tretinoin and trimethylamine

tretinoin has been researched along with trimethylamine* in 1 studies

Other Studies

1 other study(ies) available for tretinoin and trimethylamine

Article	Year
Intra-amygdala all-trans retinoic acid inhibits amygdala-kindled seizures in rats. Epilepsy research, 2007, Volume: 75, Issue:2-3 Amygdala plays an important role in induction and control of limbic seizures. There is a network of gap junctional communications in basolateral amygdala (BLA) as well. We compared the effect of intra-BLA infusion of the typical gap junction (GJ) blocker carbenoxolone (CBX), with the effect of putative GJ blocker all-trans retinoic acid (ATRA), on the afterdischarge (AD) recorded from BLA in amygdala-kindled rats. Both CBX and ATRA showed a rapid anti-seizure effect. Conversely, intra-BLA infusion of the known GJ opener, trimethylamine (TMA), enhanced seizure susceptibility by prolonging the duration of AD and generalized behavioral seizures. ATRA administered intra-BLA prevented the proconvulsant effect of TMA. The reduction of gap junctional conductance might be involved in the observed anticonvulsant effect of ATRA. Topics: Amygdala; Animals; Carbenoxolone; Dose-Response Relationship, Drug; Electric Stimulation; Gap Junctions; Kindling, Neurologic; Male; Methylamines; Microinjections; Rats; Rats, Wistar; Seizures; Stereotaxic Techniques; Tretinoin	2007

Article

Year

Intra-amygdala all-trans retinoic acid inhibits amygdala-kindled seizures in rats.

Epilepsy research, 2007, Volume: 75, Issue:2-3

Amygdala plays an important role in induction and control of limbic seizures. There is a network of gap junctional communications in basolateral amygdala (BLA) as well. We compared the effect of intra-BLA infusion of the typical gap junction (GJ) blocker carbenoxolone (CBX), with the effect of putative GJ blocker all-trans retinoic acid (ATRA), on the afterdischarge (AD) recorded from BLA in amygdala-kindled rats. Both CBX and ATRA showed a rapid anti-seizure effect. Conversely, intra-BLA infusion of the known GJ opener, trimethylamine (TMA), enhanced seizure susceptibility by prolonging the duration of AD and generalized behavioral seizures. ATRA administered intra-BLA prevented the proconvulsant effect of TMA. The reduction of gap junctional conductance might be involved in the observed anticonvulsant effect of ATRA.

Topics: Amygdala; Animals; Carbenoxolone; Dose-Response Relationship, Drug; Electric Stimulation; Gap Junctions; Kindling, Neurologic; Male; Methylamines; Microinjections; Rats; Rats, Wistar; Seizures; Stereotaxic Techniques; Tretinoin

2007