Page last updated: 2024-08-16

trazodone and zolpidem

trazodone has been researched along with zolpidem in 38 studies

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (5.26)18.2507
2000's17 (44.74)29.6817
2010's10 (26.32)24.3611
2020's9 (23.68)2.80

Authors

AuthorsStudies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Bergström, F; Giordanetto, F; Rehngren, M; Tunek, A; Wan, H1
Lombardo, F; Obach, RS; Waters, NJ1
Ahman, M; Holmén, AG; Wan, H1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Forster, P; King, J1
Baker, RW; Rush, CR; Wright, K1
Bostick, JM; Ring, PR1
Benca, RM1
Camacho, A; Ng, B1
Gammack, JK; Kamel, NS1
Hutson, PH; Ivarsson, M; Nutt, DJ; Paterson, LM; Wilson, SJ3
Irvin, W; Kim, WY; MacDonald, G; Smith, JK1
Tatman, J1
Tuya, AC1
Andreescu, C; Buysse, DJ; Cyranowski, JM; Dombrovski, AY; Frank, E; Houck, PR; Mallinger, AG; Mulsant, BH; Thase, ME1
Court, MH; Farkas, D; Greenblatt, DJ; Harmatz, JS; Volak, LP; von Moltke, LL1
Roy, AN; Smith, M1
Boudreau, DM; Ebel, BE; Grossman, DC; Hansen, RN; Sullivan, SD1
Beaulieu-Bonneau, S; Buysse, DJ; Edinger, JD; Ivers, H; Krystal, AD; Morin, CM1
Beam, AL; Chatterjee, AK; Fitzgerald, TP; Kartoun, U; Kohane, IS; Pai, JK; Shaw, SY1
Burgess, A; Burke, SL; Cadet, T; Hu, T; Li, T; Naseh, M; Spadola, CE1
Au, A; Bishop, TM; Hur, K; Kane, C; Lavigne, JE; Pigeon, WR1
Pick, CG; Schreiber, S1
Earl, DC; Van Tyle, KM1
Bertisch, SM; Buysse, DJ; Herzig, SJ; Murray Horwitz, M; Toh, S; Wong, J1
Assimon, MM; Flythe, JE1
Beaulieu-Bonneau, S; Bélanger, L; Edinger, JD; Guay, B; Ivers, H; Morin, CM; Simmons, B1
Amari, DT; Atkins, N; Frech, FH; Gor, D; Juday, TR; Wang, W; Wickwire, EM1
Amari, DT; Frech, F; Gor, D; Juday, TR; Malhotra, M; Wickwire, EM1
Amari, DT; Atkins, N; Frech, FH; Juday, T; Wang, W; Wickwire, EM; Wu, Z1
Anastassopoulos, KP; Baik, R; Bruni, O; Calisti, F; Cattaneo, A; Comandini, A; Gorini, M; Knight, T; Loreto, GD; Patel, R; Pochiero, I1

Reviews

5 review(s) available for trazodone and zolpidem

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Definitive treatment of patients with serious mental disorders in an emergency service, Part I.
    Hospital & community psychiatry, 1994, Volume: 45, Issue:9

    Topics: Antidepressive Agents; Anxiety Disorders; Depressive Disorder; Emergency Services, Psychiatric; Hospitalization; Hospitals, Psychiatric; Humans; Length of Stay; Patient Admission; Pyridines; Selective Serotonin Reuptake Inhibitors; Sleep Initiation and Maintenance Disorders; Trazodone; Zolpidem

1994
Diagnosis and treatment of chronic insomnia: a review.
    Psychiatric services (Washington, D.C.), 2005, Volume: 56, Issue:3

    Topics: Acetamides; Benzodiazepines; Diagnostic and Statistical Manual of Mental Disorders; Health Status; Humans; Hypnotics and Sedatives; Nonprescription Drugs; Office Visits; Polysomnography; Pyridines; Pyrimidines; Severity of Illness Index; Sleep Initiation and Maintenance Disorders; Trazodone; Zolpidem

2005
Insomnia in the elderly: cause, approach, and treatment.
    The American journal of medicine, 2006, Volume: 119, Issue:6

    Topics: Acetamides; Aged; Aging; Antidepressive Agents; Azabicyclo Compounds; Behavior Therapy; Benzodiazepines; Humans; Hypnotics and Sedatives; Nonprescription Drugs; Piperazines; Pyridines; Pyrimidines; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Sleep; Sleep Initiation and Maintenance Disorders; Sleep, REM; Thiophenes; Trazodone; Zolpidem

2006
New pharmacologic agents for insomnia and hypersomnia.
    Current opinion in pulmonary medicine, 2020, Volume: 26, Issue:6

    Topics: Azepines; Carbamates; Dementia; Disorders of Excessive Somnolence; GABA-A Receptor Agonists; Humans; Orexin Receptor Antagonists; Phenylalanine; Piperidines; Pyridines; Pyrimidines; Sleep Aids, Pharmaceutical; Sleep Apnea, Obstructive; Sleep Initiation and Maintenance Disorders; Trazodone; Triazoles; Zolpidem

2020

Trials

6 trial(s) available for trazodone and zolpidem

ArticleYear
A translational, caffeine-induced model of onset insomnia in rats and healthy volunteers.
    Psychopharmacology, 2007, Volume: 191, Issue:4

    Topics: Adult; Animals; Caffeine; Central Nervous System Stimulants; Cross-Over Studies; Disease Models, Animal; Dose-Response Relationship, Drug; Double-Blind Method; Electroencephalography; Electromyography; GABA Agonists; Humans; Hypnotics and Sedatives; Male; Polysomnography; Pyridines; Rats; Rats, Sprague-Dawley; Reference Values; Reproducibility of Results; Selective Serotonin Reuptake Inhibitors; Sleep; Sleep Initiation and Maintenance Disorders; Telemetry; Trazodone; Zolpidem

2007
Which symptoms predict recurrence of depression in women treated with maintenance interpersonal psychotherapy?
    Depression and anxiety, 2008, Volume: 25, Issue:12

    Topics: Adult; Affect; Anxiety Disorders; Combined Modality Therapy; Comorbidity; Depressive Disorder, Major; Female; Humans; Middle Aged; Personality Assessment; Psychometrics; Psychotherapy; Pyridines; Recurrence; Risk Assessment; Selective Serotonin Reuptake Inhibitors; Sleep Initiation and Maintenance Disorders; Trazodone; Young Adult; Zolpidem

2008
Short-term clarithromycin administration impairs clearance and enhances pharmacodynamic effects of trazodone but not of zolpidem.
    Clinical pharmacology and therapeutics, 2009, Volume: 85, Issue:6

    Topics: Adult; Anti-Anxiety Agents; Anti-Bacterial Agents; Area Under Curve; Clarithromycin; Cross-Over Studies; Double-Blind Method; Female; Humans; Hypnotics and Sedatives; Male; Middle Aged; Pyridines; Trazodone; Zolpidem

2009
Effects on sleep stages and microarchitecture of caffeine and its combination with zolpidem or trazodone in healthy volunteers.
    Journal of psychopharmacology (Oxford, England), 2009, Volume: 23, Issue:5

    Topics: Adult; Caffeine; Central Nervous System Stimulants; Cross-Over Studies; Double-Blind Method; Electroencephalography; Humans; Hypnotics and Sedatives; Male; Polysomnography; Pyridines; Sleep Initiation and Maintenance Disorders; Sleep Stages; Trazodone; Young Adult; Zolpidem

2009
Sequential psychological and pharmacological therapies for comorbid and primary insomnia: study protocol for a randomized controlled trial.
    Trials, 2016, Mar-03, Volume: 17, Issue:1

    Topics: Adult; Affect; Clinical Protocols; Cognitive Behavioral Therapy; Colorado; Combined Modality Therapy; Comorbidity; Female; Humans; Hypnotics and Sedatives; Male; Mental Disorders; North Carolina; Polysomnography; Pyridines; Quality of Life; Quebec; Research Design; Sleep; Sleep Initiation and Maintenance Disorders; Surveys and Questionnaires; Time Factors; Trazodone; Treatment Outcome; Young Adult; Zolpidem

2016
Association between insomnia patients' pre-treatment characteristics and their responses to distinctive treatment sequences.
    Sleep, 2022, 01-11, Volume: 45, Issue:1

    Topics: Adult; Cognitive Behavioral Therapy; Female; Humans; Male; Middle Aged; Sleep; Sleep Initiation and Maintenance Disorders; Trazodone; Treatment Outcome; Zolpidem

2022

Other Studies

27 other study(ies) available for trazodone and zolpidem

ArticleYear
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
High-throughput screening of drug-brain tissue binding and in silico prediction for assessment of central nervous system drug delivery.
    Journal of medicinal chemistry, 2007, Sep-20, Volume: 50, Issue:19

    Topics: Animals; Brain; Central Nervous System Agents; Dialysis; Hydrophobic and Hydrophilic Interactions; In Vitro Techniques; Mice; Models, Statistical; Protein Binding; Quantitative Structure-Activity Relationship; Rats

2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
    Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6

    Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Acute behavioral effects and abuse potential of trazodone, zolpidem and triazolam in humans.
    Psychopharmacology, 1999, Volume: 144, Issue:3

    Topics: Adult; Antidepressive Agents, Tricyclic; Humans; Hypnotics and Sedatives; Male; Memory; Mental Recall; Postural Balance; Psychomotor Performance; Pyridines; Substance-Related Disorders; Surveys and Questionnaires; Time Factors; Trazodone; Triazolam; Zolpidem

1999
Validation of a method for the determination of zolpidem in human plasma using LC with fluorescence detection.
    Journal of pharmaceutical and biomedical analysis, 2000, Volume: 22, Issue:3

    Topics: Anti-Anxiety Agents; Chromatography, High Pressure Liquid; Chromatography, Liquid; Fluorescence; Humans; Hypnotics and Sedatives; Pyridines; Reproducibility of Results; Trazodone; Zolpidem

2000
Sleeping pills without regrets. They've long been the risky quick fixes of sleep medicine. Soon some sleeping pills may be sold as long-term solutions.
    Harvard health letter, 2004, Volume: 29, Issue:10

    Topics: Acetamides; Age Factors; Azabicyclo Compounds; Benzodiazepines; Humans; Hypnotics and Sedatives; Piperazines; Pyridines; Pyrimidines; Sleep Wake Disorders; Thiophenes; Trazodone; Zolpidem

2004
Methylphenidate for alpha-interferon induced depression.
    Journal of psychopharmacology (Oxford, England), 2006, Volume: 20, Issue:5

    Topics: Affect; Aged; Antineoplastic Agents; Central Nervous System Stimulants; Depressive Disorder; Humans; Hypnotics and Sedatives; Interferon alpha-2; Interferon-alpha; Lorazepam; Male; Melanoma; Methylphenidate; Psychiatric Status Rating Scales; Pyridines; Recombinant Proteins; Trazodone; Zolpidem

2006
Dexamethasone-induced posterior reversible encephalopathy syndrome.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Jun-10, Volume: 25, Issue:17

    Topics: Anti-Inflammatory Agents; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Dexamethasone; Dopamine Antagonists; Female; Fractures, Bone; Haloperidol; Humans; Hypertensive Encephalopathy; Hypnotics and Sedatives; Inflammation; Lung Neoplasms; Middle Aged; Pyridines; Selective Serotonin Reuptake Inhibitors; Tomography, X-Ray Computed; Trazodone; Zolpidem

2007
A parent's nightmare.
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2005, Oct-15, Volume: 1, Issue:4

    Topics: Adolescent; Adult; Chronotherapy; Headache; Humans; Hypnotics and Sedatives; Male; Parents; Pyridines; Sleep Initiation and Maintenance Disorders; Sleep Stages; Trazodone; Zolpidem

2005
The management of insomnia in the older adult.
    Medicine and health, Rhode Island, 2007, Volume: 90, Issue:6

    Topics: Aged; Aged, 80 and over; Anti-Anxiety Agents; Antidepressive Agents; Baths; Exercise; Humans; Hypnotics and Sedatives; Indenes; Male; Mianserin; Mirtazapine; Pyridines; Relaxation Therapy; Sleep Initiation and Maintenance Disorders; Trazodone; Zolpidem

2007
Characterisation of the effects of caffeine on sleep in the rat: a potential model of sleep disruption.
    Journal of psychopharmacology (Oxford, England), 2009, Volume: 23, Issue:5

    Topics: Animals; Body Temperature; Caffeine; Central Nervous System Stimulants; Disease Models, Animal; Electroencephalography; Electromyography; Hypnotics and Sedatives; Male; Motor Activity; Pyridines; Rats; Rats, Sprague-Dawley; Sleep; Sleep Initiation and Maintenance Disorders; Telemetry; Trazodone; Zolpidem

2009
Prevalence and cost of insomnia in a state Medicaid fee-for-service population based on diagnostic codes and prescription utilization.
    Sleep medicine, 2010, Volume: 11, Issue:5

    Topics: Adolescent; Adult; Anti-Anxiety Agents; Child; Child, Preschool; Comorbidity; Diagnosis-Related Groups; Drug Prescriptions; Fee-for-Service Plans; Female; Humans; Hypnotics and Sedatives; Infant; Infant, Newborn; Male; Medicaid; Middle Aged; Prevalence; Pyridines; Sleep Initiation and Maintenance Disorders; Trazodone; United States; West Virginia; White People; Young Adult; Zolpidem

2010
Drugs for insomnia.
    Treatment guidelines from the Medical Letter, 2012, Volume: 10, Issue:119

    Topics: Benzodiazepines; Drug Interactions; Histamine Antagonists; Humans; Indenes; Pyridines; Sleep Initiation and Maintenance Disorders; Trazodone; Zolpidem

2012
Sedative Hypnotic Medication Use and the Risk of Motor Vehicle Crash.
    American journal of public health, 2015, Volume: 105, Issue:8

    Topics: Accidents, Traffic; Adult; Female; Humans; Hypnotics and Sedatives; Male; Middle Aged; Prescription Drugs; Proportional Hazards Models; Pyridines; Risk Factors; Temazepam; Trazodone; Washington; Zolpidem

2015
Predictive Modeling of Physician-Patient Dynamics That Influence Sleep Medication Prescriptions and Clinical Decision-Making.
    Scientific reports, 2017, 02-09, Volume: 7

    Topics: Clinical Decision-Making; Cohort Studies; Drug Prescriptions; Humans; Logistic Models; Models, Theoretical; Odds Ratio; Physician-Patient Relations; Pyridines; Sleep; Trazodone; Zolpidem

2017
Mild cognitive impairment: associations with sleep disturbance, apolipoprotein e4, and sleep medications.
    Sleep medicine, 2018, Volume: 52

    Topics: Aged; Alleles; Anti-Anxiety Agents; Apolipoprotein E4; Cognitive Dysfunction; Female; Genotype; Humans; Male; Sleep Aids, Pharmaceutical; Sleep Wake Disorders; Trazodone; Zolpidem

2018
Prescription Medications for the Treatment of Insomnia and Risk of Suicide Attempt: a Comparative Safety Study.
    Journal of general internal medicine, 2019, Volume: 34, Issue:8

    Topics: Adult; Female; Humans; Male; Middle Aged; Off-Label Use; Risk Assessment; Sleep Aids, Pharmaceutical; Sleep Initiation and Maintenance Disorders; Suicide, Attempted; Trazodone; Veterans; Young Adult; Zolpidem

2019
Trazodone and mirtazapine: A possible opioid involvement in their use (at low dose) for sleep?
    Medical hypotheses, 2020, Volume: 136

    Topics: Analgesics; Analgesics, Opioid; Animals; Antidepressive Agents; Depression; Disease Models, Animal; Male; Mice; Mice, Inbred ICR; Mirtazapine; Naloxone; Receptors, Opioid; Serotonin; Sleep; Sleep Wake Disorders; Trazodone; Zolpidem

2020
Trends in Dispensing of Zolpidem and Low-Dose Trazodone Among Commercially Insured Adults in the United States, 2011-2018.
    JAMA, 2020, 12-01, Volume: 324, Issue:21

    Topics: Adult; Drug Prescriptions; Female; Health Benefit Plans, Employee; Humans; Insurance, Medigap; Male; Practice Patterns, Physicians'; Sleep Aids, Pharmaceutical; Trazodone; United States; Zolpidem

2020
Zolpidem Versus Trazodone Initiation and the Risk of Fall-Related Fractures among Individuals Receiving Maintenance Hemodialysis.
    Clinical journal of the American Society of Nephrology : CJASN, 2020, 12-31, Volume: 16, Issue:1

    Topics: Accidental Falls; Aged; Cognitive Dysfunction; Dizziness; Drug Prescriptions; Female; Fractures, Bone; Hospitalization; Humans; Male; Medicare; Middle Aged; Registries; Renal Dialysis; Renal Insufficiency, Chronic; Retrospective Studies; Sleep Aids, Pharmaceutical; Sleep Initiation and Maintenance Disorders; Trazodone; United States; Zolpidem

2020
Fall Risk, Healthcare Resource Use, and Costs Among Adult Patients in the United States Treated for Insomnia with Zolpidem, Trazodone, or Benzodiazepines: A Retrospective Cohort Study.
    Advances in therapy, 2022, Volume: 39, Issue:3

    Topics: Adolescent; Adult; Aged; Benzodiazepines; Cohort Studies; Health Care Costs; Humans; Medicare; Patient Acceptance of Health Care; Retrospective Studies; Sleep Initiation and Maintenance Disorders; Trazodone; United States; Zolpidem

2022
Incremental health care resource use and costs among adult patients with depression and treated for insomnia with zolpidem, trazodone, or benzodiazepines.
    Current medical research and opinion, 2022, Volume: 38, Issue:5

    Topics: Adult; Aged; Benzodiazepines; Delivery of Health Care; Depression; Female; Health Care Costs; Humans; Male; Medicare; Middle Aged; Retrospective Studies; Sleep Initiation and Maintenance Disorders; Trazodone; United States; Zolpidem

2022
Falls, healthcare resources and costs in older adults with insomnia treated with zolpidem, trazodone, or benzodiazepines.
    BMC geriatrics, 2022, 06-04, Volume: 22, Issue:1

    Topics: Accidental Falls; Aged; Benzodiazepines; Delivery of Health Care; Female; Health Care Costs; Humans; Male; Medicare; Retrospective Studies; Sleep Initiation and Maintenance Disorders; Trazodone; United States; Zolpidem

2022
Real-World Characteristics and Treatment Patterns of Patients With Insomnia Prescribed Trazodone in the United States.
    Clinical therapeutics, 2022, Volume: 44, Issue:8

    Topics: Adult; Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Benzodiazepines; Child; Cohort Studies; Female; Humans; Male; Middle Aged; Retrospective Studies; Sleep Initiation and Maintenance Disorders; Trazodone; United States; Zolpidem

2022