tretinoin has been researched along with entecavir* in 1 studies
1 other study(ies) available for tretinoin and entecavir
| Article | Year |
|---|---|
Identification of Retinoic Acid Receptor Agonists as Potent Hepatitis B Virus Inhibitors via a Drug Repurposing Screen.
Currently available therapies for chronic hepatitis B virus (HBV) infection can efficiently reduce viremia but induce hepatitis B surface antigen (HBsAg) loss in very few patients; also, these therapies do not greatly affect the viral covalently closed circular DNA (cccDNA). To discover new agents with complementary anti-HBV effects, we performed a drug repurposing screen of 1,018 Food and Drug Administration (FDA)-approved compounds using HBV-infected primary human hepatocytes (PHH). Several compounds belonging to the family of retinoic acid receptor (RAR) agonists were identified that reduced HBsAg levels in a dose-dependent manner without significant cytotoxicity. Among them, tazarotene exhibited the most potent anti-HBV effect, with a half-maximal inhibitory concentration (IC Topics: Acitretin; Adapalene; Antiviral Agents; Cell Line; Cell Survival; Dermatologic Agents; Drug Repositioning; Drug Synergism; Gene Expression; Guanine; Hep G2 Cells; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatocytes; High-Throughput Screening Assays; Host-Pathogen Interactions; Humans; Keratolytic Agents; Nicotinic Acids; Receptors, Retinoic Acid; Transcription, Genetic; Tretinoin; Virus Replication | 2018 |