Page last updated: 2024-08-22

tricalcium phosphate and tetracycline

tricalcium phosphate has been researched along with tetracycline in 40 studies

Research

Studies (40)

Timeframe	Studies, this research(%)	All Research%
pre-1990	14 (35.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	16 (40.00)	29.6817
2010's	8 (20.00)	24.3611
2020's	2 (5.00)	2.80

Authors

Authors	Studies
Nygaard, VK; Simmelink, JW	1
Evans, GH; Mabry, TW; Mayer, ET; Sepe, WW; Yukna, RA	1
Berry, JL; Geiger, JM; Greenwald, AS; Moran, JM; Skraba, JS	1
Münzenberg, KJ; Rössler, H	1
Beck, CW; Spangenberg, DB	1
Past, WL	1
Jankovich, JP	1
Eger, W; Gattow, G; Kämmerer, H	1
Storey, E; West, VC	1
Kaitila, I	1
Gassner, E; Sayegh, FS	1
Gassner, E; Iida, T; Sayegh, FS	1
Burchell, RH; Corcoran, JF; Dziewiatkowski, D; Zillich, RM	1
Figiel, I; Jaworski, J; Kaczmarek, L; Proszynski, T	1
Berger, G; Driessens, FC; Fitzner, R; Gildenhaar, R; Gross, U; Knabe, C; Planell, JA; Radlanski, RJ; Reif, D	1
Best, SM; Freche, M; Gibson, IR; Lacout, JL; Ratier, A; Rodriguez, F	1
Chow, LC; Fujikawa, K; Kusama, K; Murai, S; Nishiyama, M; Sugawara, A; Takagi, S	1
Chen, X; Dohn, M; Nozell, S; Willis, A	1
BECK, CW; MULVANEY, WP; QURESHI, MA	1
Song, Z; Yin, G; Zheng, C; Zhou, D	1
Freche, M; Lacout, JL; Ratier, A; Rodriguez, F	1
Kim, HE; Kim, HW; Knowles, JC	1
Ito, A; Oyane, A; Uchida, M; Yokoyama, Y	1
Nevins, ML	1
Cortés, ME; Lopes, MT; Oliveira, MF; Pataro, AL; Sinisterra, RD; Teixeira, KI; Turchetti-Maia, RM; Wykrota, FH	1
Barralet, JE; Gbureck, U; Müller, FA; Vorndran, E	1
Büchi, R; Burckhardt-Herold, S; Funk, F; Geisser, P; Klotz, J; Petrig-Schaffland, J	1
Cochran, DL; Mellonig, JT; Ridgway, HK	1
Liu, Y; Mao, J; Yao, L; Zhou, B	1
Ball, MD; O'Connor, D; Pandit, A	1
Davies, JE; Kuzyk, PR; Schemitsch, EH	1
Hess, C; Luginbuehl, V; Nuss, K; Reichardt, D; Ruffieux, K; von Rechenberg, B	1
Gbureck, U; Germershaus, O; Jones, DB; Kissel, T; Kratz, M; Schnieders, J	1
Gandhimathi, C; Kumar, SD; Ramakrishna, S; Tham, AY; Venugopal, JR	1
Chen, L; Markel, DC; Matthew, H; Muzik, O; Ren, W; Shi, T; Song, W	1
Banik, M; Basu, T; Dutta, D; Mukherjee, R; Patra, M	1
Doble, M; Madhumathi, K; Rubaiya, Y; Sampath Kumar, TS; Venkateswari, R	1
Basu, T; Chatterjee, B; Dutta, D; Mukherjee, R; Patra, M	1
Almirall, A; Campos Mora, Y; Chan, A; Cruz, LJ; Fuentes, G; Hernández, AK; Morilla, C; Perdomo, E; Regalado, R; Schomann, T	1
Cao, Y; Mozaffari, MS; Qin, X; Sun, X; Xu, L; Yan, D	1

Reviews

1 review(s) available for tricalcium phosphate and tetracycline

Article	Year
[Significance of bone minerals for the physiology, physiopathology and clinical management of the bones]. Deutsche medizinische Wochenschrift (1946), 1970, Aug-14, Volume: 95, Issue:33 Topics: Apatites; Bone and Bones; Bone Transplantation; Calcium Phosphates; Collagen; Crystallins; Fluorine; Glycosaminoglycans; Humans; Strontium; Tetracycline; Transplantation, Autologous; Vitamin D	1970

Trials

1 trial(s) available for tricalcium phosphate and tetracycline

Article	Year
Effect of various graft materials with tetracycline in localized juvenile periodontitis. Journal of periodontology, 1989, Volume: 60, Issue:9 Topics: Adolescent; Adult; Aggressive Periodontitis; Alveolar Process; Alveoloplasty; Biocompatible Materials; Bone Transplantation; Calcium Phosphates; Ceramics; Durapatite; Female; Gingiva; Humans; Hydroxyapatites; Male; Periodontal Diseases; Periodontal Pocket; Prostheses and Implants; Surgical Flaps; Tetracycline	1989

Article

Year

Effect of various graft materials with tetracycline in localized juvenile periodontitis.

Journal of periodontology, 1989, Volume: 60, Issue:9

Topics: Adolescent; Adult; Aggressive Periodontitis; Alveolar Process; Alveoloplasty; Biocompatible Materials; Bone Transplantation; Calcium Phosphates; Ceramics; Durapatite; Female; Gingiva; Humans; Hydroxyapatites; Male; Periodontal Diseases; Periodontal Pocket; Prostheses and Implants; Surgical Flaps; Tetracycline

1989

Other Studies

38 other study(ies) available for tricalcium phosphate and tetracycline

Article	Year
Disturbances and defects in enamel development. Journal of dental research, 1979, Volume: 58, Issue:Spec Issue Topics: Acid Phosphatase; Ameloblasts; Amelogenesis; Animals; Calcium Phosphates; Crystallography; Dental Enamel; Dental Enamel Proteins; Fluorides; Organoids; Rats; Tetracycline; Tooth Diseases	1979
Use of tricalcium phosphate or electrical stimulation to enhance the bone-porous implant interface. Journal of biomedical materials research, 1986, Volume: 20, Issue:1 Topics: Animals; Bone and Bones; Calcium Phosphates; Dogs; Drug Implants; Electric Stimulation; Surface Properties; Tetracycline; Time Factors	1986
Tetracycline effects on statolith and nematocyst differentiation in Aurelia. Calcified tissue research, 1972, Volume: 9, Issue:2 Topics: Animals; Apatites; Calcification, Physiologic; Calcium; Calcium Carbonate; Calcium Phosphates; Cnidaria; Ions; Microscopy, Fluorescence; Sulfates; Tetracycline	1972
Microinterferometry of developing bone mineral. Calcified tissue research, 1974, Volume: 15, Issue:4 Topics: Animals; Apatites; Calcium Phosphates; Femur; Mice; Microscopy, Interference; Osteogenesis; Tetracycline; Time Factors	1974
The effects of mechanical vibration on bone development in the rat. Journal of biomechanics, 1972, Volume: 5, Issue:3 Topics: Aging; Animals; Bone and Bones; Bone Development; Calcium; Calcium Phosphates; Elasticity; Femur; Hardness; Male; Rats; Tetracycline; Tibia; Torsion Abnormality; Vibration	1972
[X-ray interferometry studies on tetracycline-labelled bone tissue]. Acta histochemica, 1967, Volume: 28, Issue:1 Topics: Animals; Apatites; Bone and Bones; Calcium Phosphates; Microscopy, Fluorescence; Rats; Rolitetracycline; Tetracycline; X-Ray Diffraction	1967
The in vitro effect of fluoride and tetracycline on phase transformation of a calcium phosphate. Calcified tissue research, 1972, Volume: 9, Issue:3 Topics: Calcium Phosphates; Color; Crystallization; Fluorine; Light; Temperature; Tetracycline; X-Ray Diffraction	1972
The mechanism by which tetracycline hydrochloride inhibits mineralization in vitro. Biochimica et biophysica acta, 1971, Sep-21, Volume: 244, Issue:3 Topics: Apatites; Calcium Chloride; Calcium Phosphates; Chemical Phenomena; Chemistry; Collagen; Crystallization; Hydrochloric Acid; Kinetics; Models, Biological; Osteogenesis; Phosphates; Potassium; Spectrum Analysis; Tetracycline; Tritium; X-Ray Diffraction	1971
The nature of tetracycline complex in hard tissue of bovine teeth. Archives of oral biology, 1968, Volume: 13, Issue:5 Topics: Animals; Binding Sites; Calcium Carbonate; Calcium Phosphates; Cattle; Dental Enamel; Dentin; In Vitro Techniques; Tetracycline	1968
Tetracycline in tumors. Oral surgery, oral medicine, and oral pathology, 1969, Volume: 28, Issue:3 Topics: Animals; Calcium Phosphates; Cricetinae; Male; Neoplasm Transplantation; Neoplasms, Experimental; Salivary Gland Neoplasms; Tetracycline	1969
A model system for the evaluation of techniques for destaining teeth containing tetracyclines. Journal of endodontics, 1984, Volume: 10, Issue:9 Topics: Calcium Phosphates; Durapatite; Humans; Hydrogen Peroxide; Hydroxyapatites; Models, Biological; Tetracycline; Tooth Bleaching; Tooth Discoloration	1984
Efficient expression of tetracycline-responsive gene after transfection of dentate gyrus neurons in vitro. Journal of neuroscience research, 2000, Jun-15, Volume: 60, Issue:6 Topics: Animals; Anti-Bacterial Agents; Calcium Phosphates; Cells, Cultured; Cytomegalovirus; Dentate Gyrus; Doxycycline; Gene Expression; Gene Expression Regulation; Green Fluorescent Proteins; Indicators and Reagents; Luminescent Proteins; Neurons; Promoter Regions, Genetic; Rats; Tetracycline; Transfection	2000
Evaluation of calcium phosphates and experimental calcium phosphate bone cements using osteogenic cultures. Journal of biomedical materials research, 2000, Dec-05, Volume: 52, Issue:3 Topics: Absorbable Implants; Alkaline Phosphatase; Animals; Bone Cements; Bone Marrow Cells; Bone Matrix; Calcium; Calcium Phosphates; Cell Count; Cells, Cultured; Ceramics; Culture Media, Conditioned; Evaluation Studies as Topic; Materials Testing; Microscopy, Electron, Scanning; Osteogenesis; Phosphates; Potassium; Rats; Rats, Wistar; Spectrometry, X-Ray Emission; Tetracycline	2000
Setting characteristics and mechanical behaviour of a calcium phosphate bone cement containing tetracycline. Biomaterials, 2001, Volume: 22, Issue:9 Topics: Bone Cements; Calcium Phosphates; Materials Testing; Microscopy, Electron, Scanning; Tetracycline; X-Ray Diffraction	2001
Fluorescent labeling analysis and electron probe microanalysis for alveolar ridge augmentation using calcium phosphate cement. Dental materials journal, 2002, Volume: 21, Issue:4 Topics: Alveolar Process; Alveolar Ridge Augmentation; Animals; Anthraquinones; Bone Cements; Bone Substitutes; Calcification, Physiologic; Calcium; Calcium Phosphates; Dental Implants; Dogs; Electron Probe Microanalysis; Fluoresceins; Fluorescent Dyes; Magnesium; Mandible; Microscopy, Fluorescence; Osseointegration; Osteogenesis; Phosphorus; Surface Properties; Tetracycline; Time Factors	2002
Tumor suppressor gene-inducible cell lines. Methods in molecular biology (Clifton, N.J.), 2003, Volume: 223 Topics: Calcium Phosphates; Cell Division; Cell Line; Cell Line, Tumor; Ecdysone; Genes, Tumor Suppressor; Genetic Techniques; Humans; Liposomes; Models, Biological; Plasmids; Receptors, Estrogen; Recombinant Fusion Proteins; Tetracycline; Transfection	2003
DEPOSITION OF TETRACYCLINES IN URINARY CALCULI. JAMA, 1964, Dec-21, Volume: 190 Topics: Animals; Calcium Carbonate; Calcium Phosphates; Chemistry Techniques, Analytical; Dogs; Fluorescence; Fluorometry; Magnesium; Oxalates; Oxytetracycline; Tetracycline; Tetracyclines; Toxicology; Ultraviolet Rays; Urinary Calculi	1964
[In vitro release of tetracycline hydrochloride from alpha-TCP cement]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi, 2003, Volume: 20, Issue:4 Topics: Anti-Bacterial Agents; Biocompatible Materials; Bone Cements; Calcium Phosphates; Diffusion; Drug Carriers; In Vitro Techniques; Tetracycline; X-Ray Diffraction	2003
Behaviour of an injectable calcium phosphate cement with added tetracycline. International journal of pharmaceutics, 2004, Apr-15, Volume: 274, Issue:1-2 Topics: Calcium Phosphates; Dental Cements; Microscopy, Electron, Scanning; Solubility; Tetracycline	2004
Effect of biphasic calcium phosphates on drug release and biological and mechanical properties of poly(epsilon-caprolactone) composite membranes. Journal of biomedical materials research. Part A, 2004, Sep-01, Volume: 70, Issue:3 Topics: Animals; Anti-Bacterial Agents; Biocompatible Materials; Calcium Phosphates; Cell Line, Tumor; Drug Delivery Systems; Elasticity; Guided Tissue Regeneration; Humans; Materials Testing; Membranes, Artificial; Osteoblasts; Polyesters; Stress, Mechanical; Surface Properties; Tensile Strength; Tetracycline	2004
The formation of an antibacterial agent-apatite composite coating on a polymer surface using a metastable calcium phosphate solution. Biomaterials, 2006, Volume: 27, Issue:17 Topics: Anti-Bacterial Agents; Apatites; Biocompatible Materials; Bone Substitutes; Calcium; Calcium Compounds; Calcium Phosphates; Dose-Response Relationship, Drug; Escherichia coli; Fluoroquinolones; Gatifloxacin; Ions; Kinetics; Lactoferrin; Materials Testing; Microscopy, Electron, Scanning; Phosphates; Polymers; Solutions; Spectrometry, X-Ray Emission; Staphylococcus aureus; Tetracycline; Time Factors	2006
Aesthetic and regenerative oral plastic surgery: clinical applications in tissue engineering. Dentistry today, 2006, Volume: 25, Issue:10 Topics: Alveolar Bone Loss; Anti-Bacterial Agents; Becaplermin; Bone Substitutes; Bone Transplantation; Calcium Phosphates; Connective Tissue; Dental Enamel Proteins; Esthetics, Dental; Female; Follow-Up Studies; Furcation Defects; Gingiva; Gingival Recession; Guided Tissue Regeneration, Periodontal; Humans; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Recombinant Proteins; Root Planing; Tetracycline; Tissue Engineering	2006
Polymer: bioceramic composites optimization by tetracycline addition. International journal of pharmaceutics, 2007, May-04, Volume: 336, Issue:1 Topics: Animals; Bone Substitutes; Calcium Phosphates; Cell Adhesion; Cell Line; Cell Survival; Ceramics; Durapatite; Fibroblasts; Implants, Experimental; Inflammation; Lactic Acid; Male; Materials Testing; Mice; Microscopy, Electron, Scanning; Polyesters; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Porosity; Subcutaneous Tissue; Surface Properties; Tetracycline	2007
Low temperature direct 3D printed bioceramics and biocomposites as drug release matrices. Journal of controlled release : official journal of the Controlled Release Society, 2007, Sep-26, Volume: 122, Issue:2 Topics: Adsorption; Anti-Bacterial Agents; Biocompatible Materials; Calcium Phosphates; Chemistry, Pharmaceutical; Drug Carriers; Drug Compounding; Drug Implants; Durapatite; Kinetics; Models, Chemical; Ofloxacin; Polyesters; Polyglycolic Acid; Porosity; Powders; Solubility; Surface Properties; Technology, Pharmaceutical; Temperature; Tetracycline; Vancomycin	2007
Interactions between iron(III)-hydroxide polymaltose complex and commonly used drugs / simulations and in vitro studies. Arzneimittel-Forschung, 2007, Volume: 57, Issue:6A Topics: Acetaminophen; Anaerobiosis; Ascorbic Acid; Aspartic Acid; Beverages; Calcium Phosphates; Citrus sinensis; Drug Interactions; Ferric Compounds; Food-Drug Interactions; Hydrogen-Ion Concentration; Indicators and Reagents; Methyldopa; Salicylic Acid; Spectrophotometry, Ultraviolet; Tetracycline	2007
Human histologic and clinical evaluation of recombinant human platelet-derived growth factor and beta-tricalcium phosphate for the treatment of periodontal intraosseous defects. The International journal of periodontics & restorative dentistry, 2008, Volume: 28, Issue:2 Topics: Adult; Aged; Alveolar Bone Loss; Alveolar Process; Angiogenesis Inducing Agents; Anti-Bacterial Agents; Becaplermin; Biocompatible Materials; Bone Substitutes; Calcium Phosphates; Debridement; Dental Cementum; Dental Scaling; Female; Follow-Up Studies; Gingival Recession; Guided Tissue Regeneration, Periodontal; Humans; Male; Middle Aged; Periodontal Attachment Loss; Periodontal Ligament; Periodontal Pocket; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Recombinant Proteins; Root Planing; Surgical Flaps; Tetracycline	2008
The effect of premixed schedule on the crystal formation of calcium phosphate cement-chitosan composite with added tetracycline. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 2008, Volume: 28, Issue:4 Topics: Biocompatible Materials; Bone Cements; Calcium Phosphates; Chitosan; Dental Cements; Phosphates; Tetracycline; X-Ray Diffraction	2008
Use of tissue transglutaminase and fibronectin to influence osteoblast responses to tricalcium phosphate scaffolds. Journal of materials science. Materials in medicine, 2009, Volume: 20, Issue:1 Topics: Alkaline Phosphatase; Biocompatible Materials; Calcium Phosphates; Cell Adhesion; Cell Differentiation; Cell Line; Collagen; DNA; Fibronectins; Humans; Materials Testing; Microscopy, Electron, Scanning; Osteoblasts; Tetracycline; Tissue Scaffolds; Transglutaminases; X-Ray Diffraction	2009
A biodegradable scaffold for the treatment of a diaphyseal bone defect of the tibia. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2010, Volume: 28, Issue:4 Topics: Absorbable Implants; Animals; Bone Substitutes; Bone Transplantation; Calcium Phosphates; Disease Models, Animal; Dogs; Fluoresceins; Fluorescent Dyes; Fracture Fixation, Intramedullary; Fracture Healing; Ilium; Lactic Acid; Neovascularization, Physiologic; Osteogenesis; Osteotomy; Phenols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Radiography; Sulfoxides; Tetracycline; Tibial Fractures; Time Factors; Tissue Scaffolds; Transplantation, Homologous; Xylenes	2010
Controlled release of tetracycline from biodegradable beta-tricalcium phosphate composites. Journal of biomedical materials research. Part B, Applied biomaterials, 2010, Volume: 92, Issue:2 Topics: Absorbable Implants; Animals; Anti-Bacterial Agents; Biocompatible Materials; Calcium Phosphates; Cell Line; Cell Survival; CHO Cells; Chromatography, High Pressure Liquid; Cricetinae; Cricetulus; Drug Delivery Systems; Granuloma, Foreign-Body; Lactic Acid; Materials Testing; Microscopy, Electron, Scanning; Osteoblasts; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Sheep; Tetracycline	2010
Ex vivo human trabecular bone model for biocompatibility evaluation of calcium phosphate composites modified with spray dried biodegradable microspheres. Advanced healthcare materials, 2013, Volume: 2, Issue:10 Topics: Alkaline Phosphatase; Biocompatible Materials; Bone and Bones; Bone Cements; Calcium Phosphates; Cells, Cultured; Humans; Hydrogen-Ion Concentration; Interleukin-1beta; Interleukin-6; L-Lactate Dehydrogenase; Lactic Acid; Microspheres; Models, Biological; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Tetracycline; Tumor Necrosis Factor-alpha	2013
Biomimetic hybrid nanofibrous substrates for mesenchymal stem cells differentiation into osteogenic cells. Materials science & engineering. C, Materials for biological applications, 2015, Volume: 49 Topics: Alkaline Phosphatase; Ascorbic Acid; Biocompatible Materials; Biomimetic Materials; Biomimetics; Calcium Phosphates; Cell Differentiation; Cell Proliferation; Cells, Cultured; Durapatite; Extracellular Matrix; Fibroins; Humans; Hydrophobic and Hydrophilic Interactions; Mesenchymal Stem Cells; Nanofibers; Nanostructures; Osteogenesis; Polyesters; Porosity; Regeneration; Tetracycline; Tissue Engineering; Tissue Scaffolds	2015
Flow perfusion culture of MC3T3-E1 osteogenic cells on gradient calcium polyphosphate scaffolds with different pore sizes. Journal of biomaterials applications, 2016, Volume: 30, Issue:7 Topics: 3T3 Cells; Alkaline Phosphatase; Animals; Bioreactors; Bone Substitutes; Calcium Phosphates; Cell Differentiation; Cell Proliferation; Fluorine Radioisotopes; Mice; Osteogenesis; Perfusion; Porosity; Positron-Emission Tomography; Stress, Mechanical; Tetracycline; Tissue Engineering; Tissue Scaffolds	2016
Tetracycline-loaded calcium phosphate nanoparticle (Tet-CPNP): Rejuvenation of an obsolete antibiotic to further action. Biochimica et biophysica acta, 2016, Volume: 1860, Issue:9 Topics: Animals; Anti-Bacterial Agents; Bacteria; Calcium Phosphates; Cell Membrane; Drug Resistance, Multiple, Bacterial; Larva; Nanoparticles; Particle Size; Protein Synthesis Inhibitors; Rejuvenation; Tetracycline; Zebrafish	2016
Antibacterial, anti-inflammatory, and bone-regenerative dual-drug-loaded calcium phosphate nanocarriers-in vitro and in vivo studies. Drug delivery and translational research, 2018, Volume: 8, Issue:5 Topics: 3T3 Cells; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Biocompatible Materials; Bone Regeneration; Calcium Phosphates; Delayed-Action Preparations; Disease Models, Animal; Drug Delivery Systems; Female; Hydroxyapatites; Ibuprofen; Mice; Nanoparticles; Periodontitis; Rats; Tetracycline	2018
Nanonized tetracycline cures deadly diarrheal disease 'shigellosis' in mice, caused by multidrug-resistant Shigella flexneri 2a bacterial infection. Nanomedicine : nanotechnology, biology, and medicine, 2019, Volume: 18 Topics: Animals; Calcium Phosphates; Colon; Colony Count, Microbial; Cytokines; Diarrhea; Drug Resistance, Multiple, Bacterial; Dysentery, Bacillary; Mice, Inbred BALB C; Nanoparticles; Particle Size; Shigella flexneri; Tetracycline	2019
Effect of the Addition of Alginate and/or Tetracycline on Brushite Cement Properties. Molecules (Basel, Switzerland), 2021, May-28, Volume: 26, Issue:11 Topics: 3T3-L1 Cells; Alginates; Animals; Anti-Bacterial Agents; Biocompatible Materials; Bone Cements; Bone Regeneration; Calcium Phosphates; Cell Proliferation; Cell Survival; Compressive Strength; Hydrogen-Ion Concentration; Mice; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Pressure; Stress, Mechanical; Tetracycline; Time Factors; Tissue Engineering; X-Ray Diffraction	2021
Hybrid system with stable structure of hard/soft tissue substitutes induces re-osseointegration in a rat model of biofilm-mediated peri-implantitis. Journal of biomedical materials research. Part B, Applied biomaterials, 2022, Volume: 110, Issue:11 Topics: Animals; Anti-Bacterial Agents; Biofilms; Calcium Phosphates; Cytokines; Dental Implants; Interleukin-6; Osseointegration; Peri-Implantitis; Rats; Tetracycline	2022