Page last updated: 2024-08-16

trazodone and buspirone

trazodone has been researched along with buspirone in 34 studies

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-19902 (5.88)18.7374
1990's14 (41.18)18.2507
2000's8 (23.53)29.6817
2010's10 (29.41)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Carrupt, PA; Gaillard, P; Schambel, P; Testa, B1
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Bergström, F; Giordanetto, F; Rehngren, M; Tunek, A; Wan, H1
Ahman, M; Holmén, AG; Wan, H1
Duncton, MA; Emerling, DE; Kelly, MG; Nguyen, MT; Vincent, F1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Boriss, H; Braggio, S; Corbioli, S; Fontana, S; Helmdach, L; Longhi, R; Schiller, J; Vinco, F1
Chang, G; Di, L; Huang, Y; Lin, Z; Liston, TE; Scott, DO; Troutman, MD; Umland, JP1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Ballard, TE; Henderson, JL; Kalgutkar, AS; Obach, RS; Orr, ST; Ripp, SL; Scott, DO; Sun, H1
Bellman, K; Knegtel, RM; Settimo, L1
Aleo, MD; Bonin, PD; Luo, Y; Potter, DM; Swiss, R; Will, Y1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y1
Schneider, LS; Sobin, PB1
Hawkins, JW1
Goldberg, RJ; Huk, M1
Bakish, D1
Boylan, K1
Pretorius, HW1
McBrayer, RH; Rose, FV; Ware, JC1
Fernandez, F; Levy, JK1
Tanquary, J1
Aronson, SC; Barr, LC; Goodman, WK; McDougle, CJ; Price, LH1
Lieff, S; Robillard, M1
Brawman-Mintzer, O; Mintzer, JE1
Lawlor, B1
Griffith, JC; Hudzik, TJ; Kinney, GG1
Lantz, MS1
Atherton, J; Feng, B; Hanson, J; Kalgutkar, AS; Kostrubsky, SE; Kubik, R; Kulkarni, S; Mireles, R; Mutlib, AE; Strom, SC; Urda, E1
Dunn, MC; Dykens, JA; Jamieson, JD; Marroquin, LD; Nadanaciva, S; Smith, AR; Will, Y; Xu, JJ1
Calabrese, JR; Cao, L; Chen, J; Cui, X; Fang, Y; Gao, K; Hong, W; Jiang, K; Wang, Y; Wu, Z; Xu, Y; Yi, Z; Yuan, C1

Reviews

6 review(s) available for trazodone and buspirone

ArticleYear
Mechanism-based inactivation (MBI) of cytochrome P450 enzymes: structure-activity relationships and discovery strategies to mitigate drug-drug interaction risks.
    Journal of medicinal chemistry, 2012, Jun-14, Volume: 55, Issue:11

    Topics: Animals; Apoproteins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Drug Interactions; Heme; Humans; Models, Biological; Pharmacokinetics; Structure-Activity Relationship; Time Factors

2012
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Non-neuroleptic treatment of behavioral symptoms and agitation in Alzheimer's disease and other dementia.
    Psychopharmacology bulletin, 1992, Volume: 28, Issue:1

    Topics: Adrenergic beta-Antagonists; Alzheimer Disease; Buspirone; Carbamazepine; Dementia; Humans; Lithium; Neurotransmitter Uptake Inhibitors; Selegiline; Serotonin; Trazodone

1992
Psychopharmacology in HIV spectrum disorders.
    The Psychiatric clinics of North America, 1994, Volume: 17, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; AIDS Dementia Complex; Anti-Anxiety Agents; Antipsychotic Agents; Anxiety Disorders; Benzodiazepines; Buspirone; Depressive Disorder; Humans; Lithium Carbonate; Mental Disorders; Monoamine Oxidase Inhibitors; Psychotic Disorders; Psychotropic Drugs; Trazodone

1994
Biological approaches to treatment-resistant obsessive compulsive disorder.
    The Journal of clinical psychiatry, 1993, Volume: 54 Suppl

    Topics: Behavior Therapy; Buspirone; Clonazepam; Combined Modality Therapy; Decision Trees; Drug Therapy, Combination; Electroconvulsive Therapy; Fenfluramine; Humans; Lithium; Obsessive-Compulsive Disorder; Phototherapy; Selective Serotonin Reuptake Inhibitors; Sleep Deprivation; Trazodone; Tryptophan

1993
Agitation as a possible expression of generalized anxiety disorder in demented elderly patients: toward a treatment approach.
    The Journal of clinical psychiatry, 1996, Volume: 57 Suppl 7

    Topics: Aged; Aggression; Antipsychotic Agents; Anxiety Disorders; Behavior Therapy; Buspirone; Carbamazepine; Clozapine; Combined Modality Therapy; Decision Trees; Dementia; Humans; Ondansetron; Psychomotor Agitation; Serotonin; Trazodone

1996

Trials

2 trial(s) available for trazodone and buspirone

ArticleYear
The acute effects of nefazodone, trazodone and buspirone on sleep and sleep-related penile tumescence in normal subjects.
    Sleep, 1994, Volume: 17, Issue:6

    Topics: Adult; Analysis of Variance; Antidepressive Agents; Buspirone; Double-Blind Method; Humans; Male; Penile Erection; Piperazines; Reference Values; Sleep; Trazodone; Triazoles

1994
A pilot study of the efficacy and safety of paroxetine augmented with risperidone, valproate, buspirone, trazodone, or thyroid hormone in adult Chinese patients with treatment-resistant major depression.
    Journal of clinical psychopharmacology, 2011, Volume: 31, Issue:5

    Topics: Buspirone; China; Depressive Disorder, Major; Double-Blind Method; Drug Resistance; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Paroxetine; Pilot Projects; Psychiatric Status Rating Scales; Remission Induction; Risperidone; Selective Serotonin Reuptake Inhibitors; Thyroid Hormones; Trazodone; Valproic Acid

2011

Other Studies

26 other study(ies) available for trazodone and buspirone

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
Binding of arylpiperazines, (aryloxy)propanolamines, and tetrahydropyridylindoles to the 5-HT1A receptor: contribution of the molecular lipophilicity potential to three-dimensional quantitative structure-affinity relationship models.
    Journal of medicinal chemistry, 1996, Jan-05, Volume: 39, Issue:1

    Topics: Indoles; Ligands; Models, Molecular; Molecular Conformation; Molecular Structure; Piperazines; Propanolamines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Structure-Activity Relationship; Tetrahydronaphthalenes

1996
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
    Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7

    Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties

2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
High-throughput screening of drug-brain tissue binding and in silico prediction for assessment of central nervous system drug delivery.
    Journal of medicinal chemistry, 2007, Sep-20, Volume: 50, Issue:19

    Topics: Animals; Brain; Central Nervous System Agents; Dialysis; Hydrophobic and Hydrophilic Interactions; In Vitro Techniques; Mice; Models, Statistical; Protein Binding; Quantitative Structure-Activity Relationship; Rats

2007
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
    Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6

    Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry

2009
Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors.
    Bioorganic & medicinal chemistry letters, 2009, Dec-01, Volume: 19, Issue:23

    Topics: Amidohydrolases; Carbamates; Dose-Response Relationship, Drug; Drug Design; Enzyme Inhibitors; Humans; Models, Molecular; Molecular Structure; Piperazines; Stereoisomerism; Structure-Activity Relationship

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2

    Topics: Absorption; Albumins; Animals; Brain; Brain Chemistry; Cell Membrane; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; In Vitro Techniques; Lipids; Male; Microdialysis; Pharmaceutical Preparations; Protein Binding; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine; Tissue Distribution

2011
Species independence in brain tissue binding using brain homogenates.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:7

    Topics: Animals; Brain; Dogs; Guinea Pigs; Humans; Macaca fascicularis; Mice; Rats; Species Specificity

2011
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump.
    Hepatology (Baltimore, Md.), 2014, Volume: 60, Issue:3

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Chemical and Drug Induced Liver Injury; Humans; Male; Mitochondria, Liver; Rats; Rats, Sprague-Dawley; Severity of Illness Index

2014
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
    Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16

    Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone

2016
Nonsedating treatments for Alzheimer's patients with behavioral problems.
    The Journal of clinical psychiatry, 1992, Volume: 53, Issue:3

    Topics: Alzheimer Disease; Buspirone; Fluoxetine; Humans; Selegiline; Sleep; Trazodone

1992
Serotonin syndrome from trazodone and buspirone.
    Psychosomatics, 1992,Spring, Volume: 33, Issue:2

    Topics: Aged; Buspirone; Delirium; Humans; Male; Myoclonus; Serotonin; Trazodone

1992
Fluoxetine potentiation by buspirone: three case histories.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1991, Volume: 36, Issue:10

    Topics: Adult; Buspirone; Clonazepam; Depressive Disorder; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Female; Fluoxetine; Humans; Trazodone; Tryptophan

1991
Persistent dystonia associated with buspirone.
    Neurology, 1990, Volume: 40, Issue:12

    Topics: Anxiety; Buspirone; Depression; Drug Therapy, Combination; Dystonia; Female; Follow-Up Studies; Humans; Middle Aged; Trazodone

1990
Other forms of treatment for anxiety.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1985, Oct-26, Volume: Suppl

    Topics: Adrenergic beta-Antagonists; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Anxiety; Behavior Therapy; Buspirone; Humans; Monoamine Oxidase Inhibitors; Psychotherapy; Pyrimidines; Trazodone

1985
Trichotillomania and body dysmorphic disorder.
    The Journal of clinical psychiatry, 1994, Volume: 55, Issue:1

    Topics: Adult; Buspirone; Delusions; Drug Therapy, Combination; Fluoxetine; Humans; Male; Trazodone; Trichotillomania

1994
Augmentation of antidepressant therapy by buspirone: three geriatric case histories.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1995, Volume: 40, Issue:10

    Topics: Aged; Aged, 80 and over; Antidepressive Agents; Buspirone; Depressive Disorder; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Male; Trazodone

1995
'The use of selective serotonin reuptake inhibitors for depression and psychosis complicating dementia'--1997, 12, 519-527.
    International journal of geriatric psychiatry, 1998, Volume: 13, Issue:7

    Topics: Buspirone; Dementia; Depression; Drug Therapy, Combination; Humans; Psychotic Disorders; Selective Serotonin Reuptake Inhibitors; Serotonin Receptor Agonists; Trazodone

1998
Antidepressant-like effects of 5-hydroxytryptamine1A receptor agonists on operant responding under a response duration differentiation schedule.
    Behavioural pharmacology, 1998, Volume: 9, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alprenolol; Analysis of Variance; Animals; Antidepressive Agents; Buspirone; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Inhibition, Psychological; Male; Propranolol; Rats; Rats, Long-Evans; Reaction Time; Reinforcement Schedule; Serotonin Antagonists; Serotonin Receptor Agonists; Trazodone

1998
Serotonin syndrome. A common but often unrecognized psychiatric condition.
    Geriatrics, 2001, Volume: 56, Issue:1

    Topics: Aged; Anxiety Disorders; Buspirone; Citalopram; Depression; Female; Humans; Selective Serotonin Reuptake Inhibitors; Serotonin Syndrome; Trazodone

2001
Inhibition of hepatobiliary transport as a predictive method for clinical hepatotoxicity of nefazodone.
    Toxicological sciences : an official journal of the Society of Toxicology, 2006, Volume: 90, Issue:2

    Topics: Animals; Antidepressive Agents, Second-Generation; Bile Acids and Salts; Bile Canaliculi; Biological Transport; Buspirone; Cells, Cultured; Hepatocytes; Humans; Microsomes, Liver; Piperazines; Rats; Rats, Sprague-Dawley; Trazodone; Triazoles

2006
In vitro assessment of mitochondrial dysfunction and cytotoxicity of nefazodone, trazodone, and buspirone.
    Toxicological sciences : an official journal of the Society of Toxicology, 2008, Volume: 103, Issue:2

    Topics: Adenosine Triphosphate; Animals; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Buspirone; Cell Line; Cell Respiration; Cell Survival; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Hepatocytes; Humans; Male; Membrane Potential, Mitochondrial; Metabolic Networks and Pathways; Mitochondria, Liver; Oxidative Phosphorylation; Oxygen Consumption; Piperazines; Rats; Rats, Sprague-Dawley; Trazodone; Triazoles

2008