trichostatin-a has been researched along with depudecin* in 1 studies
1 other study(ies) available for trichostatin-a and depudecin
| Article | Year |
|---|---|
A novel compound, depudecin, induces production of transformation to the flat phenotype of NIH3T3 cells transformed by ras-oncogene.
A novel compound, depudecin, induced production of the flat phenotype of Ki-ras-transformed NIH3T3 cells at the low concentration of 1 microgram/ml. This effect was reversible. Actin stress fiber was detected in these cells after depudecin treatment. Almost complete reversion to the flat phenotype was observed at 6 h after depudecin addition. The synthesis of ras-mRNA did not decrease enough with depudecin treatment at the concentration of 10 micrograms/ml to reverse the transformed morphology. Topics: 3T3 Cells; Actins; Alkadienes; Animals; Antifungal Agents; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; Epoxy Compounds; Fatty Alcohols; Gene Expression; Genes, ras; Hydroxamic Acids; Kinetics; Mice; Phenotype; RNA, Messenger | 1992 |