trehalose has been researched along with alpha-synuclein in 22 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (4.55) | 29.6817 |
| 2010's | 16 (72.73) | 24.3611 |
| 2020's | 5 (22.73) | 2.80 |
| Authors | Studies |
|---|---|
| Davies, JE; Huang, Z; Rubinsztein, DC; Sarkar, S; Tunnacliffe, A | 1 |
| Jiang, T; Lan, DM; Lu, JH; Wang, J; Yu, WB; Yue, ZY; Zhou, P | 1 |
| Chen, Y; Ding, ZT; Jiang, YP; Lan, DM; Liu, FT; Ren, HM; Wang, J; Wu, JJ; Yue, ZY; Zhao, J | 1 |
| Bergström, AL; Ejlerskov, P; Jensen, PH; Nielsen, TT; Rasmussen, I; Tohyama, Y; Vilhardt, F | 1 |
| Bousset, L; Brewee, C; Melki, R; Migliardo, F | 1 |
| Gu, JH; Guan, JJ; Hou, YS; Qin, ZH; Wu, F; Xu, HD; Zhen, XC | 1 |
| Biondi, B; Bubacco, L; Calderan, A; Hussain, R; Ruzza, P; Siligardi, G; Tessari, I | 1 |
| Brotchie, JM; He, Q; Koprich, JB; Wang, J; Wang, Y; Xiao, BG; Yu, WB | 1 |
| Imaizumi, T; Itoh, K; Maruyama, A; Matsumiya, T; Miki, Y; Mimura, J; Mori, F; Tanji, K; Wakabayashi, K | 1 |
| Kardani, J; Naik, V; Roy, I | 1 |
| Casarejos, MJ; de Yébenes, JG; Gómez, A; Mena, MÁ; Muñoz, MP; Perucho, J | 1 |
| Darley-Usmar, V; Redmann, M; Volpicelli-Daley, L; Wani, WY; Zhang, J | 1 |
| Pan, L; Zhao, J; Zhi, X; Zhou, P | 1 |
| Cho, ED; Jung Ahn, W; Lee, HJ; Lee, SJ; Won Lee, K; Yoon, YS | 1 |
| Agarwal, M; Deep, S; Katyal, N; Kumar, V; Sen, R | 1 |
| Hoffmann, AC; Kazman, A; Klucken, J; Menges, S; Mielenz, D; Minakaki, G; Salvi, R; Savitskiy, S; Vicente Miranda, H; Winkler, J; Xiang, W | 1 |
| Bellomo, G; Parnetti, L | 1 |
| Deng, Y; Jing, MJ; Liu, C; Liu, K; Liu, W; Ma, Z; Wang, C; Xu, B; Yan, DY | 1 |
| Chang, KH; Chao, CY; Chen, CM; Chen, WL; Huang, YT; Lee-Chen, GJ; Lin, CH; Lin, CY; Lin, JL; Su, MT; Wu, YR; Yen, CY | 1 |
| Dubey, SK; K C, S; Kakoty, V; Kesharwani, P; Taliyan, R; Yang, CH | 1 |
| Dubey, SK; K C, S; Kakoty, V; Taliyan, R; Yang, CH | 1 |
| Bhat, R; Jain, MK | 1 |
1 review(s) available for trehalose and alpha-synuclein
| Article | Year |
|---|---|
The gut-brain connection in the pathogenicity of Parkinson disease: Putative role of autophagy.
Topics: alpha-Synuclein; Animals; Autophagy; Brain; Disease Models, Animal; Dysbiosis; Gastrointestinal Microbiome; Humans; Intestinal Mucosa; Parkinson Disease; Protein Aggregates; Trehalose | 2021 |
21 other study(ies) available for trehalose and alpha-synuclein
| Article | Year |
|---|---|
Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.
Topics: alpha-Synuclein; Animals; Antibiotics, Antineoplastic; Autophagy; Chlorocebus aethiops; COS Cells; HeLa Cells; Humans; Huntingtin Protein; Huntington Disease; Mice; Molecular Chaperones; Mutation; Nerve Tissue Proteins; Nuclear Proteins; Parkinson Disease; Protein Kinases; Sirolimus; TOR Serine-Threonine Kinases; Trehalose | 2007 |
Trehalose inhibits fibrillation of A53T mutant alpha-synuclein and disaggregates existing fibrils.
Topics: alpha-Synuclein; Humans; Models, Molecular; Mutant Proteins; Mutation; Protein Multimerization; Protein Structure, Secondary; Trehalose | 2012 |
Effect of trehalose on PC12 cells overexpressing wild-type or A53T mutant α-synuclein.
Topics: Adenine; Alanine; alpha-Synuclein; Animals; Autophagy; Blotting, Western; Cell Survival; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Lysosomes; Microscopy, Electron, Transmission; PC12 Cells; Phagosomes; Phosphoinositide-3 Kinase Inhibitors; Point Mutation; Proteasome Inhibitors; Rats; Signal Transduction; Tetrazolium Salts; Thiazoles; Threonine; Transduction, Genetic; Trehalose; Up-Regulation | 2012 |
Tubulin polymerization-promoting protein (TPPP/p25α) promotes unconventional secretion of α-synuclein through exophagy by impairing autophagosome-lysosome fusion.
Topics: alpha-Synuclein; Animals; Autophagy; Carrier Proteins; Cell Differentiation; Cytoplasmic Vesicles; Gene Knockdown Techniques; Histone Deacetylase 6; Histone Deacetylases; Inclusion Bodies; Lysosomes; Membrane Fusion; Microtubule-Associated Proteins; Nerve Growth Factor; Neurites; PC12 Cells; Phagosomes; Protein Transport; Proteolysis; rab GTP-Binding Proteins; Rats; RNA, Small Interfering; Secretory Pathway; Sirolimus; TOR Serine-Threonine Kinases; Trehalose | 2013 |
Dynamical properties of α-synuclein in soluble and fibrillar forms by Quasi Elastic Neutron Scattering.
Topics: alpha-Synuclein; Humans; Models, Theoretical; Molecular Dynamics Simulation; Neutron Diffraction; Temperature; Trehalose; Water | 2014 |
Rotenone impairs autophagic flux and lysosomal functions in Parkinson's disease.
Topics: alpha-Synuclein; Animals; Antiparkinson Agents; Autophagy; Lysosomes; Male; Parkinsonian Disorders; Pars Compacta; PC12 Cells; Random Allocation; Rats; Rats, Inbred Lew; Rotenone; Trehalose; Tyrosine 3-Monooxygenase | 2015 |
Effects of Trehalose on Thermodynamic Properties of Alpha-synuclein Revealed through Synchrotron Radiation Circular Dichroism.
Topics: alpha-Synuclein; Circular Dichroism; Osmolar Concentration; Protein Conformation; Thermodynamics; Trehalose | 2015 |
Treatment with Trehalose Prevents Behavioral and Neurochemical Deficits Produced in an AAV α-Synuclein Rat Model of Parkinson's Disease.
Topics: alpha-Synuclein; Animals; Autophagy; Behavior, Animal; Blood Glucose; Cattle; Cell Survival; Dependovirus; Disease Models, Animal; Dopaminergic Neurons; Extremities; Female; Humans; Microtubule-Associated Proteins; Parkinson Disease; Rats, Sprague-Dawley; Solubility; Substantia Nigra; Trehalose; Tyrosine 3-Monooxygenase | 2016 |
Trehalose intake induces chaperone molecules along with autophagy in a mouse model of Lewy body disease.
Topics: Administration, Oral; alpha-Synuclein; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Brain; Disease Models, Animal; HeLa Cells; HSP90 Heat-Shock Proteins; Humans; Lewy Body Disease; Maltose; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Molecular Chaperones; Protein Aggregation, Pathological; Receptors, sigma; Sigma-1 Receptor; Solubility; Trehalose | 2015 |
Trehalose-Induced Structural Transition Accelerates Aggregation of α-Synuclein.
Topics: alpha-Synuclein; Humans; Intrinsically Disordered Proteins; Protein Conformation; Protein Folding; Trehalose | 2016 |
Trehalose rescues glial cell dysfunction in striatal cultures from HD R6/1 mice at early postnatal development.
Topics: alpha-Synuclein; Animals; Brain-Derived Neurotrophic Factor; Cells, Cultured; Corpus Striatum; Cytoskeleton; Female; Glial Cell Line-Derived Neurotrophic Factor; Gliosis; Humans; Huntingtin Protein; Huntington Disease; Male; Mice; Mice, Inbred C57BL; Neuroglia; Neuroprotective Agents; Protein Transport; Trehalose | 2016 |
Trehalose does not improve neuronal survival on exposure to alpha-synuclein pre-formed fibrils.
Topics: alpha-Synuclein; Animals; Apoptosis; Autophagy; Cell Survival; Humans; Mice; Neurons; Parkinson Disease; Protein Aggregation, Pathological; TOR Serine-Threonine Kinases; Trehalose | 2017 |
Trehalose Inhibits A53T Mutant α-Synuclein Overexpression and Neurotoxicity in Transduced PC12 Cells.
Topics: alpha-Synuclein; Amino Acid Substitution; Animals; Cell Survival; Gene Expression Regulation; Mutation; Neuroprotective Agents; PC12 Cells; Rats; Transduction, Genetic; Trehalose | 2017 |
Is trehalose an autophagic inducer? Unraveling the roles of non-reducing disaccharides on autophagic flux and alpha-synuclein aggregation.
Topics: alpha-Synuclein; Animals; Autophagosomes; Autophagy; Cell Survival; Disaccharides; Humans; Lysosomes; Microtubule-Associated Proteins; Neurons; Parkinson Disease; Primary Cell Culture; Protein Aggregation, Pathological; Rats; RNA-Binding Proteins; Trehalose | 2017 |
Paradoxical Effect of Trehalose on the Aggregation of α-Synuclein: Expedites Onset of Aggregation yet Reduces Fibril Load.
Topics: alpha-Synuclein; Amyloid; Humans; Molecular Dynamics Simulation; Parkinson Disease; Protein Aggregation, Pathological; Protein Conformation; Trehalose | 2018 |
Extracellular aggregated alpha synuclein primarily triggers lysosomal dysfunction in neural cells prevented by trehalose.
Topics: alpha-Synuclein; Animals; Autophagy; Cell Line, Tumor; Escherichia coli; Glioma; Humans; Lysosomes; Neurons; Parkinson Disease; Protein Aggregation, Pathological; Rats; Rats, Wistar; Recombinant Proteins; Sirolimus; Trehalose | 2019 |
The issue of waste disposal in Parkinson's disease pathogenesis.
Topics: alpha-Synuclein; Humans; Lysosomes; Neurons; Parkinson Disease; Trehalose | 2019 |
Protective effects of trehalose against Mn-induced α-synuclein oligomerization in mice: Involvement of oxidative stress and autophagy.
Topics: alpha-Synuclein; Animals; Autophagy; Brain; Humans; Manganese; Mice; Mice, Inbred C57BL; Molecular Chaperones; Neurons; Oxidative Stress; Protective Agents; Protein Multimerization; Trehalose | 2020 |
Lactulose and Melibiose Inhibit α-Synuclein Aggregation and Up-Regulate Autophagy to Reduce Neuronal Vulnerability.
Topics: alpha-Synuclein; Amino Acid Sequence; Antioxidants; Autophagy; Benzothiazoles; Cell Line; Cell Survival; Dopaminergic Neurons; Fluorescence; Green Fluorescent Proteins; Humans; Lactulose; Melibiose; Neuronal Outgrowth; Neurons; Neuroprotective Agents; Oxidative Stress; Protein Aggregates; Trehalose; Up-Regulation | 2020 |
Neuroprotective Effects of Trehalose and Sodium Butyrate on Preformed Fibrillar Form of α-Synuclein-Induced Rat Model of Parkinson's Disease.
Topics: alpha-Synuclein; Animals; Butyric Acid; Disease Models, Animal; Neuroprotective Agents; Parkinson Disease; Rats; Rats, Wistar; Trehalose | 2021 |
Modulation of the conformation, fibrillation, and fibril morphologies of human brain α-, β-, and γ-synuclein proteins by the disaccharide chemical chaperone trehalose.
Topics: alpha-Synuclein; Brain; Disaccharides; gamma-Synuclein; Humans; Intrinsically Disordered Proteins; Molecular Chaperones; Protein Conformation; Trehalose | 2023 |