume: 13, Issue:10 Topics: Adult; Anesthesia, Inhalation; Binding, Competitive; Diazepam; Drug Interactions; Halothane; Humans; Lorazepam; Midazolam; Middle Aged; Preanesthetic Medication; Protein Binding; Trifluoroacetic Acid	1991
Aerobic dehalogenation of halothane showing different substrate dependency from anaerobic dehalogenation in liver microsomes of guinea pig. Hiroshima journal of medical sciences, 1991, Volume: 40, Issue:1 Topics: Aerobiosis; Animals; Chemical and Drug Induced Liver Injury; Guinea Pigs; Halothane; In Vitro Techniques; Male; Microsomes, Liver; Trifluoroacetic Acid	1991
Detection of cysteine conjugate metabolite adduct formation with specific mitochondrial proteins using antibodies raised against halothane metabolite adducts. The Journal of biological chemistry, 1991, Oct-05, Volume: 266, Issue:28 Topics: Acetamides; Animals; Cross Reactions; Cysteine; Enzyme-Linked Immunosorbent Assay; Fluoroacetates; Halothane; Hydrocarbons, Fluorinated; Immunoblotting; Immunohistochemistry; Kidney Diseases; Kidney Tubules, Proximal; Kinetics; Male; Mitochondria; Rats; Rats, Inbred Strains; Trifluoroacetic Acid	1991
The effect of alcohol and anesthetic metabolites on cell membranes. A possible direct immune mechanism. Annals of the New York Academy of Sciences, 1991, Volume: 625 Topics: Acetaldehyde; Alcoholism; Animals; Antibody Formation; Cell Membrane; Chemical and Drug Induced Liver Injury; Ethanol; Flow Cytometry; Halothane; Haptens; Humans; Immunoglobulin G; Lipid Bilayers; Liver; Liver Diseases; Molecular Conformation; Phosphatidylethanolamines; Rabbits; Trifluoroacetic Acid	1991
S-ethylthiotrifluoroacetate enhancement of the immune response to halothane in the guinea pig. Advances in experimental medicine and biology, 1991, Volume: 283 Topics: Animals; Antibody Formation; Antigens; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Fluoroacetates; Guinea Pigs; Halothane; Male; Proteins; Trifluoroacetic Acid	1991
Biliary excretion of the halothane metabolite trifluoroacetic acid in infants. Anaesthesia and intensive care, 1991, Volume: 19, Issue:2 Topics: Anesthesia, Inhalation; Bile; Cholelithiasis; Female; Gallstones; Halothane; Humans; Infant; Male; Trifluoroacetic Acid	1991
A urinary cysteine-halothane metabolite: validation and measurement in children. British journal of anaesthesia, 1990, Volume: 64, Issue:4 Topics: Acetylcysteine; Anesthesia, Inhalation; Biotransformation; Child; Chromatography, High Pressure Liquid; Cysteine; Halothane; Humans; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Trifluoroacetic Acid	1990
Halothane metabolism in children. British journal of anaesthesia, 1990, Volume: 64, Issue:4 Topics: Anesthesia, Inhalation; Biotransformation; Bromides; Child; Child, Preschool; Creatinine; Fatty Liver; Fluorides; Half-Life; Halothane; Humans; Infant; Male; Respiration; Trifluoroacetic Acid	1990
Localization of halothane-induced antigen in situ by specific anti-halothane metabolite antibodies. Clinical and experimental immunology, 1989, Volume: 76, Issue:3 Topics: Animals; Antibodies; Antigen-Antibody Reactions; Antigens; Deuterium; Drug Administration Schedule; Fluoroacetates; Guinea Pigs; Halothane; Liver; Male; Rabbits; Serum Albumin; Trifluoroacetic Acid	1989
Metabolism of halothane in obese Fischer 344 rats. Anesthesiology, 1989, Volume: 71, Issue:3 Topics: Animals; Bromides; Dietary Fats; Fluorides; Halothane; Male; Obesity; Oxidation-Reduction; Rats; Rats, Inbred F344; Rats, Inbred Strains; Time Factors; Trifluoroacetic Acid	1989
Displacement of warfarin from human serum proteins by halothane anaesthesia. Acta anaesthesiologica Scandinavica, 1989, Volume: 33, Issue:7 Topics: Adult; Binding, Competitive; Blood Proteins; Female; Fluoroacetates; Halothane; Humans; In Vitro Techniques; Male; Protein Binding; Trifluoroacetic Acid; Warfarin	1989
Human anti-endoplasmic reticulum antibodies in sera of patients with halothane-induced hepatitis are directed against a trifluoroacetylated carboxylesterase. Proceedings of the National Academy of Sciences of the United States of America, 1989, Volume: 86, Issue:1 Topics: Animals; Antibodies; Carboxylesterase; Carboxylic Ester Hydrolases; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum; Fluoroacetates; Halothane; Humans; Male; Microsomes, Liver; Molecular Weight; Protein Binding; Rats; Rats, Inbred Strains; Trifluoroacetic Acid	1989
Influence of disulfiram, diethyldithiocarbamate and carbon disulfide on the metabolic formation of trifluoroacetic acid from halothane in the rat. Arzneimittel-Forschung, 1985, Volume: 35, Issue:9 Topics: Anesthesia, Inhalation; Animals; Carbon Disulfide; Disulfiram; Ditiocarb; Fluoroacetates; Halothane; Kidney; Liver; Male; Rats; Rats, Inbred Strains; Thiocarbamates; Trifluoroacetic Acid	1985
A gas chromatographic mass spectrometric method for the analysis of trifluoroacetic acid: application to the metabolism of halothane by in vitro preparations. Biomedical & environmental mass spectrometry, 1988, Volume: 17, Issue:6 Topics: Cytochrome P-450 Enzyme System; Fluoroacetates; Gas Chromatography-Mass Spectrometry; Halothane; In Vitro Techniques; Microsomes, Liver; Trifluoroacetic Acid	1988
Rat liver slices and diazepam metabolism: in vitro interactions with volatile anaesthetic drugs and albumin. British journal of anaesthesia, 1988, Volume: 60, Issue:6 Topics: Anesthetics; Animals; Diazepam; Drug Interactions; Enflurane; Halothane; In Vitro Techniques; Isoflurane; Liver; Male; Protein Binding; Rats; Rats, Inbred Strains; Serum Albumin; Trifluoroacetic Acid	1988
Effects of piperonyl butoxide on halothane hepatotoxicity and metabolism in the hyperthyroid rat. Toxicology, 1988, Volume: 50, Issue:1 Topics: Administration, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Chlorofluorocarbons; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Halothane; Hydrocarbons, Halogenated; Hyperthyroidism; Liver Diseases; Male; Piperonyl Butoxide; Rats; Rats, Inbred Strains; Trifluoroacetic Acid; Triiodothyronine	1988
Characterization of halothane oxidation by hepatic microsomes and purified cytochromes P-450 using a gas chromatographic mass spectrometric assay. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 246, Issue:2 Topics: Animals; Biotransformation; Cytochrome P-450 Enzyme System; Fluoroacetates; Gas Chromatography-Mass Spectrometry; Halothane; Humans; Imidazoles; In Vitro Techniques; Male; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rabbits; Trifluoroacetic Acid	1988
Chronology of halothane-induced antigen expression in halothane-exposed rabbits. Clinical and experimental immunology, 1988, Volume: 72, Issue:2 Topics: Animals; Antibody Formation; Antibody Specificity; Antigen-Antibody Reactions; Antigens; Dose-Response Relationship, Immunologic; Fluoroacetates; Halothane; Liver; Male; Molecular Weight; Rabbits; Serum Albumin; Time Factors; Trifluoroacetic Acid	1988
Characterization of a halothane-induced humoral immune response in rabbits. Clinical and experimental immunology, 1987, Volume: 67, Issue:2 Topics: Animals; Antibody Formation; Antibody Specificity; Binding, Competitive; Fluoroacetates; Halothane; Immunization Schedule; Immunologic Memory; Male; Oxygen; Rabbits; Serum Albumin; Trifluoroacetic Acid	1987
Halothane metabolism in cirrhotic rats. Anesthesiology, 1987, Volume: 67, Issue:5 Topics: Animals; Bromides; Fluorides; Halothane; Liver Cirrhosis, Experimental; Male; Rats; Trifluoroacetic Acid	1987
Generation of halothane-induced immune response in a guinea pig model of halothane hepatitis. Anesthesia and analgesia, 1987, Volume: 66, Issue:12 Topics: Animals; Antibody Formation; Antigens; Chemical and Drug Induced Liver Injury; Female; Guinea Pigs; Halothane; Male; Serum Albumin; Species Specificity; Trifluoroacetic Acid	1987
Concentration-dependence of halothane metabolism in rabbits. Hiroshima journal of medical sciences, 1986, Volume: 35, Issue:1 Topics: Animals; Bile; Chlorofluorocarbons; Ethane; Halothane; Male; Oxidation-Reduction; Rabbits; Trifluoroacetic Acid	1986
Halothane metabolism in acyanotic and cyanotic patients undergoing open heart surgery. Anesthesia and analgesia, 1986, Volume: 65, Issue:12 Topics: Cardiopulmonary Bypass; Cyanosis; Female; Halothane; Heart Defects, Congenital; Humans; Male; Trifluoroacetic Acid	1986
Distribution of halothane and the metabolites trifluoroacetic acid and bromide in the conceptus after halothane inhalation by pregnant mice. Acta pharmacologica et toxicologica, 1986, Volume: 59, Issue:5 Topics: Amniotic Fluid; Animals; Bromides; Dialysis; Female; Fetus; Halothane; Mice; Mice, Inbred C57BL; Pregnancy; Pregnancy, Animal; Protein Binding; Trifluoroacetic Acid	1986
Clinical effects of halothane concentration on trifluoroacetic acid excretion in urine. Hiroshima journal of medical sciences, 1985, Volume: 34, Issue:4 Topics: Anesthesia; Fluoroacetates; Halothane; Humans; Kinetics; Trifluoroacetic Acid	1985
Immunological studies on the mechanism of halothane-induced hepatotoxicity: immunohistochemical evidence of trifluoroacetylated hepatocytes. The Journal of pharmacology and experimental therapeutics, 1985, Volume: 233, Issue:3 Topics: Animals; Female; Fluorescent Antibody Technique; Fluoroacetates; Halothane; Histocytochemistry; Immunoenzyme Techniques; In Vitro Techniques; Liver; Male; Rabbits; Rats; Serum Albumin; Trifluoroacetic Acid	1985
Binding and distribution of restrictively and non-restrictively eliminated drugs to serum and liver cell cytosol: effects of volatile anaesthetics. British journal of anaesthesia, 1986, Volume: 58, Issue:1 Topics: Adult; Animals; Binding Sites; Cytosol; Diazepam; Enflurane; Halothane; Humans; Kinetics; Liver; Male; Phenytoin; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Trifluoroacetic Acid; Warfarin	1986
The interaction of enflurane, halothane and the halothane metabolite trifluoroacetic acid with the binding of acidic drugs to human serum albumin. An in vitro study. Biochemical pharmacology, 1986, Feb-15, Volume: 35, Issue:4 Topics: Binding Sites; Binding, Competitive; Enflurane; Fluoroacetates; Halothane; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Models, Chemical; Phenytoin; Protein Binding; Serum Albumin; Trifluoroacetic Acid; Warfarin	1986
Comparison of the requirements for hepatic injury with halothane and enflurane in rats. Anesthesia and analgesia, 1985, Volume: 64, Issue:10 Topics: Anesthesia, Inhalation; Animals; Biotransformation; Body Temperature; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Enflurane; Fluorides; Halothane; Hot Temperature; Hypoxia; Liver; Male; Models, Biological; Oxygen; Phenobarbital; Rats; Rats, Inbred Strains; Time Factors; Trifluoroacetic Acid	1985
Effects of hypersensitivity to a halothane metabolite on halothane-induced liver damage. Anesthesiology, 1984, Volume: 60, Issue:2 Topics: Animals; Drug Hypersensitivity; Fluoroacetates; Halothane; Liver; Male; Rats; Rats, Inbred F344; Trifluoroacetic Acid	1984
Analytical isotachophoresis utilizing computer simulation. II. Assessment of optimum separation conditions for urinary trifluoroacetic acid metabolized from anaesthetic halothane. Journal of chromatography, 1984, Feb-10, Volume: 305, Issue:2 Topics: Computers; Electrophoresis; Fluoroacetates; Halothane; Humans; Hydrogen-Ion Concentration; Trifluoroacetic Acid	1984
Displacement of some basic drugs from human serum proteins by enflurane, halothane and their major metabolites. An in vitro study. British journal of anaesthesia, 1984, Volume: 56, Issue:5 Topics: Adult; Blood Proteins; Bromides; Diazepam; Enflurane; Halothane; Humans; In Vitro Techniques; Male; Potassium; Potassium Compounds; Prazosin; Propranolol; Protein Binding; Serum Albumin; Sodium Fluoride; Trifluoroacetic Acid	1984
Halothane biotransformation in obese and nonobese patients. Anesthesiology, 1982, Volume: 57, Issue:2 Topics: Adult; Biotransformation; Bromides; Female; Fluorides; Halothane; Humans; Male; Obesity; Oxidation-Reduction; Time Factors; Trifluoroacetic Acid	1982
Detection of fluorinated anesthetic metabolities by sodium fusion. Anesthesia and analgesia, 1980, Volume: 59, Issue:1 Topics: Anesthetics; Enflurane; Fenfluramine; Fluorides; Halothane; Methods; Sodium; Trifluoroacetic Acid	1980
Quantitative analysis of trifluoroacetate in the urine and blood by isotachophoresis. Anesthesiology, 1980, Volume: 53, Issue:1 Topics: Biotransformation; Fluoroacetates; Halothane; Humans; Ions; Methods; Time Factors; Trifluoroacetic Acid; Urine	1980
[Halothane hazards for the team in the operation theatre (author's transl)]. Deutsche medizinische Wochenschrift (1946), 1981, Mar-13, Volume: 106, Issue:11 Topics: Halothane; Humans; Maximum Allowable Concentration; Monitoring, Physiologic; Operating Rooms; Trifluoroacetic Acid	1981
Time course of 72-kilodalton heat shock protein induction and appearance of trifluoroacetyl adducts in livers of halothane-exposed rats. Molecular pharmacology, 1994, Volume: 46, Issue:4 Topics: Animals; Blotting, Western; Chemical and Drug Induced Liver Injury; Electrophoresis, Polyacrylamide Gel; Halothane; Heat-Shock Proteins; Indicators and Reagents; Kinetics; Liver; Male; Rats; Rats, Sprague-Dawley; Rosaniline Dyes; Staining and Labeling; Trifluoroacetic Acid	1994
Processing of endoplasmic reticulum luminal antigens associated with halothane hepatitis in rat hepatocytes. Hepatology (Baltimore, Md.), 1995, Volume: 22, Issue:3 Topics: Animals; Antigens; Carrier Proteins; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum; Female; Half-Life; Halothane; Haptens; Liver; Proteins; Rats; Rats, Sprague-Dawley; Trifluoroacetic Acid	1995
Trifluoroacetylation potentiates the humoral immune response to halothane in the guinea pig. Immunopharmacology and immunotoxicology, 1995, Volume: 17, Issue:1 Topics: Alanine Transaminase; Animals; Antibody Formation; Antigens; Bacterial Proteins; Enzyme-Linked Immunosorbent Assay; Fluoroacetates; Guinea Pigs; Halothane; Lymphocytes; Male; Mycobacterium; Proteins; Trifluoroacetic Acid	1995
Absence of anti-trifluoroacetate antibody after halothane anaesthesia in patients exhibiting no or mild liver damage. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1994, Volume: 41, Issue:5 Pt 1 Topics: Adolescent; Adult; Aged; Alanine Transaminase; Anesthesia, Inhalation; Animals; Antibodies; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Electrophoresis, Polyacrylamide Gel; Female; Halothane; Humans; Immunoblotting; Infant; Liver Failure; Male; Middle Aged; Rabbits; Rats; Rats, Wistar; Serum Albumin; Trifluoroacetic Acid	1994
Human hepatocytes express trifluoroacetylated neoantigens after in vitro exposure to halothane. Biochemical pharmacology, 1994, Aug-03, Volume: 48, Issue:3 Topics: Antibody Specificity; Antigens; Biotransformation; Cells, Cultured; Chemical and Drug Induced Liver Injury; Fluoroacetates; Halothane; Humans; Liver; Serum Albumin; Trifluoroacetic Acid	1994
Binding of anti-trifluoroacetyl antibodies to isolated hepatocytes observed by digital fluorescence microscopy. Biochemical and biophysical research communications, 1994, Apr-15, Volume: 200, Issue:1 Topics: Animals; Antibodies; Cell Membrane; Fluoresceins; Goats; Halothane; Immunoglobulin Fab Fragments; Liver; Male; Microscopy, Fluorescence; Phosphatidylcholines; Phosphatidylethanolamines; Rabbits; Rats; Rats, Sprague-Dawley; Trifluoroacetic Acid	1994
Immunity to halothane metabolite-modified proteins in halothane hepatitis. Annals of the New York Academy of Sciences, 1993, Jun-23, Volume: 685 Topics: Animals; Antibody Formation; Antigens; Biotransformation; Chemical and Drug Induced Liver Injury; Female; Halothane; Humans; Immunoblotting; Liver; Male; Rabbits; Rats; Rats, Sprague-Dawley; Trifluoroacetic Acid	1993
Halothane hepatitis patients have serum antibodies that react with protein disulfide isomerase. Hepatology (Baltimore, Md.), 1993, Volume: 18, Issue:4 Topics: Antibodies; Antigens; Chemical and Drug Induced Liver Injury; Halothane; Humans; Isomerases; Microsomes, Liver; Molecular Weight; Protein Disulfide-Isomerases; Trifluoroacetic Acid	1993
Isoflurane acts as an inhibitor of oxidative dehalogenation while acting as an accelerator of reductive dehalogenation of halothane in guinea pig liver microsomes. Toxicology, 1995, Dec-15, Volume: 104, Issue:1-3 Topics: Anesthetics, Inhalation; Animals; Chlorofluorocarbons; Cytochrome P-450 Enzyme System; Guinea Pigs; Halothane; Isoflurane; Male; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Oxidoreductases; Spectrophotometry, Ultraviolet; Trifluoroacetic Acid	1995
Rat to human extrapolation of HCFC-123 kinetics deduced from halothane kinetics: a corollary approach to physiologically based pharmacokinetic modeling. Fundamental and applied toxicology : official journal of the Society of Toxicology, 1996, Volume: 30, Issue:1 Topics: Animals; Chlorofluorocarbons; Chlorofluorocarbons, Ethane; Halothane; Humans; Male; Models, Biological; Rats; Rats, Inbred F344; Species Specificity; Trifluoroacetic Acid	1996
Physiologically based pharmacokinetic analysis of the concentration-dependent metabolism of halothane. Xenobiotica; the fate of foreign compounds in biological systems, 1997, Volume: 27, Issue:1 Topics: Animals; Chlorofluorocarbons; Female; Halothane; Kinetics; Male; Models, Biological; Rats; Rats, Sprague-Dawley; Sex Factors; Tissue Distribution; Trifluoroacetic Acid	1997
UDP-glucose:glycoprotein glucosyltransferase associates with endoplasmic reticulum chaperones and its activity is decreased in vivo by the inhalation anesthetic halothane. Chemical research in toxicology, 1997, Volume: 10, Issue:1 Topics: Anesthetics, Inhalation; Animals; Endoplasmic Reticulum; Glucosyltransferases; Halothane; Immunoblotting; Liver; Male; Microsomes, Liver; Molecular Chaperones; Precipitin Tests; Rats; Rats, Sprague-Dawley; Trifluoroacetic Acid	1997
Demonstration of a cellular immune response in halothane-exposed guinea pigs. Toxicology and applied pharmacology, 1997, Volume: 143, Issue:2 Topics: Alanine Transaminase; Anesthetics, Inhalation; Animals; Antigen-Presenting Cells; Cell Division; Cells, Cultured; Chemical and Drug Induced Liver Injury; Coculture Techniques; Fluoroacetates; Guinea Pigs; Halothane; Immunity, Cellular; Kupffer Cells; Lymphocyte Activation; Lymphocytes; Male; Spleen; Trifluoroacetic Acid	1997
Kupffer cells from halothane-exposed guinea pigs carry trifluoroacetylated protein adducts. Toxicology, 1997, Jun-27, Volume: 120, Issue:2 Topics: Acetylation; Anesthetics, Inhalation; Animals; Antibody Formation; Antigen-Antibody Complex; Antigen-Presenting Cells; Blotting, Western; Cell Separation; Cell Survival; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Guinea Pigs; Halothane; Kupffer Cells; Lymph Nodes; Macrophages; Macrophages, Alveolar; Male; Molecular Weight; Rabbits; Serum Albumin; Specific Pathogen-Free Organisms; Spleen; Trifluoroacetic Acid	1997
Determination of the halothane metabolites trifluoroacetic acid and bromide in plasma and urine by ion chromatography. Journal of chromatography. B, Biomedical sciences and applications, 1997, May-09, Volume: 692, Issue:2 Topics: Bromides; Chromatography, High Pressure Liquid; Halothane; Humans; Ions; Sensitivity and Specificity; Trifluoroacetic Acid	1997
Cytochrome P-4502E1-dependent formation of trifluoroacetyl adducts from halothane by transduced HepG2 cells. Alcoholism, clinical and experimental research, 1997, Volume: 21, Issue:9 Topics: Animals; Cloning, Molecular; Cytochrome P-450 CYP2E1; Electrophoresis; Fomepizole; Halothane; Humans; Liver; Phorbol Esters; Pyrazoles; Trifluoroacetic Acid; Tumor Cells, Cultured	1997
Comparative immunoreactivity of anti-trifluoroacetyl (TFA) antibody and anti-lipoic acid antibody in primary biliary cirrhosis: searching for a mimic. Journal of autoimmunity, 2000, Volume: 15, Issue:1 Topics: Animals; Antigen-Antibody Reactions; Autoantibodies; Cattle; Cytosol; Dihydrolipoyllysine-Residue Acetyltransferase; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Fluoroacetates; Halothane; Haptens; Hemocyanins; Humans; Immune Sera; Immunoblotting; Immunohistochemistry; Liver Cirrhosis, Biliary; Microsomes, Liver; Molecular Mimicry; Mollusca; Pyruvate Dehydrogenase Complex; Rats; Serum Albumin; Thioctic Acid; Trifluoroacetic Acid	2000
Halothane-induced liver injury in outbred guinea pigs: role of trifluoroacetylated protein adducts in animal susceptibility. Chemical research in toxicology, 2001, Volume: 14, Issue:4 Topics: Anesthetics, Inhalation; Animals; Base Sequence; Blotting, Western; DNA Primers; Enzyme-Linked Immunosorbent Assay; Guinea Pigs; Halothane; Humans; Immunohistochemistry; Male; Proteins; Rats; Rats, Sprague-Dawley; Trifluoroacetic Acid	2001
Concordance between trifluoroacetic acid and hepatic protein trifluoroacetylation after disulfiram inhibition of halothane metabolism in rats. Acta anaesthesiologica Scandinavica, 2003, Volume: 47, Issue:6 Topics: Anesthetics, Inhalation; Animals; Blotting, Western; Bromides; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2E1 Inhibitors; Disulfiram; Enzyme Induction; Enzyme Inhibitors; Halothane; Isoniazid; Liver; Male; Oxidation-Reduction; Proteins; Rats; Rats, Sprague-Dawley; Trifluoroacetic Acid	2003
Trifluoroacetylated proteins in liver and plasma of guinea pigs treated with HCFC-123 and halothane. Toxicology letters, 2003, Sep-15, Volume: 144, Issue:1 Topics: Alanine Transaminase; Anesthetics, Inhalation; Animals; Aspartate Aminotransferases; Azo Compounds; Biomarkers; Chemical and Drug Induced Liver Injury; Chlorofluorocarbons; Chlorofluorocarbons, Ethane; Coloring Agents; Creatine Kinase; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Guinea Pigs; Halothane; Immunoblotting; Liver; Male; Proteins; Trifluoroacetic Acid	2003
Trifluoroacetylated adducts in spermatozoa, testes, liver and plasma and CYP2E1 induction in rats after subchronic inhalatory exposure to halothane. Toxicology letters, 2003, Sep-15, Volume: 144, Issue:1 Topics: Administration, Inhalation; Anesthetics, Inhalation; Animals; Biomarkers; Body Weight; Chemical and Drug Induced Liver Injury; Chromatin; Cytochrome P-450 CYP2E1; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Enzyme-Linked Immunosorbent Assay; Halothane; Immunohistochemistry; Indicators and Reagents; Liver; Male; Microsomes, Liver; Pyridines; Rats; Rats, Wistar; Spermatozoa; Testis; Trifluoroacetic Acid	2003
TRIFLUOROACETIC ACID AS METABOLITE OF HALOTHANE. Biochemical pharmacology, 1964, Volume: 13 Topics: Animals; Fluoroacetates; Halothane; Humans; Metabolism; Rabbits; Research; Spectrum Analysis; Toxicology; Trifluoroacetic Acid; Urine	1964
Role of neutrophils in a mouse model of halothane-induced liver injury. Hepatology (Baltimore, Md.), 2006, Volume: 44, Issue:6 Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Female; Fluoroacetates; Halothane; Kupffer Cells; Liver; Liver Diseases; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Neutrophils; Proteins; Trifluoroacetic Acid	2006
Trifluoroacetylated IgG4 antibodies in a child with idiosyncratic acute liver failure after first exposure to halothane. Journal of pediatric gastroenterology and nutrition, 2008, Volume: 47, Issue:2 Topics: Anesthetics, Inhalation; Autoantibodies; Child, Preschool; Diagnosis, Differential; Female; Halothane; Humans; Immunoglobulin G; Liver Failure, Acute; Risk Factors; Trifluoroacetic Acid	2008
Generation of T cell responses targeting the reactive metabolite of halothane in mice. Toxicology letters, 2010, May-04, Volume: 194, Issue:3 Topics: Animals; CD40 Antigens; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Female; Halothane; Mice; Mice, Inbred Strains; T-Lymphocytes; Toll-Like Receptors; Trifluoroacetic Acid	2010
Trifluoroacetate is an allosteric modulator with selective actions at the glycine receptor. Neuropharmacology, 2012, Volume: 63, Issue:3 Topics: Anesthetics, Inhalation; Animals; DNA; Electrophysiological Phenomena; gamma-Aminobutyric Acid; Halothane; Membranes; Molecular Conformation; Oocytes; Patch-Clamp Techniques; Receptors, GABA-A; Receptors, Glycine; Receptors, Serotonin, 5-HT3; Serotonin; Trifluoroacetic Acid; Xenopus laevis	2012