tretinoin and triphenylphosphine-oxide

We investigated the ability of group 15 compounds with a triphenyl substituent to bind to and activate human retinoic X receptor (RXR) and peroxisome proliferator-activated receptor (PPAR) γ and their ability to activate the receptor. Triphenylphosphine oxide (TPPO) transcriptionally activated both RXR and PPARγ. Triphenylbismuth (TPBi) transcriptionally activated PPARγ but not RXR. However, TPBi significantly inhibited RXR transcriptional activity induced by 9-cis retinoic acid (9cRA) and PPARγ transcriptional activity induced by rosiglitazone (Rosi). Triphenylarsine (TPAs) also significantly inhibited the 9cRA- and Rosi-induced transcriptional activity of both receptors, whereas TPAs alone had no effect on the transcriptional activity of RXR and PPARγ. Consistent with these results, TPAs and TPBi blocked the binding of [

Topics: Alitretinoin; Arsenicals; Cell Line, Tumor; DNA; Genes, Reporter; Humans; Ligands; Luciferases, Renilla; Organometallic Compounds; Organophosphorus Compounds; PPAR gamma; Retinoid X Receptors; Rosiglitazone; Terphenyl Compounds; Thiazolidinediones; Transcription, Genetic; Tretinoin