tretinoin and epalrestat

Epalrestat (EPS) is a brain penetrant aldose reductase inhibitor, an approved drug currently used for the treatment of diabetic neuropathy. At near-plasma concentration, EPS induces glutathione biosynthesis, which in turn reduces oxidative stress in the neuronal cells. In this study, we found that EPS reduces neurodegeneration by inhibiting reactive oxygen species (ROS)-induced oxidative injury, mitochondrial membrane damage, apoptosis and tauopathy. EPS treatment up to 50 μM did not show any toxic effect on SH-SY5Y cell line (neuroblastoma cells). However, we observed toxic effect at a concentration of 100 μM and above. At 50 μM concentration, EPS showed better antioxidant activity against H

Topics: Cell Differentiation; Cell Line, Tumor; Cell Survival; DNA Damage; Glycogen Synthase Kinase 3 beta; Humans; Hydrogen Peroxide; Membrane Potential, Mitochondrial; Neurons; Neuroprotective Agents; Oxidative Stress; Reactive Oxygen Species; Rhodanine; tau Proteins; Thiazolidines; Tretinoin