Page last updated: 2024-08-16

triazolam and midazolam

triazolam has been researched along with midazolam in 79 studies

Research

Studies (79)

Timeframe	Studies, this research(%)	All Research%
pre-1990	18 (22.78)	18.7374
1990's	15 (18.99)	18.2507
2000's	27 (34.18)	29.6817
2010's	18 (22.78)	24.3611
2020's	1 (1.27)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Blanco, R; Coles, R; Kharasch, ED; Mitchell, D	1
Lombardo, F; Obach, RS; Waters, NJ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Alelyunas, YW; Bui, K; Empfield, JR; McCarthy, D; Pelosi-Kilby, L; Shen, C; Spreen, RC	1
Baburin, I; Ebrahimi, SN; Eickmeier, E; Hamburger, M; Hering, S; Zaugg, J	1
Baburin, I; Eigenmann, D; Hamburger, M; Hering, S; Khom, S; Zaugg, J	1
Bracher, F; Fedorov, O; Filippakopoulos, P; Keller, M; Knapp, S; Morgenstern, O; Picaud, S; Wrobel, M	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Loeffler, PM	1
Sanger, DJ; Zivkovic, B	1
Amidon, GL; Goldberg, A; Lui, CY	1
Battegay, R; Lieberherr, S; Scollo-Lavizzari, G	1
Jones, CE; Martinez, LA; Merritt, GJ; Wians, FH	1
Bircher, J; Crevoisier, C; Sostmann, H; Sostmann, HJ	1
Gonzalez, FJ; Kronbach, T; Mathys, D; Meyer, UA; Umeno, M	1
Bixler, EO; Jacoby, JA; Kales, A; Kales, JD; Soldatos, CR	1
Christeller, S; Knüsel, R; Schelldorfer, K; Wehli, L	1
Forgo, I	1
Michenfelder, JD; Roald, OK; Stangland, K; Steen, PA	1
Francescangeli, MA; Gentili, P; Omicini, A	1
Christeller, S; Fabre, J; Hegelbach-Feller, DA; Tschopp, JM	1
Forrest, P; Galletly, DC; Yee, P	1
Hakkei, M; Kubota, A; Kuwahara, A; Nakamura, K	1
Bixler, EO; Kales, A; Kales, JD; Soldatos, CR	1
Acioli, A; Costa E Silva, JA; Ferreira, I; Jones Da Silva, C; Naylor, C	1
Marias, J; Scherschlicht, R	1
Eckert, M; Leishman, B; Schalch, E; Ziegler, WH	1
Borbély, AA; Loepfe, M; Mattmann, P; Tobler, I	1
Greenblatt, DJ; Shader, RI	1
Borbély, AA	1
Gandolfo, G; Gottesmann, C; Scherschlicht, R	1
Finder, RL; McGirl, BE; Moore, PA; Stopperich, PS; Weyant, RJ	1
Idänpään-Heikkilä, JJ; Mattila, MJ; Törnwall, M; Vanakoski, J	1
Meier-Abt, PJ; Radovanovic, D; Wyss, PA	1
Mattila, MJ; Seppälä, T; Vanakoski, J	1
Dionne, R	1
Cotreau, MM; Greenblatt, DJ; Perloff, MD; von Moltke, LL	1
Ator, NA	1
Bickel, WK; Smith, BJ	1
Balian, JD; Flockhart, DA; Yuan, R	1
Court, MH; Greenblatt, DJ; Kotegawa, T; Perloff, MD; Shader, RI; von Moltke, LL	1
France, CP; Gerak, LR; Lelas, S	1
Schrag, ML; Wienkers, LC	1
Cantrell, VE; Eckstein, J; Hall, SD; Hamman, MA; Jones, DR; Ring, BJ; Ruterbories, K; Williams, JA; Wrighton, SA	1
Feck, AS; Goodchild, JH; Silverman, MD	1
Greenblatt, DJ; Patki, KC; Von Moltke, LL	1
Chen, G; Greenblatt, DJ; Harmatz, JS; Jen, C; Kelley, CJ; LeDuc, BW; von Moltke, LL; Weemhoff, JL; Zinny, MA	1
Cook, J; Debold, JF; Gourley, SL; Miczek, KA; Yin, W	1
Masica, AL; Mayo, G; Wilkinson, GR	1
France, CP; McMahon, LR	1
Weaver, J	1
Benet, LZ	1
Baburin, I; Hering, S; Hohaus, A; Khom, S; Sieghart, W; Timin, EN	1
Dickson, SJ; Irving, RC	1
Lu, DP; Lu, WI	1
Court, MH; Farkas, D; Greenblatt, DJ; Harmatz, JS; Oleson, LE; Zhao, Y; Zinny, MA	1
Galetin, A; Hallifax, D; Houston, JB	1
Baburin, I; Hering, S; Hohaus, A; Khom, S; Sieghart, W; Timin, E	1
Mandrioli, R; Mercolini, L; Raggi, MA	1
Hanioka, N; Kuze, J; Morisaki, K; Mutoh, T; Nakura, H; Narimatsu, S; Takenaka, T	1
Court, MH; Duan, SX; Greenblatt, DJ; Harmatz, JS; Parent, SJ; Venkatakrishnan, K; von Moltke, LL; Zhao, Y	1
Weaver, JM	1
Barter, ZE; Cubitt, HE; Howgate, EM; Rostami-Hodjegan, A; Yeo, KR	1
Hanioka, N; Kuze, J; Mutoh, T; Narimatsu, S; Oda, N; Takenaka, T	1
Srinivas, NR	1
Imai, H; Iwao, M; Kotegawa, T; Nakano, S; Ohashi, K; Tsutsumi, K	1
Baneyx, G; Iliadis, A; Lavé, T; Meille, C; Parrott, N	1
Hamamura, S; Kamimura, H; Kato, K; Kawamura, A; Kazuki, Y; Nakada, N; Ohbuchi, M; Ohshita, H; Oshimura, M; Sato, K; Tateno, C; Usui, T	1
Cook, JM; Fischer, BD; Namjoshi, OA; Platt, DM; Rallapalli, SK; Rowlett, JK	1
Hasegawa, M; Tahara, H; Watanabe, M	1
Fiorello, MG; Lee, HJ; Peeler, CE; Subramanian, ML; Villani, CM	1
Gui, L; Hu, Y; Jia, W; Lan, K; Liu, C; Miao, J; Wang, C; Wei, W; Wu, Q; Zeng, W	1

Reviews

5 review(s) available for triazolam and midazolam

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Oral benzodiazepines and conscious sedation: a review. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 1992, Volume: 50, Issue:9 Topics: Administration, Oral; Alprazolam; Ambulatory Surgical Procedures; Anti-Anxiety Agents; Conscious Sedation; Diazepam; Flurazepam; Humans; Lorazepam; Midazolam; Oxazepam; Premedication; Receptors, GABA-A; Temazepam; Triazolam	1992
Rebound insomnia and elimination half-life: assessment of individual subject response. Journal of clinical pharmacology, 1985, Volume: 25, Issue:2 Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Flurazepam; Half-Life; Humans; Lorazepam; Midazolam; Middle Aged; Sleep Initiation and Maintenance Disorders; Substance Withdrawal Syndrome; Time Factors; Triazolam	1985
Pharmacokinetic and pharmacodynamic consequences of metabolism-based drug interactions with alprazolam, midazolam, and triazolam. Journal of clinical pharmacology, 1999, Volume: 39, Issue:11 Topics: Alprazolam; Anti-Anxiety Agents; Data Collection; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Humans; Itraconazole; Ketoconazole; Midazolam; Triazolam	1999
Benzodiazepine metabolism: an analytical perspective. Current drug metabolism, 2008, Volume: 9, Issue:8 Topics: Alprazolam; Animals; Anti-Anxiety Agents; Azepines; Benzodiazepines; Bromazepam; Chromatography, High Pressure Liquid; Diazepam; Humans; Lorazepam; Mass Spectrometry; Midazolam; Triazolam	2008

Trials

19 trial(s) available for triazolam and midazolam

Article	Year
Rapid clinical induction of hepatic cytochrome P4502B6 activity by ritonavir. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:5 Topics: Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Bupropion; Cross-Over Studies; Cytochrome P-450 CYP2B6; Female; HIV Protease Inhibitors; Humans; Liver; Male; Oxidoreductases, N-Demethylating; Ritonavir	2008
Dose equivalence of midazolam and triazolam. A psychometric study based on flicker sensitivity, reaction time and digit symbol substitution test. European journal of clinical pharmacology, 1989, Volume: 36, Issue:2 Topics: Adult; Double-Blind Method; Female; Flicker Fusion; Humans; Male; Midazolam; Perception; Psychometrics; Psychomotor Performance; Reaction Time; Self Concept; Sensory Thresholds; Triazolam	1989
Rebound insomnia and elimination half-life: assessment of individual subject response. Journal of clinical pharmacology, 1985, Volume: 25, Issue:2 Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Flurazepam; Half-Life; Humans; Lorazepam; Midazolam; Middle Aged; Sleep Initiation and Maintenance Disorders; Substance Withdrawal Syndrome; Time Factors; Triazolam	1985
Comparison of midazolam and triazolam for residual effects. Arzneimittel-Forschung, 1985, Volume: 35, Issue:11 Topics: Adult; Aircraft; Benzodiazepines; Circadian Rhythm; Double-Blind Method; Dreams; Humans; Male; Midazolam; Placebos; Psychomotor Performance; Random Allocation; Sleep; Triazolam; Work Schedule Tolerance	1985
[Treatment of situation-related sleep disorders with midazolam and triazolam--a comparative study of athletes]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1986, Feb-11, Volume: 75, Issue:7 Topics: Adult; Benzodiazepines; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Humans; Male; Midazolam; Random Allocation; Sleep Wake Disorders; Triazolam	1986
[Double-blind parallel comparison of midazolam and triazolam in sleep disorders in the aged]. La Clinica terapeutica, 1987, Jan-31, Volume: 120, Issue:2 Topics: Age Factors; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Midazolam; Middle Aged; Sleep Wake Disorders; Triazolam	1987
Comparison of the short-acting benzodiazepines midazolam and triazolam with placebo. Arzneimittel-Forschung, 1988, Volume: 38, Issue:3 Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Dreams; Female; Humans; Male; Midazolam; Middle Aged; Random Allocation; Sleep; Sleep Initiation and Maintenance Disorders; Triazolam	1988
Placebo controlled comparison of midazolam, triazolam and diazepam as oral premedicants for outpatient anaesthesia. Anaesthesia and intensive care, 1987, Volume: 15, Issue:3 Topics: Administration, Oral; Adult; Anesthesia Recovery Period; Anesthesia, General; Diazepam; Double-Blind Method; Humans; Midazolam; Middle Aged; Pain Measurement; Preanesthetic Medication; Random Allocation; Surveys and Questionnaires; Triazolam; Urologic Diseases	1987
Midazolam and triazolam in out-patients: a double-blind comparison of hypnotic efficacy. British journal of clinical pharmacology, 1983, Volume: 16 Suppl 1 Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Hypnotics and Sedatives; Male; Midazolam; Sleep Initiation and Maintenance Disorders; Triazolam	1983
Comparison of the effects of intravenously administered midazolam, triazolam and their hydroxy metabolites. British journal of clinical pharmacology, 1983, Volume: 16 Suppl 1 Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Humans; Hydroxylation; Injections, Intravenous; Male; Memory; Midazolam; Psychomotor Performance; Reaction Time; Triazolam	1983
Midazolam and triazolam: hypnotic action and residual effects after a single bedtime dose. Arzneimittel-Forschung, 1983, Volume: 33, Issue:10 Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Double-Blind Method; Female; Humans; Hypnotics and Sedatives; Male; Midazolam; Motor Activity; Psychomotor Performance; Sleep; Triazolam	1983
Oral triazolam pretreatment for intravenous sedation. Anesthesia progress, 1993, Volume: 40, Issue:4 Topics: Adolescent; Adult; Analysis of Variance; Anesthesia, Dental; Conscious Sedation; Dental Anxiety; Double-Blind Method; Female; Fentanyl; Humans; Male; Manifest Anxiety Scale; Methohexital; Midazolam; Pain Measurement; Preanesthetic Medication; Triazolam	1993
Oral single doses of erythromycin and roxithromycin may increase the effects of midazolam on human performance. Pharmacology & toxicology, 1993, Volume: 73, Issue:3 Topics: Administration, Oral; Adult; Brain; Capsules; Double-Blind Method; Drug Combinations; Drug Synergism; Erythromycin; Female; Humans; Male; Midazolam; Psychomotor Performance; Roxithromycin; Triazolam	1993
Grapefruit juice does not enhance the effects of midazolam and triazolam in man. European journal of clinical pharmacology, 1996, Volume: 50, Issue:6 Topics: Adult; Beverages; Citrus; Cross-Over Studies; Double-Blind Method; Erythromycin; Female; Food-Drug Interactions; Humans; Hypnotics and Sedatives; Male; Midazolam; Psychomotor Performance; Triazolam	1996
Flumazenil discrimination by humans under a two-response and a novel-response procedure. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 291, Issue:3 Topics: Adolescent; Adult; Caffeine; Central Nervous System Stimulants; Discrimination, Psychological; Dose-Response Relationship, Drug; Female; Flumazenil; GABA Modulators; Humans; Male; Midazolam; Psychomotor Performance; Triazolam	1999
Time course of recovery of cytochrome p450 3A function after single doses of grapefruit juice. Clinical pharmacology and therapeutics, 2003, Volume: 74, Issue:2 Topics: Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Beverages; Biotransformation; Chromatography, Gas; Citrus paradisi; Cytochrome P-450 CYP3A; Female; Furocoumarins; Half-Life; Humans; Hypnotics and Sedatives; Isoenzymes; Kinetics; Liver; Male; Midazolam; Middle Aged; Oxidoreductases, N-Demethylating; Triazolam	2003
In vivo comparisons of constitutive cytochrome P450 3A activity assessed by alprazolam, triazolam, and midazolam. Clinical pharmacology and therapeutics, 2004, Volume: 76, Issue:4 Topics: Administration, Oral; Adult; Alprazolam; Anti-Anxiety Agents; Aryl Hydrocarbon Hydroxylases; Benzodiazepines; Biological Availability; Cytochrome P-450 CYP3A; Female; Humans; Male; Midazolam; Oxidoreductases, N-Demethylating; Triazolam	2004
Pomegranate juice does not impair clearance of oral or intravenous midazolam, a probe for cytochrome P450-3A activity: comparison with grapefruit juice. Journal of clinical pharmacology, 2007, Volume: 47, Issue:3 Topics: Administration, Oral; Adult; Analysis of Variance; Area Under Curve; Beverages; Citrus paradisi; Cross-Over Studies; Cytochrome P-450 CYP3A; Food-Drug Interactions; GABA Modulators; Humans; Injections, Intravenous; Lythraceae; Male; Metabolic Clearance Rate; Microsomes, Liver; Midazolam; Triazolam	2007
Patient Satisfaction with Oral versus Intravenous Sedation for Cataract Surgery: A Randomized Clinical Trial. Ophthalmology, 2019, Volume: 126, Issue:9 Topics: Administration, Oral; Aged; Anesthetics, Intravenous; Anesthetics, Local; Conscious Sedation; Double-Blind Method; Eye Pain; Female; Humans; Hypnotics and Sedatives; Lens Implantation, Intraocular; Male; Midazolam; Middle Aged; Pain Measurement; Patient Satisfaction; Phacoemulsification; Prospective Studies; Triazolam	2019

Other Studies

56 other study(ies) available for triazolam and midazolam

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate. Bioorganic & medicinal chemistry letters, 2010, Dec-15, Volume: 20, Issue:24 Topics: Central Nervous System Agents; Drug Evaluation, Preclinical; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Solubility	2010
Positive GABA(A) receptor modulators from Acorus calamus and structural analysis of (+)-dioxosarcoguaiacol by 1D and 2D NMR and molecular modeling. Journal of natural products, 2011, Jun-24, Volume: 74, Issue:6 Topics: Acorus; Animals; GABA Modulators; Mice; Molecular Structure; Oocytes; Receptors, GABA-A; Rhizome; Sesquiterpenes; Xenopus laevis	2011
Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice. Journal of natural products, 2011, Aug-26, Volume: 74, Issue:8 Topics: Animals; Anti-Anxiety Agents; Diterpenes; Dose-Response Relationship, Drug; GABA Modulators; gamma-Aminobutyric Acid; Male; Mice; Motor Activity; Oocytes; Receptors, GABA-A; Thuja; Xenopus laevis	2011
Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family. Bioorganic & medicinal chemistry, 2012, Mar-15, Volume: 20, Issue:6 Topics: Alprazolam; Benzazepines; Benzodiazepines; Cell Cycle Proteins; GABA Modulators; Humans; Midazolam; Models, Molecular; Nuclear Proteins; Protein Interaction Maps; Protein Structure, Tertiary; Transcription Factors	2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Differential development of tolerance to the depressant effects of benzodiazepine and non-benzodiazepine agonists at the omega (BZ) modulatory sites of GABAA receptors. Neuropharmacology, 1992, Volume: 31, Issue:7 Topics: Animals; Anti-Anxiety Agents; Azabicyclo Compounds; Binding Sites; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Tolerance; Male; Midazolam; Piperazines; Pyridines; Rats; Rats, Wistar; Receptors, GABA-A; Reinforcement, Psychology; Triazolam; Zolpidem	1992
Intranasal absorption of flurazepam, midazolam, and triazolam in dogs. Journal of pharmaceutical sciences, 1991, Volume: 80, Issue:12 Topics: Absorption; Administration, Intranasal; Administration, Oral; Animals; Chromatography, Gas; Dogs; Flurazepam; Intestinal Absorption; Male; Midazolam; Nasal Mucosa; Triazolam	1991
[Confusional states following administration of short-acting benzodiazepines (midazolam/triazolam)]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1991, Jun-11, Volume: 80, Issue:24 Topics: Adult; Confusion; Female; Humans; Male; Memory Disorders; Midazolam; Middle Aged; Triazolam	1991
Benzodiazepines identified by capillary gas chromatography-mass spectrometry, with specific ion screening used to detect benzophenone derivatives. Clinical chemistry, 1989, Volume: 35, Issue:7 Topics: Alprazolam; Benzodiazepines; Benzophenones; Forensic Medicine; Gas Chromatography-Mass Spectrometry; Humans; Hydrolysis; Immunoenzyme Techniques; Midazolam; Triazolam	1989
Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4. Molecular pharmacology, 1989, Volume: 36, Issue:1 Topics: Animals; Autoantibodies; Cytochrome P-450 Enzyme System; DNA; Humans; Isoenzymes; Kinetics; Liver; Midazolam; Rats; Rats, Inbred Strains; Triazolam; Troleandomycin	1989
The effects of triazolam on cerebral blood flow and metabolism in the dog. Acta anaesthesiologica Scandinavica, 1986, Volume: 30, Issue:3 Topics: Animals; Benzodiazepines; Brain; Brain Chemistry; Cerebrovascular Circulation; Diazepam; Dogs; Electroencephalography; Energy Metabolism; Female; Male; Midazolam; Oxygen Consumption; Triazolam	1986
[Drug dependence tests on a new anesthesia inducer, midazolam]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1986, Volume: 88, Issue:2 Topics: Animals; Injections, Intravenous; Macaca fascicularis; Male; Midazolam; Pentobarbital; Self Administration; Substance Withdrawal Syndrome; Substance-Related Disorders; Triazolam	1986
Early morning insomnia with rapidly eliminated benzodiazepines. Science (New York, N.Y.), 1983, Apr-01, Volume: 220, Issue:4592 Topics: Anti-Anxiety Agents; Benzodiazepines; Flurazepam; Half-Life; Humans; Midazolam; Sleep; Sleep Initiation and Maintenance Disorders; Triazolam	1983
Effects of oral and intravenous midazolam, triazolam and flunitrazepam on the sleep-wakefulness cycle of rabbits. British journal of clinical pharmacology, 1983, Volume: 16 Suppl 1 Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Benzodiazepines; Electroencephalography; Electromyography; Flunitrazepam; Injections, Intravenous; Male; Midazolam; Rabbits; Sleep; Sleep, REM; Triazolam; Wakefulness	1983
Short half-life benzodiazepines. Rational drug therapy, 1984, Volume: 18, Issue:4 Topics: Anti-Anxiety Agents; Azepines; Benzodiazepines; Half-Life; Humans; Kinetics; Midazolam; Triazolam	1984
Ambulatory motor activity monitoring to study the timecourse of hypnotic action. British journal of clinical pharmacology, 1984, Volume: 18 Suppl 1 Topics: Anti-Anxiety Agents; Benzodiazepines; Flunitrazepam; Flurazepam; Humans; Hypnotics and Sedatives; Midazolam; Motor Activity; Sleep; Temazepam; Time Factors; Triazolam	1984
Benzodiazepines promote the intermediate stage at the expense of paradoxical sleep in the rat. Pharmacology, biochemistry, and behavior, 1994, Volume: 49, Issue:4 Topics: Animals; Anti-Anxiety Agents; Diazepam; Electroencephalography; Epilepsy; Eye Movements; Heart Rate; Male; Midazolam; Rats; Rats, Inbred Strains; Rats, Wistar; Sleep Stages; Sleep, REM; Species Specificity; Theta Rhythm; Triazolam	1994
[Acute overdose of Zolpidem (Stilnox)]. Schweizerische medizinische Wochenschrift, 1996, May-04, Volume: 126, Issue:18 Topics: Adolescent; Adult; Aged; Antidotes; Coma; Drug Overdose; Female; Flumazenil; Humans; Hypnotics and Sedatives; Male; Midazolam; Middle Aged; Pyridines; Retrospective Studies; Triazolam; Zolpidem	1996
Oral sedation. Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995), 1998, Volume: 19, Issue:9 Topics: Administration, Oral; Algorithms; Anesthesia, Dental; Anti-Anxiety Agents; Chloral Hydrate; Conscious Sedation; Dental Anxiety; Diazepam; Histamine H1 Antagonists; Humans; Hydroxyzine; Hypnotics and Sedatives; Midazolam; Mutagens; Premedication; Triazolam	1998
Unchanged cytochrome P450 3A (CYP3A) expression and metabolism of midazolam, triazolam, and dexamethasone in mdr(-/-) mouse liver microsomes. Biochemical pharmacology, 1999, Jun-01, Volume: 57, Issue:11 Topics: Animals; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biotransformation; Blotting, Western; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Mice; Microsomes, Liver; Midazolam; Oxidoreductases, N-Demethylating; Triazolam	1999
High-dose discrimination training with midazolam: context determines generalization profile. Pharmacology, biochemistry, and behavior, 1999, Volume: 64, Issue:2 Topics: Animals; Anti-Anxiety Agents; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; GABA-A Receptor Agonists; Generalization, Psychological; Hypnotics and Sedatives; Male; Midazolam; Pentobarbital; Rats; Rats, Long-Evans; Time Factors; Triazolam	1999
Midazolam and triazolam biotransformation in mouse and human liver microsomes: relative contribution of CYP3A and CYP2C isoforms. The Journal of pharmacology and experimental therapeutics, 2000, Volume: 292, Issue:2 Topics: Animals; Antibodies; Aryl Hydrocarbon Hydroxylases; Biotransformation; Blotting, Western; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Humans; Immunochemistry; In Vitro Techniques; Inhibitory Concentration 50; Ketoconazole; Mice; Microsomes, Liver; Midazolam; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Protein Isoforms; Species Specificity; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Triazolam	2000
Discriminative-stimulus effects of triazolam and midazolam in rhesus monkeys. Behavioural pharmacology, 1999, Volume: 10, Issue:1 Topics: Animals; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Female; Flumazenil; GABA Modulators; Generalization, Stimulus; Hypnotics and Sedatives; Macaca mulatta; Male; Midazolam; Receptors, N-Methyl-D-Aspartate; Reinforcement Schedule; Triazolam	1999
Covalent alteration of the CYP3A4 active site: evidence for multiple substrate binding domains. Archives of biochemistry and biophysics, 2001, Jul-01, Volume: 391, Issue:1 Topics: Binding Sites; Binding, Competitive; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Kinetics; Microsomes, Liver; Midazolam; Mixed Function Oxygenases; Protein Structure, Tertiary; Substrate Specificity; Testosterone; Triazolam	2001
Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7. Drug metabolism and disposition: the biological fate of chemicals, 2002, Volume: 30, Issue:8 Topics: Alprazolam; Aryl Hydrocarbon Hydroxylases; Biotransformation; Clarithromycin; Coumarins; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochromes b5; Diltiazem; Estradiol; Humans; In Vitro Techniques; Kinetics; Microsomes, Liver; Midazolam; Nifedipine; Tamoxifen; Testosterone; Triazolam	2002
Anxiolysis in general dental practice. Dentistry today, 2003, Volume: 22, Issue:3 Topics: Acetamides; Adjuvants, Anesthesia; Anesthesia, Dental; Anesthetics, Inhalation; Anti-Anxiety Agents; Clinical Protocols; Conscious Sedation; Dental Anxiety; Diazepam; GABA Modulators; General Practice, Dental; Humans; Hydroxyzine; Hypnotics and Sedatives; Lorazepam; Midazolam; Nitrous Oxide; Pyrimidines; Triazolam	2003
In vitro metabolism of midazolam, triazolam, nifedipine, and testosterone by human liver microsomes and recombinant cytochromes p450: role of cyp3a4 and cyp3a5. Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:7 Topics: Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Ketoconazole; Microsomes, Liver; Midazolam; Nifedipine; Recombinant Proteins; Testosterone; Triazolam	2003
Benzodiazepines and heightened aggressive behavior in rats: reduction by GABA(A)/alpha(1) receptor antagonists. Psychopharmacology, 2005, Volume: 178, Issue:2-3 Topics: Aggression; Agonistic Behavior; Animals; Arousal; Dose-Response Relationship, Drug; GABA Modulators; Hypnotics and Sedatives; Male; Midazolam; Motor Activity; Rats; Rats, Long-Evans; Receptors, GABA-A; Triazolam	2005
Combined discriminative stimulus effects of midazolam with other positive GABAA modulators and GABAA receptor agonists in rhesus monkeys. Psychopharmacology, 2005, Volume: 178, Issue:4 Topics: Animals; Behavior, Animal; Conditioning, Operant; Discrimination Learning; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Ethanol; GABA Modulators; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Injections, Subcutaneous; Isoxazoles; Macaca mulatta; Male; Midazolam; Pentobarbital; Pregnanolone; Receptors, GABA-A; Time Factors; Triazolam; Women	2005
Conscious sedation in dental practice in the USA. An update on drugs, techniques and monitoring. SAAD digest, 2004,Autumn, Volume: 21, Issue:2 Topics: Administration, Oral; Anesthesia Recovery Period; Anesthesia, Dental; Conscious Sedation; Emergency Treatment; Fentanyl; Humans; Hypnotics and Sedatives; Injections, Intramuscular; Injections, Intravenous; Ketamine; Midazolam; Monitoring, Intraoperative; Monitoring, Physiologic; Triazolam; United States	2004
There are no useful CYP3A probes that quantitatively predict the in vivo kinetics of other CYP3A substrates and no expectation that one will be found. Molecular interventions, 2005, Volume: 5, Issue:2 Topics: Alprazolam; Benzodiazepines; Biopharmaceutics; Chemistry, Pharmaceutical; Cytochrome P-450 CYP3A; Drug Design; Humans; Kinetics; Midazolam; Molecular Probes; Protein Binding; Solubility; Triazolam	2005
Pharmacological properties of GABAA receptors containing gamma1 subunits. Molecular pharmacology, 2006, Volume: 69, Issue:2 Topics: Animals; Azepines; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Midazolam; Oocytes; Protein Subunits; Pyrazoles; Receptors, GABA-A; Triazolam; Xenopus laevis	2006
The detection of sedatives in hair and nail samples using tandem LC-MS-MS. Forensic science international, 2007, Feb-14, Volume: 166, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Alprazolam; Azabicyclo Compounds; Benzodiazepines; Chromatography, Liquid; Clobazam; Clonazepam; Diazepam; Female; Forensic Pathology; Hair; Humans; Hypnotics and Sedatives; Male; Mass Spectrometry; Midazolam; Middle Aged; Nails; Oxazepam; Piperazines; Predictive Value of Tests; Rape; Temazepam; Triazolam	2007
Practical oral sedation in dentistry. Part II--Clinical application of various oral sedatives and discussion. Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995), 2006, Volume: 27, Issue:9 Topics: Administration, Oral; Adult; Age Factors; Aged; Aged, 80 and over; Anesthesia, Dental; Child; Child, Preschool; Chloral Hydrate; Conscious Sedation; Diazepam; Fentanyl; Humans; Hypnotics and Sedatives; Meperidine; Midazolam; Nausea; Promethazine; Triazolam; Vomiting	2006
Prediction of metabolic clearance using fresh human hepatocytes: comparison with cryopreserved hepatocytes and hepatic microsomes for five benzodiazepines. Xenobiotica; the fate of foreign compounds in biological systems, 2008, Volume: 38, Issue:4 Topics: Alprazolam; Benzodiazepines; Cell Survival; Cells, Cultured; Cryopreservation; Cytochrome P-450 CYP3A; Diazepam; Flunitrazepam; Hepatocytes; Humans; Metabolic Clearance Rate; Microsomes, Liver; Midazolam; Substrate Specificity; Triazolam	2008
Estimating the efficiency of benzodiazepines on GABA(A) receptors comprising gamma1 or gamma2 subunits. British journal of pharmacology, 2008, Volume: 155, Issue:3 Topics: Animals; Azepines; Benzodiazepines; Dose-Response Relationship, Drug; Female; GABA Modulators; Midazolam; Oocytes; Patch-Clamp Techniques; Protein Subunits; Receptors, GABA-A; Regression Analysis; Triazolam; Xenopus laevis	2008
Separate evaluation of intestinal and hepatic metabolism of three benzodiazepines in rats with cannulated portal and jugular veins: comparison with the profile in non-cannulated mice. Xenobiotica; the fate of foreign compounds in biological systems, 2009, Volume: 39, Issue:11 Topics: Administration, Oral; Alprazolam; Animals; Benzodiazepines; Biological Availability; Catheterization; Intestinal Mucosa; Jugular Veins; Liver; Male; Mice; Mice, Inbred BALB C; Midazolam; Portal Vein; Rats; Rats, Sprague-Dawley; Triazolam	2009
Mechanism of cytochrome P450-3A inhibition by ketoconazole. The Journal of pharmacy and pharmacology, 2011, Volume: 63, Issue:2 Topics: Adult; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Humans; Inhibitory Concentration 50; Ketoconazole; Male; Microsomes, Liver; Midazolam; Middle Aged; Nifedipine; Testosterone; Triazolam; Young Adult	2011
The fallacy of a lifesaving sublingual injection of flumazenil. Anesthesia progress, 2011,Spring, Volume: 58, Issue:1 Topics: Anesthesia Recovery Period; Antidotes; Benzodiazepines; Conscious Sedation; Drug Overdose; Flumazenil; GABA Modulators; Humans; Hypnotics and Sedatives; Hypoxia, Brain; Injections; Injections, Intramuscular; Injections, Intravenous; Midazolam; Receptors, GABA-A; Respiration, Artificial; Triazolam	2011
Sources of interindividual variability in IVIVE of clearance: an investigation into the prediction of benzodiazepine clearance using a mechanistic population-based pharmacokinetic model. Xenobiotica; the fate of foreign compounds in biological systems, 2011, Volume: 41, Issue:8 Topics: Alprazolam; Benzodiazepines; Cytochrome P-450 CYP3A; Humans; Kinetics; Liver; Metabolic Clearance Rate; Midazolam; Triazolam	2011
Evaluation of animal models for intestinal first-pass metabolism of drug candidates to be metabolized by CYP3A enzymes via in vivo and in vitro oxidation of midazolam and triazolam. Xenobiotica; the fate of foreign compounds in biological systems, 2013, Volume: 43, Issue:7 Topics: Animals; Beverages; Citrus paradisi; Cytochrome P-450 CYP3A; Food-Drug Interactions; Humans; Hydroxylation; Kinetics; Male; Mice; Mice, Inbred BALB C; Microsomes; Midazolam; Models, Animal; Oxidoreductases, N-Demethylating; Rats; Rats, Sprague-Dawley; Species Specificity; Tandem Mass Spectrometry; Triazolam	2013
Is pomegranate juice a potential perpetrator of clinical drug-drug interactions? Review of the in vitro, preclinical and clinical evidence. European journal of drug metabolism and pharmacokinetics, 2013, Volume: 38, Issue:4 Topics: Animals; Anti-Anxiety Agents; Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Beverages; Buspirone; Caco-2 Cells; Calcium Channel Blockers; Carbamazepine; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Evaluation, Preclinical; Drug Interactions; Flurbiprofen; Food-Drug Interactions; Humans; Hypnotics and Sedatives; Hypoglycemic Agents; Lythraceae; Midazolam; Nitrendipine; Tolbutamide; Triazolam	2013
[Determination of triazolam and midazolam in human plasma using gas chromatography with microelectron capture detection for clinical application]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2014, Volume: 134, Issue:1 Topics: Chromatography, Gas; Electrons; Humans; Midazolam; Solvents; Triazolam	2014
Physiologically based pharmacokinetic modeling of CYP3A4 induction by rifampicin in human: influence of time between substrate and inducer administration. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2014, Jun-02, Volume: 56 Topics: Alfentanil; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Hepatocytes; Humans; Midazolam; Models, Biological; Nifedipine; Rifampin; Tissue Distribution; Triazolam	2014
Development of Murine Cyp3a Knockout Chimeric Mice with Humanized Liver. Drug metabolism and disposition: the biological fate of chemicals, 2015, Volume: 43, Issue:8 Topics: Albumins; Animals; Aryl Hydrocarbon Hydroxylases; Chimera; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Glucuronosyltransferase; Hepatocytes; Humans; Intestinal Mucosa; Isoenzymes; Liver; Mice; Mice, Knockout; Mice, SCID; Mice, Transgenic; Microsomes, Liver; Midazolam; RNA, Messenger; Steroid Hydroxylases; Triazolam; Urokinase-Type Plasminogen Activator	2015
Antagonism of triazolam self-administration in rhesus monkeys responding under a progressive-ratio schedule: In vivo apparent pA2 analysis. Drug and alcohol dependence, 2016, Jan-01, Volume: 158 Topics: Animals; Benzodiazepines; Dose-Response Relationship, Drug; GABA Modulators; Humans; Macaca mulatta; Male; Midazolam; Reaction Time; Receptors, GABA-A; Reinforcement Schedule; Self Administration; Triazolam	2016
A comparative study for detecting CYP3A induction by CYP3A probe drugs and endogenous markers in cynomolgus monkeys. Biopharmaceutics & drug disposition, 2019, Volume: 40, Issue:2 Topics: Alprazolam; Animals; Area Under Curve; Biomarkers; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Dose-Response Relationship, Drug; Drug Interactions; Hydrocortisone; Hydroxycholesterols; Macaca fascicularis; Male; Midazolam; Rifampin; Triazolam	2019
Reevaluate In Vitro CYP3A Index Reactions of Benzodiazepines and Steroids between Humans and Dogs. Drug metabolism and disposition: the biological fate of chemicals, 2022, Volume: 50, Issue:6 Topics: Alprazolam; Animals; Benzodiazepines; Cytochrome P-450 CYP3A; Deoxycholic Acid; Dogs; Humans; Hydroxylation; Kinetics; Microsomes, Liver; Midazolam; Protein Isoforms; Species Specificity; Steroids; Triazolam	2022