trazodone has been researched along with 1-(3-chlorophenyl)piperazine in 58 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (22.41) | 18.7374 |
| 1990's | 24 (41.38) | 18.2507 |
| 2000's | 12 (20.69) | 29.6817 |
| 2010's | 9 (15.52) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Carrupt, PA; Gaillard, P; Schambel, P; Testa, B | 1 |
| Baumann, MH; Hufeisen, SJ; McBride, A; Rauser, L; Roth, BL; Rothman, RB; Savage, JE | 1 |
| Benwell, K; Bickerdike, M; Kennett, G; Knight, AR; Misra, A; Quirk, K; Revell, D | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Short, D; Tellian, F; Workman, EA | 1 |
| Bernstein, SE; Hill, JL; L'Heureux, F; Murphy, DL; Pigott, TA; Rubenstein, CS | 1 |
| Morrone, LA; Pimpinella, G; Romanelli, L; Troiani, MP; Valeri, P | 1 |
| Heebner, ET; Holland, ML | 1 |
| Azadzoi, KM; Goldstein, I; Krane, RJ; Payton, T | 1 |
| Azadzoi, KM; Blanco, R; Goldstein, I; Krane, RJ; Nadig, PW; Pittard, JT; Saenz de Tejada, I; Ware, JC | 1 |
| Morrone, LA; Pimpinella, G; Romanelli, L; Valeri, P | 1 |
| Hand, TH; Li, AA; Marek, GJ; Seiden, LS | 1 |
| Kesslick, JM; Martin, GE; Mathiasen, JR | 1 |
| Adamus, A; Melzacka, M; Sansone, M; Vetulani, J | 1 |
| DeVane, CL; Miller, RL | 1 |
| Melzacka, M; Sansone, M; Vetulani, J | 1 |
| Smith, TM; Suckow, RF | 1 |
| Ballabio, M; Caccia, S; Garattini, S; Samanin, R; Zanini, MG | 1 |
| Ballabio, M; Caccia, S; Cervo, L; Samanin, R | 1 |
| Caccia, S; Fong, MH; Garattini, S; Zanini, MG | 1 |
| Caccia, S; Fong, MH; Garattini, S | 1 |
| Hano, J; Melzacka, M; Sansone, M; Vetulani, J | 1 |
| Shelekhov, SL; Val'dman, AV | 1 |
| Baran, L; Hano, J; Sansone, M; Vetulani, J | 1 |
| Cioli, V; Corradino, C; Piccinelli, D; Rocchi, MG; Valeri, P | 1 |
| Fukushima, Y; Ishida, M; Kaneko, S; Kondo, T; Mihara, K; Ohkubo, T; Osanai, T; Otani, K; Sugawara, K; Yasui, N | 1 |
| Fukushima, Y; Ishida, M; Kaneko, S; Ohkubo, T; Osanai, T; Otani, K; Sugawara, K; Yasui, N | 1 |
| Ishida, M; Mihara, K; Ohkubo, T; Osanai, T; Otani, K; Sugawara, K; Yasui, N | 1 |
| Hambalek, R; Kin, NM; Krishnan, B; Lal, S; Thavundayil, JX | 1 |
| Callahan, PM; Cunningham, KA | 1 |
| Higuchi, H; Ishida, M; Kaneko, S; Mihara, K; Ohkubo, T; Osanai, T; Otani, K; Sugawara, K; Yasui, N | 1 |
| Ishida, M; Kaneko, S; Mihara, K; Ohkubo, T; Osanai, T; Otani, K; Sugawara, K | 1 |
| Ishida, M; Kaneko, S; Mihara, K; Ohkubo, T; Osanai, T; Otani, K; Sugawara, K; Suzuki, A; Yasui, N | 1 |
| Lawlor, BA; Martinez, R; Murphy, DL; Radcliffe, J; Sunderland, T | 1 |
| Ishida, M; Kaneko, S; Kondo, T; Mihara, K; Ohkubo, T; Osanai, T; Otani, K; Sugawara, K; Tokinaga, N; Yasui, N | 1 |
| Dysken, MW; Hazel, DK; Holden, LA; Vatassery, GT | 1 |
| Demedts, P; Maes, M; Meltzer, HY; Neels, H; Vandoolaeghe, E; Wauters, A; Westenberg, H | 1 |
| Gonzalez, FJ; Kaneko, S; Meng, X; Mihara, K; Nagasaki, T; Nakano, H; Ohkubo, T; Otani, K; Sugawara, K; Suzuki, A; Tsuchida, S; Yasui, N | 1 |
| Baker, GB; Fang, J; Rotzinger, S | 1 |
| Chen, CF; Cheng, FC; Kuo, JS; Tsai, TH; Wu, YS | 1 |
| Granda, BW; Greenblatt, DJ; Harmatz, JS; Shader, RI; von Moltke, LL; Zalma, A | 1 |
| Kaneko, S; Kondo, T; Mihara, K; Ono, S; Otani, K; Suzuki, A; Yasui-Furukori, N | 1 |
| Ishida, M; Kaneko, S; Kondo, T; Mihara, K; Ohkubo, T; Ono, S; Osanai, T; Otani, K; Sugawara, K; Yasui-Furukori, N | 1 |
| Odagaki, Y; Toyoshima, R; Yamauchi, T | 1 |
| Jovanovska, A; Kraus, RL; Li, Y; Renger, JJ | 1 |
| Ma, L; Rodrigues, AD; Wen, B; Zhu, M | 1 |
| Amore, M; Colliva, C; Fanali, S; Mercolini, L; Raggi, MA | 1 |
| Patel, BN; Sanyal, M; Sharma, N; Shrivastav, PS | 1 |
| Kast, RE | 1 |
| Groenewoud, G; Karhu, D; Mould, DR; Potgieter, MA | 1 |
| Costantino, AG; Logan, BK; Rieders, EF; Sanders, D | 1 |
| Baron, JM; Flood, JG; Griggs, DA; Long, WH; Nixon, AL | 1 |
| Cronjé, T; Fradette, C; Gossen, ER; Karhu, D; Mostert, A | 1 |
| Horowitz, GL; Lynch, KL; Petrie, MS; Steinhardt, AA; Wu, AH | 1 |
| Ganetsky, M | 1 |
| Milone, MC | 1 |
| Davis, JL; Medlin, E; Schirmer, J | 1 |
9 trial(s) available for trazodone and 1-(3-chlorophenyl)piperazine
| Article | Year |
|---|---|
A double-blind, placebo controlled study of trazodone in patients with obsessive-compulsive disorder.
Topics: Adolescent; Adult; Blood Platelets; Double-Blind Method; Female; Humans; Male; Middle Aged; Obsessive-Compulsive Disorder; Piperazines; Psychiatric Status Rating Scales; Serotonin; Trazodone | 1992 |
Pathophysiology of prolonged penile erection associated with trazodone use.
Topics: Adolescent; Adult; Dose-Response Relationship, Drug; Double-Blind Method; Humans; In Vitro Techniques; Male; Muscle, Smooth; Penile Erection; Penis; Piperazines; Placebos; Priapism; Sleep; Trazodone; Trimipramine | 1991 |
Increases in plasma concentration of m-chlorophenylpiperazine, but not trazodone, with low-dose haloperidol.
Topics: Adult; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Cytochrome P-450 CYP2D6 Inhibitors; Depressive Disorder; Drug Interactions; Female; Haloperidol; Humans; Male; Middle Aged; Piperazines; Trazodone | 1997 |
Plasma levels of m-chlorophenylpiperazine following single oral dose administration of m-chlorophenylpiperazine and trazodone in human volunteers.
Topics: Antidepressive Agents, Second-Generation; Chromatography, High Pressure Liquid; Cross-Over Studies; Double-Blind Method; Drug Interactions; Female; Humans; Male; Middle Aged; Piperazines; Serotonin Receptor Agonists; Trazodone | 1997 |
Effects of trazodone and fluoxetine in the treatment of major depression: therapeutic pharmacokinetic and pharmacodynamic interactions through formation of meta-chlorophenylpiperazine.
Topics: Adult; Aged; Antidepressive Agents, Second-Generation; Depressive Disorder, Major; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Female; Fluoxetine; Humans; Male; Middle Aged; Personality Inventory; Pindolol; Piperazines; Trazodone; Treatment Outcome | 1997 |
Relationship between plasma concentrations of trazodone and its active metabolite, m-chlorophenylpiperazine, and its clinical effect in depressed patients.
Topics: Adult; Antidepressive Agents, Second-Generation; Chromatography, High Pressure Liquid; Depressive Disorder; Female; Humans; Male; Middle Aged; Piperazines; Trazodone | 2002 |
Dose proportionality of once-daily trazodone extended-release caplets under fasting conditions.
Topics: Adult; Antidepressive Agents, Second-Generation; Cross-Over Studies; Delayed-Action Preparations; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Male; Models, Biological; Models, Statistical; Piperazines; Tablets; Therapeutic Equivalency; Trazodone; Young Adult | 2010 |
Safety, tolerability, and pharmacokinetics of once-daily trazodone extended-release caplets in healthy subjects.
Topics: Adolescent; Adult; Antidepressive Agents, Second-Generation; Area Under Curve; Biological Availability; Delayed-Action Preparations; Female; Food-Drug Interactions; Humans; Male; Middle Aged; Piperazines; Trazodone | 2011 |
Pharmacokinetics, pharmacodynamics and clinical use of trazodone and its active metabolite m-chlorophenylpiperazine in the horse.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Area Under Curve; Cross-Over Studies; Dose-Response Relationship, Drug; Half-Life; Horses; Male; Piperazines; Serotonin Receptor Agonists; Trazodone | 2018 |
49 other study(ies) available for trazodone and 1-(3-chlorophenyl)piperazine
| Article | Year |
|---|---|
Binding of arylpiperazines, (aryloxy)propanolamines, and tetrahydropyridylindoles to the 5-HT1A receptor: contribution of the molecular lipophilicity potential to three-dimensional quantitative structure-affinity relationship models.
Topics: Indoles; Ligands; Models, Molecular; Molecular Conformation; Molecular Structure; Piperazines; Propanolamines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Structure-Activity Relationship; Tetrahydronaphthalenes | 1996 |
Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications.
Topics: Dose-Response Relationship, Drug; Ergotamine; Fenfluramine; Heart Valve Diseases; Humans; Methylergonovine; Norfenfluramine; Receptors, Serotonin; Serotonin Antagonists | 2000 |
Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors.
Topics: Binding Sites; Binding, Competitive; Cell Line; Humans; Radioligand Assay; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2B; Receptor, Serotonin, 5-HT2C; Recombinant Proteins; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Trazodone induction of migraine headache through mCPP.
Topics: Adult; Depressive Disorder; Humans; Male; Migraine Disorders; Piperazines; Trazodone | 1992 |
Effects of trazodone and m-chlorophenylpiperazine (m-CPP) on acute dependence in mice.
Topics: Acute Disease; Animals; Behavior, Animal; Male; Mice; Morphine Dependence; Piperazines; Receptors, Serotonin; Substance Withdrawal Syndrome; Trazodone | 1991 |
High-performance liquid chromatographic assay with ultraviolet detection for the determination of etoperidone and two active metabolites, 5-(1-hydroxyethyl) etoperidone and 1-(3-chlorophenyl)piperazine, in plasma.
Topics: Animals; Chromatography, High Pressure Liquid; Dogs; Humans; Indicators and Reagents; Injections, Intravenous; Mice; Piperazines; Rats; Reference Standards; Spectrophotometry, Ultraviolet; Trazodone | 1991 |
Effects of intracavernosal trazodone hydrochloride: animal and human studies.
Topics: Adrenergic alpha-Antagonists; Adult; Animals; Erectile Dysfunction; Humans; Male; Penile Erection; Penis; Piperazines; Rabbits; Trazodone | 1990 |
Antinociceptive effects of trazodone and m-chlorophenylpiperazine (mCPP) in mice: interaction with morphine.
Topics: Analgesics; Animals; Antidepressive Agents; Drug Interactions; Male; Mice; Morphine; Naloxone; Piperazines; Reaction Time; Trazodone | 1991 |
Antidepressant-like effects of trazodone on a behavioral screen are mediated by trazodone, not the metabolite m-chlorophenylpiperazine.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Piperazines; Proadifen; Rats; Rats, Inbred Strains; Reinforcement Schedule; Trazodone | 1990 |
Blockade of conditioned avoidance responding by trazodone, etoperidone, and MCPP.
Topics: Animals; Antidepressive Agents; Avoidance Learning; Conditioning, Psychological; Male; Metergoline; Piperazines; Rats; Rats, Inbred F344; Receptors, Serotonin; Trazodone | 1989 |
Prolongation of thiopentone-induced sleep by trazodone and its metabolite, m-chlorophenylpiperazine.
Topics: Anesthesia; Animals; Brain; Drug Synergism; Male; Mice; Mice, Inbred C57BL; Piperazines; Thiopental; Time Factors; Trazodone | 1985 |
Analysis of trazodone and m-chlorophenylpiperazine in plasma and brain tissue by high-performance liquid chromatography.
Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Indicators and Reagents; Piperazines; Rats; Trazodone | 1986 |
The role of trazodone metabolism in its inhibitory action on avoidance response.
Topics: Animals; Avoidance Learning; Biotransformation; Brain; Male; Mice; Mice, Inbred BALB C; Piperazines; Proadifen; Trazodone | 1985 |
Trazodone and m-chlorophenylpiperazine. Concentration in brain and receptor activity in regions in the brain associated with anxiety.
Topics: Animals; Anxiety; Brain; Clonidine; Flunitrazepam; In Vitro Techniques; Isomerism; Male; Membranes; Piperazines; Rats; Rats, Inbred Strains; Receptors, Drug; Structure-Activity Relationship; Trazodone | 1985 |
(--)-m-Chlorophenyl-piperazine, a central 5-hydroxytryptamine agonist, is a metabolite of trazodone.
Topics: Animals; Biotransformation; Brain; Male; Piperazines; Rats; Serotonin; Time Factors; Trazodone | 1981 |
Blockade by trazodone of naloxone-precipitated jumping on morphine-dependent rats: correlation with brain levels of m-chlorophenylpiperazine.
Topics: Animals; Brain; Brain Chemistry; Humans; Male; Morphine Dependence; Motor Activity; Naloxone; Piperazines; Rats; Rats, Inbred Strains; Trazodone | 1981 |
Plasma concentrations of trazodone and 1-(3-chlorophenyl)piperazine in man after a single oral dose of trazodone.
Topics: Adult; Half-Life; Humans; Piperazines; Time Factors; Trazodone | 1982 |
1-m-Chlorophenylpiperazine is an active metabolite common to the psychotropic drugs trazodone, etoperidone and mepiprazole.
Topics: Animals; Biotransformation; Brain; Kinetics; Male; Piperazines; Rats; Trazodone | 1982 |
Reversal of depressant action of trazodone on avoidance behaviour by its metabolite m-chlorophenylpiperazine.
Topics: Animals; Avoidance Learning; Biotransformation; Male; Mice; Mice, Inbred BALB C; Piperazines; Trazodone | 1983 |
[Effect of serotoninergic substances on escape behavior in acute stress situations].
Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents; Brompheniramine; Cyproheptadine; Escape Reaction; Humans; Male; Piperazines; Piperidines; Quipazine; Rats; Rats, Inbred Strains; Serotonin; Stress, Psychological; Tranquilizing Agents; Trazodone; Zimeldine | 1983 |
Opposite action of m-chlorophenylpiperazine on avoidance depression induced by trazodone and pimozide in CD-1 mice.
Topics: Animals; Avoidance Learning; Conditioning, Psychological; Male; Mice; Mice, Inbred Strains; Pimozide; Piperazines; Trazodone | 1984 |
A comparative pharmacological study of trazodone, etoperidone and 1-(m-chlorophenyl)piperazine.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Blood Pressure; Bronchial Spasm; Central Nervous System; Female; Guinea Pigs; Male; Mice; Motor Activity; Piperazines; Rats; Trazodone | 1984 |
Inhibition of trazodone metabolism by thioridazine in humans.
Topics: Adult; Aged; Antidepressive Agents, Second-Generation; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Female; Humans; Male; Middle Aged; Mixed Function Oxygenases; Piperazines; Thioridazine; Trazodone | 1995 |
Trazodone treatment increases plasma prolactin concentrations in depressed patients.
Topics: Adult; Depressive Disorder; Female; Follow-Up Studies; Humans; Male; Middle Aged; Piperazines; Prolactin; Trazodone | 1995 |
High-performance liquid chromatographic determination of trazodone and 1-m-chlorophenylpiperazine with ultraviolet and electrochemical detector.
Topics: Chromatography, High Pressure Liquid; Electrochemistry; Humans; Piperazines; Trazodone; Ultraviolet Rays | 1995 |
Prolonged penile erections induced by hydroxyzine: possible mechanism of action.
Topics: Adult; Humans; Hydroxyzine; Insect Bites and Stings; Male; Models, Molecular; Molecular Conformation; Piperazines; Priapism; Serotonin Receptor Agonists; Structure-Activity Relationship; Trazodone | 1994 |
Involvement of 5-HT2C receptors in mediating the discriminative stimulus properties of m-chlorophenylpiperazine (mCPP).
Topics: Animals; Discrimination, Psychological; Dopamine Antagonists; Ergolines; Fenfluramine; Lysergic Acid Diethylamide; Male; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Trazodone | 1994 |
Effects of various factors on steady state plasma concentrations of trazodone and its active metabolite m-chlorophenylpiperazine.
Topics: Adult; Benzodiazepines; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Pharmacokinetics; Piperazines; Serotonin Receptor Agonists; Sex Factors; Smoking; Trazodone | 1995 |
Effects of carbamazepine coadministration on plasma concentrations of trazodone and its active metabolite, m-chlorophenylpiperazine.
Topics: Anticonvulsants; Antidepressive Agents, Second-Generation; Carbamazepine; Female; Humans; Male; Middle Aged; Piperazines; Serotonin Receptor Agonists; Trazodone | 1996 |
Plasma concentrations of trazodone and m-chlorophenylpiperazine at steady state can be predicted from those after an initial dose of trazodone.
Topics: Adult; Aged; Depressive Disorder; Female; Humans; Male; Middle Aged; Piperazines; Trazodone | 1997 |
Determination of trazodone and its metabolite, 1-m-chlorophenyl-piperazine, in human plasma and red blood cell samples by HPLC.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Erythrocytes; Humans; Male; Middle Aged; Piperazines; Serotonin Receptor Agonists; Trazodone | 1997 |
Relationship between the CYP2D6 genotype and the steady-state plasma concentrations of trazodone and its active metabolite m-chlorophenylpiperazine.
Topics: Adult; Antidepressive Agents, Second-Generation; Cytochrome P-450 CYP2D6; Depressive Disorder; Female; Humans; Male; Middle Aged; Pharmacogenetics; Piperazines; Selective Serotonin Reuptake Inhibitors; Trazodone | 1997 |
Trazodone is metabolized to m-chlorophenylpiperazine by CYP3A4 from human sources.
Topics: Antidepressive Agents, Second-Generation; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Ketoconazole; Microsomes, Liver; Mixed Function Oxygenases; Piperazines; Serotonin Receptor Agonists; Trazodone | 1998 |
Pharmacokinetic and pharmacodynamic analyses of trazodone in rat striatum by in vivo microdialysis.
Topics: Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Dialysis Solutions; Drug Monitoring; Hydroxyindoleacetic Acid; Male; Microdialysis; Piperazines; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Selective Serotonin Reuptake Inhibitors; Sensitivity and Specificity; Serotonin; Serotonin Receptor Agonists; Trazodone | 1999 |
In vitro metabolism of trazodone by CYP3A: inhibition by ketoconazole and human immunodeficiency viral protease inhibitors.
Topics: Antidepressive Agents, Second-Generation; Antifungal Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; HIV Protease Inhibitors; Humans; In Vitro Techniques; Indinavir; Ketoconazole; Microsomes, Liver; Nelfinavir; Oxidoreductases, N-Demethylating; Piperazines; Ritonavir; Saquinavir; Selective Serotonin Reuptake Inhibitors; Serotonin Receptor Agonists; Trazodone | 2000 |
Effects of genetic polymorphism of CYP1A2 inducibility on the steady-state plasma concentrations of trazodone and its active metabolite m-chlorophenylpiperazine in depressed Japanese patients.
Topics: Adult; Alleles; Antidepressive Agents, Second-Generation; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Depression; Dose-Response Relationship, Drug; Enzyme Induction; Female; Humans; Japan; Male; Middle Aged; Piperazines; Point Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Smoking; Time Factors; Trazodone | 2001 |
Trazodone and its active metabolite m-chlorophenylpiperazine as partial agonists at 5-HT1A receptors assessed by [35S]GTPgammaS binding.
Topics: Animals; Antidepressive Agents, Second-Generation; Cell Membrane; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Male; Piperazines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Serotonin Receptor Agonists; Sulfur Radioisotopes; Trazodone | 2005 |
Trazodone inhibits T-type calcium channels.
Topics: Animals; Animals, Newborn; Brain; Calcium Channels, T-Type; Cell Line, Transformed; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Electric Stimulation; Humans; In Vitro Techniques; Inhibitory Concentration 50; Membrane Potentials; Neural Inhibition; Neurons; Patch-Clamp Techniques; Piperazines; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin Receptor Agonists; Transfection; Trazodone | 2007 |
Detection of novel reactive metabolites of trazodone: evidence for CYP2D6-mediated bioactivation of m-chlorophenylpiperazine.
Topics: Antidepressive Agents, Second-Generation; Biotransformation; Cytochrome P-450 CYP2D6; Glutathione; Humans; Microsomes, Liver; Piperazines; Recombinant Proteins; Serotonin Receptor Agonists; Trazodone | 2008 |
HPLC analysis of the antidepressant trazodone and its main metabolite m-CPP in human plasma.
Topics: Acetonitriles; Antidepressive Agents; Buffers; Chromatography, High Pressure Liquid; Depression; Drug Stability; Ethylamines; Feasibility Studies; Freezing; Humans; Hydrogen-Ion Concentration; Molecular Structure; Phosphates; Piperazines; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Time Factors; Trazodone; Water | 2008 |
High throughput and sensitive determination of trazodone and its primary metabolite, m-chlorophenylpiperazine, in human plasma by liquid chromatography-tandem mass spectrometry.
Topics: Chromatography, Liquid; Humans; Piperazines; Sensitivity and Specificity; Tandem Mass Spectrometry; Therapeutic Equivalency; Trazodone | 2008 |
Trazodone generates m-CPP: in 2008 risks from m-CPP might outweigh benefits of trazodone.
Topics: Animals; Antidepressive Agents, Second-Generation; Anxiety; Biotransformation; Brain; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Humans; Mice; Panic; Piperazines; Receptor, Serotonin, 5-HT2B; Receptor, Serotonin, 5-HT2C; Risk Factors; Serotonin Receptor Agonists; Structure-Activity Relationship; Trazodone | 2009 |
Trazodone, meta-chlorophenylpiperazine (an hallucinogenic drug and trazodone metabolite), and the hallucinogen trifluoromethylphenylpiperazine cross-react with the EMIT®II ecstasy immunoassay in urine.
Topics: Antidepressive Agents; Cross Reactions; False Positive Reactions; Hallucinogens; Humans; Illicit Drugs; Immunoassay; N-Methyl-3,4-methylenedioxyamphetamine; Piperazines; Reagent Kits, Diagnostic; Substance Abuse Detection; Substance-Related Disorders; Trazodone | 2010 |
The trazodone metabolite meta-chlorophenylpiperazine can cause false-positive urine amphetamine immunoassay results.
Topics: Amphetamine; Anti-Anxiety Agents; False Positive Reactions; Humans; Immunoassay; Piperazines; Substance Abuse Detection; Substance-Related Disorders; Trazodone | 2011 |
Prescription compliance or illicit designer drug abuse?
Topics: Amphetamine-Related Disorders; Antidepressive Agents; Bupropion; Cross Reactions; Designer Drugs; False Positive Reactions; Female; Humans; Immunoassay; Medication Adherence; Middle Aged; Piperazines; Trazodone | 2012 |
Commentary.
Topics: Amphetamine-Related Disorders; Antidepressive Agents; Designer Drugs; Female; Humans; Medication Adherence; Piperazines; Trazodone | 2012 |
Commentary.
Topics: Amphetamine-Related Disorders; Antidepressive Agents; Designer Drugs; Female; Humans; Medication Adherence; Piperazines; Trazodone | 2012 |