tretinoin and monorden

tretinoin has been researched along with monorden* in 1 studies

Other Studies

1 other study(ies) available for tretinoin and monorden

Article	Year
Enhanced cell differentiation when RB is hypophosphorylated and down-regulated by radicicol, a SRC-kinase inhibitor. Experimental cell research, 1994, Volume: 214, Issue:1 Radicicol, an inhibitor of src or src-like kinases, causes hypophosphorylation and down-regulation of the RB retinoblastoma tumor suppressor protein in HL-60 human promyelocytic leukemia cells. Both of these changes in the RB protein typically are associated with myeloid or monocytic differentiation of these cells induced by retinoic acid or 1,25-dihydroxy vitamin D3. When added with either inducer, radicicol caused the typically induced myeloid or monocytic differentiation of these cells to be accelerated. By itself radicicol caused a transient inhibition of G1 to S transit, but did not cause phenotypic conversion. The down-regulation and dephosphorylation of RB by radicicol may thus facilitate cell differentiation. Topics: Calcitriol; Cell Differentiation; Down-Regulation; Humans; Lactones; Leukemia, Promyelocytic, Acute; Macrolides; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Retinoblastoma Protein; Tretinoin; Tumor Cells, Cultured	1994

Article

Year

Enhanced cell differentiation when RB is hypophosphorylated and down-regulated by radicicol, a SRC-kinase inhibitor.

Experimental cell research, 1994, Volume: 214, Issue:1

Radicicol, an inhibitor of src or src-like kinases, causes hypophosphorylation and down-regulation of the RB retinoblastoma tumor suppressor protein in HL-60 human promyelocytic leukemia cells. Both of these changes in the RB protein typically are associated with myeloid or monocytic differentiation of these cells induced by retinoic acid or 1,25-dihydroxy vitamin D3. When added with either inducer, radicicol caused the typically induced myeloid or monocytic differentiation of these cells to be accelerated. By itself radicicol caused a transient inhibition of G1 to S transit, but did not cause phenotypic conversion. The down-regulation and dephosphorylation of RB by radicicol may thus facilitate cell differentiation.

Topics: Calcitriol; Cell Differentiation; Down-Regulation; Humans; Lactones; Leukemia, Promyelocytic, Acute; Macrolides; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Retinoblastoma Protein; Tretinoin; Tumor Cells, Cultured

1994