trichostatin-a has been researched along with 2-3-trimethylene-4-quinazolone* in 1 studies
1 other study(ies) available for trichostatin-a and 2-3-trimethylene-4-quinazolone
| Article | Year |
|---|---|
Accommodation of ring C expanded deoxyvasicinone in the HDAC inhibitory pharmacophore culminates into a tractable anti-lung cancer agent and pH-responsive nanocarrier.
A fragment recruitment process was conducted to pinpoint a suitable fragment for installation in the HDAC inhibitory template to furnish agents endowed with the potential to treat lung cancer. Resultantly, Ring C expanded deoxyvasicinone was selected as an appropriate surface recognition part that was accommodated in the HDAC three-component model. Delightfully, fused quinazolinone 6 demonstrating a magnificent anticancer profile against KRAS and EGFR mutant lung cancer cell lines (IC Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Histone Deacetylase Inhibitors; Hydrogen-Ion Concentration; Lung Neoplasms; Mice; Nanoparticle Drug Delivery System; Quinazolines; Quinazolinones | 2022 |