tretinoin has been researched along with phenosafranine* in 1 studies
1 other study(ies) available for tretinoin and phenosafranine
| Article | Year |
|---|---|
Phenosafranin inhibits nuclear localization of transglutaminase 2 without affecting its transamidase activity.
Transglutaminase 2 (TG2) localizes to the nucleus and induces apoptosis through a crosslinking inactivation of Sp1 in JHH-7 cells treated with acyclic retinoid. We screened an inhibitor suppressing transamidase activity in the nucleus without affecting transamidase activity itself. Phenosafranin was found to inhibit nuclear localization of EGFP-tagged TG2 and dose-dependently reduce nuclear transamidase activity without affecting the activity in a tube. We concluded that phenosafranin was a novel TG2 inhibitor capable of suppressing its nuclear localization. Topics: Active Transport, Cell Nucleus; Amino Acid Sequence; Cell Line, Tumor; Cell Nucleus; Cytosol; Gene Expression; Genetic Vectors; Green Fluorescent Proteins; GTP-Binding Proteins; Hepatocytes; High-Throughput Screening Assays; Humans; Phenazines; Protein Domains; Protein Glutamine gamma Glutamyltransferase 2; Staining and Labeling; Transfection; Transglutaminases; Tretinoin | 2017 |