trapoxin a has been researched along with vorinostat in 4 studies
Studies (trapoxin a) | Trials (trapoxin a) | Recent Studies (post-2010) (trapoxin a) | Studies (vorinostat) | Trials (vorinostat) | Recent Studies (post-2010) (vorinostat) |
---|---|---|---|---|---|
8 | 0 | 1 | 2,529 | 181 | 1,840 |
Protein | Taxonomy | trapoxin a (IC50) | vorinostat (IC50) |
---|---|---|---|
Chain A, Histone deacetylase-like amidohydrolase | Alcaligenaceae bacterium FB188 | 0.95 | |
Chain A, Histone deacetylase-like amidohydrolase | Alcaligenaceae bacterium FB188 | 0.95 | |
Histone deacetylase 8 | Schistosoma mansoni | 1.3147 | |
Histone deacetylase | Rattus norvegicus (Norway rat) | 0.165 | |
Gli1 | Mus musculus (house mouse) | 2.23 | |
nuclear receptor subfamily 0 group B member 1 | Homo sapiens (human) | 0.7472 | |
cystic fibrosis transmembrane conductance regulator | Homo sapiens (human) | 1.55 | |
Histone deacetylase 1 | Mus musculus (house mouse) | 0.1121 | |
Histone deacetylase 3 | Homo sapiens (human) | 0.3382 | |
Bromodomain-containing protein 4 | Homo sapiens (human) | 0.2644 | |
Nuclear receptor corepressor 1 | Homo sapiens (human) | 0.0382 | |
Epidermal growth factor receptor | Homo sapiens (human) | 0.456 | |
Tubulin alpha-1A chain | Sus scrofa (pig) | 1.5 | |
Tubulin beta chain | Sus scrofa (pig) | 1.5 | |
Albumin | Homo sapiens (human) | 0.1072 | |
Leukotriene A-4 hydrolase | Homo sapiens (human) | 4.66 | |
Cytochrome P450 2C8 | Homo sapiens (human) | 0.0903 | |
Cytochrome P450 2D6 | Homo sapiens (human) | 0.011 | |
Cytochrome P450 2C9 | Homo sapiens (human) | 0.24 | |
Androgen receptor | Rattus norvegicus (Norway rat) | 0.1582 | |
Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | 2.8 | |
5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 0.053 | |
Cannabinoid receptor 1 | Rattus norvegicus (Norway rat) | 0.116 | |
Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | 2.8 | |
Leukotriene A-4 hydrolase | Mus musculus (house mouse) | 6.15 | |
Cytochrome P450 2C19 | Homo sapiens (human) | 0.042 | |
Prostaglandin G/H synthase 2 | Homo sapiens (human) | 0.13 | |
Delta-type opioid receptor | Homo sapiens (human) | 7.2 | |
Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | 2.8 | |
Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | 7.2 | |
Histone deacetylase 4 | Homo sapiens (human) | 0.6096 | |
Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | 0.086 | |
Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | 0.322 | |
Platelet-activating factor acetylhydrolase | Homo sapiens (human) | 0.1 | |
Histone deacetylase 1 | Homo sapiens (human) | 0.2701 | |
Histone deacetylase 1 | Rattus norvegicus (Norway rat) | 0.165 | |
Histone deacetylase | Rattus norvegicus (Norway rat) | 0.165 | |
Sigma non-opioid intracellular receptor 1 | Cavia porcellus (domestic guinea pig) | 0.07 | |
Renin | Macaca fascicularis (crab-eating macaque) | 0.067 | |
Histone deacetylase 3 | Rattus norvegicus (Norway rat) | 0.165 | |
Histone deacetylase-like amidohydrolase | Alcaligenaceae bacterium FB188 | 1 | |
Histone deacetylase | Plasmodium falciparum 3D7 | 0.1 | |
Histone deacetylase 7 | Homo sapiens (human) | 0.6115 | |
Histone deacetylase 2 | Homo sapiens (human) | 0.3746 | |
HD2 type histone deacetylase HDA106 | Zea mays | 0.2227 | |
Polyamine deacetylase HDAC10 | Homo sapiens (human) | 0.4211 | |
Histone deacetylase 11 | Homo sapiens (human) | 0.5235 | |
Carboxypeptidase B2 | Homo sapiens (human) | 0.362 | |
Histone deacetylase 7 | Rattus norvegicus (Norway rat) | 0.165 | |
Histone deacetylase 6 | Rattus norvegicus (Norway rat) | 0.165 | |
Histone deacetylase 4 | Rattus norvegicus (Norway rat) | 0.165 | |
Histone deacetylase 8 | Homo sapiens (human) | 0.9141 | |
Histone deacetylase 6 | Homo sapiens (human) | 0.2634 | |
Histone deacetylase 9 | Homo sapiens (human) | 0.5614 | |
Histone deacetylase 5 | Homo sapiens (human) | 0.5926 | |
Histone deacetylase | Plasmodium falciparum (malaria parasite P. falciparum) | 0.0945 | |
Nuclear receptor corepressor 2 | Homo sapiens (human) | 0.0905 | |
Histone deacetylase 6 | Mus musculus (house mouse) | 0.3742 | |
Histone deacetylase | Zea mays | 0.029 |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 4 (100.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Brosch, G; Esposito, M; Loidl, P; Mai, A; Massa, S; Ragno, R; Sbardella, G | 1 |
Atadja, P; Bair, KW; Cornell, WD; Green, MA; Howell, KL; Jung, M; Kwon, P; Remiszewski, SW; Sambucetti, LC; Trogani, N; Walker, H | 1 |
Atadja, P; Bair, KW; Bontempo, J; Cesarz, D; Chandramouli, N; Chen, R; Cheung, M; Cornell-Kennon, S; Dean, K; Diamantidis, G; France, D; Green, MA; Howell, KL; Kashi, R; Kwon, P; Lassota, P; Martin, MS; Mou, Y; Perez, LB; Remiszewski, SW; Sambucetti, LC; Sharma, S; Smith, T; Sorensen, E; Taplin, F; Trogani, N; Versace, R; Walker, H; Weltchek-Engler, S; Wood, A; Wu, A | 1 |
Altucci, L; Brosch, G; Loidl, P; Mai, A; Massa, S; Nebbioso, A; Pezzi, R; Rotili, D; Scognamiglio, A; Simeoni, S | 1 |
4 other study(ies) available for trapoxin a and vorinostat
Article | Year |
---|---|
3-(4-aroyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides, a new class of synthetic histone deacetylase inhibitors.
Topics: Drug Design; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histone Deacetylases; Models, Molecular; Molecular Conformation; Pyrroles | 2001 |
Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates.
Topics: Antineoplastic Agents; Benzamides; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Hydroxylamines; Models, Molecular; Promoter Regions, Genetic; Structure-Activity Relationship; Tumor Cells, Cultured | 2002 |
N-hydroxy-3-phenyl-2-propenamides as novel inhibitors of human histone deacetylase with in vivo antitumor activity: discovery of (2E)-N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide (NVP-LAQ824).
Topics: Acetyltransferases; Acrylamides; Animals; Antineoplastic Agents; Body Weight; Cell Division; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Female; Histone Acetyltransferases; Humans; Hydroxamic Acids; Indicators and Reagents; Mice; Mice, Nude; Molecular Conformation; Neoplasm Transplantation; Saccharomyces cerevisiae Proteins | 2003 |
Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides.
Topics: Amides; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Differentiation; Drug Screening Assays, Antitumor; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Propane; Pyrroles; Repressor Proteins; Structure-Activity Relationship; U937 Cells; Zea mays | 2005 |