Page last updated: 2024-08-21

triethylenephosphoramide and thiotepa

triethylenephosphoramide has been researched along with thiotepa in 46 studies

Research

Studies (46)

TimeframeStudies, this research(%)All Research%
pre-199021 (45.65)18.7374
1990's12 (26.09)18.2507
2000's10 (21.74)29.6817
2010's2 (4.35)24.3611
2020's1 (2.17)2.80

Authors

AuthorsStudies
Li, SW; Rao, NU; Sosnovsky, G1
Lukszo, J; Rao, NU; Sosnovsky, G1
Bowman, MC1
Srám, RJ1
Belousova, AK1
Hagen, B; Neverdal, G; Nilsen, OG; Walstad, RA1
Bibby, MC; Fenwick, E; Jenkins, WE; Loadman, PM; Masters, JR; McDermott, BJ; Mundy, AR; Shah, PJ1
Hagen, B1
Ng, SF; Waxman, DJ1
Cole, D; DeLap, RJ; DeVito, J; Engstrom, PF; LaCreta, F; Litwin, S; O'Dwyer, PJ; Peter, R; Poplack, D; Tartaglia, L1
Ashar, B; Cohen, NA; Egorin, MJ; Hilton, J; Pan, SS; Ross, DD; Snyder, SW; Wietharn, BE1
Azri, S; Dale, O; Hagen, B; Neverdal, G; Nilsen, OG1
Cohen, BE; Egorin, MJ; Gutierrez, PL; Kohlhepp, EA1
Aisner, J; Cohen, BE; Egorin, MJ; Gutierrez, PL; Kohlhepp, EA1
Gutierrez, PL; Miller, B; Rao, NU; Sosnovsky, G1
Bibby, MC; Burgess, L; Double, JA; Loadman, PM; McDermott, BJ; Phillips, RM1
Matsutani, S; Sano, A; Takitani, S1
Li, SW; Sosnovsky, G2
Bibby, MC; Double, JA; Loadman, PM; McDermott, BJ; Turner, RL; Wilman, DE1
Fye, RL; LaBrecque, GC; Morgan, J1
Bowman, MC; Labrecque, GC; Patterson, RS; Seawright, JA1
Breau, AP; Field, L; Mitchell, WM1
Howe, GR; Steward, R1
Lytkin, GV1
Bero, T; Bolovin, LM; Javor, T; Kaplan, MA; Medvedev, VN; Verchovskaja, NI1
Paul, BD; Sosnovsky, G1
Konieczny, M; Laib, F; Lukszo, J; Purgstaller, K; Sosnovsky, G1
Bibby, MC; Harland, S; Loadman, PM; Masters, JR; McDermott, BJ1
Beijnen, JH; Huitema, AD; Kerbusch, T; Rodenhuis, S; Tibben, MM; Zwikker, JW1
Beijnen, JH; Huitema, AD; Rodenhuis, S; van Maanen, RJ; van Ooijen, RD; Zwikker, JW1
Aidoo, A; Casciano, DA; Chen, T; Heflich, RH; Manjanatha, MG; Mittelstaedt, RA1
Beijnen, JH; Damen, JM; Tijhof, IM; van Maanen, RJ; Zwikker, JW1
Beijnen, JH; Damen, JM; Doesburg Smits, K; Heck, AJ; van Maanen, MJ1
Beijnen, JH; Smits, KD; van Maanen, MJ1
Beijnen, JH; Huitema, AD; Mathôt, RA; Rodenhuis, S; Schellens, JH; Tibben, MM1
Beijnen, JH; Huitema, AD; Rodenhuis, S; van Maanen, MJ1
Birnbaum, A; Green, K; Jacobson, PA; Remmel, RP1
Beijnen, JH; Dalesio, O; de Jonge, ME; Huitema, AD; Mathôt, RA; Rodenhuis, S1
GRECO, T1
Beijnen, JH; de Jonge, ME; Hillebrand, MJ; Huitema, AD; Rodenhuis, S; Rosing, H; van Dam, SM1
Beijnen, JH; de Jonge, ME; Huitema, AD; Rodenhuis, S; van Dam, SM1
Beijnen, JH; Doodeman, VD; Ekhart, C; Huitema, AD; Rodenhuis, S; Smits, PH1
Fattahi, A; Torabifard, H1
Di, L; Lyerly, HK; Ren, J; Shao, H; Song, G; Song, Q; Wang, X; Yang, H; Yu, J; Zhou, X; Zhu, X1
Carlow, DC; Schofield, RC; Scordo, M; Shah, G1

Reviews

2 review(s) available for triethylenephosphoramide and thiotepa

ArticleYear
The mechanisms of action of antitumor compounds.
    National Cancer Institute monograph, 1977, Issue:45

    Topics: Alkylating Agents; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Aziridines; Cell Cycle; Folic Acid; Folic Acid Antagonists; Humans; Melphalan; Mitochondria; Nitrogen Mustard Compounds; Nitrosourea Compounds; Oligonucleotides; Pyrimidine Nucleosides; Thiotepa; Triethylenephosphoramide

1977
Hprt mutant frequency and molecular analysis of Hprt mutations in rats treated with mutagenic carcinogens.
    Mutation research, 1999, Dec-17, Volume: 431, Issue:2

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Animals, Genetically Modified; Carcinogens; Cell Culture Techniques; Cells, Cultured; Electrophoresis; Ethylnitrosourea; Female; Hypoxanthine Phosphoribosyltransferase; Lymphocytes; Mutagenicity Tests; Mutagens; Mutation; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Thiotepa; Triethylenephosphoramide

1999

Trials

4 trial(s) available for triethylenephosphoramide and thiotepa

ArticleYear
ThioTEPA pharmacokinetics during intravesical chemotherapy and the influence of Tween 80.
    Cancer chemotherapy and pharmacology, 1990, Volume: 25, Issue:4

    Topics: Absorption; Administration, Intravesical; Aged; Carcinoma, Transitional Cell; Female; Humans; Hydrogen-Ion Concentration; Leukocyte Count; Male; Middle Aged; Osmolar Concentration; Polysorbates; Random Allocation; Thiotepa; Triethylenephosphoramide; Urinary Bladder Neoplasms

1990
Phase I/pharmacokinetic reevaluation of thioTEPA.
    Cancer research, 1991, Jun-15, Volume: 51, Issue:12

    Topics: Dose-Response Relationship, Drug; Drug Evaluation; Female; Humans; Leukocyte Count; Leukopenia; Male; Metabolic Clearance Rate; Middle Aged; Neoplasms; Neutrophils; Thiotepa; Thrombocytopenia; Triethylenephosphoramide

1991
ThioTEPA pharmacokinetics during intravesical chemotherapy: the influence of dose and volume of instillate on systemic uptake and dose rate to the tumour.
    Cancer chemotherapy and pharmacology, 1996, Volume: 38, Issue:1

    Topics: Absorption; Administration, Intravesical; Aged; Analysis of Variance; Antineoplastic Agents, Alkylating; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Thiotepa; Triethylenephosphoramide; Urinary Bladder; Urinary Bladder Neoplasms

1996
Population pharmacokinetics of cyclophosphamide and its metabolites 4-hydroxycyclophosphamide, 2-dechloroethylcyclophosphamide, and phosphoramide mustard in a high-dose combination with Thiotepa and Carboplatin.
    Therapeutic drug monitoring, 2005, Volume: 27, Issue:6

    Topics: Adolescent; Adult; Algorithms; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Breast Neoplasms; Carboplatin; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Half-Life; Humans; Infusions, Intravenous; Male; Middle Aged; Models, Biological; Neoplasms; Neoplasms, Germ Cell and Embryonal; Ovarian Neoplasms; Phosphoramide Mustards; Prodrugs; Thiotepa; Time Factors; Triethylenephosphoramide

2005

Other Studies

40 other study(ies) available for triethylenephosphoramide and thiotepa

ArticleYear
In the search for new anticancer drugs. 19. A predictive design of N,N:N',N':N'',N''-tri-1,2-ethanediylphosphorothioic triamide (TEPA) analogues.
    Journal of medicinal chemistry, 1986, Volume: 29, Issue:11

    Topics: Animals; Antineoplastic Agents; Azirines; Male; Mice; Solubility; Structure-Activity Relationship; Triethylenephosphoramide

1986
In the search for new anticancer drugs. 17. Linear and cyclic polyether analogues of N,N:N',N':N'',N''-tri-1,2-ethanediylphosphoric triamide and N,N:N',N':N'',N''-tri-1,2-ethanediylphosphorothioic triamide.
    Journal of medicinal chemistry, 1986, Volume: 29, Issue:7

    Topics: Animals; Antineoplastic Agents; Drug Evaluation, Preclinical; Indicators and Reagents; Leukemia P388; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred Strains; Spectrophotometry, Infrared; Structure-Activity Relationship

1986
Analysis of insect chemosterilants.
    Journal of chromatographic science, 1975, Volume: 13, Issue:7

    Topics: Animals; Aziridines; Chemosterilants; Chromatography, Gas; Culicidae; Hempa; Houseflies; Insect Control; Methods; Solvents; Temperature; Thiotepa; Triethylenephosphoramide

1975
Relationship between acute and chronic exposures in mutagenicity studies in mice.
    Mutation research, 1976, Nov-01, Volume: 41, Issue:1 spel. no

    Topics: Animals; Arsenic; Bone Marrow; Bone Marrow Cells; Chromosome Aberrations; Cyclophosphamide; Dose-Response Relationship, Drug; Ethyl Methanesulfonate; Genes, Dominant; Genes, Lethal; Genetic Techniques; Karyometry; Mice; Mutagens; Thiotepa; Time Factors; Triethylenephosphoramide

1976
Long-term pharmacokinetics of thio-TEPA, TEPA and total alkylating activity following i.v. bolus administration of thio-TEPA in ovarian cancer patients.
    Cancer chemotherapy and pharmacology, 1990, Volume: 25, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Alkylation; Female; Half-Life; Humans; Injections, Intravenous; Middle Aged; Ovarian Neoplasms; Thiotepa; Triethylenephosphoramide; Urine

1990
Pharmacokinetics of thio-TEPA and TEPA in the conventional dose-range and its correlation to myelosuppressive effects.
    Cancer chemotherapy and pharmacology, 1991, Volume: 27, Issue:5

    Topics: Aged; Aged, 80 and over; Bilirubin; Bone Marrow Diseases; Creatinine; Female; Humans; Leukocyte Count; Middle Aged; Ovarian Neoplasms; Platelet Count; Regression Analysis; Thiotepa; Triethylenephosphoramide

1991
N,N',N''-triethylenethiophosphoramide (thio-TEPA) oxygenation by constitutive hepatic P450 enzymes and modulation of drug metabolism and clearance in vivo by P450-inducing agents.
    Cancer research, 1991, May-01, Volume: 51, Issue:9

    Topics: Animals; Biotransformation; Cisplatin; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Male; Microsomes, Liver; Oxidation-Reduction; Rats; Rats, Inbred F344; Sex Characteristics; Thiotepa; Triethylenephosphoramide

1991
Interaction of N,N',N''-triethylenethiophosphoramide and N,N',N''-triethylenephosphoramide with cellular DNA.
    Cancer research, 1991, Aug-15, Volume: 51, Issue:16

    Topics: Animals; Aroclors; Biotransformation; Cell Division; Cell Line; Chlorodiphenyl (54% Chlorine); DNA Damage; DNA Repair; DNA Replication; DNA, Neoplasm; Humans; Kinetics; Leukemia L1210; Mice; Microsomes, Liver; Rats; Thiotepa; Triethylenephosphoramide

1991
Metabolism and alkylating activity of thio-TEPA in rat liver slice incubation.
    Cancer chemotherapy and pharmacology, 1991, Volume: 28, Issue:6

    Topics: Alkylation; Allylisopropylacetamide; Animals; Dose-Response Relationship, Drug; In Vitro Techniques; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains; Thiotepa; Time Factors; Tissue Survival; Triethylenephosphoramide

1991
Gas-liquid chromatographic analysis of N,N',N''-triethylene thiophosphoramide and N,N',N''-triethylene phosphoramide in biological samples.
    Journal of chromatography, 1985, Sep-13, Volume: 343, Issue:1

    Topics: Azirines; Breast Neoplasms; Chromatography, Gas; Female; Humans; Kinetics; Middle Aged; Thiotepa; Triethylenephosphoramide

1985
Human plasma pharmacokinetics and urinary excretion of thiotepa and its metabolites.
    Cancer treatment reports, 1986, Volume: 70, Issue:7

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chromatography, Gas; Half-Life; Humans; Hydrogen-Ion Concentration; Kinetics; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Thiotepa; Triethylenephosphoramide

1986
In the search for new anticancer drugs. XX: A comparison of the in vitro growth inhibition of P388 cells by TEPA and N,N;N',N'-bis (1,2-ethanediyl)-N''-(1-oxyl-2,2,6,6-tetramethyl-4- piperidinylaminocarbonyl) phosphoric triamide and congeners.
    Cancer letters, 1987, Volume: 34, Issue:1

    Topics: Animals; Antineoplastic Agents; Azirines; Cell Line; Leukemia P388; Leukemia, Experimental; Structure-Activity Relationship; Thiotepa; Triethylenephosphoramide

1987
Influence of the tissue distribution of ThioTEPA and its metabolite, TEPA, on the response of murine colon tumours.
    Cancer chemotherapy and pharmacology, 1987, Volume: 20, Issue:3

    Topics: Adenocarcinoma; Animals; Azirines; Colonic Neoplasms; Female; Male; Mice; Mice, Inbred Strains; Sex Factors; Thiotepa; Tissue Distribution; Triethylenephosphoramide

1987
High-performance liquid chromatography of the anti-tumour agent triethylenethiophosphoramide and its metabolite triethylenephosphoramide with sodium sulphide, taurine and o-phthalaldehyde as pre-column fluorescent derivatization reagents.
    Journal of chromatography, 1988, Dec-23, Volume: 458

    Topics: Animals; Azirines; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Indicators and Reagents; o-Phthalaldehyde; Rabbits; Spectrometry, Fluorescence; Sulfides; Taurine; Thiotepa; Triethylenephosphoramide

1988
In the search for new anticancer drugs XI. Anticancer activity of nitroxyl labeled phosphoric N,N;N',N';N",N"-tris[1,2-ethanediyl]triamide(TEPA) and phosphorothioic N,N;N',N';N",N"-tris[1,2-ethanediyl]triamide(thio-TEPA) derivatives.
    Cancer letters, 1985, Volume: 25, Issue:3

    Topics: Animals; Antineoplastic Agents; Azirines; Drug Evaluation, Preclinical; Leukemia L1210; Male; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Nitrogen Oxides; Structure-Activity Relationship; Thiotepa; Triethylenephosphoramide

1985
In the search for new anticancer drugs. X. N,N; N',N'-bis(1,2-ethanediyl)-N''-(1-oxyl-2,2,6,6-tetramethyl- 4-piperidinylaminocarbonyl) phosphoric triamide--a new potential anticancer drug of high activity and low toxicity.
    Life sciences, 1985, Apr-15, Volume: 36, Issue:15

    Topics: Animals; Antineoplastic Agents; Azirines; Lethal Dose 50; Leukemia L1210; Leukemia P388; Male; Mice; Structure-Activity Relationship; Thiotepa; Triethylenephosphoramide

1985
Gas chromatographic analysis of triethylenethiophosphoramide and triethylenephosphoramide in biological specimens.
    Journal of chromatography, 1985, Mar-22, Volume: 338, Issue:2

    Topics: Animals; Azirines; Chromatography, Gas; Female; gamma-Globulins; Half-Life; Humans; Kinetics; Mice; Nandrolone; Protein Binding; Species Specificity; Thiotepa; Triethylenephosphoramide; Ultrafiltration

1985
Induction of sterility in adult house flies and stable flies by chemosterilization of pupae.
    Journal of economic entomology, 1972, Volume: 65, Issue:3

    Topics: Animals; Aziridines; Azirines; Chemosterilants; Diptera; Female; Houseflies; Insect Control; Male; Pupa; Thiotepa; Triethylenephosphoramide

1972
Persistence of thiotepa and tepa in pupae and adults of Culex pipiens fatigans Wiedemann.
    Bulletin of the World Health Organization, 1972, Volume: 47, Issue:5

    Topics: Animals; Azirines; Chemosterilants; Chromatography, Gas; Culex; Pesticide Residues; Pupa; Thiotepa; Triethylenephosphoramide

1972
Thiono compounds. 4. In vitro mutagenic and antineoplastic activity of TEPA and thio-TEPA.
    Cell biology and toxicology, 1984, Volume: 1, Issue:1

    Topics: Antineoplastic Agents; Azirines; Fibroblasts; Humans; Mutagenicity Tests; Thiotepa; Triethylenephosphoramide; Tumor Cells, Cultured

1984
Fertility regulation in male rats and hamsters with alkylating agents.
    Contraception, 1980, Volume: 22, Issue:2

    Topics: Animals; Azirines; Contraceptive Agents, Male; Cricetinae; Female; Fertility; Injections; Litter Size; Male; Pregnancy; Rats; Testis; Thiotepa; Triethylenephosphoramide

1980
[Endolymphatic use of solutions of alkylating substances in a mixture with iodolipol in malignant neoplasms].
    Voprosy onkologii, 1981, Volume: 27, Issue:7

    Topics: Alkylating Agents; Cyclophosphamide; Drug Evaluation; Female; Humans; Injections, Intralymphatic; Iodized Oil; Lymphatic Metastasis; Lymphography; Male; Neoplasms; Solutions; Thiotepa; Time Factors; Triethylenephosphoramide

1981
[Whole body radiometric study of 59Fe absorption during chemotherapy of breast cancer].
    Radiobiologia, radiotherapia, 1982, Volume: 23, Issue:6

    Topics: Antineoplastic Agents; Breast Neoplasms; Cyclophosphamide; Female; Fluorouracil; Humans; Iron; Iron Radioisotopes; Middle Aged; Thiotepa; Triethylenephosphoramide

1982
In the search for new anticancer drugs. 9. Synthesis and anticancer activity of spin-labeled analogues of N,N:N',N':N",N"-Tri-1,2-ethanediylphosphoric triamide and N,N:N',N':N",N"-tri-1,2-ethanediylphosphorothioic triamide.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:6

    Topics: Animals; Antineoplastic Agents; Azirines; Leukemia P388; Male; Mice; Structure-Activity Relationship; Thiotepa; Triethylenephosphoramide

1984
In the search for new anticancer drugs. 26. A comparison of anticancer activities of several TEPA, thio-TEPA, Seleno-TEPA, and azetidine analogs, including congeners containing an aminoxyl moiety.
    Journal of pharmaceutical sciences, 1994, Volume: 83, Issue:7

    Topics: Animals; Antineoplastic Agents; Azetidines; Chemical Phenomena; Chemistry, Physical; Drug Screening Assays, Antitumor; Leukemia P388; Male; Mice; Mice, Inbred DBA; Organoselenium Compounds; Thiotepa; Triethylenephosphoramide

1994
Simultaneous determination of N,N',N"-triethylenethiophosphoramide, cyclophosphamide and some of their metabolites in plasma using capillary gas chromatography.
    Journal of chromatography. B, Biomedical sciences and applications, 1998, Sep-25, Volume: 716, Issue:1-2

    Topics: Antineoplastic Agents, Alkylating; Chromatography, Gas; Cyclophosphamide; Drug Stability; Humans; Quality Control; Sensitivity and Specificity; Thiotepa; Triethylenephosphoramide

1998
Determination of N,N',N"-triethylenethiophosphoramide and its active metabolite N,N',N"-triethylenephosphoramide in plasma and urine using capillary gas chromatography.
    Journal of chromatography. B, Biomedical sciences and applications, 1998, Nov-20, Volume: 719, Issue:1-2

    Topics: Chromatography, Gas; Humans; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Thiotepa; Triethylenephosphoramide

1998
The degradation of N,N',N"-triethylenephosphoramide in aqueous solutions: a qualitative and kinetic study.
    International journal of pharmaceutics, 2000, Feb-25, Volume: 196, Issue:1

    Topics: Antineoplastic Agents, Alkylating; Chromatography, Gas; Drug Stability; Gas Chromatography-Mass Spectrometry; Hydrogen-Ion Concentration; Kinetics; Solutions; Spectrophotometry, Ultraviolet; Thiotepa; Triethylenephosphoramide; Water

2000
Stability of thioTEPA and its metabolites, TEPA, monochloroTEPA and thioTEPA-mercapturate, in plasma and urine.
    International journal of pharmaceutics, 2000, May-10, Volume: 200, Issue:2

    Topics: Acetylcysteine; Antineoplastic Agents, Alkylating; Aziridines; Drug Stability; Mass Spectrometry; Thiotepa; Triethylenephosphoramide

2000
Simultaneous determination of thioTEPA, TEPA and a novel, recently identified thioTEPA metabolite, monochloroTEPA, in urine using capillary gas chromatography.
    Journal of chromatography. B, Biomedical sciences and applications, 2000, Jun-09, Volume: 742, Issue:2

    Topics: Antineoplastic Agents, Alkylating; Aziridines; Chromatography, Gas; Humans; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Thiotepa; Triethylenephosphoramide

2000
Population pharmacokinetics of thioTEPA and its active metabolite TEPA in patients undergoing high-dose chemotherapy.
    British journal of clinical pharmacology, 2001, Volume: 51, Issue:1

    Topics: Adolescent; Adult; Algorithms; Analysis of Variance; Antineoplastic Agents, Alkylating; Area Under Curve; Bayes Theorem; Female; Humans; Male; Middle Aged; Models, Biological; Neoplasms; Population; Thiotepa; Triethylenephosphoramide

2001
Urinary excretion of thioTEPA and its metabolites in patients treated with high-dose cyclophosphamide, thioTEPA and carboplatin.
    Anti-cancer drugs, 2001, Volume: 12, Issue:6

    Topics: Acetylcysteine; Adolescent; Adult; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Aziridines; Breast Neoplasms; Carboplatin; Creatinine; Cyclophosphamide; Dose-Response Relationship, Drug; Female; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Models, Chemical; Neoplasms, Germ Cell and Embryonal; Thiotepa; Time Factors; Triethylenephosphoramide

2001
Cytochrome P450 isozymes 3A4 and 2B6 are involved in the in vitro human metabolism of thiotepa to TEPA.
    Cancer chemotherapy and pharmacology, 2002, Volume: 49, Issue:6

    Topics: Antibodies; Antineoplastic Agents, Alkylating; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; Isoenzymes; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Thiotepa; Transfection; Triethylenephosphoramide

2002
Relationship between irreversible alopecia and exposure to cyclophosphamide, thiotepa and carboplatin (CTC) in high-dose chemotherapy.
    Bone marrow transplantation, 2002, Volume: 30, Issue:9

    Topics: Adolescent; Adult; Alopecia; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Carboplatin; Cyclophosphamide; Drug Evaluation; Female; Humans; Male; Middle Aged; Neoplasms; Thiotepa; Triethylenephosphoramide

2002
[Triethylene-phosphoramide or thio-TEPA in therapy of recurrent cancer of the breast].
    La Presse medicale, 1959, Jan-24, Volume: 67, Issue:4

    Topics: Antineoplastic Agents; Breast; Breast Neoplasms; Humans; Neoplasm Recurrence, Local; Neoplasms; Phosphoramides; Thiotepa; Triethylenephosphoramide

1959
Simultaneous quantification of cyclophosphamide, 4-hydroxycyclophosphamide, N,N',N"-triethylenethiophosphoramide (thiotepa) and N,N',N"-triethylenephosphoramide (tepa) in human plasma by high-performance liquid chromatography coupled with electrospray ion
    Journal of mass spectrometry : JMS, 2004, Volume: 39, Issue:3

    Topics: Antineoplastic Agents, Alkylating; Chromatography, High Pressure Liquid; Cyclophosphamide; Drug Monitoring; Humans; Neoplasms; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Thiotepa; Triethylenephosphoramide

2004
Polymorphisms of drug-metabolizing enzymes (GST, CYP2B6 and CYP3A) affect the pharmacokinetics of thiotepa and tepa.
    British journal of clinical pharmacology, 2009, Volume: 67, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Aryl Hydrocarbon Hydroxylases; Breast Neoplasms; Carboplatin; Chromatography, High Pressure Liquid; Cohort Studies; Cyclophosphamide; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Female; Glutathione S-Transferase pi; Glutathione Transferase; Humans; Male; Neoplasms, Germ Cell and Embryonal; Ovarian Neoplasms; Oxidoreductases, N-Demethylating; Polymorphism, Genetic; Thiotepa; Triethylenephosphoramide

2009
Mechanisms and kinetics of thiotepa and tepa hydrolysis: DFT study.
    Journal of molecular modeling, 2012, Volume: 18, Issue:8

    Topics: Algorithms; Aziridines; Catalysis; Computer Simulation; Guanine; Hydrogen Bonding; Hydrolysis; Isomerism; Kinetics; Models, Molecular; Molecular Conformation; Quantum Theory; Thermodynamics; Thiotepa; Triethylenephosphoramide

2012
Transformation of alkylating regimen of thiotepa into tepa determines the disease progression through GSTP1 gene polymorphism for metastatic breast cancer patients receiving thiotepa containing salvage chemotherapy.
    International journal of clinical pharmacology and therapeutics, 2015, Volume: 53, Issue:11

    Topics: Aged; Antineoplastic Agents, Alkylating; Biotransformation; Breast Neoplasms; Chi-Square Distribution; China; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Disease Progression; Disease-Free Survival; Female; Genotype; Glutathione S-Transferase pi; Humans; Logistic Models; Middle Aged; Multivariate Analysis; Neoplasm Metastasis; Odds Ratio; Patient Selection; Pharmacogenetics; Phenotype; Polymorphism, Single Nucleotide; Retrospective Studies; Risk Factors; Salvage Therapy; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thiotepa; Time Factors; Treatment Outcome; Triethylenephosphoramide

2015
Measurement of ThioTEPA and Its Metabolite TEPA in Plasma and Cerebrospinal Fluid by Turbulent Flow Chromatography-Tandem Mass Spectrometry.
    Methods in molecular biology (Clifton, N.J.), 2024, Volume: 2737

    Topics: Chromatography, Liquid; Gas Chromatography-Mass Spectrometry; Tandem Mass Spectrometry; Thiotepa; Triethylenephosphoramide

2024