Page last updated: 2024-08-16

triamterene and methotrexate

triamterene has been researched along with methotrexate in 31 studies

Research

Studies (31)

Timeframe	Studies, this research(%)	All Research%
pre-1990	12 (38.71)	18.7374
1990's	3 (9.68)	18.2507
2000's	10 (32.26)	29.6817
2010's	5 (16.13)	24.3611
2020's	1 (3.23)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J	1
Gibson, CL; Huggan, JK; Hunter, WN; Iulek, J; Lee, JH; Martini, VP; Smith, TK; Suckling, CJ; Tulloch, LB	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Takahashi, H; Tsukada, T	1
Furst, DE	1
Gauldie, J; Hiebert, M; Hillcoat, BL; Marshall, L	1
Bertino, JR; Perkins, JP	1
Bertino, JR; Hillcoat, BL; Perkins, JP	1
Heischkeil, R	1
Dayton, PG; Kinkade, JM; Vogler, WR	1
Hall, TC; Roberts, D	1
Baugh, CM; Gaut, ZN; Solomon, HM	1
Buck, AT; Taylor, DM; Threlfall, G	1
Botterill, V; Hall, TC; Kessel, D	1
Scott, JM; Weir, DG	1
Bamberger, U; Boven, E; Feller, N; Jansen, WJ; Pinedo, HM; van der Wilt, CL	1
Lambert, CM; McRorie, ER; Ogden, DA; Richmond, R	1
Perazella, MA	1
Bermejo, M; García-Valcárcel, I; Garrigues, TM; Merino, V; Montalar, M; Nalda-Molina, R; Rodríguez-Ibáñez, M	1
Berzas Nevado, JJ; Durán Merás, I; Rodríguez Flores, J; Rodríguez Gómez, MJ	1
Carmona-Martínez, V; García-Peñarrubia, P; Guirado, A; Martínez-Esparza, M; Ruiz-Alcaraz, AJ; Vera, M	1
Califano, A; Hirschhorn, T; Shimada, K; Small, JC; Stockwell, BR; Stokes, ME; Vasciaveo, A	1

Reviews

5 review(s) available for triamterene and methotrexate

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Clinically important interactions of nonsteroidal antiinflammatory drugs with other medications. The Journal of rheumatology. Supplement, 1988, Volume: 17 Topics: Adrenal Cortex Hormones; Adrenergic beta-Antagonists; Antacids; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Diuretics; Drug Interactions; Humans; Hypoglycemic Agents; Lithium; Methotrexate; Phenytoin; Probenecid; Salicylates; Triamterene	1988
Drug-induced megaloblastic change. Clinics in haematology, 1980, Volume: 9, Issue:3 Topics: Cyclophosphamide; Cytarabine; DNA; Erythrocytes, Abnormal; Floxuridine; Fluorouracil; Folic Acid Antagonists; Humans; Hydroxyurea; Megaloblasts; Methotrexate; Phenytoin; Pyrimethamine; Ribonucleotides; Thymidine Monophosphate; Thymidylate Synthase; Triamterene; Trimethoprim	1980
Crystal-induced acute renal failure. The American journal of medicine, 1999, Volume: 106, Issue:4 Topics: Acute Kidney Injury; Acyclovir; Humans; Indinavir; Kidney; Methotrexate; Risk; Sulfonamides; Triamterene	1999
Therapeutic potential of pteridine derivatives: A comprehensive review. Medicinal research reviews, 2019, Volume: 39, Issue:2 Topics: Aminopterin; Animals; Anti-Infective Agents; Antidepressive Agents; Antihypertensive Agents; Antineoplastic Agents; Antiparasitic Agents; Clinical Trials as Topic; Humans; Inhibitory Concentration 50; Methotrexate; Pteridines; Triamterene	2019

Other Studies

26 other study(ies) available for triamterene and methotrexate

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Rational use of in vitro P-glycoprotein assays in drug discovery. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera	2001
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nature chemical biology, 2009, Volume: 5, Issue:10 Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection	2009
Structure-based design of pteridine reductase inhibitors targeting African sleeping sickness and the leishmaniases. Journal of medicinal chemistry, 2010, Jan-14, Volume: 53, Issue:1 Topics: Catalytic Domain; Dose-Response Relationship, Drug; Drug Design; Enzyme Inhibitors; Leishmania major; Leishmaniasis; Models, Molecular; Molecular Structure; Oxidoreductases; Parasitic Sensitivity Tests; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Trypanosoma brucei brucei; Trypanosomiasis, African	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Triamterene-induced immune haemolytic anaemia with acute intravascular haemolysis and acute renal failure. Scandinavian journal of haematology, 1979, Volume: 23, Issue:2 Topics: Acute Kidney Injury; Anemia, Hemolytic, Autoimmune; Chemical Phenomena; Chemistry; Complement System Proteins; Coombs Test; Erythrocytes; Female; Haptens; Hemagglutination Tests; Humans; Immunoglobulins; Methotrexate; Middle Aged; Neutralization Tests; Triamterene	1979
Stabilization of dihydrofolate reductase by inhibitors in vivo and in vitro. Annals of the New York Academy of Sciences, 1971, Nov-30, Volume: 186 Topics: Animals; Biodegradation, Environmental; Carcinoma, Hepatocellular; Cell Line; Cells, Cultured; Chromatography, Gel; Cycloheximide; Drug Stability; Electrophoresis; Enzyme Activation; Folic Acid Antagonists; Humans; Leucovorin; Leukemia L1210; Liver Neoplasms; Methotrexate; Mice; Rats; Tetrahydrofolate Dehydrogenase; Triamterene; Trimethoprim	1971
Dihydrofolate reductase from the L1210R murine lymphoma. Fluorometric measurements of the interaction of the enzyme with coenzymes, substrates, and inhibitors. Biochemistry, 1966, Volume: 5, Issue:3 Topics: Animals; Chemical Phenomena; Chemistry; Enzymes; Fluorometry; Folic Acid; Leukemia L1210; Lymphoma; Methotrexate; Mice; NADP; Triamterene	1966
Dihydrofolate reductase from the L1210 R murine lymphoma. Further studies on the binding of substrates and inhibitors to the enzyme. The Journal of biological chemistry, 1967, Oct-25, Volume: 242, Issue:20 Topics: Animals; Binding Sites; Chemical Phenomena; Chemistry, Physical; Fluorometry; Folic Acid; Folic Acid Antagonists; Hydrogen-Ion Concentration; Leukemia L1210; Methotrexate; Mice; NADP; Protein Binding; Pyrimidines; Tetrahydrofolate Dehydrogenase; Triamterene	1967
[Antimetabolites of folic acid metabolism with chemotherapeutic activity against rodent malaria (Plasmodium vinckei)]. Zeitschrift fur Tropenmedizin und Parasitologie, 1973, Volume: 24, Issue:4 Topics: Aminopterin; Animals; Cycloheximide; Female; Folic Acid; Folic Acid Antagonists; Hydantoins; Malaria; Male; Methotrexate; Mice; Mice, Inbred Strains; Phenobarbital; Phenytoin; Plasmodium; Primidone; Pyrimethamine; Thalidomide; Triamterene	1973
Plasma levels of methotrexate in cancer patients as studied by an improved spectrophotofluorometric method. Biochemical medicine, 1974, Volume: 10, Issue:4 Topics: Adult; Aged; Chromatography, Ion Exchange; Creatinine; Cytarabine; Diatrizoate; Female; Folic Acid; Heparin; Humans; Hydrogen-Ion Concentration; Male; Methods; Methotrexate; Middle Aged; Neoplasms; Oxidation-Reduction; Potassium Permanganate; Spectrometry, Fluorescence; Time Factors; Triamterene; Tritium; Tryptophan; Tungsten	1974
Triamterene-induced elevation of dihydrofolate reductase activity in human leukocytes. Biochemical pharmacology, 1968, Volume: 17, Issue:3 Topics: Carcinoma; Carcinoma, Squamous Cell; Enzyme Induction; Head and Neck Neoplasms; Humans; Leukocytes; Lung Neoplasms; Methotrexate; Stimulation, Chemical; Tetrahydrofolate Dehydrogenase; Triamterene	1968
Accumulation of (3',5'-3H2)folic acid by human blood platelets. Effect of dihydrofolic acid reductase inhibitors. Biochimica et biophysica acta, 1970, Jul-21, Volume: 215, Issue:1 Topics: Aminopterin; Biological Transport, Active; Blood Platelets; Diffusion; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Methotrexate; Pyrimethamine; Triamterene; Tritium	1970
Chemically-induced renal hypertrophy in the rat. Biochemical pharmacology, 1968, Volume: 17, Issue:8 Topics: Animals; DNA; Folic Acid; Hypertrophy; Kidney; Kidney Diseases; Male; Methotrexate; Organ Size; Pyridines; Pyrimidines; Rats; RNA; Triamterene; Ureteral Obstruction; Xanthopterin	1968
Stimulation by pteridines of the uptake of amethopterin by human lymphocytes. Biochemical pharmacology, 1968, Volume: 17, Issue:8 Topics: Aniline Compounds; Biological Transport; Carbon Isotopes; Humans; Leukemia, Lymphoid; Lymphocytes; Methotrexate; Pteridines; Stimulation, Chemical; Triamterene	1968
The influence of BIBW22BS, a dipyridamole derivative, on the antiproliferative effects of 5-fluorouracil, methotrexate and gemcitabine in vitro and in human tumour xenografts. European journal of cancer (Oxford, England : 1990), 1995, Volume: 31A, Issue:13-14 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Deoxycytidine; Dipyridamole; Doxorubicin; Drug Resistance; Female; Floxuridine; Fluorouracil; Gemcitabine; Humans; Methotrexate; Mice; Mice, Nude; Morpholines; Neoplasms; Neoplasms, Experimental; Protein Binding; Transplantation, Heterologous; Triamterene; Tumor Cells, Cultured; Vincristine	1995
Methotrexate and triamterene--a potentially fatal combination? Annals of the rheumatic diseases, 1997, Volume: 56, Issue:3 Topics: Adult; Bone Marrow; Drug Synergism; Drug Therapy, Combination; Female; Folic Acid Antagonists; Humans; Male; Methotrexate; Triamterene	1997
Kinetic modeling of triamterene intestinal absorption and its inhibition by folic acid and methotrexate. Journal of drug targeting, 2003, Volume: 11, Issue:4 Topics: Animals; Folic Acid; Intestinal Absorption; Male; Methotrexate; Models, Biological; Rats; Rats, Wistar; Triamterene	2003
Capillary electrophoretic determination of triamterene, methotrexate, and creatinine in human urine. Journal of separation science, 2005, Volume: 28, Issue:7 Topics: Adult; Aged; Antimetabolites, Antineoplastic; Child; Child, Preschool; Creatinine; Diuretics; Electrophoresis, Capillary; Female; Humans; Hydrogen-Ion Concentration; Male; Methotrexate; Molecular Structure; Pregnancy; Reproducibility of Results; Sensitivity and Specificity; Temperature; Time Factors; Triamterene	2005
Mesenchymal subtype neuroblastomas are addicted to TGF-βR2/HMGCR-driven protein geranylgeranylation. Scientific reports, 2020, 07-01, Volume: 10, Issue:1 Topics: Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Cell Line, Tumor; Fluvastatin; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipids; Lovastatin; Methotrexate; N-Myc Proto-Oncogene Protein; Neuroblastoma; Protein Prenylation; Receptor, Transforming Growth Factor-beta Type II; RNA, Small Interfering; Signal Transduction; Triamterene	2020