Page last updated: 2024-08-16

trazodone and desipramine

trazodone has been researched along with desipramine in 36 studies

Research

Studies (36)

Timeframe	Studies, this research(%)	All Research%
pre-1990	13 (36.11)	18.7374
1990's	5 (13.89)	18.2507
2000's	8 (22.22)	29.6817
2010's	10 (27.78)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET	1
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	2
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahman, M; Holmén, AG; Wan, H	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Gozalbes, R; Pineda-Lucena, A	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Chang, G; Di, L; Huang, Y; Lin, Z; Liston, TE; Scott, DO; Troutman, MD; Umland, JP	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Carruba, MO; Mantegazza, P; Parenti, M; Picotti, GB; Ricciardi, S	1
Agnoli, A; Decina, P; Dionisio, A; Piccione, M	1
Altemus, M; Cizza, G; Gold, PW	1
Bradshaw, CM; Shah, K; Szabadi, E	1
Becker, CA; Commissaris, RL; Ellis, DM; Fontana, DJ; Hill, TJ; Schefke, DM	1
Boudoulas, H; Bridges, M; Pohl, R; Rainey, JM; Yeragani, VK	1
Cardamone, J; Cook, PE; Dermer, SW	1
Atwood, C; Beck, NC; Brownlee-Duffeck, M; Elliott, TR; Frank, RG; Haut, AE; Kashani, JH; Kay, DR; Parker, JC; Smith, E	1
el-Awar, M; Freedman, M; Goldenberg, L; Little, J; Seeman, P; Solomon, P	1
Clifford, DB; Hicks, FG; Rutherford, JL; Zorumski, CF	1
Arana, GW; Kaplan, GB	1
Al-Yassiri, MM; Ankier, SI; Bridges, PK	1
Napier, TC; Peterson, SL; Pirch, JH; Rigdon, GC	1
Burgess, CD; George, CF; Hames, TK	1
Avdulov, NA; Maĭsov, NI	1
Boyeson, MG; Harmon, RL	1
Hatsuda, S; Matsubara, M; Miura, K; Murakami, H; Nakazawa, K; Ohara, M; Sugita, S; Suzuki, S; Terashima, M	1
Hatsuda, S; Hayashi, T; Kimura, H; Matsubara, M; Miura, K; Mori, T; Murakami, H; Ohara, M; Ohta, T; Sugita, S; Suzuki, S; Terashima, M	1
Gaur, V; Kumar, A	1

Reviews

1 review(s) available for trazodone and desipramine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

3 trial(s) available for trazodone and desipramine

Article	Year
[Fast-acting antidepressive agents: comparison of trazodone and desipramine in a controlled double-blind trial]. La Clinica terapeutica, 1975, Jan-15, Volume: 72, Issue:1 Topics: Adult; Aged; Clinical Trials as Topic; Depression; Desipramine; Drug Evaluation; Female; Humans; Male; Middle Aged; Piperazines; Time Factors; Trazodone	1975
Antidepressant analgesia in rheumatoid arthritis. The Journal of rheumatology, 1988, Volume: 15, Issue:11 Topics: Aged; Amitriptyline; Antidepressive Agents; Arthritis, Rheumatoid; Depression; Desipramine; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Pain; Random Allocation; Trazodone	1988
A double blind comparison of the efficacy and safety of trazodone and imipramine in endogenous depression. Journal of affective disorders, 1983, Volume: 5, Issue:4 Topics: Adult; Clinical Trials as Topic; Depressive Disorder; Desipramine; Double-Blind Method; Female; Humans; Imipramine; Male; Middle Aged; Piperazines; Psychiatric Status Rating Scales; Psychometrics; Trazodone	1983

Other Studies

32 other study(ies) available for trazodone and desipramine

Article	Year
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. Journal of medicinal chemistry, 1985, Volume: 28, Issue:3 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium	1985
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability. Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7 Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6 Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry	2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
QSAR-based solubility model for drug-like compounds. Bioorganic & medicinal chemistry, 2010, Oct-01, Volume: 18, Issue:19 Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Species independence in brain tissue binding using brain homogenates. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:7 Topics: Animals; Brain; Dogs; Guinea Pigs; Humans; Macaca fascicularis; Mice; Rats; Species Specificity	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
Effect of etoperidone on the depletion of brain 5-hydroxytryptamine and catecholamines induced respectively by p-chloromethamphetamine and 6-hydroxydopamine in rats. Pharmacological research communications, 1979, Volume: 11, Issue:2 Topics: Animals; Antidepressive Agents; Brain; Catecholamines; Clomipramine; Desipramine; Dopamine; Hydroxydopamines; Male; Methamphetamine; Norepinephrine; Piperazines; Rats; Serotonin; Time Factors; Trazodone	1979
Chronic fluoxetine treatment reduces hypothalamic vasopressin secretion in vitro. Brain research, 1992, Oct-16, Volume: 593, Issue:2 Topics: Animals; Arginine Vasopressin; Desipramine; Fluoxetine; Hypothalamus; Male; Rats; Rats, Sprague-Dawley; Reference Values; Trazodone	1992
Interaction between antidepressants and d-amphetamine on variable-interval performance. Psychopharmacology, 1990, Volume: 100, Issue:4 Topics: Animals; Antidepressive Agents; Desipramine; Dextroamphetamine; Dose-Response Relationship, Drug; Female; Fluvoxamine; Imipramine; Oximes; Psychomotor Performance; Rats; Rats, Inbred Strains; Reinforcement Schedule; Serotonin Antagonists; Trazodone	1990
Chronic antidepressant and clonidine treatment effects on conflict behavior in the rat. Pharmacology, biochemistry, and behavior, 1990, Volume: 37, Issue:1 Topics: Animals; Antidepressive Agents; Behavior, Animal; Bupropion; Clonidine; Conflict, Psychological; Desipramine; Female; Mianserin; Panic; Propiophenones; Rats; Rats, Inbred Strains; Time Factors; Trazodone	1990
Effects of trazodone and desipramine on cardiac rate and rhythm in a patient with preexisting cardiovascular disease. Journal of clinical psychopharmacology, 1986, Volume: 6, Issue:6 Topics: Arrhythmias, Cardiac; Cardiac Complexes, Premature; Depressive Disorder; Desipramine; Female; Heart Rate; Humans; Middle Aged; Myocardial Infarction; Trazodone	1986
Imipramine-flupenthixol decanoate interaction. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1986, Volume: 31, Issue:3 Topics: Adult; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Desipramine; Drug Interactions; Flupenthixol; Humans; Imipramine; Male; Schizophrenia, Paranoid; Thioxanthenes; Trazodone	1986
Response of tardive and L-dopa-induced dyskinesias to antidepressants. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1987, Volume: 14, Issue:4 Topics: Aged; Antidepressive Agents; Depressive Disorder; Desipramine; Dyskinesia, Drug-Induced; Humans; Levodopa; Male; Middle Aged; Parkinson Disease, Secondary; Trazodone	1987
Acute effects of antidepressants on hippocampal seizures. Annals of neurology, 1985, Volume: 18, Issue:6 Topics: Amitriptyline; Animals; Anticonvulsants; Antidepressive Agents; Bupropion; Desipramine; Epilepsy; Hippocampus; Imipramine; Maprotiline; Propiophenones; Rats; Trazodone	1985
Trazodone-induced mania following desipramine-induced mania in major depressive disorders. The American journal of psychiatry, 1985, Volume: 142, Issue:3 Topics: Aged; Bipolar Disorder; Depressive Disorder; Desipramine; Female; Humans; Male; Middle Aged; Piperazines; Trazodone	1985
Dissimilar responses of cortical neurons to chronic trazodone or desipramine treatment. Progress in neuro-psychopharmacology & biological psychiatry, 1983, Volume: 7, Issue:2-3 Topics: Animals; Desipramine; Dose-Response Relationship, Drug; Male; Membrane Potentials; Neurons; Piperazines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Receptors, Serotonin; Synaptic Transmission; Trazodone	1983
The electrocardiographic and anticholinergic effects of trazodone and imipramine in man. European journal of clinical pharmacology, 1982, Volume: 23, Issue:5 Topics: Adult; Desipramine; Electrocardiography; Humans; Imipramine; Male; Parasympatholytics; Piperazines; Salivation; Time Factors; Trazodone	1982
[Atypical antidepressants: effect on synaptosomal uptake of serotonin and GABA]. Biulleten' eksperimental'noi biologii i meditsiny, 1981, Volume: 92, Issue:11 Topics: Animals; Antidepressive Agents; Brain; Carbazoles; Carbolines; Clomipramine; Depression, Chemical; Desipramine; gamma-Aminobutyric Acid; Imipramine; In Vitro Techniques; Oxazines; Piperazines; Rats; Serotonin; Synaptosomes; Trazodone	1981
Effects of trazodone and desipramine on motor recovery in brain-injured rats. American journal of physical medicine & rehabilitation, 1993, Volume: 72, Issue:5 Topics: Analysis of Variance; Animals; Brain Injuries; Desipramine; Hemiplegia; Male; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Trazodone	1993
[A study of the effects of antidepressants on the GABAA receptor and its complex based on the drug actions on the power-spectral changes of rat hippocampal EEG induced by GABA antagonists and inverse agonists]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 1997, Volume: 17, Issue:2 Topics: Animals; Antidepressive Agents; Carbolines; Depression, Chemical; Desipramine; Electroencephalography; Fluoxetine; GABA Antagonists; Hippocampus; Imipramine; Male; Norepinephrine; Pentylenetetrazole; Rats; Rats, Wistar; Receptors, GABA-A; Serotonin; Trazodone	1997
Electrophysiologic analysis of antidepressant drug effects on the GABA(A) receptor complex based upon antagonist-induced encephalographic power spectrum changes. Neuropsychobiology, 2000, Volume: 42, Issue:3 Topics: Animals; Antidepressive Agents; Desipramine; Electroencephalography; Fluoxetine; Fourier Analysis; GABA Antagonists; Hippocampus; Imipramine; Male; Nortriptyline; Pentylenetetrazole; Rats; Rats, Wistar; Trazodone	2000
Protective effect of desipramine, venlafaxine and trazodone against experimental animal model of transient global ischemia: possible involvement of NO-cGMP pathway. Brain research, 2010, Sep-24, Volume: 1353 Topics: Analysis of Variance; Animals; Antidepressive Agents; Arginine; Brain; Catalase; Cyclic GMP; Cyclohexanols; Desipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Electron Transport Chain Complex Proteins; Enzyme Inhibitors; Glutathione; Ischemic Attack, Transient; Lipid Peroxidation; Mice; Models, Biological; Nitric Oxide; Signal Transduction; Trazodone; Venlafaxine Hydrochloride	2010