tretinoin and 2-3-7-8-tetrabromodibenzo-4-dioxin

tretinoin has been researched along with 2-3-7-8-tetrabromodibenzo-4-dioxin* in 1 studies

Other Studies

1 other study(ies) available for tretinoin and 2-3-7-8-tetrabromodibenzo-4-dioxin

Article	Year
Retinoids inhibit 2,3,7,8-tetrachlorodibenzo-p-dioxine-induced activity of benzo[a]pyrene metabolizing enzymes in human diploid fibroblasts. Carcinogenesis, 1980, Volume: 1, Issue:9 Retinoids are known to inhibit the substrate mediated enzyme induction of benzo[a]pyrene metabolizing enzymes. Consequently, the effect of two retinoids on the induction of benzo[a]pyrene metabolizing enzymes by the more potent inductor 2,3,7,8-tetrachlorodibenzo-p-dioxine (TCDD) was investigated. The studies were performed with human diploid fibroblasts in culture. Vitamin A palmitate and all-trans-retinoic-acid were found to prevent the TCDD induced increase of benzo[a]pyrene metabolism in a dose-dependent manner. The fact that this effect was immediately reversible makes it unlikely that it was due to non-specific toxic effects. The data suggest that retinoids cause a preferential inhibition of the de novo synthesis of benzo[a]pyrene metabolizing enzymes. Topics: Anticarcinogenic Agents; Benzo(a)pyrene; Cells, Cultured; Dioxins; Diploidy; Diterpenes; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Induction; Fibroblasts; Humans; Retinyl Esters; Skin; Solubility; Tretinoin; Tritium; Vitamin A	1980

Article

Year

Retinoids inhibit 2,3,7,8-tetrachlorodibenzo-p-dioxine-induced activity of benzo[a]pyrene metabolizing enzymes in human diploid fibroblasts.

Carcinogenesis, 1980, Volume: 1, Issue:9

Retinoids are known to inhibit the substrate mediated enzyme induction of benzo[a]pyrene metabolizing enzymes. Consequently, the effect of two retinoids on the induction of benzo[a]pyrene metabolizing enzymes by the more potent inductor 2,3,7,8-tetrachlorodibenzo-p-dioxine (TCDD) was investigated. The studies were performed with human diploid fibroblasts in culture. Vitamin A palmitate and all-trans-retinoic-acid were found to prevent the TCDD induced increase of benzo[a]pyrene metabolism in a dose-dependent manner. The fact that this effect was immediately reversible makes it unlikely that it was due to non-specific toxic effects. The data suggest that retinoids cause a preferential inhibition of the de novo synthesis of benzo[a]pyrene metabolizing enzymes.

Topics: Anticarcinogenic Agents; Benzo(a)pyrene; Cells, Cultured; Dioxins; Diploidy; Diterpenes; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Induction; Fibroblasts; Humans; Retinyl Esters; Skin; Solubility; Tretinoin; Tritium; Vitamin A

1980