triethyllead and diethyllead

Triethyl neopentoxy lead (TEneoPOL: (C2H5)3Pb [OCH2C(CH3)3] liquid) was administered to rabbits in a single dose of 10 mg/kg body weight (5.4 mg Pb/kg body weight), and the urinary and fecal excretions of lead were measured to determine the fate of this triethyllead derivative. About 4% of the administered amount of was excreted into the urine during the 7 days after the injection; and about 68%, into the feces. In other words, the fecal excretion of total lead was about 17 times as great as the urinary excretion. About 85% of the urinary excretion of total lead was composed of diethyllead (Et2Pb2+), and about 92% of the fecal excretion consisted of inorganic lead (Pb2+). The major chemical species of lead excreted in the urine was Et2Pb2+, while the major species excreted in the feces was Pb2+. These results were similar to those of administration of tetraethyllead (Et4Pb) to rabbits. One of the 7 rabbits died on the day following the injection, and TEneoPOL, a triethyllead derivative, proved to be no less toxic than Et4Pb. However, this compound is immediately hydrolyzed by the ambient moisture to form a white solid compound, so that it is not accompanied by as great a risk of airway exposure as Et4Pb.

Topics: Animals; Feces; Injections, Intravenous; Kinetics; Lead; Organometallic Compounds; Rabbits; Urine

One group of rabbits were injected intraperitoneally with diethyllead dichloride (7.7 mg Pb/kg) and another group of rabbits were likewise injected with an equivalent lead dose of lead acetate. These rabbits were followed up for changes in the lead amounts excreted daily in the urine and feces from 24 h through 7 d after the injection, respectively. In the group of rabbits injected with diethyllead dichloride (one of 3 rabbits died during the observation), an amount of lead equivalent to about 25% of the injected dose was excreted in the urine during the first 24 h after the injection. Also, an amount of lead equivalent to about 28% of the injected lead was excreted in the feces during the first 3 d, and the total lead excretion during the 7 d after the injection corresponded to about 60% of the injected dose of diethyllead. One day after dosing, the total lead in the urine was made up of about 92% diethyllead, about 7% inorganic lead and about 1% triethyllead. One day after dosing, the total lead in the feces consisted of about 63% inorganic lead, about 28% diethyllead and about 9% triethyllead. Three days after dosing, the total lead in feces comprised about 98% inorganic lead, about 1% diethyllead and about 1% triethyllead. In the group of 3 rabbits injected with lead acetate, the total lead amount excreted in both the urine and feces during the 7 d after the injection corresponded to only about 9% of the injected dose of lead acetate.(ABSTRACT TRUNCATED AT 250 WORDS)

Topics: Animals; Bone and Bones; Bone Marrow; Feces; Female; Injections, Intraperitoneal; Lead; Lead Poisoning; Organometallic Compounds; Rabbits

Topics: Humans; Indicators and Reagents; Lead; Male; Middle Aged; Organometallic Compounds; Spectrophotometry, Atomic; Tetraethyl Lead

Topics: Humans; Hydrogen-Ion Concentration; Lead; Organometallic Compounds; Spectrophotometry, Atomic

Topics: Animals; Feces; Female; Injections; Lead; Organometallic Compounds; Rabbits; Tetraethyl Lead; Tissue Distribution

Topics: Administration, Oral; Animals; Chlorides; Lead; Lead Poisoning; Organometallic Compounds; Rats; Tetraethyl Lead