triclabendazole sulfoxide has been researched along with triclabendazole in 30 studies
| Studies (triclabendazole sulfoxide) | Trials (triclabendazole sulfoxide) | Recent Studies (post-2010) (triclabendazole sulfoxide) | Studies (triclabendazole) | Trials (triclabendazole) | Recent Studies (post-2010) (triclabendazole) |
|---|---|---|---|---|---|
| 30 | 1 | 16 | 497 | 44 | 209 |
| Protein | Taxonomy | triclabendazole sulfoxide (IC50) | triclabendazole (IC50) |
|---|---|---|---|
| Transthyretin | Homo sapiens (human) | 3.5 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (6.67) | 18.2507 |
| 2000's | 10 (33.33) | 29.6817 |
| 2010's | 16 (53.33) | 24.3611 |
| 2020's | 2 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Fairweather, I; Stitt, AW | 2 |
| Brennan, GP; Fairweather, I; Meaney, M; Ramasamy, P; Subramanian, PB | 1 |
| Fairweather, I; Hoey, EM; Lawson, J; Robinson, MW; Trudgett, A | 1 |
| Boray, JC; Brennan, GP; Fairweather, I; Fletcher, H; Hoey, EM; McKinstry, B; Trudgett, A; Walker, SM | 1 |
| Alvarez, L; Ceballos, L; Lanusse, C; Mottier, L | 1 |
| Lanusse, C; Lifschitz, A; Pis, A; Sallovitz, J; Virkel, G | 1 |
| Barakat, R; Chollet, J; Diab, T; El Ela, NA; El Komy, E; El Lakkany, N; Keiser, J; Utzinger, J | 1 |
| Alvarez, L; Fairweather, I; Lanusse, C; Mottier, L | 1 |
| Errecalde, JO; Fernandez, C; Formentini, EA; Hernández, EM; Lucas, MF; Mestorino, N; Modamio, P | 1 |
| Brennan, GP; Fairweather, I; Halferty, L; Hoey, L; Trudgett, A | 1 |
| Ebeid, SM; El-Samak, MY; Hussein, NM; Shehab, AY | 1 |
| Alvarez, L; Ceballos, L; Fairweather, I; Lanusse, C; Moreno, L; Shaw, L | 1 |
| Alvarez, LI; Brennan, GP; Devine, C; Fairweather, I; Hoey, E; Lanusse, CE; Trudgett, A | 2 |
| Alvarez, L; Cabrera, M; Farias, C; Iezzi, S; Imperiale, F; Lanusse, C; Ortiz, P; Pérez, J; Sallovitz, JM | 1 |
| Brennan, GP; Ellison, SE; Fairweather, I; McShane, DD; O'Hagan, NT; Shaw, L; Trudgett, A; York, EA | 1 |
| Álvarez, AI; Barrera, B; Egido, E; Merino, G; Otero, JA; Prieto, JG; Seelig, A | 1 |
| Braissant, O; Keiser, J; Kirchhofer, C; Manneck, T | 1 |
| El Khateeb, RM; Kutkat, MA; Mahmoud, MS; Massoud, AM; Shalaby, HA | 1 |
| Brennan, GP; Fairweather, I; Hoey, E; Meaney, M; Savage, J; Trudgett, A | 2 |
| Álvarez, AI; Barrera, B; González-Lobato, L; Merino, G; Otero, JA; Prieto, JG; Real, R | 1 |
| Alvarez, L; Ceballos, L; Fairweather, I; Lanusse, C; Moreno, L | 1 |
| Barenys, M; Boix, N; Ibáñez, E; Llobet, JM; Ortiz, P; Teixido, E; Vila-Cejudo, M | 1 |
| Carradori, S; Casulli, A; Cirilli, R; Ferretti, R; Guglielmi, P; Pierini, M | 1 |
| Giri, P; Giri, S; Gupta, L; Joshi, V; Naidu, S; Patel, N; Srinivas, NR | 1 |
| Akiyama, H; Kikuchi, H; Nemoto, S; Okura, T; Sakai, T | 1 |
| Brophy, PM; MacKintosh, ND; Morphew, RM; Stuart, RB; Witikornkul, B; Zwaanswijk, S | 1 |
| Beltrán, JF; Fonseca-Salamanca, F; Olivares-Ferretti, P; Salazar, LA | 1 |
1 trial(s) available for triclabendazole sulfoxide and triclabendazole
| Article | Year |
|---|---|
Pharmacokinetic disposition of triclabendazole in cattle and sheep; discrimination of the order and the rate of the absorption process of its active metabolite triclabendazole sulfoxide.
Topics: Animals; Anthelmintics; Benzimidazoles; Biological Availability; Cattle; Female; Intestinal Absorption; Sheep; Sulfoxides; Triclabendazole | 2008 |
29 other study(ies) available for triclabendazole sulfoxide and triclabendazole
| Article | Year |
|---|---|
Fasciola hepatica: tegumental surface changes in adult and juvenile flukes following treatment in vitro with the sulphoxide metabolite of triclabendazole (Fasinex).
Topics: Aging; Animals; Anthelmintics; Benzimidazoles; Epidermis; Fasciola hepatica; Microscopy, Electron, Scanning; Rats; Rats, Wistar; Sulfoxides; Triclabendazole | 1993 |
Fasciola hepatica: disruption of the vitelline cells in vitro by the sulphoxide metabolite of triclabendazole.
Topics: Animals; Anthelmintics; Benzimidazoles; Cell Nucleolus; Endoplasmic Reticulum; Fasciola hepatica; Male; Microscopy, Electron; Rats; Rats, Wistar; Sulfoxides; Time Factors; Triclabendazole | 1996 |
Fasciola gigantica: tegumental surface alterations following treatment in vitro with the sulphoxide metabolite of triclabendazole.
Topics: Animals; Anthelmintics; Benzimidazoles; Epidermis; Fasciola hepatica; In Vitro Techniques; Microscopy, Electron, Scanning; Sulfoxides; Time Factors; Triclabendazole | 2002 |
The comparative metabolism of triclabendazole sulphoxide by triclabendazole-susceptible and triclabendazole-resistant Fasciola hepatica.
Topics: Albendazole; Animals; Anthelmintics; Benzimidazoles; Biotransformation; Chromatography, High Pressure Liquid; Drug Resistance; Fasciola hepatica; Sheep; Sulfones; Sulfoxides; Triclabendazole | 2004 |
Response of two isolates of Fasciola hepatica to treatment with triclabendazole in vivo and in vitro.
Topics: Animals; Antiplatyhelmintic Agents; Benzimidazoles; Cattle; Cattle Diseases; Fasciola hepatica; Fascioliasis; Female; Male; Parasitic Sensitivity Tests; Rats; Rats, Sprague-Dawley; Sheep; Sheep Diseases; Sulfoxides; Triclabendazole | 2004 |
Drug transport mechanisms in helminth parasites: passive diffusion of benzimidazole anthelmintics.
Topics: Animals; Anthelmintics; Ascaris suum; Benzimidazoles; Biological Transport; Cattle; Cestoda; Diffusion; Fasciola hepatica; Female; Fenbendazole; Linear Models; Monieziasis; Sheep; Sulfoxides; Swine; Triclabendazole | 2006 |
Assessment of the main metabolism pathways for the flukicidal compound triclabendazole in sheep.
Topics: Animals; Animals, Newborn; Anthelmintics; Benzimidazoles; Enzyme Inhibitors; Fasciola hepatica; Fascioliasis; Male; Microsomes, Liver; Sheep; Sheep Diseases; Stomach, Ruminant; Sulfoxides; Triclabendazole | 2006 |
Triclabendazole and its two main metabolites lack activity against Schistosoma mansoni in the mouse model.
Topics: Animals; Anthelmintics; Benzimidazoles; Disease Models, Animal; Feces; Female; Liver; Male; Mesenteric Veins; Mice; Parasite Egg Count; Praziquantel; Schistosoma mansoni; Schistosomiasis mansoni; Sulfoxides; Triclabendazole | 2006 |
Resistance-induced changes in triclabendazole transport in Fasciola hepatica: ivermectin reversal effect.
Topics: Albendazole; Animals; Anthelmintics; Antiparasitic Agents; Benzimidazoles; Drug Resistance; Fasciola hepatica; Ivermectin; Sheep; Sulfoxides; Triclabendazole | 2006 |
Relative activity of triclabendazole metabolites against the liver fluke, Fasciola hepatica.
Topics: Animals; Anthelmintics; Benzimidazoles; Fasciola hepatica; Sulfoxides; Triclabendazole | 2009 |
Detoxifying and anti-oxidant enzymes of Fasciola gigantica worms under triclabendazole sulphoxide (TCBZ-SX): an in vitro study.
Topics: Animals; Anthelmintics; Benzimidazoles; Fasciola; Glutathione; Peroxidases; Sulfoxides; Triclabendazole | 2009 |
Unchanged triclabendazole kinetics after co-administration with ivermectin and methimazole: failure of its therapeutic activity against triclabendazole-resistant liver flukes.
Topics: Animals; Anthelmintics; Area Under Curve; Benzimidazoles; Drug Resistance; Drug Therapy, Combination; Fasciola hepatica; Fascioliasis; Ivermectin; Male; Methimazole; Random Allocation; Sheep; Sheep Diseases; Sulfoxides; Triclabendazole | 2010 |
Potentiation of triclabendazole sulphoxide-induced tegumental disruption by methimazole in a triclabendazole-resistant isolate of Fasciola hepatica.
Topics: Animals; Anthelmintics; Benzimidazoles; Drug Resistance; Fasciola hepatica; Male; Methimazole; Microscopy, Electron, Transmission; Rats; Rats, Sprague-Dawley; Sulfoxides; Triclabendazole | 2010 |
Residual concentrations of the flukicidal compound triclabendazole in dairy cows' milk and cheese.
Topics: Animals; Anthelmintics; Benzimidazoles; Biotransformation; Cattle; Cheese; Chromatography, High Pressure Liquid; Drug Residues; Female; Food Contamination; Half-Life; Lactation; Limit of Detection; Milk; Reproducibility of Results; Sulfones; Sulfoxides; Tissue Distribution; Triclabendazole; Veterinary Drugs | 2011 |
Inhibition of triclabendazole metabolism in vitro by ketoconazole increases disruption to the tegument of a triclabendazole-resistant isolate of Fasciola hepatica.
Topics: Animals; Anthelmintics; Benzimidazoles; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Resistance; Drug Synergism; Fasciola hepatica; Fascioliasis; Golgi Apparatus; Ketoconazole; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Mitochondria; NADP; Rats; Rats, Sprague-Dawley; Sulfoxides; Triclabendazole | 2011 |
Development of an egg hatch assay for the diagnosis of triclabendazole resistance in Fasciola hepatica: proof of concept.
Topics: Analysis of Variance; Animals; Antiplatyhelmintic Agents; Benzimidazoles; Cattle; Cattle Diseases; Dose-Response Relationship, Drug; Drug Resistance; Fasciola hepatica; Ovum; Parasitic Sensitivity Tests; Sheep; Sheep Diseases; Species Specificity; Sulfoxides; Triclabendazole | 2012 |
The anthelmintic triclabendazole and its metabolites inhibit the membrane transporter ABCG2/BCRP.
Topics: Animals; Anthelmintics; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzimidazoles; Cell Line; Chromatography, High Pressure Liquid; Dogs; Enzyme Activation; Female; Humans; Male; Mice; Mice, Knockout; Sulfoxides; Triclabendazole | 2012 |
Isothermal microcalorimetry to study the activity of triclabendazole and its metabolites on juvenile and adult Fasciola hepatica.
Topics: Animals; Anthelmintics; Benzimidazoles; Calorimetry; Fasciola hepatica; Fascioliasis; Movement; Rats; Sulfones; Sulfoxides; Thermogenesis; Triclabendazole | 2013 |
Effects of Mirazid(®) and myrrh volatile oil on adult Fasciola gigantica under laboratory conditions.
Topics: Animals; Anthelmintics; Benzimidazoles; Commiphora; Fasciola; Microscopy, Electron, Scanning; Resins, Plant; Sulfoxides; Terpenes; Triclabendazole | 2012 |
Effect of the P-glycoprotein inhibitor, R(+)-verapamil on the drug susceptibility of a triclabendazole-resistant isolate of Fasciola hepatica.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; Benzimidazoles; Drug Resistance; Fasciola hepatica; Fascioliasis; Male; Microscopy, Electron, Scanning; Rats; Rats, Sprague-Dawley; Sulfoxides; Triclabendazole; Verapamil | 2013 |
Increased susceptibility of a triclabendazole (TCBZ)-resistant isolate of Fasciola hepatica to TCBZ following co-incubation in vitro with the P-glycoprotein inhibitor, R(+)-verapamil.
Topics: Animals; Anthelmintics; Benzimidazoles; Drug Resistance; Fasciola hepatica; Male; Microscopy, Electron, Scanning; Random Allocation; Rats; Rats, Sprague-Dawley; Sulfoxides; Triclabendazole; Verapamil | 2013 |
Effects of triclabendazole on secretion of danofloxacin and moxidectin into the milk of sheep: role of triclabendazole metabolites as inhibitors of the ruminant ABCG2 transporter.
Topics: Animals; Antiplatyhelmintic Agents; ATP-Binding Cassette Transporters; Benzimidazoles; Cattle; Chromatography, High Pressure Liquid; Dogs; Drug Combinations; Female; Fluoroquinolones; Lactation; Macrolides; Madin Darby Canine Kidney Cells; Milk; Sheep, Domestic; Sulfoxides; Triclabendazole | 2013 |
Time-course and accumulation of triclabendazole and its metabolites in bile, liver tissues and flukes collected from treated sheep.
Topics: Animals; Anthelmintics; Area Under Curve; Benzimidazoles; Bile; Fasciola hepatica; Fascioliasis; Liver; Male; Sheep; Sheep Diseases; Sulfones; Sulfoxides; Triclabendazole | 2014 |
Triclabendazole sulfoxide causes stage-dependent embryolethality in zebrafish and mouse in vitro.
Topics: Animals; Benzimidazoles; Embryo Culture Techniques; Embryo Implantation; Embryo, Mammalian; Embryo, Nonmammalian; Female; Mice; Mice, Inbred C57BL; Rats, Sprague-Dawley; Sulfoxides; Triclabendazole; Zebrafish | 2015 |
Enantiomers of triclabendazole sulfoxide: Analytical and semipreparative HPLC separation, absolute configuration assignment, and transformation into sodium salt.
Topics: Benzimidazoles; Chromatography, High Pressure Liquid; Hexanes; Sodium; Stereoisomerism; Sulfoxides; Triclabendazole | 2017 |
In Vitro Drug-Drug Interaction Potential of Sulfoxide and/or Sulfone Metabolites of Albendazole, Triclabendazole , Aldicarb, Methiocarb, Montelukast and Ziprasidone.
Topics: Acetates; Albendazole; Aldicarb; Biotransformation; Cyclopropanes; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Humans; Isoenzymes; Methiocarb; Microsomes, Liver; Piperazines; Quinolines; Risk Assessment; Sulfides; Sulfones; Sulfoxides; Thiazoles; Triclabendazole | 2018 |
Total determination of triclabendazole and its metabolites in bovine tissues using liquid chromatography-tandem mass spectrometry.
Topics: Adipose Tissue; Animals; Cattle; Chromatography, Liquid; Drug Residues; Linear Models; Liver; Muscle, Skeletal; Reproducibility of Results; Sensitivity and Specificity; Sulfoxides; Tandem Mass Spectrometry; Tissue Distribution; Triclabendazole | 2019 |
The soluble glutathione transferase superfamily: role of Mu class in triclabendazole sulphoxide challenge in Fasciola hepatica.
Topics: Animals; Anthelmintics; Drug Resistance; Fasciola hepatica; Glutathione Transferase; Helminth Proteins; Isoenzymes; Proteomics; Sulfoxides; Triclabendazole | 2021 |
Protein Modelling and Molecular Docking Analysis of Fasciola hepatica β-Tubulin's Interaction Sites, with Triclabendazole, Triclabendazole Sulphoxide and Triclabendazole Sulphone.
Topics: Animals; Anthelmintics; Benzimidazoles; Fasciola hepatica; Fascioliasis; Ligands; Molecular Docking Simulation; Sulfones; Triclabendazole; Tubulin | 2023 |