tretinoin and phosphatidylethanol

tretinoin has been researched along with phosphatidylethanol* in 1 studies

Other Studies

1 other study(ies) available for tretinoin and phosphatidylethanol

Article	Year
Retinoic acid specifically activates an oleate-dependent phospholipase D in the nuclei of LA-N-1 neuroblastoma cells. FEBS letters, 2003, Apr-24, Volume: 541, Issue:1-3 Earlier studies showed that treatment of LA-N-1 cells with TPA, a tumoral promoter, leads to the stimulation of a G protein-regulated phospholipase D (PLD) in the nuclei. Now we demonstrate that retinoic acid, a cellular differentiation inducing agent, activates a nuclear oleate-dependent PLD in LA-N-1 cells. Treatment of the nuclei with retinoic acid induces the breakdown of phosphatidylcholine (PtdCho). Our results indicate that PLD is regulated differentially depending on the nature of the stimulatory agent. These results strongly suggest the existence of two nuclear PLD isoforms in LA-N-1 nuclei that hydrolyze PtdCho. Topics: Cell Nucleus; Diglycerides; Enzyme Activation; Glycerophospholipids; Humans; Neuroblastoma; Oleic Acid; Phosphatidic Acids; Phosphatidylcholines; Phospholipase D; Tretinoin; Tumor Cells, Cultured	2003

Article

Year

Retinoic acid specifically activates an oleate-dependent phospholipase D in the nuclei of LA-N-1 neuroblastoma cells.

FEBS letters, 2003, Apr-24, Volume: 541, Issue:1-3

Earlier studies showed that treatment of LA-N-1 cells with TPA, a tumoral promoter, leads to the stimulation of a G protein-regulated phospholipase D (PLD) in the nuclei. Now we demonstrate that retinoic acid, a cellular differentiation inducing agent, activates a nuclear oleate-dependent PLD in LA-N-1 cells. Treatment of the nuclei with retinoic acid induces the breakdown of phosphatidylcholine (PtdCho). Our results indicate that PLD is regulated differentially depending on the nature of the stimulatory agent. These results strongly suggest the existence of two nuclear PLD isoforms in LA-N-1 nuclei that hydrolyze PtdCho.

Topics: Cell Nucleus; Diglycerides; Enzyme Activation; Glycerophospholipids; Humans; Neuroblastoma; Oleic Acid; Phosphatidic Acids; Phosphatidylcholines; Phospholipase D; Tretinoin; Tumor Cells, Cultured

2003