tretinoin and cyclopentenyl-cytosine

tretinoin has been researched along with cyclopentenyl-cytosine* in 1 studies

Other Studies

1 other study(ies) available for tretinoin and cyclopentenyl-cytosine

Article	Year
Retinoic acid reduces the cytotoxicity of cyclopentenyl cytosine in neuroblastoma cells. FEBS letters, 2002, Sep-11, Volume: 527, Issue:1-3 In this paper, it is demonstrated that all-trans, 9-cis and 13-cis retinoic acid (RA) decreased the sensitivity of SK-N-BE(2)c neuroblastoma cells towards the chemotherapeutic agent cyclopentenyl cytosine (CPEC), a potent inhibitor of cytosine-5'-triphosphate synthetase. Retinoic acid attenuated CPEC-induced apoptosis as reflected by a decreased caspase-3 induction. Retinoic acid decreased the accumulation of CPEC, whereas the salvage of cytidine was strongly increased. Metabolic labeling studies using [(3)H]uridine showed a strongly decreased biosynthesis of CTP via CTP synthetase. Retinoic acid likely confers resistance of neuroblastoma cells to CPEC in part by slowing down proliferation, and in part by shifting the synthesis of CTP towards the salvage of cytidine, thereby bypassing CTP synthetase. Topics: Antineoplastic Agents; Apoptosis; Cell Differentiation; Cell Division; Cytidine; Cytidine Triphosphate; Drug Interactions; Humans; Neuroblastoma; Polyphosphates; Tretinoin; Tumor Cells, Cultured	2002

Article

Year

Retinoic acid reduces the cytotoxicity of cyclopentenyl cytosine in neuroblastoma cells.

FEBS letters, 2002, Sep-11, Volume: 527, Issue:1-3

In this paper, it is demonstrated that all-trans, 9-cis and 13-cis retinoic acid (RA) decreased the sensitivity of SK-N-BE(2)c neuroblastoma cells towards the chemotherapeutic agent cyclopentenyl cytosine (CPEC), a potent inhibitor of cytosine-5'-triphosphate synthetase. Retinoic acid attenuated CPEC-induced apoptosis as reflected by a decreased caspase-3 induction. Retinoic acid decreased the accumulation of CPEC, whereas the salvage of cytidine was strongly increased. Metabolic labeling studies using [(3)H]uridine showed a strongly decreased biosynthesis of CTP via CTP synthetase. Retinoic acid likely confers resistance of neuroblastoma cells to CPEC in part by slowing down proliferation, and in part by shifting the synthesis of CTP towards the salvage of cytidine, thereby bypassing CTP synthetase.

Topics: Antineoplastic Agents; Apoptosis; Cell Differentiation; Cell Division; Cytidine; Cytidine Triphosphate; Drug Interactions; Humans; Neuroblastoma; Polyphosphates; Tretinoin; Tumor Cells, Cultured

2002