tretinoin and 1-((3-5-dichloro)-2-6-dihydroxy-4-methoxyphenyl)-1-hexanone

tretinoin has been researched along with 1-((3-5-dichloro)-2-6-dihydroxy-4-methoxyphenyl)-1-hexanone* in 1 studies

Other Studies

1 other study(ies) available for tretinoin and 1-((3-5-dichloro)-2-6-dihydroxy-4-methoxyphenyl)-1-hexanone

Article	Year
DIF-1, putative morphogen of D. discoideum, suppresses cell growth and promotes retinoic acid-induced cell differentiation in HL-60. Biochemical and biophysical research communications, 1997, Jul-18, Volume: 236, Issue:2 Differentiation-inducing factor-1 (DIF-1) is a putative morphogen that induces stalk cell formation in the cellular slime mold Dictyostelium discoideum. In this study, we have examined the effects of DIF-1 on the human leukemia HL-60 cells. DIF-1 at 10-40 microM suppressed cell growth in a dose-dependent manner, and approximately 50% growth inhibition was attained with 15-20 microM DIF-1. FACS analysis of cell-cycle phase distribution using propidium iodide revealed that many cells were accumulated in the G1 phase after treatment with 15-20 microM DIF-1. These concentrations of DIF-1 also raised [Ca2+]i in a dose-dependent manner irrespective of the presence of extracellular Ca2+, indicating that DIF-1 elicited Ca2+-release from some intracellular Ca2+ store(s). Most importantly, relatively low concentrations of DIF-1 (1-5 microM) were found to promote retinoic acid-induced cell differentiation. The present results indicate that DIF-1 may be a useful tool for the analysis of myeloid cell differentiation and have therapeutic potential in the treatment of human myeloid leukemia. Topics: Animals; Calcium; Cell Differentiation; Cell Division; Cyclic AMP; Dictyostelium; Hexanones; HL-60 Cells; Humans; Tretinoin	1997

Article

Year

DIF-1, putative morphogen of D. discoideum, suppresses cell growth and promotes retinoic acid-induced cell differentiation in HL-60.

Biochemical and biophysical research communications, 1997, Jul-18, Volume: 236, Issue:2

Differentiation-inducing factor-1 (DIF-1) is a putative morphogen that induces stalk cell formation in the cellular slime mold Dictyostelium discoideum. In this study, we have examined the effects of DIF-1 on the human leukemia HL-60 cells. DIF-1 at 10-40 microM suppressed cell growth in a dose-dependent manner, and approximately 50% growth inhibition was attained with 15-20 microM DIF-1. FACS analysis of cell-cycle phase distribution using propidium iodide revealed that many cells were accumulated in the G1 phase after treatment with 15-20 microM DIF-1. These concentrations of DIF-1 also raised [Ca2+]i in a dose-dependent manner irrespective of the presence of extracellular Ca2+, indicating that DIF-1 elicited Ca2+-release from some intracellular Ca2+ store(s). Most importantly, relatively low concentrations of DIF-1 (1-5 microM) were found to promote retinoic acid-induced cell differentiation. The present results indicate that DIF-1 may be a useful tool for the analysis of myeloid cell differentiation and have therapeutic potential in the treatment of human myeloid leukemia.

Topics: Animals; Calcium; Cell Differentiation; Cell Division; Cyclic AMP; Dictyostelium; Hexanones; HL-60 Cells; Humans; Tretinoin

1997