tretinoin and edatrexate

Recent development of new anticancer drugs in Japan was reviewed. Since there are a high incidence of cancer of the digestive organs, lung cancer and breast cancer in Japan, we have been looking for novel anticancer drugs effective against these solid cancers. Currently, some of fluoropyrimidine compounds, methotrexate analogues, tubulin inhibitors from plant origins have shown their clinical activities against human non-small cell lung cancer and/or breast cancer. As the end-point on these drug development, we have put an emphasis to find drugs to contribute for the survival prolongation and improvement of quality of life of the treated patients.

Topics: Aminopterin; Antineoplastic Agents; Camptothecin; Cisplatin; Cytarabine; Irinotecan; Methotrexate; Paclitaxel; Tretinoin; Tubulin Modulators; Vinblastine; Vinorelbine