trichostatin-a has been researched along with microcystin* in 1 studies
1 other study(ies) available for trichostatin-a and microcystin
| Article | Year |
|---|---|
Histone acetylation plays an important role in MC-LR-induced apoptosis and cycle disorder in SD rat testicular cells.
Microcystin-leucine arginine (MC-LR) is a variant of microcystins (MCs), which poses a serious threat to the reproductive system. Histone acetylation modification can regulate the expressions of apoptosis-related genes. However the mechanisms of histone acetylation involving MC-LR-induced apoptosis were not understood. This study investigated the change of histone acetylation and its role in apoptosis and cell cycle arrest induced by MC-LR. MC-LR enhanced the activity of histone deacetylase (HDAC), decreased the activity of histone acetylase (HAT), up-regulated the expression of HDAC1, and down-regulated the expressions of Ac-H3 and Ac-H4 in vitro and vivo. Meanwhile, MC-LR induced testicular tissue injury and increased the expressions of apoptosis-related genes, such as Bax, Caspase3 and Caspase8, ultimately causing cells apoptosis in testicular tissues. Furthermore, MC-LR also induced cell cycle arrest in S phase, increased the expression of P21 Topics: Acetylation; Animals; Apoptosis; Arginine; Cell Cycle; Histones; Humans; Hydroxamic Acids; Male; Microcystins; Rats; Rats, Sprague-Dawley; Reproduction; Testis | 2020 |