trehalose has been researched along with sirolimus in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (14.29) | 29.6817 |
| 2010's | 13 (61.90) | 24.3611 |
| 2020's | 5 (23.81) | 2.80 |
| Authors | Studies |
|---|---|
| Davies, JE; Huang, Z; Rubinsztein, DC; Sarkar, S; Tunnacliffe, A | 1 |
| Rubinsztein, DC; Sarkar, S | 2 |
| Carp, RI; Choi, EK; Kim, YS; Oh, JM | 1 |
| Bergström, AL; Ejlerskov, P; Jensen, PH; Nielsen, TT; Rasmussen, I; Tohyama, Y; Vilhardt, F | 1 |
| Cortes, CJ; La Spada, AR | 1 |
| Lin, F; Qin, ZH | 1 |
| Fuentes, JM; Gómez-Sánchez, R; González-Polo, RA; Pedro, JM; Pizarro-Estrella, E; Rodríguez-Arribas, M; Yakhine-Diop, SM | 1 |
| Chen, S; Dai, H; Deng, Z; Du, H; Hei, TK; Liu, Y; Nie, Y; Wang, J; Wang, M; Wang, X; Wu, L; Xu, A | 1 |
| Kotake, Y; Miyara, M; Ohta, S; Sanoh, S; Tokunaga, W | 1 |
| Barrachina, MD; Calatayud, S; Cosín-Roger, J; Esplugues, JV; Hernández, C; Macias-Ceja, DC; Ortiz-Masiá, D; Salvador, P | 1 |
| Byun, S; Lee, E; Lee, KW | 1 |
| Cheerathodi, MR; Hurwitz, SN; Meckes, DG; Nkosi, D; York, SB | 1 |
| Cicardi, ME; Cristofani, R; Fontana, F; Limonta, P; Marzagalli, M; Montagnani Marelli, M; Moretti, RM; Poletti, A | 1 |
| Akopyan, AA; Dubrovina, NI; Korolenko, TA; Pupyshev, AB; Tenditnik, MV; Tikhonova, MA | 1 |
| Hoffmann, AC; Kazman, A; Klucken, J; Menges, S; Mielenz, D; Minakaki, G; Salvi, R; Savitskiy, S; Vicente Miranda, H; Winkler, J; Xiang, W | 1 |
| Chen, L; Fu, Y; Lu, Y; Shao, C; Sun, H; Wu, N; Yan, D; Yao, Q; Zhou, M | 1 |
| Abdellatif, M; Ljubojevic-Holzer, S; Madeo, F; Sedej, S | 1 |
| Akopyan, AA; Dubrovina, NI; Ovsyukova, MV; Pupyshev, AB; Tenditnik, MV; Tikhonova, MA | 1 |
| Akopyan, AA; Amstislavskaya, TG; Bashirzade, AA; Belichenko, VM; Dubrovina, NI; Fedoseeva, LA; Korolenko, TA; Ovsyukova, MV; Pupyshev, AB; Tenditnik, MV; Tikhonova, MA | 1 |
| Coupland, G; Feil, R; Krämer, U; Krause, M; Pietzenuk, B; Quintana, J; Romera-Branchat, M; Scholle, M; Schulten, A; Severing, E; Wahl, V | 1 |
7 review(s) available for trehalose and sirolimus
| Article | Year |
|---|---|
Huntington's disease: degradation of mutant huntingtin by autophagy.
Topics: Autophagy; Humans; Huntingtin Protein; Huntington Disease; Inositol; Lithium Compounds; Mutation; Nerve Tissue Proteins; Nuclear Proteins; Protein Kinases; Sirolimus; TOR Serine-Threonine Kinases; Trehalose | 2008 |
Small molecule enhancers of autophagy for neurodegenerative diseases.
Topics: Animals; Autophagy; Inositol; Models, Biological; Neurodegenerative Diseases; Protein Folding; Protein Kinases; Proteins; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Trehalose | 2008 |
The many faces of autophagy dysfunction in Huntington's disease: from mechanism to therapy.
Topics: Animals; Autophagy; Endoplasmic Reticulum Stress; Humans; Huntingtin Protein; Huntington Disease; Nerve Tissue Proteins; Sirolimus; Trehalose | 2014 |
Degradation of misfolded proteins by autophagy: is it a strategy for Huntington's disease treatment?
Topics: Autophagy; Carbamazepine; Humans; Huntingtin Protein; Huntington Disease; Lithium; Mutant Proteins; Nerve Tissue Proteins; Oxazoles; Peptides; Rilmenidine; Sirolimus; Trehalose; Trinucleotide Repeat Expansion; Valproic Acid | 2013 |
Is the Modulation of Autophagy the Future in the Treatment of Neurodegenerative Diseases?
Topics: Animals; Autophagy; Disease Models, Animal; Food; Humans; Isothiocyanates; Lithium; Neurodegenerative Diseases; Resveratrol; Sirolimus; Spermidine; Stilbenes; Sulfoxides; Trehalose; Valproic Acid | 2015 |
Therapeutic Implications of Autophagy Inducers in Immunological Disorders, Infection, and Cancer.
Topics: Adaptive Immunity; Animals; Autoimmune Diseases; Autophagy; Benzylisoquinolines; Cholecalciferol; Humans; Immune System Diseases; Immunity, Innate; Indoles; Infections; Isoquinolines; Lysosomes; Maprotiline; Metformin; Neoplasms; Phenols; Pyrroles; Resveratrol; Sirolimus; Spermidine; Stilbenes; Tetrahydroisoquinolines; Trehalose | 2017 |
Autophagy in cardiovascular health and disease.
Topics: Aging; Animals; Autophagosomes; Autophagy; Autophagy-Related Proteins; Caloric Restriction; Cardiovascular Diseases; Cardiovascular Physiological Phenomena; Embryonic Development; Endothelium, Vascular; Homeostasis; Humans; Mice; Mice, Transgenic; Mitochondria, Heart; Myocytes, Cardiac; Oxidative Stress; Sirolimus; Spermidine; Trehalose; Ubiquitin-Protein Ligases | 2020 |
14 other study(ies) available for trehalose and sirolimus
| Article | Year |
|---|---|
Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.
Topics: alpha-Synuclein; Animals; Antibiotics, Antineoplastic; Autophagy; Chlorocebus aethiops; COS Cells; HeLa Cells; Humans; Huntingtin Protein; Huntington Disease; Mice; Molecular Chaperones; Mutation; Nerve Tissue Proteins; Nuclear Proteins; Parkinson Disease; Protein Kinases; Sirolimus; TOR Serine-Threonine Kinases; Trehalose | 2007 |
Oxidative stress impairs autophagic flux in prion protein-deficient hippocampal cells.
Topics: Adenine; Animals; Apoptosis; Autophagy; Caspases; Enzyme Activation; Gene Knockdown Techniques; Hippocampus; Hydrogen Peroxide; Mice; Models, Biological; Neurons; Oxidative Stress; Prions; Protective Agents; Sirolimus; Time Factors; Trehalose | 2012 |
Tubulin polymerization-promoting protein (TPPP/p25α) promotes unconventional secretion of α-synuclein through exophagy by impairing autophagosome-lysosome fusion.
Topics: alpha-Synuclein; Animals; Autophagy; Carrier Proteins; Cell Differentiation; Cytoplasmic Vesicles; Gene Knockdown Techniques; Histone Deacetylase 6; Histone Deacetylases; Inclusion Bodies; Lysosomes; Membrane Fusion; Microtubule-Associated Proteins; Nerve Growth Factor; Neurites; PC12 Cells; Phagosomes; Protein Transport; Proteolysis; rab GTP-Binding Proteins; Rats; RNA, Small Interfering; Secretory Pathway; Sirolimus; TOR Serine-Threonine Kinases; Trehalose | 2013 |
Graphene Oxide Attenuates the Cytotoxicity and Mutagenicity of PCB 52 via Activation of Genuine Autophagy.
Topics: Adenine; Androstadienes; Animals; Autophagy; CD59 Antigens; Cell Line; Cricetinae; Graphite; Humans; Hybrid Cells; Mutagens; Oxides; Polychlorinated Biphenyls; Sirolimus; Trehalose; Wortmannin | 2016 |
Mild MPP
Topics: 1-Methyl-4-phenylpyridinium; Acids; Autophagy; Cathepsin D; Cell Death; Cell Line; Dopamine Agents; Humans; Lysosomes; Parkinson Disease, Secondary; Phagosomes; Sirolimus; Trehalose | 2016 |
Stimulation of autophagy prevents intestinal mucosal inflammation and ameliorates murine colitis.
Topics: Administration, Rectal; Animals; Autophagy; Betacyanins; Colitis; Female; Inflammation; Injections, Intraperitoneal; Intestinal Mucosa; Male; Mice; Mice, Inbred BALB C; Sirolimus; Trehalose; Trinitrobenzenesulfonic Acid | 2017 |
Tetraspanin CD63 Bridges Autophagic and Endosomal Processes To Regulate Exosomal Secretion and Intracellular Signaling of Epstein-Barr Virus LMP1
Topics: Autophagy; Cell Proliferation; Endosomes; Epstein-Barr Virus Infections; Exocytosis; Exosomes; HEK293 Cells; Herpesviridae; Herpesvirus 4, Human; Humans; Microscopy, Electron, Transmission; Protein Binding; Protein Transport; Secretory Vesicles; Signal Transduction; Sirolimus; Tetraspanin 30; Tetraspanins; TOR Serine-Threonine Kinases; Trehalose; Vacuoles; Viral Matrix Proteins; Virus Assembly | 2018 |
Dual role of autophagy on docetaxel-sensitivity in prostate cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Cytochromes c; Docetaxel; Humans; Male; Microtubule-Associated Proteins; Mitochondria; Mitophagy; PC-3 Cells; Prostatic Neoplasms, Castration-Resistant; RNA-Binding Proteins; Sirolimus; TOR Serine-Threonine Kinases; Trehalose | 2018 |
Therapeutic activation of autophagy by combined treatment with rapamycin and trehalose in a mouse MPTP-induced model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Autophagy; Behavior, Animal; Cognition; Corpus Striatum; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Drug Therapy, Combination; Male; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; MPTP Poisoning; Neuroprotective Agents; Neurotoxins; Parkinson Disease; Sirolimus; Substantia Nigra; Trehalose; Tyrosine 3-Monooxygenase | 2019 |
Extracellular aggregated alpha synuclein primarily triggers lysosomal dysfunction in neural cells prevented by trehalose.
Topics: alpha-Synuclein; Animals; Autophagy; Cell Line, Tumor; Escherichia coli; Glioma; Humans; Lysosomes; Neurons; Parkinson Disease; Protein Aggregation, Pathological; Rats; Rats, Wistar; Recombinant Proteins; Sirolimus; Trehalose | 2019 |
Trehalose attenuates TGF-β1-induced fibrosis of hSCFs by activating autophagy.
Topics: Autophagy; Cells, Cultured; Collagen Type I; Conjunctiva; Disease Progression; Extracellular Matrix; Fibroblasts; Fibronectins; Fibrosis; Humans; Inflammation; Myofibroblasts; Phosphorylation; Sirolimus; Smad2 Protein; Transforming Growth Factor beta1; Trehalose | 2020 |
Restoration of Parkinson's Disease-Like Deficits by Activating Autophagy through mTOR-Dependent and mTOR-Independent Mechanisms in Pharmacological and Transgenic Models of Parkinson's Disease in Mice.
Topics: Adenine; Animals; Autophagy; Disease Models, Animal; Mice; Mice, Inbred C57BL; Mice, Transgenic; MTOR Inhibitors; Neuroinflammatory Diseases; Neuroprotective Agents; Parkinson Disease; Parkinson Disease, Secondary; Signal Transduction; Sirolimus; Substantia Nigra; TOR Serine-Threonine Kinases; Trehalose | 2021 |
Combined induction of mTOR-dependent and mTOR-independent pathways of autophagy activation as an experimental therapy for Alzheimer's disease-like pathology in a mouse model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Autophagy; Disease Models, Animal; Mice; Mice, Transgenic; Sirolimus; Therapies, Investigational; TOR Serine-Threonine Kinases; Trehalose | 2022 |
Energy status-promoted growth and development of Arabidopsis require copper deficiency response transcriptional regulator SPL7.
Topics: Adenosine Triphosphate; Arabidopsis; Arabidopsis Proteins; Chromatin; Copper; DNA-Binding Proteins; Electron Transport Complex IV; Gene Expression Regulation, Plant; Growth and Development; NAD; Phosphates; Sirolimus; Soil; Superoxides; Transcription Factors; Trehalose | 2022 |