tretinoin and 4-vinylguaiacol

3,4-Methylenedioxypyrovalerone (MDPV), one of the most commonly abused synthetic cathinones, has caused several intoxications and deaths despite its short presence on the market. Apart from its effects on the monoamine systems in the brain, recent in vitro investigations have revealed cytotoxicity. In this study, the effects of increasing concentrations (10-1000 μM) of 3,4-Catechol-PV, one of major MDPV metabolites, on cell viability, morphology, and apoptosis have been evaluated after acute exposure (24-48 h) in human neuroblastoma SH-SY5Y cells-undifferentiated and differentiated to a more mature neuronal-like phenotype. Results indicated the following: (i) Cell viability: concentration-dependent decrease (15-55%) in differentiated SH-SY5Y after 24 h, with no exacerbation after 48 h (LC

Topics: Antineoplastic Agents; Benzodioxoles; Caspase 3; Cell Differentiation; Cell Line, Tumor; Cell Size; Dopamine; Dopamine beta-Hydroxylase; Dopamine Uptake Inhibitors; Dopaminergic Neurons; Dose-Response Relationship, Drug; Guaiacol; Humans; Mitochondria; Nerve Tissue Proteins; Neuroblastoma; Pyrrolidines; Statistics, Nonparametric; Synthetic Cathinone; Time Factors; Tretinoin; Tyrosine 3-Monooxygenase