trichostatin-a and fosbretabulin

trichostatin-a has been researched along with fosbretabulin* in 1 studies

Other Studies

1 other study(ies) available for trichostatin-a and fosbretabulin

Article	Year
Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4. Journal of medicinal chemistry, 2018, Aug-09, Volume: 61, Issue:15 Designing multitarget drugs have raised considerable interest due to their advantages in the treatment of complex diseases such as cancer. Their design constitutes a challenge in antitumor drug discovery. The present study reports a dual inhibition of tubulin polymerization and HDAC activity. On the basis of 1,1-diarylethylenes ( isoCA-4) and belinostat, a series of hybrid molecules was successfully designed and synthesized. In particular compounds, 5f and 5h were proven to be potent inhibitors of both tubulin polymerization and HDAC8 leading to excellent antiproliferative activity. Topics: Antineoplastic Agents; Cell Proliferation; Chemistry Techniques, Synthetic; Drug Design; HCT116 Cells; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; K562 Cells; Protein Conformation; Stilbenes; Tubulin	2018

Article

Year

Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4.

Journal of medicinal chemistry, 2018, Aug-09, Volume: 61, Issue:15

Designing multitarget drugs have raised considerable interest due to their advantages in the treatment of complex diseases such as cancer. Their design constitutes a challenge in antitumor drug discovery. The present study reports a dual inhibition of tubulin polymerization and HDAC activity. On the basis of 1,1-diarylethylenes ( isoCA-4) and belinostat, a series of hybrid molecules was successfully designed and synthesized. In particular compounds, 5f and 5h were proven to be potent inhibitors of both tubulin polymerization and HDAC8 leading to excellent antiproliferative activity.

Topics: Antineoplastic Agents; Cell Proliferation; Chemistry Techniques, Synthetic; Drug Design; HCT116 Cells; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; K562 Cells; Protein Conformation; Stilbenes; Tubulin

2018