Compounds > trientine
Page last updated: 2024-08-16

trientine and penicillamine

trientine has been researched along with penicillamine in 137 studies

Research

Studies (137)

TimeframeStudies, this research(%)All Research%
pre-199039 (28.47)18.7374
1990's28 (20.44)18.2507
2000's31 (22.63)29.6817
2010's29 (21.17)24.3611
2020's10 (7.30)2.80

Authors

AuthorsStudies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Cohnen, E; Harders, H1
Clarke, R; Laurie, SH; Sarkar, B; Sass-Kortsak, A; Wei, P1
May, PM; Williams, DR1
Baselt, RC; Horak, E; Mitchell, J; Sunderman, FW1
Walshe, JM6
Gibbs, K; Walshe, JM1
Hashimoto, T; Morita, J; Motohiro, T; Okano, Y; Watari, H; Yamashita, F; Yoshida, I; Yoshino, M1
Botha, CJ; Guthrie, AJ; Naude, TW; Swan, GE1
Cramarossa, L; D'Angelo, D; D'Ascanio, I; Ferri, GB; Piane, E1
Aichner, F; Felber, S; Kiechl, SG; Willeit, J1
Friedman, LS; Martin, P; Muñoz, SJ; Yarze, JC1
Bachmann, H; Günther, K; Kühn, HJ; Lössner, J; Siegemund, R1
Edo, K; Mochizuki, R; Ohyama, Y; Sahara, M; Saito, H; Watanabe, K1
Johnson, PJ; Williams, R1
Scheinberg, IH; Schilsky, ML; Sternlieb, I1
Mason, J; McQuaid, A1
Berardelli, A; Fabri, S; Fieschi, C; Inghilleri, M; Manfredi, M; Priori, A; Thompson, PD1
Dubois, RS; Hambidge, KM; Rodgerson, DO1
Brewer, GJ; Yuzbasiyan-Gurkan, V1
Chikazawa, S; Ishitsu, T1
Eybl, V; Koutenská, M; Koutenský, J; Smolíková, V; Sýkora, J1
Dubick, MA; Keen, CL; Rucker, RB1
Kuck, JF; Kuck, KD1
Brewer, GJ; Young, AB; Yuzbasiyan-Gurkan, V1
Günther, K; Kühn, HJ; Lössner, J; Siegemund, R1
Kolarski, V1
Lingam, S; Mowat, AP; Nazer, H; Wilson, J1
Jaffe, ME; Scheinberg, IH; Sternlieb, I1
Ritland, S1
Kleinman, J; Leitersdorf, E; Rave, D; Vengrover, D1
Warnes, TW1
Jones, DC; May, PM; Williams, DR1
Bird, HA; Dixon, JS; Martin, MF; Pickup, ME; Sitton, NG; Surrall, KE1
Gilsanz García, V1
Aguilar Barberá, M; Dalmau Obrador, J; Martí-Vilalta, JL1
Ede, RJ; Mowat, AP1
Bird, HA; Dixon, JS; Sitton, NG; Surrall, KE; Wright, V1
Deiss, A1
Hurley, LS; Keen, CL; Lönnerdal, B1
Cohen, NL; Hurley, LS; Keen, CL; Lönnerdal, B2
Asatoor, AM; Milne, MD; Walshe, JM1
Boss, M; Evans, J; Nuttall, L; Sherlock, S; Zerpa, H1
Sherlock, S1
Case, RM; Smith, PA; Sunter, JP1
Walshe, JM; Williams, FJ1
Berg, M; Haslam, RH; Sass-Kortsak, A; Stout, W1
Goulding, P; Hawthorne, B; Maresh, M; Nunns, D1
Dahlman, T; Hartvig, P; Löfholm, M; Lööf, L; Nordlinder, H; Westermark, K1
Arima, M1
Yarze, JC1
Bisbocci, D; Gallo, V; Riva, P; Sidoli, L1
Botha, CJ; Dauth, J; Dreyer, MJ; Naude, TW; Swan, GE; Williams, MC1
McIntyre, N1
Walshe, JM; Yealland, M1
Aoki, T; Fujioka, Y; Kubota, J; Saito, Y; Suda, M; Yamaguchi, Y1
Brewer, GJ; Dick, RD; Johnson, V; Wang, Y; Yuzbasiyan-Gurkan, V1
Brewer, GJ5
Ashtari, M; Fletcher, A; Golden, NH; Jacobson, MS; Kohn, MR; Patel, M; Shenker, IR1
Schilsky, ML3
Bascone, F; Bonfissuto, G; Carroccio, A; Costanza, G; Magliarisi, C; Montalto, G; Soresi, M1
Alexander, S; Furuta, GT; Herrin, J; Jonas, MM; Siafakas, CG1
Smolarek, C; Stremmel, W1
Sternlieb, I1
Barnham, KJ; Beyreuther, K; Bush, AI; Cherny, RA; Li, QX; Lynch, T; Masters, CL; McLean, CA; Multhaup, G; Tanzi, RE; Volitakis, I1
De Lorenzo, MS; Fukui, H; Gomez, DE; Ikenaka, Y; Kishida, H; Kuriyama, S; Nakae, D; Nakatani, T; Noguchi, R; Okuda, H; Tejera, AM; Tsujinoue, H; Yoshii, J; Yoshiji, H1
Bronstein, JM; Subramanian, I; Vanek, ZF1
Bavdekar, A; Bhave, S; Pandit, A1
Pérez-Aguilar, F1
Brechbiel, M; Camphausen, K; Sproull, M1
El-Youssef, M1
Shimizu, N2
Szalay, F1
Csák, T; Folhoffer, A; Horváth, A; Nagy, J; Vincze, Z; Zelkó, R1
Davie, CA; Lees, AJ; MacManus, D; Miller, DH; Miszkiel, KA; Page, RA; Schapira, AH; Walshe, JM1
Au-Yeung, KM; Chan, KH; Cheng, TS; Cheung, RT; Ho, SL; Mak, W1
Inuzuka, R; Kobayashi, S; Kodama, H; Mori, Y; Yanagawa, Y1
Noble, JA1
Ferenci, P; Merle, U; Schaefer, M; Stremmel, W1
Seo, JK1
Hierro Llanillo, L; Jara Vega, P1
Ala, A; Ashkan, K; Dooley, JS; Schilsky, ML; Walker, AP1
Awaisu, A; Aziz, NA; Ghazali, R; Hassan, Y; Ping, CC1
Medici, V; Rossaro, L; Sturniolo, GC1
Bandmann, O; Czlonkowska, A; Günther, P; Hefter, H; Lang, CJ; Leinweber, B; Möller, JC; Oertel, WH; Reuner, U; Scherag, A; Schmidt, HH; Schrader, C1
Palumbo, E1
Choi, WC; Kim, SY; Seo, JY1
Creim, JA; Curry, TL; Levinson, B; Levitskaia, TG; Luders, T; Morris, JE; Thrall, KD; Woodstock, AD1
Chan, YK; Chen, X; Choong, SY; Cooper, GJ; Fitzpatrick, S; Glyn-Jones, S; Gong, D; Lu, J; Nakamura, T; Obolonkin, V; Phillips, AR; Poppitt, SD; Ruggiero, K; Xu, H; Zhang, S1
Bucur, A; Dumitriu, AS; Kaplan, I; Parlatescu, I; Tovaru, S1
Bost, M; Broussolle, E; Brunet, AS; Des Portes, V; Lachaux, A; Lion-François, L; Wagner, S1
Coates, RA1
Battolu, F; Civolani, A; Demelia, L; Faa, G; Fanni, D; Sanna, F; Sini, M; Sorbello, O1
Ferenci, P; Ferenci-Foerster, D; Gotthardt, DN; Hefter, H; Houwen, RH; Maieron, A; Merle, U; Reuner, U; Schäfer, M; Schmidt, HH; Stauber, R; Stremmel, W; Teufel, U; Thurik, F; Trocello, JM; Weiss, KH; Wiegand, F; Zoller, H1
Filipský, T; Hrdina, R; Karlíčková, J; Macáková, K; Mladěnka, P; Říha, M1
Purchase, R1
Brůha, R; Mareček, Z1
Kanwar, P; Kowdley, KV1
Stremmel, W; Weiss, KH1
Aaseth, J; Andersen, O; Cao, Y; Skaug, MA2
Ferenci, P; Gohdes, A; Gotthardt, DN; Pfeiffenberger, J; Schäfer, M; Seessle, J; Stremmel, W; Weiss, KH1
Gotthardt, D; Pfeiffenberger, J; Schaefer, M; Seessle, J; Stremmel, W; Weber, L; Weiss, KH1
Bridoux, L; Debray, D; Gottrand, F; Lachaux, A; Lamireau, T; Lapeyre, D; Morali, A; Santiago, R1
Chen, C; Li, WJ; Wang, XP; Yang, RM; You, ZF1
Alhonen, L; Hyvönen, MT; Keinänen, TA; Khomutov, AR; Khomutov, M; Pasanen, M; Peräniemi, S; Ucal, S; Vepsäläinen, J; Weisell, J1
Beck, E; Dathe, K; Schaefer, C1
Członkowska, A; Litwin, T1
Chang, MH; Chen, HL; Hsu, HY; Ni, YH; Tai, CS; Wu, JF1
Avan, A; de Bie, RMA; Hoogenraad, TU1
Bragina, O; Järving, I; Kabin, E; Palumaa, P; Plitz, T; Smirnova, J; Tõugu, V1
Gauss, A; Gotthardt, D; Lohse, CM; Pfeiffenberger, J; Rupp, C; Teufel, U; Weiler, M; Weiss, KH1
Appenzeller-Herzog, C; Ewald, H; Heeres, MLS; Houwen, RHJ; Mathes, T; Weiss, KH1
Wang, XP; Yang, RM; Yuan, XZ1
Corey, K; Hawryluk, EB; Schmidt, B; Sheu Song, J; Yu, Z1
Bätzing, J; Holstiege, J; Janka, SS; Laux, G; Mehrabi, A; Merle, U; Mieth, M; Mohr, I; Wahler, S; Weiss, KH1
Demain, A; Gastellier, N; Jacquelet, E; Pheulpin, MC; Poujois, A; Tinant, N; Woimant, F1
Darak, H; Giri, S; Gopan, A; Irtaza, M; Kale, A; Kumar, S; Patra, BR; Rao, PK; Shukla, A1
de Koning, CE; Dhawan, A; Ferenci, P; Kruse, C; Manolaki, N; van Scheppingen, D; Weiss, KH; Wijnberg, L; Zuin, M1
Kerkar, N; Rana, A1
Ala, A; Cassiman, D; Couchonnal-Bedoya, E; Cury, RG; Czlonkowska, A; D'Hollander, K; D'Inca, R; Denk, G; Dubois, N; Gondim, FAA; Kamlin, COF; Moore, J; Ott, P; Poujois, A; Schilsky, ML; Twardowschy, C; Weiss, KH; Zuin, M1
Ala, A; Eker, E; Merle, U; Mohr, I; Pfeiffenberger, J; Poujois, A; Weiss, KH1
Antos, A; Bembenek, J; Członkowska, A; Kurkowska-Jastrzębska, I; Litwin, T; Przybyłkowski, A; Skowrońska, M; Smolinski, L1

Reviews

42 review(s) available for trientine and penicillamine

ArticleYear
A comparative study of in vitro and in vivo interaction of D-penicillamine and triethylenetetramine with copper.
    Proceedings of the Royal Society of Medicine, 1977, Volume: 70 Suppl 3

    Topics: Alkylating Agents; Copper; Humans; Penicillamine; Tissue Distribution; Trientine

1977
[Wilson's disease].
    Recenti progressi in medicina, 1992, Volume: 83, Issue:5

    Topics: Acetates; Acetic Acid; Adult; Diagnosis, Differential; Diet; Female; Hepatolenticular Degeneration; Humans; Male; Molybdenum; Penicillamine; Pyridoxine; Sulfates; Trientine; Zinc; Zinc Sulfate

1992
Wilson's disease: current status.
    The American journal of medicine, 1992, Volume: 92, Issue:6

    Topics: Administration, Oral; Ceruloplasmin; Copper; Copper Radioisotopes; Drug Monitoring; Genetic Testing; Hepatolenticular Degeneration; Humans; Liver; Liver Transplantation; Ophthalmoscopy; Penicillamine; Sulfates; Trientine; Zinc; Zinc Sulfate

1992
Wilson's disease: an update, with emphasis on new approaches to treatment.
    Digestive diseases (Basel, Switzerland), 1989, Volume: 7, Issue:4

    Topics: Copper; Female; Hepatolenticular Degeneration; Humans; Molybdenum; Penicillamine; Pregnancy; Trientine; Zinc

1989
Treatment of Wilson's disease.
    Seminars in neurology, 1987, Volume: 7, Issue:2

    Topics: Copper; Ethylenediamines; Female; Hepatolenticular Degeneration; Humans; Penicillamine; Pregnancy; Trientine; Zinc

1987
Treatment of primary biliary cirrhosis.
    Seminars in liver disease, 1985, Volume: 5, Issue:3

    Topics: Adrenal Cortex Hormones; Autoimmune Diseases; Azathioprine; Chlorambucil; Cholelithiasis; Colchicine; Cyclosporins; Female; Humans; Hyperlipidemias; Hypertension, Portal; Levamisole; Liver Cirrhosis, Biliary; Liver Transplantation; Nutrition Disorders; Osteomalacia; Osteoporosis; Penicillamine; Pruritus; Trientine; Vitamin A Deficiency; Vitamin E Deficiency; Zinc

1985
[Current problems in Wilson's disease].
    Anales de la Real Academia Nacional de Medicina, 1984, Volume: 101, Issue:1

    Topics: Basal Ganglia; Ceruloplasmin; Copper; Cornea; Hepatolenticular Degeneration; Humans; Kidney; Liver; Penicillamine; Prognosis; Trientine; Zinc

1984
[Wilson's disease (hepatolenticular degeneration)].
    Medicina clinica, 1984, Jun-09, Volume: 83, Issue:2

    Topics: Adolescent; Adult; Anemia, Hemolytic; Central Nervous System Diseases; Child; Combined Modality Therapy; Eye Diseases; Hepatolenticular Degeneration; Humans; Kidney Diseases; Liver; Penicillamine; Thrombocytopenia; Trientine

1984
Treatment and prognosis of primary biliary cirrhosis.
    Seminars in liver disease, 1981, Volume: 1, Issue:4

    Topics: Antigen-Antibody Complex; Azathioprine; Collagen; Copper; Cyclosporins; Humans; Liver; Liver Cirrhosis, Biliary; Penicillamine; Prednisolone; Prognosis; Trientine

1981
Practical recommendations and new therapies for Wilson's disease.
    Drugs, 1995, Volume: 50, Issue:2

    Topics: Chelating Agents; Copper; Female; Hepatolenticular Degeneration; Humans; Liver; Metallothionein; Molybdenum; Penicillamine; Pregnancy; Trientine; Zinc

1995
Wilson disease: genetic basis of copper toxicity and natural history.
    Seminars in liver disease, 1996, Volume: 16, Issue:1

    Topics: Adenosine Triphosphatases; Carrier Proteins; Cation Transport Proteins; Chelating Agents; Chelation Therapy; Chromosome Mapping; Copper; Copper-Transporting ATPases; Environment; Genetic Therapy; Genome, Human; Hepatitis; Hepatolenticular Degeneration; Humans; Liver Transplantation; Molybdenum; Mutation; Penicillamine; Risk Factors; Trientine; Zinc

1996
[Therapy of Wilson disease].
    Zeitschrift fur Gastroenterologie, 1999, Volume: 37, Issue:4

    Topics: Adolescent; Adult; Ceruloplasmin; Chelating Agents; Child; Copper; Female; Hepatolenticular Degeneration; Humans; Liver Transplantation; Male; Penicillamine; Trientine; Zinc

1999
Recognition, diagnosis, and management of Wilson's disease.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 2000, Volume: 223, Issue:1

    Topics: Adolescent; Adult; Chelating Agents; Child; Copper; Hepatolenticular Degeneration; Humans; Penicillamine; Trientine; Zinc

2000
Wilson's disease and pregnancy.
    Hepatology (Baltimore, Md.), 2000, Volume: 31, Issue:2

    Topics: Chelating Agents; Female; Hepatolenticular Degeneration; Humans; Penicillamine; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Trientine

2000
Treatment of Wilson's disease: what are the relative roles of penicillamine, trientine, and zinc supplementation?
    Current gastroenterology reports, 2001, Volume: 3, Issue:1

    Topics: Adenosine Triphosphatases; Chelating Agents; Drug Therapy, Combination; Female; Hepatolenticular Degeneration; Humans; Molybdenum; Penicillamine; Pregnancy; Trientine; Zinc

2001
Diagnosis and treatment of Wilson's disease.
    Current neurology and neuroscience reports, 2002, Volume: 2, Issue:4

    Topics: Chelating Agents; Copper; Dimercaprol; Enzyme Inhibitors; Female; Hepatolenticular Degeneration; Humans; Liver Transplantation; Male; Molybdenum; Penicillamine; Trientine; Zinc

2002
Wilson's disease.
    Indian journal of pediatrics, 2002, Volume: 69, Issue:9

    Topics: Adolescent; Biopsy, Needle; Blood Chemical Analysis; Child; Child, Preschool; Combined Modality Therapy; Diet; Female; Hepatolenticular Degeneration; Humans; India; Liver Transplantation; Male; Monitoring, Physiologic; Penicillamine; Prognosis; Severity of Illness Index; Treatment Outcome; Trientine

2002
[Wilson's disease: physiopathological, clinical and therapeutic considerations].
    Gastroenterologia y hepatologia, 2003, Volume: 26, Issue:1

    Topics: Adenosine Triphosphatases; Adolescent; Adult; Basal Ganglia Diseases; Brain; Cation Transport Proteins; Ceruloplasmin; Chelating Agents; Chelation Therapy; Copper; Copper-Transporting ATPases; Descemet Membrane; Female; Genes, Recessive; Hepatitis, Chronic; Hepatolenticular Degeneration; Humans; Liver Transplantation; Male; Mental Disorders; Middle Aged; Molybdenum; Penicillamine; Pregnancy; Pregnancy Complications; Prognosis; Recombinant Fusion Proteins; Trientine; Zinc

2003
Antiangiogenic therapy through copper chelation.
    Expert opinion on therapeutic targets, 2003, Volume: 7, Issue:3

    Topics: Angiogenesis Inhibitors; Animals; Chelating Agents; Chelation Therapy; Copper; Corneal Neovascularization; Cyclohexylamines; Hepatolenticular Degeneration; Humans; Molybdenum; Neoplasms; Neovascularization, Pathologic; Penicillamine; Pyridines; Rabbits; Trientine

2003
Wilson disease.
    Mayo Clinic proceedings, 2003, Volume: 78, Issue:9

    Topics: Adenosine Triphosphatases; Chelating Agents; Copper; Hepatolenticular Degeneration; Humans; Liver Transplantation; Molybdenum; Penicillamine; Trientine; Zinc

2003
[Wilson disease].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl

    Topics: Adenosine Triphosphatases; Age of Onset; Biomarkers; Cation Transport Proteins; Ceruloplasmin; Chelating Agents; Chromosomes, Human, Pair 13; Copper; Copper-Transporting ATPases; Dementia; Diagnosis, Differential; Hepatolenticular Degeneration; Humans; Liver Transplantation; Molecular Diagnostic Techniques; Mutation; Penicillamine; Trientine; Zinc

2004
[Wilson disease in 2003].
    Orvosi hetilap, 2003, Dec-14, Volume: 144, Issue:50

    Topics: Adenosine Triphosphatases; Cation Transport Proteins; Chelating Agents; Copper; Copper-Transporting ATPases; Diagnosis, Differential; Family Planning Services; Genetic Counseling; Genotype; Hepatolenticular Degeneration; Humans; Molybdenum; Penicillamine; Phenotype; Trientine; Zinc Acetate; Zinc Sulfate

2003
Neurologically presenting Wilson's disease: epidemiology, pathophysiology and treatment.
    CNS drugs, 2005, Volume: 19, Issue:3

    Topics: Behavior; Chelating Agents; Enzyme Inhibitors; Hepatolenticular Degeneration; Humans; Molybdenum; Nervous System Diseases; Penicillamine; Trientine; Zinc

2005
Anticopper therapy against cancer and diseases of inflammation and fibrosis.
    Drug discovery today, 2005, Aug-15, Volume: 10, Issue:16

    Topics: Animals; Copper; Fibrosis; Humans; Inflammation; Molybdenum; Neoplasms; Neovascularization, Pathologic; Penicillamine; Trientine

2005
A case study: identifying a new case of Wilson's disease.
    Journal of the American Academy of Nurse Practitioners, 2005, Volume: 17, Issue:12

    Topics: Abdominal Pain; Adult; Chelating Agents; Diagnosis, Differential; Drug Monitoring; Drug Therapy, Combination; Hepatolenticular Degeneration; Humans; Male; Nausea; Nurse Practitioners; Nursing Assessment; Patient Education as Topic; Penicillamine; Physical Examination; Primary Health Care; Trientine; Vomiting; Zinc Acetate

2005
[Wilson disease: an update].
    The Korean journal of hepatology, 2006, Volume: 12, Issue:3

    Topics: Adenosine Triphosphatases; Cation Transport Proteins; Copper; Copper-Transporting ATPases; Diagnosis, Differential; Genetic Testing; Hepatolenticular Degeneration; Humans; Liver; Mutation; Penicillamine; Trientine; Zinc

2006
Wilson's disease.
    Lancet (London, England), 2007, Feb-03, Volume: 369, Issue:9559

    Topics: Chelating Agents; Copper; Hepatolenticular Degeneration; Humans; Liver Transplantation; Penicillamine; Trientine

2007
Wilson disease--a practical approach to diagnosis, treatment and follow-up.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2007, Volume: 39, Issue:7

    Topics: Ceruloplasmin; Chelating Agents; Copper; Hepatolenticular Degeneration; Humans; Liver Transplantation; Molybdenum; Mutation; Penicillamine; Trace Elements; Treatment Outcome; Trientine; Zinc

2007
The risks of free copper in the body and the development of useful anticopper drugs.
    Current opinion in clinical nutrition and metabolic care, 2008, Volume: 11, Issue:6

    Topics: Alzheimer Disease; Angiogenesis Inhibitors; Autoimmunity; Copper; Fibrosis; Hepatolenticular Degeneration; Humans; Inflammation; Molybdenum; Neurodegenerative Diseases; Penicillamine; Trientine

2008
The treatment of Wilson's disease, a rare genetic disorder of copper metabolism.
    Science progress, 2013, Volume: 96, Issue:Pt 1

    Topics: Brain; Chelating Agents; Copper; Cornea; Dimercaprol; Drug Discovery; Hepatolenticular Degeneration; History, 20th Century; Humans; Liver; Molybdenum; Penicillamine; Rare Diseases; Trientine; Zinc Sulfate

2013
[Wilsons disease].
    Vnitrni lekarstvi, 2013, Volume: 59, Issue:7

    Topics: Adenosine Triphosphatases; Adult; Cation Transport Proteins; Chelating Agents; Copper; Copper-Transporting ATPases; Czech Republic; Female; Hepatolenticular Degeneration; Humans; Liver Cirrhosis; Liver Transplantation; Male; Molybdenum; Mutation; Penicillamine; Trientine; Zinc

2013
Metal storage disorders: Wilson disease and hemochromatosis.
    The Medical clinics of North America, 2014, Volume: 98, Issue:1

    Topics: Biopsy; Chelating Agents; Disease Progression; Genetic Predisposition to Disease; Genetic Testing; Hemochromatosis; Hepatolenticular Degeneration; Humans; Liver; Liver Failure; Liver Transplantation; Penicillamine; Phlebotomy; Prognosis; Trientine

2014
Clinical considerations for an effective medical therapy in Wilson's disease.
    Annals of the New York Academy of Sciences, 2014, Volume: 1315

    Topics: Ceruloplasmin; Chelating Agents; Copper; Hepatolenticular Degeneration; Humans; Molybdenum; Penicillamine; Trientine; Zinc

2014
Chelation therapy in intoxications with mercury, lead and copper.
    Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 2015, Volume: 31

    Topics: Administration, Oral; Animals; Chelating Agents; Chelation Therapy; Copper; Drug Therapy, Combination; Evidence-Based Medicine; Free Radical Scavengers; Humans; Infusions, Parenteral; Lead Poisoning; Mercury Poisoning; Penicillamine; Succimer; Trientine; Unithiol

2015
Chelation in metal intoxication--Principles and paradigms.
    Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 2015, Volume: 31

    Topics: Administration, Oral; Antidotes; Benzoates; Chelating Agents; Deferasirox; Deferiprone; Deferoxamine; Heavy Metal Poisoning; Humans; Penicillamine; Poisoning; Pyridones; Succimer; Triazoles; Trientine; Unithiol

2015
Current Drug Managements of Wilson's Disease: From West to East.
    Current neuropharmacology, 2016, Volume: 14, Issue:4

    Topics: Chelating Agents; Copper; Hepatolenticular Degeneration; Humans; Medicine, Chinese Traditional; Molybdenum; Penicillamine; Succimer; Treatment Outcome; Trientine; Zinc

2016
Wilson disease - currently used anticopper therapy.
    Handbook of clinical neurology, 2017, Volume: 142

    Topics: Chelating Agents; Copper; Enzyme Inhibitors; Hepatolenticular Degeneration; Humans; Molybdenum; Penicillamine; Prospective Studies; Trientine

2017
Wilson Disease: Diagnosis, Treatment, and Follow-up.
    Clinics in liver disease, 2017, Volume: 21, Issue:4

    Topics: Aftercare; Biopsy; Ceruloplasmin; Chelating Agents; Copper; Copper-Transporting ATPases; Disease Management; Hepatolenticular Degeneration; Humans; Liver; Liver Failure, Acute; Liver Transplantation; Penicillamine; Trientine

2017
Comparative effectiveness of common therapies for Wilson disease: A systematic review and meta-analysis of controlled studies.
    Liver international : official journal of the International Association for the Study of the Liver, 2019, Volume: 39, Issue:11

    Topics: Chelating Agents; Copper; Hepatolenticular Degeneration; Humans; Liver; Molybdenum; Penicillamine; Randomized Controlled Trials as Topic; Trientine; Zinc

2019
[Diagnosis and treatment of Wilson disease in Japan].
    Rinsho shinkeigaku = Clinical neurology, 2019, Sep-25, Volume: 59, Issue:9

    Topics: Adolescent; Adult; Biomarkers; Ceruloplasmin; Chelating Agents; Child; Child, Preschool; Copper; Copper-Transporting ATPases; Diagnosis, Differential; Drug Therapy, Combination; Hepatolenticular Degeneration; Humans; Japan; Liver; Middle Aged; Mutation; Penicillamine; Severity of Illness Index; Trientine; Young Adult; Zinc Acetate

2019
Wilson Disease in Children.
    Clinics in liver disease, 2022, Volume: 26, Issue:3

    Topics: Chelating Agents; Copper; Hepatolenticular Degeneration; Humans; Penicillamine; Trientine

2022
Early neurological deterioration in Wilson's disease: a systematic literature review and meta-analysis.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2023, Volume: 44, Issue:10

    Topics: Copper; Hepatolenticular Degeneration; Humans; Nervous System Diseases; Penicillamine; Trientine

2023

Trials

1 trial(s) available for trientine and penicillamine

ArticleYear
Trientine tetrahydrochloride versus penicillamine for maintenance therapy in Wilson disease (CHELATE): a randomised, open-label, non-inferiority, phase 3 trial.
    The lancet. Gastroenterology & hepatology, 2022, Volume: 7, Issue:12

    Topics: Adult; Chelating Agents; Copper; Hepatolenticular Degeneration; Humans; Penicillamine; Trientine

2022

Other Studies

94 other study(ies) available for trientine and penicillamine

ArticleYear
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Preparation of and clinical experiences with trien for the treatment of Wilson's disease in absolute intolerance of D-penicillamine.
    Proceedings of the Royal Society of Medicine, 1977, Volume: 70 Suppl 3

    Topics: Adult; Drug Tolerance; Female; Hepatolenticular Degeneration; Humans; Penicillamine; Trientine

1977
Computer models of metal ion-low molecular weight equilibria in plasma and the influence of D-penicillamine, triethylenetetramine and EDTA.
    Proceedings of the Royal Society of Medicine, 1977, Volume: 70 Suppl 3

    Topics: Computer Simulation; Edetic Acid; Humans; Metals; Molecular Weight; Penicillamine; Trientine

1977
Comparisons of antidotal efficacy of sodium diethyldithiocarbamate, D-penicillamine and triethylenetetramine upon acute toxicity of nickel carbonyl in rats.
    Research communications in chemical pathology and pharmacology, 1977, Volume: 18, Issue:4

    Topics: Animals; Ditiocarb; Ethylenediamines; Female; Nickel; Penicillamine; Rats; Rats, Inbred F344; Thiocarbamates; Time Factors; Trientine

1977
The management of Wilson's disease with trienthylene tetramine 2HC1 (Trien 2HC1).
    Progress in clinical and biological research, 1979, Volume: 34

    Topics: Drug Hypersensitivity; Ethylenediamines; Female; Hepatolenticular Degeneration; Humans; Male; Penicillamine; Trientine

1979
The effect of certain chelating compounds on the urinary excretion of copper by the rat: observations on their clinical significance.
    Clinical science and molecular medicine, 1977, Volume: 53, Issue:4

    Topics: Animals; Chelating Agents; Copper; Drug Evaluation, Preclinical; Ethylenediamines; Hepatolenticular Degeneration; Penicillamine; Rats; Trientine

1977
Wilson's disease treatment by triethylene tetramine dihydrochloride (trientine, 2HCl): long-term observations.
    Developmental pharmacology and therapeutics, 1992, Volume: 19, Issue:1

    Topics: Adolescent; Adult; Alanine Transaminase; Aspartate Aminotransferases; Chelating Agents; Copper; Female; Hepatolenticular Degeneration; Humans; Iron; Male; Penicillamine; Trientine

1992
Evaluation of the efficacy of d-penicillamine and trientine as copper chelators using an in vitro technique involving ovine red blood cells.
    The Onderstepoort journal of veterinary research, 1992, Volume: 59, Issue:3

    Topics: Animals; Copper; Erythrocytes; Female; Hemolysis; In Vitro Techniques; Penicillamine; Sheep; Trientine

1992
Treatment of Wilson's disease: penicillamine or triene?
    Acta neurologica Scandinavica, 1992, Volume: 85, Issue:2

    Topics: Copper; Hepatolenticular Degeneration; Humans; Magnetic Resonance Imaging; Penicillamine; Trientine; Zinc

1992
Mode of action of triethylenetetramine dihydrochloride on copper metabolism in Wilson's disease.
    Acta neurologica Scandinavica, 1991, Volume: 83, Issue:6

    Topics: Adult; Copper; Drug Administration Schedule; Drug Therapy, Combination; Female; Hepatolenticular Degeneration; Humans; Male; Middle Aged; Penicillamine; Sulfates; Trientine; Zinc; Zinc Sulfate

1991
Triethylene-tetramine (trien) therapy for Wilson's disease.
    The Tohoku journal of experimental medicine, 1991, Volume: 164, Issue:1

    Topics: Adolescent; Adult; Chelating Agents; Copper; Female; Hepatolenticular Degeneration; Humans; Male; Penicillamine; Trientine

1991
Excellent prognosis in Wilsonian chronic active hepatitis: new data or an article of faith?
    Hepatology (Baltimore, Md.), 1991, Volume: 14, Issue:6

    Topics: Hepatitis, Chronic; Hepatolenticular Degeneration; Humans; Liver Cirrhosis; Penicillamine; Prognosis; Trientine

1991
Prognosis of Wilsonian chronic active hepatitis.
    Gastroenterology, 1991, Volume: 100, Issue:3

    Topics: Adolescent; Adult; Alanine Transaminase; Aspartate Aminotransferases; Bilirubin; Child; Copper; Female; Hepatitis, Chronic; Hepatolenticular Degeneration; Humans; Liver; Liver Cirrhosis; Male; Penicillamine; Prognosis; Serum Albumin; Trientine

1991
A comparison of the effects of penicillamine, trientine, and trithiomolybdate on [35S]-labeled metallothionein in vitro; implications for Wilson's disease therapy.
    Journal of inorganic biochemistry, 1991, Feb-01, Volume: 41, Issue:2

    Topics: Animals; Copper; Cytosol; Hepatolenticular Degeneration; Liver; Male; Metallothionein; Molybdenum; Penicillamine; Rats; Rats, Inbred Strains; Sulfur Radioisotopes; Trientine

1991
Involvement of corticospinal tract in Wilson's disease. A study of three cases with transcranial stimulation.
    Movement disorders : official journal of the Movement Disorder Society, 1990, Volume: 5, Issue:4

    Topics: Adolescent; Adult; Electric Stimulation; Female; Hepatolenticular Degeneration; Humans; Male; Muscle Contraction; Muscles; Penicillamine; Pyramidal Tracts; Reaction Time; Trientine

1990
Treatment of Wilson's disease with triethylene tetramine hydrochloride (Trientine).
    Journal of pediatric gastroenterology and nutrition, 1990, Volume: 10, Issue:1

    Topics: Administration, Oral; Adolescent; Adult; Drug Evaluation; Ethylenediamines; Female; Hepatolenticular Degeneration; Humans; Male; Penicillamine; Trientine

1990
Wilson's disease presenting with features of hepatic dysfunction: a clinical analysis of eighty-seven patients.
    The Quarterly journal of medicine, 1989, Volume: 70, Issue:263

    Topics: Adolescent; Child; Copper; Female; Hepatolenticular Degeneration; Humans; Liver Function Tests; Male; Penicillamine; Trientine

1989
[A case of Wilson's disease recovering from severe brain damage--special reference to trientine and D-penicillamine therapy].
    No to hattatsu = Brain and development, 1989, Volume: 21, Issue:3

    Topics: Adolescent; Ethylenediamines; Female; Hepatolenticular Degeneration; Humans; Penicillamine; Trientine

1989
Influence of triethylenetetramine and D-penicillamine on zinc metabolism in mice.
    Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1989, Volume: 13

    Topics: Animals; Body Burden; Ethylenediamines; Kidney; Liver; Male; Mice; Mice, Inbred ICR; Penicillamine; Trientine; Zinc; Zinc Radioisotopes

1989
Elastin metabolism during perinatal lung development in the copper-deficient rat.
    Experimental lung research, 1985, Volume: 8, Issue:4

    Topics: Animals; Animals, Newborn; Collagen; Copper; Elastin; Female; Liver; Lung; Penicillamine; Pregnancy; Protein-Lysine 6-Oxidase; Rats; Rats, Inbred Strains; Trientine

1985
Diagnosis and treatment of presymptomatic Wilson's disease.
    Lancet (London, England), 1988, Aug-20, Volume: 2, Issue:8608

    Topics: Adolescent; Adult; Chelating Agents; Child; Copper; Female; Hepatolenticular Degeneration; Humans; Liver; Male; Penicillamine; Trientine

1988
The Emory mouse cataract: the effects on cataractogenesis of alpha-tocopherol, penicillamine, triethylenetetramine, and mercaptopropionylglycine.
    Journal of ocular pharmacology, 1988,Fall, Volume: 4, Issue:3

    Topics: Animals; Cataract; Ethylenediamines; Mice; Mice, Inbred Strains; Penicillamine; Tiopronin; Trientine; Vitamin E

1988
[Control of the therapeutic prevention of copper uptake in the liver in Wilson's disease following oral administration of 64Cu].
    Radiobiologia, radiotherapia, 1988, Volume: 29, Issue:2

    Topics: Copper Radioisotopes; Ethylenediamines; Hepatolenticular Degeneration; Humans; Liver; Penicillamine; Sulfates; Trientine; Zinc; Zinc Sulfate

1988
[New possibilities in the treatment of Wilson-Konovalov disease (hepatolenticular degeneration)].
    Vutreshni bolesti, 1987, Volume: 26, Issue:5

    Topics: Adolescent; Adult; Drug Evaluation; Drug Tolerance; Female; Hepatolenticular Degeneration; Humans; Penicillamine; Trientine

1987
Neurological abnormalities in Wilson's disease are reversible.
    Neuropediatrics, 1987, Volume: 18, Issue:1

    Topics: Adolescent; Child; Child Behavior Disorders; Ethylenediamines; Female; Hepatolenticular Degeneration; Humans; Intelligence; Male; Penicillamine; Seizures; Trientine

1987
The use of trientine in preventing the effects of interrupting penicillamine therapy in Wilson's disease.
    The New England journal of medicine, 1987, Jul-23, Volume: 317, Issue:4

    Topics: Ethylenediamines; Female; Hepatolenticular Degeneration; Humans; Male; Middle Aged; Patient Compliance; Penicillamine; Substance Withdrawal Syndrome; Trientine

1987
[Trientin in Wilson's disease. Therapeutic possibilities in patients who cannot tolerate penicillamine].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1987, Aug-10, Volume: 107, Issue:22

    Topics: Adult; Drug Hypersensitivity; Ethylenediamines; Hepatolenticular Degeneration; Humans; Male; Penicillamine; Trientine

1987
[Triethylene tetramine in Wilson's disease].
    Harefuah, 1986, Feb-16, Volume: 110, Issue:4

    Topics: Adult; Ethylenediamines; Hepatolenticular Degeneration; Humans; Male; Penicillamine; Trientine

1986
Trientine for Wilson's disease.
    The Medical letter on drugs and therapeutics, 1986, Jul-04, Volume: 28, Issue:717

    Topics: Ethylenediamines; Hepatolenticular Degeneration; Humans; Penicillamine; Trientine

1986
Treatment of Wilson's disease with trientine (triethylene tetramine) dihydrochloride.
    Lancet (London, England), 1982, Mar-20, Volume: 1, Issue:8273

    Topics: Adolescent; Adult; Brain; Ethylenediamines; Female; Hepatolenticular Degeneration; Humans; Male; Penicillamine; Pregnancy; Tomography, X-Ray Computed; Trientine

1982
Wilson's disease, an end to the search for new therapy?
    Lancet (London, England), 1982, May-15, Volume: 1, Issue:8281

    Topics: Animals; Ethylenediamines; Hepatolenticular Degeneration; Humans; Penicillamine; Risk; Trientine

1982
The effect of drugs on serum histidine levels in rheumatoid arthritis.
    Rheumatology international, 1983, Volume: 3, Issue:4

    Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Captopril; Clofibrate; Drug Combinations; Female; Histidine; Humans; Hydroxychloroquine; Male; Middle Aged; Penicillamine; Sulfates; Trientine; Zinc; Zinc Sulfate

1983
Wilson's disease: a 1984 perspective.
    Comprehensive therapy, 1984, Volume: 10, Issue:12

    Topics: Adolescent; Adult; Bone and Bones; Ceruloplasmin; Child; Child, Preschool; Copper; Diagnosis, Differential; Eye; Hepatitis, Chronic; Hepatolenticular Degeneration; Humans; Joints; Kidney; Liver Diseases; Middle Aged; Nervous System Diseases; Penicillamine; Prognosis; Trientine; Zinc

1984
A comparison of therapies which may influence trace metals in rheumatoid arthritis.
    Clinical rheumatology, 1984, Volume: 3, Issue:4

    Topics: Arthritis, Rheumatoid; Ethylenediamines; Female; Humans; Male; Middle Aged; Penicillamine; Sulfates; Time Factors; Trace Elements; Trientine; Zinc; Zinc Sulfate

1984
Treatment of Wilson's disease.
    Annals of internal medicine, 1983, Volume: 99, Issue:3

    Topics: Copper; Diagnostic Errors; Hepatolenticular Degeneration; Humans; Penicillamine; Trientine; Zinc

1983
Drug-induced copper deficiency: a model for copper deficiency teratogenicity.
    Teratology, 1983, Volume: 28, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Copper; Female; Humans; Penicillamine; Pregnancy; Teratogens; Trientine

1983
Molecular localization of copper and zinc in rat fetal liver in dietary and drug-induced copper deficiency.
    Biochemical and biophysical research communications, 1984, Feb-14, Volume: 118, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Chromatography, Gel; Copper; Ethylenediamines; Female; Liver; Maternal-Fetal Exchange; Metallothionein; Penicillamine; Pregnancy; Rats; Rats, Inbred Strains; Superoxide Dismutase; Trientine; Zinc

1984
The effect of chelation therapy on the amino aciduria and peptiduria of Wilson's disease.
    Journal of the Royal College of Physicians of London, 1983, Volume: 17, Issue:2

    Topics: Adolescent; Adult; Amino Acids; Chelating Agents; Child; Ethylenediamines; Female; Follow-Up Studies; Hepatolenticular Degeneration; Humans; Male; Oligopeptides; Penicillamine; Peptides; Trientine

1983
Copper chelation therapy in intrahepatic cholestasis of childhood.
    Gut, 1983, Volume: 24, Issue:1

    Topics: Adolescent; Adult; Child; Child, Preschool; Cholestasis, Intrahepatic; Copper; Ethylenediamines; Female; Humans; Liver; Liver Function Tests; Male; Penicillamine; Pruritus; Trientine

1983
The effect of copper chelating drugs on liver iron mobilization in the adult rat.
    Biochemical and biophysical research communications, 1983, May-31, Volume: 113, Issue:1

    Topics: Animals; Ceruloplasmin; Copper; Ethylenediamines; Female; Iron; Liver; Penicillamine; Rats; Rats, Inbred Strains; Time Factors; Trientine

1983
Progressive atrophy of pancreatic acinar tissue in rats fed a copper-deficient diet supplemented with D-penicillamine or triethylene tetramine: morphological and physiological studies.
    Digestion, 1982, Volume: 23, Issue:1

    Topics: Animals; Atrophy; Copper; Ethylenediamines; Male; Organ Size; Pancreas; Penicillamine; Rats; Rats, Inbred Strains; Trientine

1982
Wilson's disease. An analysis of the cranial computerized tomographic appearances found in 60 patients and the changes in response to treatment with chelating agents.
    Brain : a journal of neurology, 1981, Volume: 104, Issue:Pt 4

    Topics: Adolescent; Adult; Atrophy; Brain; Cerebral Ventricles; Child; Dilatation, Pathologic; Ethylenediamines; Female; Hepatolenticular Degeneration; Humans; Male; Motor Skills; Penicillamine; Tomography, X-Ray Computed; Trientine

1981
Treatment of Wilson's disease with triethylene tetramine dihydrochloride. A case report.
    Developmental pharmacology and therapeutics, 1980, Volume: 1, Issue:5

    Topics: Adolescent; Copper; Ethylenediamines; Female; Hepatolenticular Degeneration; Humans; Penicillamine; Trientine

1980
Wilson's disease in pregnancy.
    European journal of obstetrics, gynecology, and reproductive biology, 1995, Volume: 62, Issue:1

    Topics: Adolescent; Copper; Female; Hepatolenticular Degeneration; Humans; Liver; Male; Penicillamine; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Trientine

1995
Long-term treatment of Wilson's disease with triethylene tetramine dihydrochloride (trientine).
    QJM : monthly journal of the Association of Physicians, 1995, Volume: 88, Issue:9

    Topics: Adolescent; Adult; Biopsy; Chelating Agents; Child; Colon; Drug Administration Schedule; Duodenum; Female; Follow-Up Studies; Hepatolenticular Degeneration; Humans; Intestinal Mucosa; Liver; Male; Penicillamine; Trientine

1995
[Wilson's disease--evolutive panorama of diagnosis and treatment in the last forty years].
    No to hattatsu = Brain and development, 1995, Volume: 27, Issue:2

    Topics: Adult; Hepatolenticular Degeneration; History, 20th Century; Humans; Penicillamine; Trientine

1995
The mechanisms of penicillamine, trientine, and zinc in the treatment of Wilson's disease.
    The American journal of gastroenterology, 1995, Volume: 90, Issue:6

    Topics: Hepatolenticular Degeneration; Humans; Penicillamine; Trientine; Zinc

1995
[Wilson's disease: physiopathology, therapeutic approach and case report].
    Minerva gastroenterologica e dietologica, 1994, Volume: 40, Issue:4

    Topics: Adult; Copper; Hepatolenticular Degeneration; Humans; Liver; Male; Nephrotic Syndrome; Penicillamine; Trientine

1994
The cupruretic effect of two chelators following copper loading in sheep.
    Veterinary and human toxicology, 1993, Volume: 35, Issue:5

    Topics: Animals; Copper; Food Contamination; Male; Penicillamine; Sheep; Treatment Outcome; Trientine

1993
Neurological Wilson's disease.
    The Quarterly journal of medicine, 1993, Volume: 86, Issue:5

    Topics: Child; Hepatolenticular Degeneration; Humans; Penicillamine; Trientine

1993
Chelation treatment of neurological Wilson's disease.
    The Quarterly journal of medicine, 1993, Volume: 86, Issue:3

    Topics: Adolescent; Adult; Cause of Death; Chelation Therapy; Copper; Drug Administration Schedule; Female; Hepatolenticular Degeneration; Humans; Male; Middle Aged; Penicillamine; Time Factors; Treatment Outcome; Trientine

1993
[A study of trientine therapy in Wilson's disease with neurological symptoms].
    No to hattatsu = Brain and development, 1993, Volume: 25, Issue:5

    Topics: Adolescent; Adult; Dysarthria; Dystonia; Female; Hepatolenticular Degeneration; Humans; Male; Penicillamine; Penicillin Resistance; Tremor; Trientine

1993
Treatment of Wilson's disease with zinc: XI. Interaction with other anticopper agents.
    Journal of the American College of Nutrition, 1993, Volume: 12, Issue:1

    Topics: Ascorbic Acid; Copper; Copper Radioisotopes; Drug Interactions; Drug Therapy, Combination; Hepatolenticular Degeneration; Humans; Penicillamine; Trientine; Zinc

1993
Reversibility of cerebral ventricular enlargement in anorexia nervosa, demonstrated by quantitative magnetic resonance imaging.
    The Journal of pediatrics, 1996, Volume: 128, Issue:2

    Topics: Adolescent; Adult; Anorexia Nervosa; Body Mass Index; Body Weight; Cerebral Ventricles; Child; Drug Therapy, Combination; Female; Hospitalization; Humans; Magnetic Resonance Imaging; Nutrition Disorders; Penicillamine; Sulfates; Trientine; Zinc Compounds; Zinc Sulfate

1996
[Wilson's disease].
    Recenti progressi in medicina, 1997, Volume: 88, Issue:1

    Topics: Adolescent; Adult; Chelating Agents; Diagnosis, Differential; Hepatolenticular Degeneration; Humans; Penicillamine; Trientine; Zinc

1997
Early onset of nephrotic syndrome after treatment with D-penicillamine in a patient with Wilson's disease.
    The American journal of gastroenterology, 1998, Volume: 93, Issue:12

    Topics: Chelating Agents; Child; Hepatolenticular Degeneration; Humans; Male; Nephrotic Syndrome; Penicillamine; Retreatment; Time Factors; Trientine

1998
Chelation and intercalation: complementary properties in a compound for the treatment of Alzheimer's disease.
    Journal of structural biology, 2000, Volume: 130, Issue:2-3

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Chelating Agents; Copper; Humans; Mice; Mice, Transgenic; Nuclear Magnetic Resonance, Biomolecular; Penicillamine; Peptides; Phenanthrolines; Pilot Projects; Solubility; Trientine; Zinc

2000
The copper-chelating agent, trientine, suppresses tumor development and angiogenesis in the murine hepatocellular carcinoma cells.
    International journal of cancer, 2001, Dec-15, Volume: 94, Issue:6

    Topics: Animals; Apoptosis; Cell Division; Chelating Agents; Copper; Female; Liver Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Neovascularization, Pathologic; Penicillamine; Trientine

2001
[Pathogenesis and treatment of Wilson's disease].
    Acta pharmaceutica Hungarica, 2003, Volume: 73, Issue:4

    Topics: Chelating Agents; Copper; Hepatolenticular Degeneration; Humans; Intestinal Absorption; Penicillamine; Trientine

2003
Clinical correlation of brain MRI and MRS abnormalities in patients with Wilson disease.
    Neurology, 2004, Aug-24, Volume: 63, Issue:4

    Topics: Adult; Aged; Aspartic Acid; Atrophy; Brain; Brain Chemistry; Chelation Therapy; Copper; Dipeptides; Female; Hepatolenticular Degeneration; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Mitochondria; Nervous System Diseases; Penicillamine; Severity of Illness Index; Single-Blind Method; Trientine

2004
Wilson's disease with depression and parkinsonism.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2005, Volume: 12, Issue:3

    Topics: Adult; Antiparkinson Agents; Brain; Bromocriptine; Chelating Agents; Depressive Disorder; Female; Hepatolenticular Degeneration; Humans; Magnetic Resonance Imaging; Parkinsonian Disorders; Penicillamine; Suicide, Attempted; Tomography, X-Ray Computed; Trientine; Trihexyphenidyl

2005
Combination treatment with penicillamine and trientine in a patient with Wilson's disease.
    Pediatrics international : official journal of the Japan Pediatric Society, 2005, Volume: 47, Issue:5

    Topics: Adult; Chelating Agents; Drug Therapy, Combination; Hepatolenticular Degeneration; Humans; Male; Penicillamine; Trientine

2005
Clinical presentation, diagnosis and long-term outcome of Wilson's disease: a cohort study.
    Gut, 2007, Volume: 56, Issue:1

    Topics: Adenosine Triphosphatases; Adolescent; Adult; Cation Transport Proteins; Ceruloplasmin; Chelating Agents; Child; Child, Preschool; Cohort Studies; Copper; Copper-Transporting ATPases; DNA Mutational Analysis; Female; Genotype; Hepatolenticular Degeneration; Humans; Infant; Liver; Male; Middle Aged; Penicillamine; Phenotype; Retrospective Studies; Trace Elements; Treatment Outcome; Trientine; Zinc

2007
[Wilson's disease: forms of presentation in childhood].
    Gastroenterologia y hepatologia, 2006, Volume: 29, Issue:9

    Topics: Chelating Agents; Child; Early Diagnosis; Hepatolenticular Degeneration; Humans; Penicillamine; Prognosis; Trientine

2006
Discontinuation of penicillamine in the absence of alternative orphan drugs (trientine-zinc): a case of decompensated liver cirrhosis in Wilson's disease.
    Journal of clinical pharmacy and therapeutics, 2007, Volume: 32, Issue:1

    Topics: Adult; Chelating Agents; Fatal Outcome; Female; Hepatolenticular Degeneration; Humans; Liver Cirrhosis; Malaysia; Orphan Drug Production; Penicillamine; Recurrence; Trace Elements; Trientine; Zinc

2007
Wilson's disease.
    Lancet (London, England), 2007, Mar-17, Volume: 369, Issue:9565

    Topics: Chelating Agents; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Hepatolenticular Degeneration; Humans; Penicillamine; Trientine; Zinc

2007
Evaluation of the Unified Wilson's Disease Rating Scale (UWDRS) in German patients with treated Wilson's disease.
    Movement disorders : official journal of the Movement Disorder Society, 2008, Volume: 23, Issue:1

    Topics: Adult; Age of Onset; Antirheumatic Agents; Chelating Agents; Drug Therapy, Combination; Female; Germany; Hepatolenticular Degeneration; Humans; Liver Diseases; Lower Extremity; Male; Penicillamine; Posture; Prevalence; Surveys and Questionnaires; Torticollis; Tremor; Trientine; Upper Extremity; Zinc

2008
[Wilson's disease in paediatric age: diagnosis and treatment. Recent advances].
    Recenti progressi in medicina, 2008, Volume: 99, Issue:11

    Topics: Adenosine Triphosphatases; Astringents; Cation Transport Proteins; Ceruloplasmin; Chelating Agents; Child; Copper; Copper-Transporting ATPases; Diagnosis, Differential; Drug Therapy, Combination; Genetic Markers; Hepatolenticular Degeneration; Humans; Liver; Mutation; Penicillamine; Treatment Outcome; Trientine; Zinc Sulfate

2008
Education and imaging. Hepatobiliary and pancreatic: hypersensitivity pneumonitis induced by penicillamine.
    Journal of gastroenterology and hepatology, 2009, Volume: 24, Issue:4

    Topics: Alveolitis, Extrinsic Allergic; Chelating Agents; Female; Hepatolenticular Degeneration; Humans; Liver Cirrhosis; Middle Aged; Penicillamine; Radiography, Thoracic; Tomography, X-Ray Computed; Trientine

2009
Evaluation of Cuprimine and Syprine for decorporation of (60)Co and (210)Po.
    Health physics, 2010, Volume: 98, Issue:3

    Topics: Animals; Chelating Agents; Cobalt Radioisotopes; Humans; Male; Penicillamine; Polonium; Rats; Rats, Wistar; Tissue Distribution; Trientine

2010
Copper(II)-selective chelation improves function and antioxidant defences in cardiovascular tissues of rats as a model of diabetes: comparisons between triethylenetetramine and three less copper-selective transition-metal-targeted treatments.
    Diabetologia, 2010, Volume: 53, Issue:6

    Topics: Adult; Aged; Analysis of Variance; Animals; Aorta; Chelating Agents; Deferiprone; Diabetes Mellitus, Experimental; Heart; Heparitin Sulfate; Humans; Kidney; Male; Middle Aged; Oxidative Stress; Penicillamine; Pyridones; Rats; Rats, Wistar; Trientine; Zinc Acetate

2010
Oral complications associated with D-penicillamine treatment for Wilson disease: a clinicopathologic report.
    Journal of periodontology, 2010, Volume: 81, Issue:8

    Topics: Adult; Candidiasis, Oral; Cheilitis; Chelating Agents; Elastic Tissue; Female; Follow-Up Studies; Gingival Hemorrhage; Gingival Hyperplasia; Gingival Recession; Granuloma; Hepatolenticular Degeneration; Humans; Lip Diseases; Middle Aged; Mouth Diseases; Penicillamine; Periodontal Pocket; Periodontitis; Tongue Diseases; Trientine

2010
Serum 'free' copper in Wilson disease.
    QJM : monthly journal of the Association of Physicians, 2012, Volume: 105, Issue:5

    Topics: Adolescent; Adult; Ceruloplasmin; Chelating Agents; Child; Child, Preschool; Copper; Hepatolenticular Degeneration; Humans; Penicillamine; Trientine; Young Adult

2012
[Diagnosis and care of Wilson disease with neurological revelation].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2012, Volume: 19, Issue:3

    Topics: Adolescent; Brain; Chelating Agents; Female; Hepatolenticular Degeneration; Humans; Liver Transplantation; Magnetic Resonance Imaging; Male; Nervous System Diseases; Neurologic Examination; Penicillamine; Trientine; Zinc

2012
A copper for your thoughts.
    Journal of insurance medicine (New York, N.Y.), 2012, Volume: 43, Issue:2

    Topics: Adult; Chelating Agents; Copper; Female; Hepatolenticular Degeneration; Humans; Insurance, Life; Penicillamine; Trace Elements; Trientine; Zinc Acetate

2012
Histologic evolution and long-term outcome of Wilson's disease: results of a single-center experience.
    European journal of gastroenterology & hepatology, 2013, Volume: 25, Issue:1

    Topics: Adolescent; Adult; Biopsy; Chelating Agents; Chi-Square Distribution; Child; Child, Preschool; Disease Progression; Female; Hepatolenticular Degeneration; Humans; Italy; Liver; Liver Cirrhosis; Male; Middle Aged; Penicillamine; Retrospective Studies; Time Factors; Treatment Outcome; Trientine; Young Adult; Zinc Sulfate

2013
Efficacy and safety of oral chelators in treatment of patients with Wilson disease.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2013, Volume: 11, Issue:8

    Topics: Adolescent; Adult; Austria; Chelating Agents; Child; Child, Preschool; Cohort Studies; Drug-Related Side Effects and Adverse Reactions; Female; Germany; Hepatolenticular Degeneration; Humans; Infant; Male; Middle Aged; Penicillamine; Retrospective Studies; Treatment Outcome; Trientine; Young Adult

2013
Novel method for rapid copper chelation assessment confirmed low affinity of D-penicillamine for copper in comparison with trientine and 8-hydroxyquinolines.
    Journal of inorganic biochemistry, 2013, Volume: 123

    Topics: Copper; Oxyquinoline; Penicillamine; Phenanthrolines; Trientine

2013
Concomitant immune-related events in Wilson disease: implications for monitoring chelator therapy.
    Journal of inherited metabolic disease, 2016, Volume: 39, Issue:1

    Topics: Adolescent; Adult; Antibodies, Antinuclear; Autoimmune Diseases; Chelating Agents; Child; Cross-Sectional Studies; Drug Monitoring; Drug-Related Side Effects and Adverse Reactions; Female; Hepatolenticular Degeneration; Humans; Male; Penicillamine; Retrospective Studies; Trientine; Young Adult; Zinc

2016
Coagulation Parameters in Wilson Disease.
    Journal of gastrointestinal and liver diseases : JGLD, 2015, Volume: 24, Issue:2

    Topics: Adult; Biomarkers; Blood Coagulation; Blood Coagulation Factors; Chelating Agents; Cross-Sectional Studies; Female; Hepatolenticular Degeneration; Humans; International Normalized Ratio; Liver Function Tests; Male; Partial Thromboplastin Time; Penicillamine; Predictive Value of Tests; Prospective Studies; Tertiary Care Centers; Trientine; Zinc Compounds

2015
Zinc Therapy for Wilson Disease in Children in French Pediatric Centers.
    Journal of pediatric gastroenterology and nutrition, 2015, Volume: 61, Issue:6

    Topics: Abdominal Pain; Adolescent; Chelating Agents; Child; Child, Preschool; Copper; Female; France; Health Care Surveys; Health Facilities; Hepatolenticular Degeneration; Humans; Infant; Liver; Male; Pediatrics; Penicillamine; Retrospective Studies; Stomach; Trace Elements; Transaminases; Treatment Outcome; Trientine; Zinc; Zinc Acetate

2015
Triethylenetetramine modulates polyamine and energy metabolism and inhibits cancer cell proliferation.
    The Biochemical journal, 2016, 05-15, Volume: 473, Issue:10

    Topics: Amine Oxidase (Copper-Containing); Cell Line, Tumor; Cell Proliferation; Eflornithine; Energy Metabolism; Female; Humans; Male; MCF-7 Cells; Molybdenum; Penicillamine; Polyamines; Putrescine; Reactive Oxygen Species; Spermine; Trientine

2016
Pregnancy outcome after chelation therapy in Wilson disease. Evaluation of the German Embryotox Database.
    Reproductive toxicology (Elmsford, N.Y.), 2016, Volume: 65

    Topics: Adult; Chelating Agents; Chelation Therapy; Copper; Databases, Factual; Female; Germany; Hepatolenticular Degeneration; Humans; Penicillamine; Pregnancy; Pregnancy Outcome; Trientine; Young Adult

2016
Modality of treatment and potential outcome of Wilson disease in Taiwan: A population-based longitudinal study.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2018, Volume: 117, Issue:5

    Topics: Adolescent; Adult; Child; Child, Preschool; Female; Hepatolenticular Degeneration; Humans; Liver Transplantation; Longitudinal Studies; Male; Middle Aged; Penicillamine; Trientine; Young Adult; Zinc

2018
Wilson's Disease Should Be Treated with Zinc rather than Trientine or Penicillamine.
    Neuropediatrics, 2017, Volume: 48, Issue:5

    Topics: Hepatolenticular Degeneration; Humans; Penicillamine; Trientine; Zinc

2017
Copper(I)-binding properties of de-coppering drugs for the treatment of Wilson disease. α-Lipoic acid as a potential anti-copper agent.
    Scientific reports, 2018, 01-23, Volume: 8, Issue:1

    Topics: Apoptosis; Carrier Proteins; Cell Line; Cell Proliferation; Chelating Agents; Copper; Copper Transport Proteins; Hepatocytes; Hepatolenticular Degeneration; Humans; Metallothionein; Penicillamine; Thioctic Acid; Trientine

2018
Long-term evaluation of urinary copper excretion and non-caeruloplasmin associated copper in Wilson disease patients under medical treatment.
    Journal of inherited metabolic disease, 2019, Volume: 42, Issue:2

    Topics: Adolescent; Adult; Ceruloplasmin; Chelating Agents; Child; Child, Preschool; Copper; Female; Germany; Hepatolenticular Degeneration; Humans; Infant; Male; Middle Aged; Penicillamine; Regression Analysis; Retrospective Studies; Trientine; Young Adult; Zinc

2019
Management Perspective of Wilson's Disease: Early Diagnosis and Individualized Therapy.
    Current neuropharmacology, 2021, Volume: 19, Issue:4

    Topics: Copper; Early Diagnosis; Hepatolenticular Degeneration; Humans; Penicillamine; Trientine

2021
Pediatric Pseudo-pseudoxanthoma Elasticum Resulting From D-Penicillamine Treatment for Wilson Disease.
    Journal of pediatric gastroenterology and nutrition, 2020, Volume: 71, Issue:6

    Topics: Adolescent; Adult; Hepatolenticular Degeneration; Humans; Male; Penicillamine; Pseudoxanthoma Elasticum; Skin Diseases; Trientine

2020
[Retrospective cross-sectional study based on nationwide data of drug prescriptions and contractional data of outpatient offices regarding Morbus Wilson's disease].
    Zeitschrift fur Gastroenterologie, 2020, Volume: 58, Issue:11

    Topics: Cross-Sectional Studies; Drug Prescriptions; Germany; Hepatolenticular Degeneration; Humans; Penicillamine; Prevalence; Retrospective Studies; Trientine; Zinc

2020
Adherence to treatment, a challenge even in treatable metabolic rare diseases: A cross sectional study of Wilson's disease.
    Journal of inherited metabolic disease, 2021, Volume: 44, Issue:6

    Topics: Adolescent; Adult; Anxiety; Chelating Agents; Child; Copper; Cross-Sectional Studies; Depression; Female; Hepatolenticular Degeneration; Humans; Male; Patient Compliance; Penicillamine; Treatment Outcome; Trientine; Young Adult; Zinc

2021
Adverse Events with D-penicillamine Therapy in Hepatic Wilson's Disease: A Single-Center Retrospective Audit.
    Clinical drug investigation, 2022, Volume: 42, Issue:2

    Topics: Chelating Agents; Hepatolenticular Degeneration; Humans; Penicillamine; Retrospective Studies; Trientine; Zinc

2022
Multicentre, retrospective study to assess long-term outcomes of chelator based treatment with trientine in Wilson disease patients withdrawn from therapy with d -penicillamine.
    European journal of gastroenterology & hepatology, 2022, 09-01, Volume: 34, Issue:9

    Topics: Chelating Agents; Hepatolenticular Degeneration; Humans; Penicillamine; Retrospective Studies; Trientine

2022
Neurological worsening in Wilson disease - clinical classification and outcome.
    Journal of hepatology, 2023, Volume: 79, Issue:2

    Topics: Copper; Female; Hepatolenticular Degeneration; Humans; Penicillamine; Trientine; Zinc

2023