trehalose has been researched along with mannitol in 154 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (10.39) | 18.7374 |
| 1990's | 19 (12.34) | 18.2507 |
| 2000's | 36 (23.38) | 29.6817 |
| 2010's | 71 (46.10) | 24.3611 |
| 2020's | 12 (7.79) | 2.80 |
| Authors | Studies |
|---|---|
| Adam, S | 1 |
| Musílek, V; Volc, J; Wurst, M | 1 |
| Hammond, JB; Nichols, R | 1 |
| Dickerson, AG; Mantle, PG; Nisbet, LJ | 1 |
| Bremner, DA; Gavin, JB; Joshi, KR; Parr, DN | 1 |
| Brennan, PJ; Byrne, PF | 1 |
| Jayaswal, RK; Upadhyay, RS; Visintin, L | 1 |
| Haverkamp, U; Pötter, R; Wiezorek, C | 1 |
| Furtula, V; Khan, IA; Nothnagel, EA | 1 |
| Knapp, CC; Washington, JA | 1 |
| Hall, GS; Knapp, CC; Pratt, K; Rutherford, I; Woods, GL | 1 |
| Mohan, K | 1 |
| Coykendall, AL; Samol, HH; Specht, PA | 1 |
| Holligan, PM; Lewis, DH | 1 |
| Jones, C; Stevens, DL | 1 |
| Alvarado, F; Brot-Laroche, E | 1 |
| da Costa, MS; Niederpruem, DJ | 1 |
| Tarelli, E; White, CA | 1 |
| Hallsworth, JE; Magan, N | 1 |
| Boutron, P; Peyridieu, JF | 1 |
| Broadhead, J; Hau, I; Rhodes, CT; Rouan, SK | 1 |
| Arakawa, T; Carpenter, JF; Prestrelski, SJ | 2 |
| Mulder, JG | 1 |
| d'Enfert, C; Fontaine, T | 1 |
| Costantino, HR; Curley, JG; Hsu, CC | 1 |
| Lindquist, S; Singer, MA | 1 |
| Bodmer, D; Helk, B; Leuenberger, H; Lueckel, B | 1 |
| Carpenter, JF; Flink, JM; Frokjaer, S; Kreilgaard, L; Randolph, TW | 2 |
| Byron, PR; Naini, V; Phillips, EM | 1 |
| Bago, B; Bécard, G; Brouillette, J; Douds, DD; Pfeffer, PE; Shachar-Hill, Y | 1 |
| Aben, EM; Op den Camp, HJ; van der Drift, C; Van Griensven, LJ; Vogels, GD; Wannet, WJ | 1 |
| Aguirre, J; Caplan, A; Couto, RM; Goldman, GH; Goldman, MHS; Iyer, S; Noventa-Jordão, MA; Terenzi, HF | 1 |
| Hermans, JH; Op Den Camp, HJ; van Der Drift, C; Wannet, WJ | 1 |
| Choi, SH; Gu, MB; Kim, SW | 1 |
| Costantino, HR; Middaugh, CR; Rytting, JH; Souillac, PO | 1 |
| Juneau, G; Kubicek, CP; Liu, J; Peksel, A; Torres, NV | 1 |
| Chen, TH; Murata, N | 1 |
| Lee, G; Maa, YF; Sonner, C | 1 |
| Cairney, JW; Sanders, FE; Tibbett, M | 1 |
| Hugenholtz, J; Smid, EJ | 1 |
| Kalonia, DS; Sharma, VK | 1 |
| Gloger, O; Müller, BW; Witthohn, K | 1 |
| BALLIO, A; DIVITTORIO, V; RUSSI, S | 1 |
| Chakraborty, TK; Das, N; Mukherjee, M | 1 |
| Lu, X; Pikal, MJ | 1 |
| Etcheverry, M; Magan, N; Nesci, A | 1 |
| Fontao, MJ; Landín, M; Martínez-Pacheco, R | 1 |
| Bertrand, A; Bois, G; Fung, M; Khasa, DP; Piché, Y | 1 |
| Anderson, AJ; Rangel, DE; Roberts, DW | 2 |
| Jörgens, CI; Lowe, RG; Oliver, RP; Rechberger, J; Solomon, PS; Trengove, RD; Waters, OD | 1 |
| Chesko, J; Kazzaz, J; O'Hagan, D; Singh, M; Soewanan, E; Ugozzoli, M; Wendorf, J | 1 |
| Bakaltcheva, I; Hmel, P; O'Sullivan, AM; Ogbu, H | 1 |
| Cho, JS; Hong, SM; Joo, SY; Kim, DI; Yoo, JS | 1 |
| Cutrignelli, A; Denora, N; Laquintana, V; Latrofa, A; Liso, G; Lopedota, A; Trapani, A; Trapani, G | 1 |
| Krishnamurthy, R; Liao, X; Suryanarayanan, R | 1 |
| Lee, G; Rochelle, C | 1 |
| Caron, V; Descamps, M; Dudognon, E; Willart, JF | 1 |
| Lee, G; Schiffter, H | 1 |
| Gieseler, H; Lee, G | 1 |
| Bonner, MC; Forbes, RT; Getrost, M; Hulse, WL | 1 |
| Daub, ME; Glassbrook, NJ; Vélëz, H | 1 |
| Anhorn, MG; Langer, K; Mahler, HC | 1 |
| Kalonia, DS; Kumar, V; Sharma, VK | 1 |
| Feng, MG; Jiang, XH; Liu, Q; Ying, SH | 1 |
| Chi, C; Desikan, S; Hussain, M; Mathias, N; Moench, P; Qian, F; Smith, RL | 1 |
| Bligny, R; Chinnici, G; Cotton, P; Dulermo, T; Gout, E; Rascle, C | 1 |
| Irisawa, Y; Okimoto, K; Okuda, Y; Osawa, T; Yamashita, S | 1 |
| Besman, M; Bjornson, E; Jameel, F; Lu, X; Pikal, M; Tchessalov, S | 1 |
| Hickey, AJ; Mansour, HM; Xu, Z | 1 |
| Dietz, S; Göhringer, F; Nehls, U; Wittulsky, S | 1 |
| Arpagaus, C; Friess, W; Schmid, K | 1 |
| Condliffe, J; Schiffter, H; Vonhoff, S | 1 |
| Forsberg, F; Solis, C; Wheatley, MA | 1 |
| Llabrés, M; Piñero, MJ; Santoveña, A | 1 |
| Sundaramurthi, P; Suryanarayanan, R | 1 |
| Fujita, Y; Ikemoto, T; Jackson, A; Kobayashi, N; Levy, MF; Matsumoto, S; Naziruddin, B; Noguchi, H; Onaca, N; Shimoda, M | 1 |
| Cai, C; Guan, T; He, H; Miao, Y; Tang, X; Wang, J; Xu, H; Xu, L; Yang, S | 1 |
| Borkovich, KA; Kaiser, K; Kim, JD; Larive, CK | 1 |
| Dooley, N; Elliott, M; Ford, SJ; Halbert, GW; Schmidt, E | 1 |
| De Beer, T; Huyge, K; Landman, WJ; Remon, JP; van Eck, JH; Van Reeth, K; Vervaet, C | 1 |
| Barros, L; Ferreira, IC; Heleno, SA; Martins, A; Reis, FS; Santos-Buelga, C; Sousa, MJ | 1 |
| Bie, XM; Lu, YP; Lu, ZX; Lv, FX; Zhang, C | 1 |
| Bassarab, S; Betz, O; Garidel, P; Muehlau, S; Schersch, K; Winter, G | 1 |
| Bolko, K; Gašperlin, M; Zvonar, A | 1 |
| Carlberg, R; Kaminskas, LM; McIntosh, MP; Morton, DA; Nguyen, TH; Sou, T | 1 |
| Eissens, AC; Hinrichs, WL; Murugappan, S; Quax, WJ; van Merkerk, R; Visser, MR; Wahjudi, M | 1 |
| Barzegar, M; Moharramipour, S; Saeidi, F | 1 |
| Andersen, P; Christensen, D; Foged, C; Hinrichs, WL; Ingvarsson, PT; Larsen, NB; Nielsen, HM; Rantanen, J; Schmidt, ST; Yang, M | 1 |
| Bano, F; Fatma, T; Habib, K; Ningthoujam, M; Zutshi, S | 1 |
| Bellich, B; Blasi, P; Borgogna, M; Cesàro, A; Rampino, A | 1 |
| Barros, L; Calhelha, RC; Cirić, A; Ferreira, IC; Reis, FS; Soković, M; van Griensven, LJ | 1 |
| Devi, S; Williams, D | 1 |
| Ketolainen, J; Molnár, F; Peters, BH | 1 |
| Ajmera, A; Altrichter, J; Carroll, MW; Dennis, M; Kemter, K; Marriott, AC; Scherließ, R; Scholz, M; Silman, NJ | 1 |
| Cho, YK; Doty, MJ; Kuu, WY; Nisipeanu, E; Rebbeck, CL; Smit, MH | 1 |
| Dijksterhuis, J; Golovina, EA; Hallsworth, JE; van Leeuwen, R; Wösten, HA; Wyatt, TT | 1 |
| Chen, W; Feng, J; Li, W; Li, X; Liu, Y; Yang, Y; Yu, H; Zhou, S | 1 |
| Erber, M; Lee, G | 1 |
| Garza-López, PM; Hamdan-Partida, A; Loera, O; Suárez-Vergel, G | 1 |
| Lee, G; Schaefer, J | 1 |
| Li, S; Liu, X; Zhang, G; Zhang, J; Zhong, X | 1 |
| Chen, X; Crichton, ML; Falconer, RJ; Fernando, GJ; Huang, H; Kendall, MA; Meliga, S; Raphael, AP | 1 |
| Hu, M; Li, J; Li, L; Luan, X; Wang, K; Xu, H; Ye, F; Yu, X; Zhang, D | 1 |
| Britton, WJ; Carrigy, NB; Chan, HK; Finlay, WH; Gao, FG; Kutter, E; Leung, SS; Morales, S; Parumasivam, T; Vehring, R | 1 |
| Cranston, ED; LeClair, DA; Thompson, MR; Xing, Z | 1 |
| Barroetaveña, C; Barros, L; Fernandes, Â; Ferreira, IC; Toledo, CV | 1 |
| Coroller, L; Dantigny, P; Le Panse, S; Mounier, J; Nguyen Van Long, N; Rigalma, K; Vasseur, V; Weill, A | 1 |
| Aksan, A; Friess, W; Horn, J; Jena, S; Suryanarayanan, R | 1 |
| Afkhami, S; Cranston, ED; Ertl, HC; Haddadi, S; Lai, R; LeClair, DA; Thompson, MR; Toniolo, SP; Xing, Z | 1 |
| Anderson, DE; Kirchmeier, M; McNeil, SE; Perrie, Y; Wilkhu, JS | 1 |
| Agnoletti, M; Boetker, JP; Bohr, A; Foged, C; Thanki, K; Wan, F; Yang, M; Zeng, X | 1 |
| Hardwick, LM; Nail, SL; Srinivasan, JM; Wegiel, LA | 1 |
| Darkwah, J; Ermolina, I; Hackl, E; Smith, G | 1 |
| Hubloher, J; Lamosa, P; Müller, V; Santos, H; Schabacker, K; Zeidler, S | 1 |
| Moussa, EM; Nema, S; Singh, SK; Topp, EM; Wilson, NE; Zhou, QT | 1 |
| Bosquillon, C; Childerhouse, N; Coghlan, D; Falcone, FH; Mantovani, G; Nieto-Orellana, A; Rothery, M; Stolnik, S | 1 |
| Holtappels, J; Lee, G; Zimmermann, R | 1 |
| Ghosh, D; Peng, X; Watts, AB; Zhang, H; Zhang, Y | 1 |
| Gieseler, H; Kunz, C | 1 |
| Geidobler, R; Gitter, JH; Presser, I; Winter, G | 2 |
| Jakobs-Schoenwandt, D; Krell, V; Patel, AV; Persicke, M | 1 |
| Rangel, DEN; Roberts, DW | 1 |
| Aghababaie, S; Amini Pouya, M; Daneshmand, B; Darabi, M; Faghihi, H; Vatanara, A | 1 |
| Abulateefeh, SR; Al-Qaoud, KM; Alkilany, AM; Hamaly, MA | 1 |
| Koranne, S; Suryanarayanan, R; Thakral, S | 1 |
| Aksan, A; Friess, W; Horn, J; Jena, S | 1 |
| Afkhami, S; Cranston, ED; Fradin, C; Lichty, BD; Mahmood, A; Miller, MS; Thompson, MR; Toniolo, SP; Xing, Z | 1 |
| Ianutsevich, EA; Tereshina, VM | 1 |
| Arsiccio, A; Duru, C; Ferguson, J; Malik, K; Matejtschuk, P; Oddone, I; Pisano, R | 1 |
| Burgess, DJ; Jog, R | 1 |
| Danilova, OA; Ianutsevich, EA; Kamzolkina, OV; Kozlova, MV; Tereshina, VM | 1 |
| Suryanarayanan, R; Thorat, AA | 1 |
| Kumar, NSK; Randolph, TW; Snell, JR; Suryanarayanan, R | 1 |
| Grohganz, H; Holm, TP; Jorgensen, L; Meng-Lund, H; Poso, A; Rantanen, J | 1 |
| McComiskey, KPM; McDonagh, A; Tajber, L | 1 |
| Kammari, R; Topp, EM | 1 |
| da Silva Brandão, M; Geris, R; Silva Abreu, L | 1 |
| Aksan, A; Jena, S; Krishna Kumar, NS; Suryanarayanan, R | 1 |
| Costabile, G; da Rocha, S; Feldmann, DP; Keil, TWM; Merkel, OM; Zhong, Q | 1 |
| Nelson, KM; Rautiola, D; Siegel, RA; Updyke, JL | 1 |
| Ellis, R; Kunda, NK; Muttil, P; Price, DN | 1 |
| Feng, MG; Tong, SM | 1 |
| Afkhami, S; Cranston, ED; D'Agostino, MR; Lichty, BD; Thompson, MR; Toniolo, SP; Xing, Z | 1 |
| Depciuch, J; Durak, R; Durak, T; Kapusta, I; Kisała, J | 1 |
| Mikani, A; Moharramipour, S; Saeidi, F | 1 |
| Bogner, RH; Kim, R; Lu, X; Luo, WC; O'Reilly Beringhs, A; Patel, SM; Zhang, W | 1 |
| Cranston, ED; Feng, X; Manser, M; Thompson, MR; Xing, Z | 1 |
| Chisholm, CF; Sonje, J; Suryanarayanan, R | 1 |
| Alexeenko, A; Darwish, A; Mutukuri, TT; Peroulis, D; Strongrich, AD; Zhou, QT | 1 |
| Bidart, GN; Gharabli, H; Welner, DH | 1 |
4 review(s) available for trehalose and mannitol
| Article | Year |
|---|---|
Enhancement of tolerance of abiotic stress by metabolic engineering of betaines and other compatible solutes.
Topics: Adaptation, Physiological; Betaine; Choline; Fructans; Genetic Engineering; Glycine; Mannitol; Oxidative Stress; Plants; Plants, Genetically Modified; Proline; Sorbitol; Stress, Mechanical; Trehalose | 2002 |
Nutraceutical production with food-grade microorganisms.
Topics: Antioxidants; Bacteria; Carbohydrate Metabolism; Folic Acid; Hexoses; Humans; Intestines; Lactococcus lactis; Mannitol; Probiotics; Riboflavin; Sorbitol; Species Specificity; Trehalose; Vitamin B 12 | 2002 |
Fungal carbohydrate support in the ectomycorrhizal symbiosis: a review.
Topics: beta-Fructofuranosidase; Carbohydrate Metabolism; Mannitol; Mycorrhizae; Photosynthesis; Plant Roots; Soil; Sucrose; Symbiosis; Trees; Trehalose | 2010 |
Phenotypic and molecular insights into heat tolerance of formulated cells as active ingredients of fungal insecticides.
Topics: Animals; Cell Wall; Fungi; Genes, Fungal; Genetic Engineering; Genetic Variation; Insecticides; Mannitol; Pest Control, Biological; Spores, Fungal; Thermotolerance; Trehalose | 2020 |
1 trial(s) available for trehalose and mannitol
| Article | Year |
|---|---|
Freeze-dried whole plasma: evaluating sucrose, trehalose, sorbitol, mannitol and glycine as stabilizers.
Topics: Blood Preservation; Excipients; Freeze Drying; Glycine; Humans; Mannitol; Plasma; Sorbitol; Sucrose; Trehalose | 2007 |
149 other study(ies) available for trehalose and mannitol
| Article | Year |
|---|---|
gamma-radiolysis of N2O-saturated aqueous solutions of trehalose and trehalose/amino acid mixtures.
Topics: Amino Acids; Chromatography, Gas; Cobalt Radioisotopes; Deoxyglucose; Disaccharides; Gamma Rays; Glucose; Hexanols; Mannitol; Mass Spectrometry; Nitrous Oxide; Solutions; Spectrum Analysis; Trehalose | 1977 |
Soluble sugars in the mycelium of the basidiomycete Oudemansiella mucida.
Topics: Basidiomycota; Chromatography, Gas; Chromatography, Paper; Glucose; Glycerol; Inositol; Mannitol; Sugar Alcohols; Trehalose | 1978 |
Carbohydrate metabolism in Agaricus bisporus (Lange) Sing: changes in soluble carbohydrates during growth of mycelium and sporophore.
Topics: Basidiomycota; Carbohydrate Metabolism; Fungal Proteins; Glucose; Mannitol; Solubility; Spores, Fungal; Sucrose; Trehalose | 1976 |
Carbon assimilation by Claviceps purpurea growing as a parasite.
Topics: Carbon; Claviceps; Edible Grain; Hexoses; Mannitol; Oligosaccharides; Secale; Sucrose; Trehalose | 1976 |
The morphological identification of pathogenic yeasts using carbohydrate media.
Topics: Agar; Candida; Candida albicans; Carbohydrates; Cryptococcus; Cryptococcus neoformans; Culture Media; Dextrins; Fructose; Galactitol; Galactose; Glucose; Glycogen; Inulin; Maltose; Mannitol; Oryza; Peptones; Saccharomyces cerevisiae; Spores, Fungal; Sucrose; Trehalose; Xylose; Yeasts | 1975 |
The lipids of Agaricus bisporus.
Topics: Agaricales; Fatty Acids, Nonesterified; Glucose; Glycolipids; Linoleic Acids; Lipids; Mannitol; Phosphatidylethanolamines; Phosphatidylserines; Phospholipids; Sterols; Trehalose | 1975 |
Environmental factors affecting the antagonism of Pseudomonas cepacia against Trichoderma viride.
Topics: Burkholderia cepacia; Glucose; Hydrogen-Ion Concentration; Mannitol; Nitrogen; Spores, Fungal; Temperature; Trehalose; Trichoderma; Xylose | 1991 |
Applicability of LLD in neutron dosimetry.
Topics: Glucose; Humans; Leucine; Luminescent Measurements; Mannitol; Models, Structural; Neutrons; Radiotherapy Dosage; Trehalose; Xylitol | 1990 |
Selective osmotic effect on diffusion of plasma membrane lipids in maize protoplasts.
Topics: Cell Membrane; Diffusion; Mannitol; Membrane Lipids; Phospholipids; Protoplasts; Trehalose; Zea mays | 1990 |
Evaluation of trehalose-mannitol broth for differentiation of Staphylococcus epidermidis from other coagulase-negative staphylococcal species.
Topics: Culture Media; Disaccharides; Humans; Mannitol; Staphylococcal Infections; Staphylococcus epidermidis; Trehalose | 1989 |
Rapid identification of Staphylococcus epidermidis.
Topics: Alkaline Phosphatase; Bacteriological Techniques; Mannitol; Staphylococcus; Staphylococcus epidermidis; Sucrose; Trehalose; Xylose | 1987 |
Mycobacterium senegalense from bovines in Eastern Nigeria.
Topics: Animals; Benzoates; Carbohydrate Metabolism; Cattle; Citrates; Lung; Lymph Nodes; Mannitol; Mycobacterium; Nigeria; Species Specificity; Thorax; Trehalose; Tuberculosis, Bovine | 1985 |
Streptococcus mutans in a wild, sucrose-eating rat population.
Topics: Animals; Arginine; Bacteriological Techniques; Cariogenic Agents; Dental Caries; DNA, Bacterial; Genetics, Microbial; Glucose; Mannitol; Mouth Mucosa; Nucleic Acid Hybridization; Polysaccharides, Bacterial; Rats; Streptococcus; Sucrose; Thymidine; Tooth; Trehalose; Tritium; Viral Plaque Assay | 1974 |
The soluble carbohydrates of Aspergillus clavatus.
Topics: Arabinose; Aspergillus; Carbohydrates; Chromatography, Gas; Chromatography, Paper; Culture Media; Erythritol; Fructose; Glucose; Glycerol; Inositol; Mannitol; Sugar Alcohols; Trehalose | 1973 |
Use of trehalose-mannitol-phosphatase agar to differentiate Staphylococcus epidermidis and Staphylococcus saprophyticus from other coagulase-negative staphylococci.
Topics: Agar; Coagulase; Culture Media; Hydrogen-Ion Concentration; Mannitol; Phosphoric Monoester Hydrolases; Staphylococcus; Staphylococcus epidermidis; Trehalose | 1984 |
Disaccharide uptake by brush-border membrane vesicles lacking the corresponding hydrolases.
Topics: Animals; Chickens; Disaccharidases; Disaccharides; Glucose; Intestines; Lactose; Mannitol; Microvilli; Osmolar Concentration; Sucrose; Swine; Trehalose | 1984 |
Temporal accumulation of mannitol and arabitol in Geotrichum candidum.
Topics: Arabinose; Carbohydrate Metabolism; Geotrichum; Kinetics; Mannitol; Mitosporic Fungi; Spores, Fungal; Sugar Alcohols; Trehalose | 1980 |
Additives to biological substances. II. Relative stabilities of some carbohydrate additives at and around neutral pH values in phosphate buffers and water.
Topics: Buffers; Carbohydrates; Freeze Drying; Hydrogen-Ion Concentration; Lactose; Mannitol; Phosphates; Preservation, Biological; Solutions; Sucrose; Trehalose; Water | 1982 |
Manipulation of intracellular glycerol and erythritol enhances germination of conidia at low water availability.
Topics: Culture Media; Erythritol; Glycerol; Mannitol; Mitosporic Fungi; Paecilomyces; Species Specificity; Sugar Alcohols; Trehalose; Water | 1995 |
Reduction in toxicity for red blood cells in buffered solutions containing high concentrations of 2,3-butanediol by trehalose, sucrose, sorbitol, or mannitol.
Topics: Blood Preservation; Butylene Glycols; Cryopreservation; Cryoprotective Agents; Erythrocytes; Evaluation Studies as Topic; Hemolysis; Humans; In Vitro Techniques; Mannitol; Solutions; Sorbitol; Sucrose; Time Factors; Trehalose | 1994 |
The effect of process and formulation variables on the properties of spray-dried beta-galactosidase.
Topics: Arginine; beta-Galactosidase; Excipients; Humidity; Hydrogen-Ion Concentration; Mannitol; Microscopy, Electron, Scanning; Particle Size; Sucrose; Technology, Pharmaceutical; Temperature; Trehalose | 1994 |
Separation of freezing- and drying-induced denaturation of lyophilized proteins using stress-specific stabilization. I. Enzyme activity and calorimetric studies.
Topics: Animals; Calorimetry, Differential Scanning; Crystallization; Enzyme Stability; Freeze Drying; Glucose; L-Lactate Dehydrogenase; Lactose; Mannitol; Phosphofructokinase-1; Polyethylene Glycols; Protein Denaturation; Rabbits; Thermodynamics; Trehalose | 1993 |
Separation of freezing- and drying-induced denaturation of lyophilized proteins using stress-specific stabilization. II. Structural studies using infrared spectroscopy.
Topics: Animals; Enzyme Stability; Freeze Drying; Glucose; L-Lactate Dehydrogenase; Lactose; Mannitol; Phosphofructokinase-1; Polyethylene Glycols; Protein Conformation; Protein Denaturation; Rabbits; Spectrophotometry, Infrared; Trehalose | 1993 |
A simple and inexpensive method for the identification of Staphylococcus epidermidis and Staphylococcus hominis.
Topics: Deferoxamine; Fermentation; Mannitol; Microbial Sensitivity Tests; Reagent Kits, Diagnostic; Staphylococcus; Staphylococcus epidermidis; Sucrose; Trehalose | 1995 |
Molecular characterization of the Aspergillus nidulans treA gene encoding an acid trehalase required for growth on trehalose.
Topics: Amino Acid Sequence; Aspergillus nidulans; Base Sequence; Carbon; Disaccharidases; DNA, Fungal; Fungal Proteins; Glycerol; Mannitol; Molecular Sequence Data; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Solubility; Spores, Fungal; Trehalase; Trehalose | 1997 |
Determining the water sorption monolayer of lyophilized pharmaceutical proteins.
Topics: Adsorption; Antibodies, Monoclonal; Deoxyribonuclease I; Excipients; Freeze Drying; Human Growth Hormone; Humans; Insulin-Like Growth Factor I; Interferon-gamma; Mannitol; Recombinant Proteins; Tissue Plasminogen Activator; Trehalose; Water | 1997 |
Multiple effects of trehalose on protein folding in vitro and in vivo.
Topics: Animals; Betaine; Coleoptera; Fluorescence Polarization; Fungal Proteins; Genes, Reporter; Glucose; Glycerol; Heat-Shock Proteins; Luciferases; Maltose; Mannitol; Molecular Chaperones; Proline; Protein Folding; Sorbitol; Sucrose; Temperature; Trehalose; Yeasts | 1998 |
Effects of formulation and process variables on the aggregation of freeze-dried interleukin-6 (IL-6) after lyophilization and on storage.
Topics: Dextrans; Drug Stability; Drug Storage; Freeze Drying; Glycine; Interleukin-6; Mannitol; Trehalose | 1998 |
Effects of additives on the stability of recombinant human factor XIII during freeze-drying and storage in the dried solid.
Topics: Dextrans; Drug Stability; Drug Storage; Excipients; Factor XIII; Freeze Drying; Humans; Mannitol; Polyethylene Glycols; Polysorbates; Protein Folding; Recombinant Proteins; Sucrose; Time Factors; Trehalose; Water | 1998 |
Physicochemical stability of crystalline sugars and their spray-dried forms: dependence upon relative humidity and suitability for use in powder inhalers.
Topics: Calorimetry, Differential Scanning; Carbohydrates; Chemical Phenomena; Chemistry, Physical; Crystallization; Drug Stability; Excipients; Humidity; Lactose; Mannitol; Nebulizers and Vaporizers; Pressure; Sucrose; Temperature; Trehalose | 1998 |
Effects of additives on the stability of Humicola lanuginosa lipase during freeze-drying and storage in the dried solid.
Topics: Dextrans; Disaccharides; Drug Storage; Enzyme Stability; Excipients; Freeze Drying; Fungal Proteins; Lipase; Mannitol; Mitosporic Fungi; Polysorbates; Protein Structure, Secondary; Solutions; Sucrose; Time Factors; Trehalose; Water | 1999 |
Carbon metabolism in spores of the arbuscular mycorrhizal fungus Glomus intraradices as revealed by nuclear magnetic resonance spectroscopy.
Topics: Amino Acids; Betaine; Carbon; Carbon Dioxide; Darkness; Fungi; Hexoses; Lipid Metabolism; Magnetic Resonance Spectroscopy; Mannitol; Spores, Fungal; Symbiosis; Time Factors; Trehalose | 1999 |
Trehalose phosphorylase activity and carbohydrate levels during axenic fruiting in three Agaricus bisporus strains.
Topics: Agaricus; Carbohydrate Metabolism; Chromatography, High Pressure Liquid; Culture Media; Glucose; Glucosyltransferases; Mannitol; Trehalose | 1999 |
Catalase activity is necessary for heat-shock recovery in Aspergillus nidulans germlings.
Topics: Aspergillus nidulans; Blotting, Northern; Catalase; Chromatography, Gas; Fungal Proteins; Gene Deletion; Heat-Shock Proteins; Hydrogen Peroxide; Mannitol; RNA, Fungal; RNA, Messenger; Time Factors; Trehalose | 1999 |
HPLC detection of soluble carbohydrates involved in mannitol and trehalose metabolism in the edible mushroom Agaricus bisporus.
Topics: Agaricales; Carbohydrates; Chromatography, High Pressure Liquid; Glucosyltransferases; Mannitol; Plants, Edible; Solubility; Trehalose | 2000 |
Some observations in freeze-drying of recombinant bioluminescent Escherichia coli for toxicity monitoring.
Topics: Biosensing Techniques; Chlorophenols; Cryoprotective Agents; Escherichia coli; Freeze Drying; Luminescent Measurements; Mannitol; Microbiological Techniques; Microscopy, Electron, Scanning; Sorbitol; Sucrose; Toxicity Tests; Trehalose | 2001 |
Investigation of protein/carbohydrate interactions in the dried state. 1. Calorimetric studies.
Topics: Calorimetry, Differential Scanning; Carbohydrates; Dextrans; Freeze Drying; Humans; Mannitol; Proteins; Solutions; Sucrose; Trehalose | 2002 |
13C-NMR analysis of glucose metabolism during citric acid production by Aspergillus niger.
Topics: Aspergillus niger; Carbon Isotopes; Citric Acid; Glucose; Magnetic Resonance Spectroscopy; Mannitol; Phosphoenolpyruvate; Pyruvic Acid; Trehalose | 2002 |
Spray-freeze-drying for protein powder preparation: particle characterization and a case study with trypsinogen stability.
Topics: Chromatography, Gel; Crystallography, X-Ray; Dextrans; Drug Compounding; Drug Stability; Electrophoresis, Polyacrylamide Gel; Freeze Drying; Humidity; Kinetics; Mannitol; Microscopy, Electron, Scanning; Particle Size; Porosity; Powders; Proteins; Trehalose; Trypsinogen | 2002 |
Low-temperature-induced changes in trehalose, mannitol and arabitol associated with enhanced tolerance to freezing in ectomycorrhizal basidiomycetes (Hebeloma spp.).
Topics: Agaricales; Biomass; Freezing; Mannitol; Mycelium; Mycorrhizae; Soil; Sugar Alcohols; Temperature; Trehalose | 2002 |
Steady-state tryptophan fluorescence spectroscopy study to probe tertiary structure of proteins in solid powders.
Topics: Chemical Phenomena; Chemical Precipitation; Chemistry, Physical; Crystallization; Guanidine; Interferon alpha-2; Interferon-alpha; Lactoglobulins; Mannitol; Polyethylene Glycols; Powders; Protein Denaturation; Protein Structure, Tertiary; Recombinant Proteins; Spectrometry, Fluorescence; Trehalose; Tryptophan | 2003 |
Lyoprotection of aviscumine with low molecular weight dextrans.
Topics: Antineoplastic Agents; Calorimetry, Differential Scanning; Crystallization; Dextrans; Drug Stability; Enzyme-Linked Immunosorbent Assay; Excipients; Freeze Drying; Hot Temperature; Mannitol; Molecular Weight; Plant Preparations; Plant Proteins; Ribosome Inactivating Proteins, Type 2; Toxins, Biological; Trehalose; Water; X-Ray Diffraction | 2003 |
THE ISOLATION OF TREHALOSE AND POLYOLS FROM THE CONIDIA OF PENICILLIUM CHRYSOGENUM THOM.
Topics: Alcohols; Chemistry Techniques, Analytical; Chromatography; Disaccharides; Glycerol; Mannitol; Metabolism; Penicillium; Penicillium chrysogenum; Polymers; Research; Spores, Fungal; Trehalose | 1964 |
Evidences of high carbon catabolic enzyme activities during sporulation of Pleurotus ostreatus (Florida).
Topics: Carbohydrate Metabolism; Citric Acid Cycle; Gluconeogenesis; Glucose; Glutamate Dehydrogenase (NADP+); Glycolysis; Mannitol; Mannitol Dehydrogenases; Mycelium; Pentose Phosphate Pathway; Pleurotus; Spores, Fungal; Trehalose | 2003 |
Freeze-drying of mannitol-trehalose-sodium chloride-based formulations: the impact of annealing on dry layer resistance to mass transfer and cake structure.
Topics: Chemistry, Pharmaceutical; Freeze Drying; Mannitol; Sodium Chloride; Technology, Pharmaceutical; Trehalose | 2004 |
Osmotic and matric potential effects on growth, sugar alcohol and sugar accumulation by Aspergillus section Flavi strains from Argentina.
Topics: Argentina; Aspergillus; Carbohydrate Metabolism; Culture Media; Dehydration; Ecosystem; Erythritol; Glucose; Glycerol; Mannitol; Mycelium; Osmosis; Soil Microbiology; Sugar Alcohols; Temperature; Trehalose | 2004 |
A comparison of trehalose dihydrate and mannitol as stabilizing agents for dicalcium phosphate dihydrate based tablets.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Calcium Phosphates; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Drug Stability; Drug Storage; Mannitol; Sweetening Agents; Tablets; Trehalose | 2005 |
Growth, compatible solute and salt accumulation of five mycorrhizal fungal species grown over a range of NaCl concentrations.
Topics: Chlorine; Culture Media; Mannitol; Mycelium; Mycorrhizae; Proline; Sodium; Sodium Chloride; Soil Microbiology; Soil Pollutants; Species Specificity; Trehalose | 2006 |
Growth of Metarhizium anisopliae on non-preferred carbon sources yields conidia with increased UV-B tolerance.
Topics: Animals; Carbohydrate Metabolism; Culture Media; Glucose; Mannitol; Metarhizium; Nitrogen; Radiation Tolerance; Spores, Fungal; Trehalose; Ultraviolet Rays | 2006 |
Mannitol is required for asexual sporulation in the wheat pathogen Stagonospora nodorum (glume blotch).
Topics: Ascomycota; Blotting, Southern; Cloning, Molecular; Culture Media; Gene Expression Regulation, Fungal; Mannitol; Mannitol Dehydrogenases; Molecular Sequence Data; Plant Diseases; Plant Leaves; RNA, Messenger; Sequence Analysis, DNA; Spores, Fungal; Sugar Alcohol Dehydrogenases; Trehalose; Triticum; Virulence | 2006 |
A practical approach to the use of nanoparticles for vaccine delivery.
Topics: Animals; Bacterial Proteins; Chemistry, Pharmaceutical; Drug Combinations; Drug Delivery Systems; Excipients; Female; Filtration; Freeze Drying; Immunoglobulin G; Isatin; Mannitol; Meningococcal Vaccines; Mice; Mice, Inbred Strains; Nanoparticles; Ovalbumin; Polyglactin 910; Polyvinyl Alcohol; Pyridines; Serum Albumin, Bovine; Succinates; Surface-Active Agents; Trehalose | 2006 |
Cryopreservation of transgenic rice suspension cells producing recombinant hCTLA4Ig.
Topics: Abatacept; Cell Survival; Cryopreservation; Humans; Immunoconjugates; Mannitol; Oryza; Plants, Genetically Modified; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Sodium Chloride; Sorbitol; Sucrose; Time Factors; Trehalose | 2007 |
Comparative effects of some hydrophilic excipients on the rate of gabapentin and baclofen lactamization in lyophilized formulations.
Topics: Amines; Anticonvulsants; Baclofen; beta-Cyclodextrins; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Cyclohexanecarboxylic Acids; Drug Stability; Excipients; Freeze Drying; Gabapentin; gamma-Aminobutyric Acid; Humidity; Kinetics; Lactams; Lactose; Mannitol; Models, Chemical; Molecular Structure; Parasympatholytics; Povidone; Raffinose; Technology, Pharmaceutical; Temperature; Thermogravimetry; Trehalose; Water | 2007 |
Influence of processing conditions on the physical state of mannitol--implications in freeze-drying.
Topics: Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Crystallography, X-Ray; Freeze Drying; Mannitol; Temperature; Thermogravimetry; Trehalose | 2007 |
Dextran or hydroxyethyl starch in spray-freeze-dried trehalose/mannitol microparticles intended as ballistic particulate carriers for proteins.
Topics: Animals; Calorimetry, Differential Scanning; Catalase; Cattle; Dextrans; Drug Carriers; Drug Compounding; Freeze Drying; Hydroxyethyl Starch Derivatives; Liver; Mannitol; Microscopy, Electron, Scanning; Microspheres; Particle Size; Powders; Proteins; Trehalose | 2007 |
Transformation of pharmaceutical compounds upon milling and comilling: the role of T(g).
Topics: Anti-Inflammatory Agents; Budesonide; Chemistry, Pharmaceutical; Crystallization; Drug Compounding; Drug Stability; Excipients; Lactose; Mannitol; Models, Chemical; Sorbitol; Technology, Pharmaceutical; Transition Temperature; Trehalose; Water | 2007 |
Single-droplet evaporation kinetics and particle formation in an acoustic levitator. Part 2: drying kinetics and particle formation from microdroplets of aqueous mannitol, trehalose, or catalase.
Topics: Catalase; Chemistry, Pharmaceutical; Desiccation; Drug Compounding; Excipients; Kinetics; Mannitol; Microscopy, Electron, Scanning; Particle Size; Surface Tension; Trehalose; Vibration | 2007 |
Effects of vial packing density on drying rate during freeze-drying of carbohydrates or a model protein measured using a vial-weighing technique.
Topics: Carbohydrates; Freeze Drying; Mannitol; Serum Albumin, Bovine; Sucrose; Technology, Pharmaceutical; Trehalose | 2008 |
Do co-spray dried excipients offer better lysozyme stabilisation than single excipients?
Topics: Calorimetry, Differential Scanning; Drug Compounding; Drug Stability; Excipients; Mannitol; Micrococcus; Muramidase; Sorbitol; Thermogravimetry; Trehalose; X-Ray Diffraction | 2008 |
Mannitol biosynthesis is required for plant pathogenicity by Alternaria alternata.
Topics: Alternaria; Fungal Proteins; Mannitol; Nicotiana; Plant Diseases; Spores, Fungal; Sugar Alcohol Dehydrogenases; Trehalose | 2008 |
Freeze drying of human serum albumin (HSA) nanoparticles with different excipients.
Topics: Chemistry, Pharmaceutical; Cryoprotective Agents; Doxorubicin; Drug Carriers; Drug Stability; Excipients; Freeze Drying; Humans; Mannitol; Nanoparticles; Particle Size; Polyethylene Glycols; Protein Stability; Serum Albumin; Sucrose; Technology, Pharmaceutical; Time Factors; Transition Temperature; Trehalose | 2008 |
In situ precipitation and vacuum drying of interferon alpha-2a: development of a single-step process for obtaining dry, stable protein formulation.
Topics: Chemical Precipitation; Circular Dichroism; Desiccation; Drug Stability; Drug Storage; Excipients; Freeze Drying; Interferon alpha-2; Interferon-alpha; Mannitol; Polyethylene Glycols; Recombinant Proteins; Spectroscopy, Fourier Transform Infrared; Temperature; Trehalose; Vacuum | 2009 |
Physiological implication of intracellular trehalose and mannitol changes in response of entomopathogenic fungus Beauveria bassiana to thermal stress.
Topics: Animals; Beauveria; Fungal Proteins; Insecta; Mannitol; Mannitol Dehydrogenases; Sugar Alcohol Dehydrogenases; Temperature; Trehalose | 2009 |
Evaluating physical and nutritional stress during mycelial growth as inducers of tolerance to heat and UV-B radiation in Metarhizium anisopliae conidia.
Topics: Animals; Hot Temperature; Mannitol; Metarhizium; Molecular Sequence Data; Mycelium; Spores, Fungal; Tenebrio; Trehalose; Ultraviolet Rays | 2008 |
Pulmonary delivery of a GLP-1 receptor agonist, BMS-686117.
Topics: Administration, Inhalation; Animals; Biological Availability; Excipients; Freeze Drying; Glucagon-Like Peptide-1 Receptor; Hypoglycemic Agents; Lung; Male; Mannitol; Oligopeptides; Particle Size; Powders; Rats; Rats, Sprague-Dawley; Receptors, Glucagon; Trehalose | 2009 |
Dynamic carbon transfer during pathogenesis of sunflower by the necrotrophic fungus Botrytis cinerea: from plant hexoses to mannitol.
Topics: Biological Transport; Botrytis; Carbon; Fructose; Gene Expression Regulation; Genes, Fungal; Glucose; Glycogen; Helianthus; Hexoses; Mannitol; Metabolic Networks and Pathways; Monosaccharide Transport Proteins; Plant Diseases; Sequence Analysis, Protein; Trehalose | 2009 |
A new formulation for orally disintegrating tablets using a suspension spray-coating method.
Topics: Administration, Oral; Chemistry, Pharmaceutical; Excipients; Hardness; Kinetics; Lactose; Linear Models; Mannitol; Models, Chemical; Particle Size; Porosity; Povidone; Silicic Acid; Solubility; Starch; Stearic Acids; Surface Properties; Tablets; Technology, Pharmaceutical; Trehalose | 2009 |
Development of freeze-dried biosynthetic Factor VIII: I. A case study in the optimization of formulation.
Topics: Alanine; Antioxidants; Arginine; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Drug Stability; Factor VIII; Freeze Drying; Glutathione; Glycerol; Glycine; Histidine; Hydroxyethyl Starch Derivatives; Kinetics; Mannitol; Oxidation-Reduction; Partial Thromboplastin Time; Protein Stability; Raffinose; Sodium Chloride; Sucrose; Temperature; Transition Temperature; Trehalose; X-Ray Diffraction | 2009 |
Dry powder aerosols generated by standardized entrainment tubes from alternative sugar blends: 3. Trehalose dihydrate and D-mannitol carriers.
Topics: Aerosols; Algorithms; Bronchodilator Agents; Calorimetry, Differential Scanning; Carbohydrates; Chemistry, Pharmaceutical; Differential Thermal Analysis; Drug Carriers; Drug Compounding; Ipratropium; Lasers; Mannitol; Microscopy, Electron, Scanning; Particle Size; Trehalose | 2010 |
Evaluation of the Nano Spray Dryer B-90 for pharmaceutical applications.
Topics: Aerosols; Equipment Design; Excipients; Griseofulvin; Mannitol; Microscopy, Electron, Scanning; Nanoparticles; Particle Size; Pharmaceutical Preparations; Powders; Surface Properties; Surface Tension; Technology, Pharmaceutical; Trehalose | 2011 |
Spray-freeze-drying of nanosuspensions: the manufacture of insulin particles for needle-free ballistic powder delivery.
Topics: Chemistry, Pharmaceutical; Chromatography, Gel; Chromatography, Reverse-Phase; Desiccation; Dextrans; Dosage Forms; Excipients; Feasibility Studies; Freeze Drying; Insulin; Mannitol; Microscopy, Electron, Scanning; Nanoparticles; Particle Size; Powders; Proteins; Trehalose | 2010 |
Preserving enhancement in freeze-dried contrast agent ST68: Examination of excipients.
Topics: Acoustics; Animals; Contrast Media; Excipients; Feasibility Studies; Freeze Drying; Glucose; Hexoses; Kidney; Mannitol; Microbubbles; Microscopy, Electron, Scanning; Microscopy, Polarization; Polysorbates; Rabbits; Sucrose; Surface Properties; Technology, Pharmaceutical; Temperature; Time Factors; Trehalose; Ultrasonography, Doppler, Pulsed | 2010 |
Comparison between DSC and TMDSC in the investigation into frozen aqueous cryoprotectants solutions.
Topics: Calorimetry, Differential Scanning; Cryoprotective Agents; Crystallization; Freezing; Glycine; Hot Temperature; Mannitol; Phase Transition; Solutions; Sorbitol; Sucrose; Transition Temperature; Trehalose; Water | 2010 |
The effect of crystallizing and non-crystallizing cosolutes on succinate buffer crystallization and the consequent pH shift in frozen solutions.
Topics: Buffers; Calorimetry, Differential Scanning; Cold Temperature; Crystallization; Freeze Drying; Freezing; Glucose; Glycine; Hydrogen-Ion Concentration; Mannitol; Solutions; Succinates; Succinic Acid; Sucrose; Synchrotrons; Trehalose; Water; X-Ray Diffraction | 2011 |
Comparison of modified Celsior solution and M-kyoto solution for pancreas preservation in human islet isolation.
Topics: Adenosine Triphosphate; Animals; Biological Assay; Disaccharides; Electrolytes; Female; Gluconates; Glutamates; Glutathione; Glycoproteins; Histidine; Humans; Islets of Langerhans; Male; Mannitol; Mice; Mice, Nude; Middle Aged; Organ Preservation; Organ Preservation Solutions; Trehalose; Trypsin Inhibitors | 2010 |
Injectable nimodipine-loaded nanoliposomes: preparation, lyophilization and characteristics.
Topics: Calcium Channel Blockers; Calorimetry, Differential Scanning; Cholesterol Esters; Cryoprotective Agents; Drug Storage; Emulsions; Excipients; Freeze Drying; Liposomes; Mannitol; Microscopy, Electron, Scanning; Nanoparticles; Nimodipine; Particle Size; Surface-Active Agents; Trehalose; X-Ray Diffraction | 2011 |
Use of 1H nuclear magnetic resonance to measure intracellular metabolite levels during growth and asexual sporulation in Neurospora crassa.
Topics: Adenosine; Allantoin; Amino Acids; Choline; Culture Media; Fumarates; Fungal Proteins; Gene Knockout Techniques; Glucose; Magnetic Resonance Spectroscopy; Mannitol; Metabolome; Metabolomics; Neurospora crassa; Principal Component Analysis; Spores, Fungal; Sucrose; Transcription, Genetic; Trehalose | 2011 |
Physicochemical investigation of the influence of saccharide-based parenteral formulation excipients on L-p-boronphenylalanine solubilisation for boron neutron capture therapy.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; beta-Cyclodextrins; Boranes; Boron Neutron Capture Therapy; Boronic Acids; Chemical Precipitation; Chemistry, Pharmaceutical; Excipients; Fructose; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mannitol; Pharmacokinetics; Phenylalanine; Solubility; Trehalose | 2012 |
Suitability of differently formulated dry powder Newcastle disease vaccines for mass vaccination of poultry.
Topics: Administration, Inhalation; Animals; Cattle; Chemistry, Pharmaceutical; Desiccation; Drug Design; Drug Stability; Drug Storage; Dry Powder Inhalers; Excipients; Humidity; Inositol; Mannitol; Mass Vaccination; Newcastle Disease; Newcastle disease virus; Particle Size; Poultry; Povidone; Powders; Serum Albumin, Bovine; Trehalose; Viral Vaccines; Wettability | 2012 |
Toward the antioxidant and chemical characterization of mycorrhizal mushrooms from northeast Portugal.
Topics: Agaricales; Amanita; Antioxidants; Arabinose; Ascorbic Acid; Basidiomycota; Carbohydrates; Cortinarius; Fatty Acids; Lipids; Mannitol; Mycorrhizae; Phenols; Plant Roots; Portugal; Species Specificity; Tocopherols; Trees; Trehalose; Tricholoma | 2011 |
Study on the electro-transformation conditions of improving transformation efficiency for Bacillus subtilis.
Topics: Bacillus subtilis; Culture Media; DNA; Electroporation; Genetic Techniques; Mannitol; Plasmids; Sorbitol; Transformation, Genetic; Trehalose | 2012 |
Systematic investigation of the effect of lyophilizate collapse on pharmaceutically relevant proteins, part 2: stability during storage at elevated temperatures.
Topics: Animals; Calorimetry, Differential Scanning; Drug Storage; Freeze Drying; Hot Temperature; Immunoglobulin G; L-Lactate Dehydrogenase; Mannitol; Protein Conformation; Protein Stability; Rabbits; Spectroscopy, Fourier Transform Infrared; Sucrose; Tissue Plasminogen Activator; Transition Temperature; Trehalose | 2012 |
Microencapsulation of self-microemulsifying systems: optimization of shell-formation phase and hardening process.
Topics: Alginates; Drug Compounding; Drug Delivery Systems; Furosemide; Glucuronic Acid; Glycerides; Glycerol; Hexuronic Acids; Lactose; Mannitol; Oleic Acids; Organic Chemicals; Pectins; Sorbitol; Trehalose; Triglycerides | 2012 |
The effect of amino acid excipients on morphology and solid-state properties of multi-component spray-dried formulations for pulmonary delivery of biomacromolecules.
Topics: Administration, Inhalation; Amino Acids; Chemistry, Pharmaceutical; Crystallization; Drug Delivery Systems; Dry Powder Inhalers; Excipients; Lung; Mannitol; Particle Size; Powders; Surface Properties; Trehalose | 2013 |
Development of a dry, stable and inhalable acyl-homoserine-lactone-acylase powder formulation for the treatment of pulmonary Pseudomonas aeruginosa infections.
Topics: Acyl-Butyrolactones; Administration, Inhalation; Amidohydrolases; Anti-Bacterial Agents; Bacterial Proteins; Drug Stability; Escherichia coli; Excipients; Inulin; Mannitol; Microscopy, Electron, Scanning; Powder Diffraction; Powders; Pseudomonas aeruginosa; Pseudomonas Infections; Trehalose; X-Ray Diffraction | 2013 |
Seasonal patterns of cold hardiness and cryoprotectant profiles in Brevicoryne brassicae (Hemiptera: Aphididae).
Topics: Adaptation, Physiological; Animals; Aphids; Chromatography, High Pressure Liquid; Cold Temperature; Cryoprotective Agents; Freezing; Glucose; Inositol; Mannitol; Seasons; Trehalose | 2012 |
Designing CAF-adjuvanted dry powder vaccines: spray drying preserves the adjuvant activity of CAF01.
Topics: Adjuvants, Immunologic; Animals; Cations; Desiccation; Drug Compounding; Female; Glycolipids; Lactose; Liposomes; Mannitol; Mice; Mice, Inbred C57BL; Powders; Quaternary Ammonium Compounds; Recombinant Fusion Proteins; Trehalose; Vaccines | 2013 |
Exogenous osmolytes suppresses the toxic effects of malathion on Anabaena variabilis.
Topics: Anabaena variabilis; Ascorbate Peroxidases; Catalase; Cholinesterase Inhibitors; Glycogen; Hydrogen Peroxide; Insecticides; Malathion; Malondialdehyde; Mannitol; Proline; Sucrose; Superoxide Dismutase; Trehalose | 2013 |
Chitosan nanoparticles: preparation, size evolution and stability.
Topics: Animals; Chick Embryo; Chitosan; Chorioallantoic Membrane; Cryoprotective Agents; Drug Compounding; Drug Stability; Insulin; Mannitol; Nanoparticles; Ovalbumin; Particle Size; Polyethylene Glycols; Polyphosphates; Serum Albumin, Bovine; Trehalose | 2013 |
The methanolic extract of Cordyceps militaris (L.) Link fruiting body shows antioxidant, antibacterial, antifungal and antihuman tumor cell lines properties.
Topics: Animals; Anti-Bacterial Agents; Antifungal Agents; Antineoplastic Agents, Phytogenic; Antioxidants; Cell Line, Tumor; Cell Proliferation; Cordyceps; Drug Evaluation, Preclinical; Fatty Acids, Unsaturated; Humans; Liver; Mannitol; MCF-7 Cells; Methanol; Plant Extracts; Swine; Tocopherols; Trehalose | 2013 |
Morphological and compressional mechanical properties of freeze-dried mannitol, sucrose, and trehalose cakes.
Topics: Elastic Modulus; Excipients; Freeze Drying; Mannitol; Sucrose; Trehalose | 2013 |
Structural attributes of model protein formulations prepared by rapid freeze-drying cycles in a microscale heating stage.
Topics: Animals; Chemistry, Pharmaceutical; Chickens; Equipment Design; Freeze Drying; Mannitol; Microscopy, Electron, Scanning; Miniaturization; Muramidase; Porosity; Protein Conformation; Sucrose; Surface Properties; Technology, Pharmaceutical; Time Factors; Trehalose; Water; X-Ray Microtomography | 2014 |
Induction of protective immunity against H1N1 influenza A(H1N1)pdm09 with spray-dried and electron-beam sterilised vaccines in non-human primates.
Topics: Animals; Desiccation; Drug Storage; Excipients; Female; Glycyrrhizic Acid; Hemagglutination Inhibition Tests; Influenza A Virus, H1N1 Subtype; Influenza Vaccines; Macaca fascicularis; Male; Mannitol; Neutralization Tests; Orthomyxoviridae Infections; Powders; Sterilization; Trehalose; Vaccine Potency | 2014 |
Modeling of heat and mass transfer processes for the gap-lyophilization system using the mannitol-trehalose-NaCl formulation.
Topics: Algorithms; Chemistry, Pharmaceutical; Desiccation; Freeze Drying; Freezing; Hot Temperature; Mannitol; Models, Chemical; Sodium Chloride; Trehalose | 2014 |
A decrease in bulk water and mannitol and accumulation of trehalose and trehalose-based oligosaccharides define a two-stage maturation process towards extreme stress resistance in ascospores of Neosartorya fischeri (Aspergillus fischeri).
Topics: Cytoplasm; Electron Spin Resonance Spectroscopy; Hot Temperature; Mannitol; Neosartorya; Oxidation-Reduction; Spores, Fungal; Trehalose; Viscosity; Water | 2015 |
Analysis and evaluation of tasty components in the pileus and stipe of Lentinula edodes at different growth stages.
Topics: Amino Acids; Citric Acid; Glucose; Malates; Mannitol; Nucleotides; Shiitake Mushrooms; Succinic Acid; Sugar Alcohols; Taste; Trehalose | 2015 |
The influence of excipients commonly used in freeze drying on whole blood coagulation dynamics assessed by rotational thromboelastometry.
Topics: Blood Coagulation Tests; Blood Platelets; Excipients; Fibrin; Fibrinogen; Freeze Drying; Glycine; Humans; Mannitol; Sucrose; Thrombelastography; Trehalose | 2015 |
Variations in oxygen concentration cause differential antioxidant response and expression of related genes in Beauveria bassiana.
Topics: Antioxidants; Beauveria; Culture Media; Gene Expression Profiling; Mannitol; Oxygen; RGS Proteins; Spores, Fungal; Stress, Physiological; Sugar Alcohol Dehydrogenases; Trehalose | 2015 |
Arrhenius activation energy of damage to catalase during spray-drying.
Topics: Catalase; Desiccation; Mannitol; Technology, Pharmaceutical; Temperature; Trehalose | 2015 |
Metabolic characterization of natural and cultured Ophicordyceps sinensis from different origins by 1H NMR spectroscopy.
Topics: Alanine; Cordyceps; Discriminant Analysis; Fermentation; Hydroxyproline; Least-Squares Analysis; Mannitol; Metabolomics; Multivariate Analysis; Principal Component Analysis; Proton Magnetic Resonance Spectroscopy; Sorbitol; Trehalose | 2015 |
Formulations for microprojection/microneedle vaccine delivery: Structure, strength and release profiles.
Topics: Administration, Cutaneous; Animals; Carboxymethylcellulose Sodium; Chemistry, Pharmaceutical; Dextrans; Drug Liberation; Excipients; Female; Mannitol; Mice; Mice, Inbred C57BL; Microinjections; Needles; Ovalbumin; Rhodamines; Skin; Skin Absorption; Sucrose; Trehalose; Vaccines | 2016 |
Influence of type and proportion of lyoprotectants on lyophilized ginsenoside Rg3 liposomes.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; beta-Cyclodextrins; Cell Line, Tumor; Freeze Drying; Ginsenosides; Glucose; Humans; Inositol; Lactose; Liposomes; Mannitol; Particle Size; Phospholipids; Polyethylene Glycols; Protective Agents; Sucrose; Trehalose; X-Ray Diffraction | 2016 |
Production of Inhalation Phage Powders Using Spray Freeze Drying and Spray Drying Techniques for Treatment of Respiratory Infections.
Topics: Administration, Inhalation; Aerosols; Freeze Drying; Leucine; Lung; Mannitol; Microbial Viability; Nebulizers and Vaporizers; Phage Therapy; Podoviridae; Powders; Pseudomonas; Pseudomonas Infections; Respiratory Tract Infections; Trehalose; Ultrasonics | 2016 |
Evaluation of excipients for enhanced thermal stabilization of a human type 5 adenoviral vector through spray drying.
Topics: A549 Cells; Adenoviruses, Human; Calorimetry, Differential Scanning; Dextranase; Excipients; Genetic Vectors; Humans; Humidity; Lactose; Leucine; Mannitol; Microscopy, Electron, Scanning; Powders; Temperature; Time Factors; Trehalose; X-Ray Diffraction | 2016 |
Chemical and Antioxidant Properties of Wild Edible Mushrooms from Native Nothofagus spp. Forest, Argentina.
Topics: Agaricales; alpha-Tocopherol; Antioxidants; Argentina; beta-Tocopherol; Dicarboxylic Acids; Food Analysis; Forests; Mannitol; Nutritive Value; Species Specificity; Trehalose | 2016 |
Temperature, water activity and pH during conidia production affect the physiological state and germination time of Penicillium species.
Topics: Cold Temperature; Environment; Food Contamination; Germination; Glucose; Mannitol; Microscopy, Electron, Transmission; Mycelium; Penicillium; Spores, Fungal; Trehalose; Water | 2017 |
Effects of Excipient Interactions on the State of the Freeze-Concentrate and Protein Stability.
Topics: Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Crystallization; Excipients; Freeze Drying; Freezing; Mannitol; Protein Stability; Proteins; Spectroscopy, Fourier Transform Infrared; Trehalose; X-Ray Diffraction | 2017 |
Spray dried human and chimpanzee adenoviral-vectored vaccines are thermally stable and immunogenic in vivo.
Topics: Adenoviridae; Adenoviruses, Simian; Animals; Desiccation; Drug Storage; Humans; Immunogenicity, Vaccine; Mannitol; Pan troglodytes; Powders; Temperature; Trehalose; Tuberculosis Vaccines; Vaccine Potency; Vaccines, Synthetic | 2017 |
Development of a solid dosage platform for the oral delivery of bilayer vesicles.
Topics: Administration, Oral; Antigens, Viral; Chemistry, Pharmaceutical; Dextrans; Drug Delivery Systems; Drug Stability; Excipients; Freeze Drying; Hardness; Humans; Influenza A Virus, H3N2 Subtype; Influenza Vaccines; Liposomes; Mannitol; Nanoparticles; Particle Size; Solubility; Tablets; Trehalose | 2017 |
Inhalable siRNA-loaded nano-embedded microparticles engineered using microfluidics and spray drying.
Topics: Administration, Inhalation; Dosage Forms; Excipients; Gene Silencing; Inulin; Mannitol; Microfluidics; Nanoparticles; Particle Size; Pharmaceutical Preparations; Powders; RNA, Small Interfering; Trehalose | 2017 |
The Influence of Mannitol Hemihydrate on the Secondary Drying Dynamics of a Protein Formulation: A Case Study.
Topics: Chemistry, Pharmaceutical; Crystallization; Desiccation; Disaccharides; Excipients; Freeze Drying; Mannitol; Powders; Proteins; Sodium Chloride; Sucrose; Temperature; Trehalose; X-Ray Diffraction | 2017 |
Effect of Arginine on the Aggregation of Protein in Freeze-Dried Formulations Containing Sugars and Polyol: 1-Formulation Development.
Topics: Arginine; Drug Compounding; Drug Stability; Freeze Drying; Lactose; Mannitol; Polymers; Protein Aggregates; Proteins; Sucrose; Sugars; Trehalose | 2018 |
Trehalose, a temperature- and salt-induced solute with implications in pathobiology of Acinetobacter baumannii.
Topics: Acinetobacter baumannii; Adaptation, Physiological; Desiccation; Glucosyltransferases; Hot Temperature; Mannitol; Osmolar Concentration; Osmotic Pressure; Phosphoric Monoester Hydrolases; Sodium Chloride; Trehalose | 2017 |
Effects of Drying Process on an IgG1 Monoclonal Antibody Using Solid-State Hydrogen Deuterium Exchange with Mass Spectrometric Analysis (ssHDX-MS).
Topics: Chemistry, Pharmaceutical; Crystallization; Deuterium; Deuterium Exchange Measurement; Freeze Drying; Humans; Hydrogen; Immunoglobulin G; Mannitol; Mass Spectrometry; Microscopy, Electron, Scanning; Powders; Protein Binding; Protein Conformation; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Sucrose; Trehalose; X-Ray Diffraction | 2018 |
Dry-powder formulations of non-covalent protein complexes with linear or miktoarm copolymers for pulmonary delivery.
Topics: Administration, Inhalation; Aerosols; Drug Carriers; Drug Compounding; Drug Stability; Dry Powder Inhalers; Excipients; Glutamic Acid; Leucine; Mannitol; Molecular Structure; Muramidase; Particle Size; Polyethylene Glycols; Polyglutamic Acid; Polymers; Protein Stability; Proteolysis; Technology, Pharmaceutical; Transition Temperature; Trehalose | 2018 |
A Cryopellet Containing Silica Can Activate Intrinsic Blood Coagulation in Rotational Thromboelastometry.
Topics: Blood Coagulation; Blood Coagulation Tests; Humans; Mannitol; Silicon Dioxide; Thrombelastography; Time Factors; Trehalose | 2018 |
Manufacturing and ambient stability of shelf freeze dried bacteriophage powder formulations.
Topics: Bacteriophage M13; Drug Stability; Excipients; Freeze Drying; Mannitol; Polyethylene Glycols; Powders; Sucrose; Trehalose | 2018 |
Merits and Limitations of Dynamic Vapor Sorption Studies on the Morphology and Physicochemical State of Freeze-Dried Products.
Topics: Algorithms; Crystallization; Excipients; Freeze Drying; Mannitol; Povidone; Steam; Sucrose; Trehalose | 2018 |
Significant Drying Time Reduction Using Microwave-Assisted Freeze-Drying for a Monoclonal Antibody.
Topics: Antibodies, Monoclonal; Arginine; Chemistry, Pharmaceutical; Crystallization; Desiccation; Drug Stability; Excipients; Freeze Drying; Mannitol; Microwaves; Organophosphorus Compounds; Sucrose; Trehalose | 2018 |
Endogenous arabitol and mannitol improve shelf life of encapsulated Metarhizium brunneum.
Topics: Animals; Biomass; Desiccation; Erythritol; Larva; Mannitol; Metarhizium; Microbial Viability; Mycelium; Pest Control, Biological; Polymers; Sugar Alcohols; Temperature; Trehalose; Virulence | 2018 |
Possible source of the high UV-B and heat tolerance of Metarhizium acridum (isolate ARSEF 324).
Topics: Mannitol; Metarhizium; Spores, Fungal; Thermotolerance; Trehalose; Ultraviolet Rays | 2018 |
A Comparison of Controlled Ice Nucleation Techniques for Freeze-Drying of a Therapeutic Antibody.
Topics: Antibodies, Monoclonal; Drug Compounding; Excipients; Freeze Drying; Ice; Immunoglobulin G; Mannitol; Powder Diffraction; Protein Aggregates; Sucrose; Trehalose; X-Ray Diffraction | 2018 |
Application of disaccharides alone and in combination, for the improvement of stability and particle properties of spray-freeze dried IgG.
Topics: Chemistry, Pharmaceutical; Disaccharides; Drug Combinations; Drug Compounding; Drug Stability; Excipients; Freeze Drying; Immunoglobulin G; Mannitol; Particle Size; Trehalose | 2019 |
Freeze-drying of monoclonal antibody-conjugated gold nanorods: Colloidal stability and biological activity.
Topics: Antigens, CD20; Colloids; Cryoprotective Agents; Drug Stability; Freeze Drying; Gold; Humans; Lymphoma, B-Cell; Mannitol; Nanotubes; Rituximab; Trehalose | 2018 |
Intra-Vial Heterogeneity in Physical Form of Mannitol in Colyophilized Binary Systems.
Topics: Animals; Chickens; Crystallization; Excipients; Freeze Drying; Mannitol; Muramidase; Phase Transition; Sucrose; Trehalose | 2018 |
Freeze/thaw of IGG solutions.
Topics: Antibodies, Monoclonal; Chemistry, Pharmaceutical; Chromatography, Gel; Circular Dichroism; Cryoprotective Agents; Crystallization; Drug Storage; Excipients; Freezing; Hydrogen-Ion Concentration; Immunoglobulin G; Mannitol; Protein Stability; Trehalose | 2019 |
Excipient selection for thermally stable enveloped and non-enveloped viral vaccine platforms in dry powders.
Topics: Adenovirus Vaccines; Desiccation; Drug Compounding; Drug Stability; Excipients; Humans; Influenza Vaccines; Mannitol; Powders; Transition Temperature; Trehalose; Vesiculovirus | 2019 |
Combinatorial impact of osmotic and heat shocks on the composition of membrane lipids and osmolytes in Aspergillus niger.
Topics: Aspergillus niger; Glycerol; Hot Temperature; Mannitol; Membrane Lipids; Osmosis; Phospholipids; Sodium Chloride; Trehalose | 2019 |
Vacuum-Induced Surface Freezing for the Freeze-Drying of the Human Growth Hormone: How Does Nucleation Control Affect Protein Stability?
Topics: Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Chromatography, Gel; Crystallization; Freeze Drying; Freezing; Human Growth Hormone; Mannitol; Protein Stability; Surface Properties; Technology, Pharmaceutical; Trehalose; Vacuum | 2020 |
Comprehensive quality by design approach for stable nanocrystalline drug products.
Topics: Desiccation; Drug Compounding; Drug Design; Drug Liberation; Excipients; Hydrogen-Ion Concentration; Mannitol; Nanoparticles; Trehalose | 2019 |
Lipids and soluble carbohydrates in the mycelium and ascomata of alkaliphilic fungus Sodiomyces alkalinus.
Topics: Ascomycota; Carbohydrate Metabolism; Fatty Acids; Fruiting Bodies, Fungal; Lipid Metabolism; Mannitol; Membrane Lipids; Mycelium; Trehalose | 2019 |
Characterization of Phosphate Buffered Saline (PBS) in Frozen State and after Freeze-Drying.
Topics: Buffers; Crystallization; Freeze Drying; Freezing; Hydrogen-Ion Concentration; Mannitol; Phosphates; Potassium Chloride; Saline Solution; Sodium Chloride; Temperature; Trehalose | 2019 |
Nanobubbles in Reconstituted Lyophilized Formulations: Interaction With Proteins and Mechanism of Formation.
Topics: Crystallization; Drug Compounding; Drug Stability; Freeze Drying; Humans; Interleukin 1 Receptor Antagonist Protein; Mannitol; Nanoparticles; Particle Size; Protein Aggregates; Recombinant Proteins; Sucrose; Trehalose | 2020 |
Exploring the chemical space for freeze-drying excipients.
Topics: Calorimetry, Differential Scanning; Excipients; Freeze Drying; Glycine; Mannitol; Powder Diffraction; Sucrose; Trehalose; X-Ray Diffraction | 2019 |
Isolation of Itraconazole Nanostructured Microparticles via Spray Drying with Rational Selection of Optimum Base for Successful Reconstitution and Compaction.
Topics: Desiccation; Excipients; Itraconazole; Mannitol; Nanostructures; Particle Size; Powders; Tablets; Tensile Strength; Trehalose | 2019 |
Solid-State Hydrogen-Deuterium Exchange Mass Spectrometry (ssHDX-MS) of Lyophilized Poly-d,l-Alanine.
Topics: Chemistry, Pharmaceutical; Deuterium; Drug Compounding; Excipients; Freeze Drying; Guanidine; Humidity; Hydrogen Deuterium Exchange-Mass Spectrometry; Kinetics; Mannitol; Models, Chemical; Peptides; Protein Structure, Secondary; Sodium Chloride; Sucrose; Trehalose | 2019 |
Phialomyces macrosporus: Chemical Constituents, Antimicrobial Activity and Complete NMR Assignments for the 7,7'-Biphyscion.
Topics: Anthraquinones; Anti-Bacterial Agents; Bacillus subtilis; Dose-Response Relationship, Drug; Magnetic Resonance Spectroscopy; Mannitol; Microbial Sensitivity Tests; Molecular Structure; Salmonella; Staphylococcus aureus; Trehalose; Xanthones | 2019 |
Stability of lyophilized albumin formulations: Role of excipient crystallinity and molecular mobility.
Topics: Crystallization; Drug Stability; Excipients; Freeze Drying; Mannitol; Serum Albumin, Bovine; Trehalose | 2019 |
Characterization of spray dried powders with nucleic acid-containing PEI nanoparticles.
Topics: A549 Cells; Administration, Inhalation; Aerosols; Calorimetry, Differential Scanning; Cell Line, Tumor; Chemistry, Pharmaceutical; Desiccation; Excipients; Humans; Mannitol; Microscopy, Electron, Scanning; Nanoparticles; Nucleic Acids; Particle Size; Polyethyleneimine; Powders; Trehalose | 2019 |
Diazepam Prodrug Stabilizes Human Aminopeptidase B during Lyophilization.
Topics: Aminopeptidases; Biocatalysis; Diazepam; Dipeptides; Drug Stability; Enzyme Stability; Freeze Drying; Freezing; Humans; Mannitol; Prodrugs; Proteolysis; Trehalose | 2020 |
Design and Optimization of a Temperature-Stable Dry Powder BCG Vaccine.
Topics: Aerosols; Animals; BCG Vaccine; Cell Line; Cell Survival; Desiccation; Drug Compounding; Drug Stability; Drug Storage; Excipients; Female; Humans; Leucine; Mannitol; Mice, Inbred C57BL; Mycobacterium bovis; Povidone; Powders; Serum Albumin, Bovine; Temperature; Tissue Distribution; Trehalose | 2019 |
Spray dried VSV-vectored vaccine is thermally stable and immunologically active in vivo.
Topics: Desiccation; Drug Stability; Excipients; Hot Temperature; Humidity; Mannitol; Powders; Refrigeration; Temperature; Trehalose; Vaccines; Vesiculovirus | 2020 |
Changes in Chemical Composition and Accumulation of Cryoprotectants as the Adaptation of Anholocyclic Aphid
Topics: Adaptation, Physiological; Animals; Aphids; Chromatography, High Pressure Liquid; Climate Change; Cold Temperature; Cryoprotective Agents; Ecosystem; Glucose; Insecta; Larva; Mannitol; Seasons; Spectroscopy, Fourier Transform Infrared; Trehalose | 2021 |
Thermal tolerance variations and physiological adjustments in a winter active and a summer active aphid species.
Topics: Animals; Aphids; Cold Temperature; Glucose; Hot Temperature; HSP70 Heat-Shock Proteins; Insect Proteins; Mannitol; Polymers; Seasons; Thermotolerance; Trehalose | 2021 |
Impact of formulation on the quality and stability of freeze-dried nanoparticles.
Topics: Chemistry, Pharmaceutical; Drug Compounding; Excipients; Freeze Drying; Humans; Liposomes; Mannitol; Nanoparticles; Nanotechnology; Particle Size; Quality Improvement; Sucrose; Technology, Pharmaceutical; Trehalose | 2021 |
Cryoprotective agents influence viral dosage and thermal stability of inhalable dry powder vaccines.
Topics: Administration, Inhalation; Aerosols; Cryoprotective Agents; Dry Powder Inhalers; Humans; Mannitol; Particle Size; Powders; Trehalose; Vaccines | 2022 |
Frozen storage of proteins: Use of mannitol to generate a homogenous freeze-concentrate.
Topics: Excipients; Freeze Drying; Freezing; Humans; Ice; Mannitol; Proteins; Sucrose; Trehalose | 2023 |
Radio Frequency - Assisted Ultrasonic Spray Freeze Drying for Pharmaceutical Protein Solids.
Topics: Excipients; Freeze Drying; Mannitol; Powders; Serum Albumin, Bovine; Trehalose; Ultrasonics | 2023 |
Functional characterization of the phosphotransferase system in Parageobacillus thermoglucosidasius.
Topics: Acetylglucosamine; Arbutin; Bacteria; Bacterial Proteins; Carbohydrates; Mannitol; Phosphoenolpyruvate Sugar Phosphotransferase System; Phosphotransferases; Sorbitol; Trehalose | 2023 |