trapoxin a has been researched along with trichostatin a in 24 studies
| Studies (trapoxin a) | Trials (trapoxin a) | Recent Studies (post-2010) (trapoxin a) | Studies (trichostatin a) | Trials (trichostatin a) | Recent Studies (post-2010) (trichostatin a) |
|---|---|---|---|---|---|
| 42 | 0 | 7 | 3,365 | 7 | 1,382 |
| 8 | 0 | 1 | 3,365 | 7 | 1,382 |
| Protein | Taxonomy | trapoxin a (IC50) | trichostatin a (IC50) |
|---|---|---|---|
| Chain A, HDLP (HISTONE DEACETYLASE-LIKE PROTEIN) | Aquifex aeolicus | 0.4 | |
| Chain B, HDLP (HISTONE DEACETYLASE-LIKE PROTEIN) | Aquifex aeolicus | 0.4 | |
| Chain A, Histone deacetylase 7a | Homo sapiens (human) | 0.3 | |
| Chain A, Histone deacetylase 7a | Homo sapiens (human) | 0.3 | |
| Histone deacetylase 8 | Schistosoma mansoni | 3.62 | |
| Histone deacetylase | Rattus norvegicus (Norway rat) | 0.1854 | |
| Histone deacetylase 1 | Mus musculus (house mouse) | 0.0047 | |
| Histone deacetylase 3 | Homo sapiens (human) | 0.3388 | |
| 5-hydroxytryptamine receptor 3A | Cavia porcellus (domestic guinea pig) | 7.69 | |
| Histone deacetylase 3 | Mus musculus (house mouse) | 0.0014 | |
| Plasma kallikrein | Homo sapiens (human) | 0.034 | |
| Integrin beta-3 | Homo sapiens (human) | 0.0263 | |
| Cytochrome P450 1A2 | Homo sapiens (human) | 0.02 | |
| Integrin alpha-IIb | Homo sapiens (human) | 0.0263 | |
| Coagulation factor VII | Homo sapiens (human) | 0.034 | |
| Cytochrome P450 2D6 | Homo sapiens (human) | 0.005 | |
| Vitamin D3 receptor | Homo sapiens (human) | 0.087 | |
| Cytochrome P450 2C9 | Homo sapiens (human) | 0.028 | |
| Tissue factor | Homo sapiens (human) | 0.032 | |
| Adenosine receptor A1 | Bos taurus (cattle) | 0.19 | |
| Cytochrome P450 2C19 | Homo sapiens (human) | 0.005 | |
| Delta-type opioid receptor | Homo sapiens (human) | 0.1 | |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | 0.1 | |
| Histone deacetylase 4 | Homo sapiens (human) | 0.8532 | |
| Histone deacetylase 2 | Mus musculus (house mouse) | 0.0014 | |
| Histone deacetylase 1 | Homo sapiens (human) | 0.2343 | |
| Splicing factor 3B subunit 3 | Homo sapiens (human) | 0.5944 | |
| Histone deacetylase 1 | Rattus norvegicus (Norway rat) | 0.1854 | |
| Adenosine receptor A1 | Sus scrofa (pig) | 0.2 | |
| Histone deacetylase | Rattus norvegicus (Norway rat) | 0.1854 | |
| Histone deacetylase 4 | Mus musculus (house mouse) | 0.0014 | |
| Polyamine deacetylase HDAC10 | Mus musculus (house mouse) | 0.0014 | |
| Histone deacetylase 3 | Rattus norvegicus (Norway rat) | 0.1854 | |
| Histone deacetylase-like amidohydrolase | Alcaligenaceae bacterium FB188 | 1.2 | |
| Histone deacetylase 7 | Mus musculus (house mouse) | 0.0014 | |
| Histone deacetylase 8 | Mus musculus (house mouse) | 0.0207 | |
| Histone deacetylase 7 | Homo sapiens (human) | 0.5052 | |
| Histone deacetylase 11 | Mus musculus (house mouse) | 0.0014 | |
| Histone deacetylase 2 | Homo sapiens (human) | 0.3475 | |
| HD2 type histone deacetylase HDA106 | Zea mays | 0.006 | |
| Polyamine deacetylase HDAC10 | Homo sapiens (human) | 0.3266 | |
| Histone deacetylase 11 | Homo sapiens (human) | 0.5027 | |
| Histone deacetylase 9 | Mus musculus (house mouse) | 0.0014 | |
| Histone deacetylase 7 | Rattus norvegicus (Norway rat) | 0.1854 | |
| Histone deacetylase 6 | Rattus norvegicus (Norway rat) | 0.1854 | |
| Histone deacetylase 4 | Rattus norvegicus (Norway rat) | 0.1854 | |
| Histone deacetylase 8 | Homo sapiens (human) | 0.4994 | |
| Histone deacetylase 6 | Homo sapiens (human) | 0.2559 | |
| Histone deacetylase 9 | Homo sapiens (human) | 0.5627 | |
| Histone deacetylase 5 | Homo sapiens (human) | 0.5332 | |
| Histone deacetylase | Plasmodium falciparum (malaria parasite P. falciparum) | 0.0006 | |
| Nuclear receptor corepressor 2 | Homo sapiens (human) | 0.0138 | |
| Histone deacetylase 6 | Mus musculus (house mouse) | 0.0387 | |
| Histone deacetylase 5 | Mus musculus (house mouse) | 0.0107 | |
| Histone deacetylase | Zea mays | 0.0004 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (41.67) | 18.2507 |
| 2000's | 13 (54.17) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Schultz, RM; Turner, BM; Worrad, DM | 1 |
| Beppu, T; Horinouchi, S; Yoshida, M | 1 |
| Beppu, T; Horinouchi, S; Kijima, M; Sugita, K; Yoshida, M | 1 |
| Hassig, CA; Schreiber, SL; Taunton, J | 1 |
| Emiliani, S; Van Lint, C; Verdin, E | 1 |
| Yoshida, M | 1 |
| Belyaev, ND; Schultz, RM; Stein, P; Turner, BM; Worrad, DM | 1 |
| Jones, KA; Mayall, TP; Sheridan, PL; Verdin, E | 1 |
| Al-Abed, Y; Emiliani, S; Fischle, W; Van Lint, C; Verdin, E | 1 |
| Hatano, S; Kawashima, K; Kinoshita, T; Kitamura, K; Kiyoi, H; Kosugi, H; Murate, T; Naoe, T; Saito, H; Tanimoto, M; Towatari, M | 1 |
| Horinouchi, S; Yoshida, M | 1 |
| Davie, JR; Lucktong, A; Melkoumian, ZK; Moniwa, M; Strobl, JS; Zhou, Q | 1 |
| Furumai, R; Horinouchi, S; Khochbin, S; Komatsu, Y; Nishino, N; Yoshida, M | 1 |
| Furumai, R; Horinouchi, S; Komatsu, Y; Nishino, N; Nishiyama, M; Yoshida, M | 1 |
| Kerkhofs, P; Kettmann, R; Merezak, C; Portetelle, D; Reichert, M; Van Lint, C; Willems, L | 1 |
| Nielsen, J | 1 |
| Cao, H; Jung, M; Stamatoyannopoulos, G | 1 |
| Du, GH; Liu, AL; Long, J; Wang, N | 1 |
| Koch, BEV; Meijer, AH; Spaink, HP | 1 |
| Brosch, G; Esposito, M; Loidl, P; Mai, A; Massa, S; Ragno, R; Sbardella, G | 1 |
| Atadja, P; Bair, KW; Cornell, WD; Green, MA; Howell, KL; Jung, M; Kwon, P; Remiszewski, SW; Sambucetti, LC; Trogani, N; Walker, H | 1 |
| Atadja, P; Bair, KW; Bontempo, J; Cesarz, D; Chandramouli, N; Chen, R; Cheung, M; Cornell-Kennon, S; Dean, K; Diamantidis, G; France, D; Green, MA; Howell, KL; Kashi, R; Kwon, P; Lassota, P; Martin, MS; Mou, Y; Perez, LB; Remiszewski, SW; Sambucetti, LC; Sharma, S; Smith, T; Sorensen, E; Taplin, F; Trogani, N; Versace, R; Walker, H; Weltchek-Engler, S; Wood, A; Wu, A | 1 |
| Boyle, GM; Fairlie, DP; Glenn, MP; Hans, D; Hansford, KA; Kahnberg, P; Martyn, AC; Parsons, PG | 1 |
| Altucci, L; Brosch, G; Loidl, P; Mai, A; Massa, S; Nebbioso, A; Pezzi, R; Rotili, D; Scognamiglio, A; Simeoni, S | 1 |
6 review(s) available for trapoxin a and trichostatin a
| Article | Year |
|---|---|
Trichostatin A and trapoxin: novel chemical probes for the role of histone acetylation in chromatin structure and function.
Topics: Acetylation; Animals; Anti-Bacterial Agents; Chromatin; Gene Expression Regulation; Histones; Hydroxamic Acids; Peptides; Transcription, Genetic | 1995 |
[Molecular targets of cell cycle inhibitors and their mode of action].
Topics: Acetylation; Animals; Anti-Bacterial Agents; Antifungal Agents; Cell Cycle; Chromatin; Depression, Chemical; Gene Expression Regulation, Developmental; Histones; Hydroxamic Acids; Peptides; Signal Transduction | 1996 |
[Histone deacetylase inhibitors--new anticancer agents?].
Topics: Acetyltransferases; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Depsipeptides; Drug Design; Enzyme Inhibitors; Histone Acetyltransferases; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Peptides; Peptides, Cyclic; Saccharomyces cerevisiae Proteins; Transcription, Genetic; Tumor Suppressor Protein p53 | 2000 |
Histone deacetylase as a new target for cancer chemotherapy.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Melanoma, Experimental; Mice; Peptides; Peptides, Cyclic | 2001 |
Combinatorial synthesis of natural products.
Topics: Anti-Bacterial Agents; Biological Products; Combinatorial Chemistry Techniques; Hydroxamic Acids; Peptides; Vitamin D | 2002 |
[A new target of cancer therapy: advances in the study of histone deacetylase].
Topics: Acetylation; Animals; Apoptosis; Benzamides; Drug Delivery Systems; Enzyme Inhibitors; Histone Acetyltransferases; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Neoplasms; Peptides; Pyridines; Valproic Acid | 2005 |
18 other study(ies) available for trapoxin a and trichostatin a
| Article | Year |
|---|---|
Temporally restricted spatial localization of acetylated isoforms of histone H4 and RNA polymerase II in the 2-cell mouse embryo.
Topics: Acetylation; Animals; Anti-Bacterial Agents; Chromatin; DNA Replication; Fluorescent Antibody Technique; Gene Expression Regulation, Developmental; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Immunoblotting; Isoenzymes; Lysine; Mice; Mice, Inbred Strains; Microscopy, Confocal; Nucleic Acid Conformation; Peptides; RNA Polymerase II; Transcriptional Activation; Zygote | 1995 |
Trapoxin, an antitumor cyclic tetrapeptide, is an irreversible inhibitor of mammalian histone deacetylase.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Anti-Bacterial Agents; Antifungal Agents; Antineoplastic Agents; Cell Cycle; Cell Division; Cell Transformation, Neoplastic; G1 Phase; Histone Deacetylase Inhibitors; Hydroxamic Acids; Kinetics; Mammary Neoplasms, Experimental; Mice; Molecular Sequence Data; Molecular Structure; Oncogenes; Peptides; Teratocarcinoma; Tumor Cells, Cultured | 1993 |
A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p.
Topics: Amino Acid Sequence; Animals; Anti-Bacterial Agents; Cattle; Cell Cycle; Cloning, Molecular; Enzyme Inhibitors; Fungal Proteins; Gene Expression Regulation; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Molecular Sequence Data; Molecular Weight; Peptides; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; T-Lymphocytes; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured | 1996 |
The expression of a small fraction of cellular genes is changed in response to histone hyperacetylation.
Topics: Acetylation; Anti-Bacterial Agents; Cell Line; Chromatin; Enzyme Inhibitors; Gene Expression Regulation; Genes, myc; Genes, Viral; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; HIV-1; Humans; Hydroxamic Acids; Peptides; Protein Processing, Post-Translational | 1996 |
Stage-dependent redistributions of acetylated histones in nuclei of the early preimplantation mouse embryo.
Topics: Acetylation; Amanitins; Animals; Anti-Bacterial Agents; Aphidicolin; Blastocyst; Cell Nucleus; DNA Replication; Enzyme Inhibitors; Fluorescent Dyes; Gene Expression Regulation, Developmental; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Immune Sera; Mice; Microscopy, Confocal; Nucleic Acid Synthesis Inhibitors; Peptides; Staining and Labeling; Transcription, Genetic | 1997 |
Histone acetyltransferases regulate HIV-1 enhancer activity in vitro.
Topics: Acetyltransferases; Animals; Anti-Bacterial Agents; Cell-Free System; Chromatin; Deoxyribonucleases, Type II Site-Specific; DNA-Binding Proteins; Fungal Proteins; Histone Acetyltransferases; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; HIV Enhancer; HIV-1; Humans; Hydroxamic Acids; Lymphoid Enhancer-Binding Factor 1; Peptides; Saccharomyces cerevisiae Proteins; Site-Specific DNA-Methyltransferase (Adenine-Specific); Transcription Factors; Transcription, Genetic | 1997 |
Characterization of a human RPD3 ortholog, HDAC3.
Topics: Amino Acid Sequence; Anti-Bacterial Agents; Base Sequence; Butyrates; Butyric Acid; DNA, Complementary; Gene Expression; Gene Library; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Molecular Sequence Data; Nuclear Proteins; Nucleosomes; Peptides; Sequence Homology, Amino Acid; Transcription Factors | 1998 |
Histone deacetylase inhibitors are the potent inducer/enhancer of differentiation in acute myeloid leukemia: a new approach to anti-leukemia therapy.
Topics: 3T3 Cells; Acute Disease; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Cell Differentiation; Cell Line; Enzyme Inhibitors; Erythroid Precursor Cells; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Hydroxamic Acids; Leukemia, Myeloid; Megakaryocytes; Mice; Peptides; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured | 1999 |
Rapid induction of histone hyperacetylation and cellular differentiation in human breast tumor cell lines following degradation of histone deacetylase-1.
Topics: Acetylation; Acetylcysteine; Animals; Anti-Bacterial Agents; Breast Neoplasms; Cell Cycle; Cell Differentiation; Cell Division; Chickens; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoskeleton; Down-Regulation; Enzyme Inhibitors; Female; G1 Phase; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Immunoblotting; Keratins; Leupeptins; Multienzyme Complexes; Peptides; Phosphorylation; Proteasome Endopeptidase Complex; Quinidine; Retinoblastoma Protein; Time Factors; Tumor Cells, Cultured | 2000 |
Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin.
Topics: 3T3 Cells; Acetylation; Animals; Anti-Bacterial Agents; Cell Cycle; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Flow Cytometry; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Histone Deacetylases; Hydroxamic Acids; Inhibitory Concentration 50; Isoenzymes; Mice; Molecular Structure; Peptides; Peptides, Cyclic; Recombinant Proteins; Structure-Activity Relationship; Tumor Cells, Cultured | 2001 |
Inhibition of histone deacetylases induces bovine leukemia virus expression in vitro and in vivo.
Topics: Animals; Anti-Bacterial Agents; B-Lymphocytes; Cattle; Cell Line; Cells, Cultured; Dogs; Enzyme Inhibitors; Female; Gene Expression Regulation, Viral; Histone Deacetylase Inhibitors; Hydroxamic Acids; Ionomycin; Leukemia Virus, Bovine; Leukocytes, Mononuclear; Peptides; Phorbol Esters; Sheep; Transcription, Genetic; Virus Replication | 2002 |
Induction of human gamma globin gene expression by histone deacetylase inhibitors.
Topics: Amides; Enzyme Inhibitors; Gene Expression Regulation; Globins; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Hydroxylamines; Peptides; Quinolines | 2004 |
A quantitative in vivo assay for craniofacial developmental toxicity of histone deacetylases.
Topics: Animals; Animals, Genetically Modified; Antibiotics, Antineoplastic; Anticonvulsants; Antifungal Agents; Butyrates; Collagen Type II; Craniofacial Abnormalities; Gene Expression Regulation, Developmental; Genes, Reporter; Histone Deacetylases; Hydroxamic Acids; Luminescent Proteins; Peptides; Red Fluorescent Protein; Valproic Acid; Zebrafish | 2021 |
3-(4-aroyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides, a new class of synthetic histone deacetylase inhibitors.
Topics: Drug Design; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histone Deacetylases; Models, Molecular; Molecular Conformation; Pyrroles | 2001 |
Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates.
Topics: Antineoplastic Agents; Benzamides; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Hydroxylamines; Models, Molecular; Promoter Regions, Genetic; Structure-Activity Relationship; Tumor Cells, Cultured | 2002 |
N-hydroxy-3-phenyl-2-propenamides as novel inhibitors of human histone deacetylase with in vivo antitumor activity: discovery of (2E)-N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide (NVP-LAQ824).
Topics: Acetyltransferases; Acrylamides; Animals; Antineoplastic Agents; Body Weight; Cell Division; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Female; Histone Acetyltransferases; Humans; Hydroxamic Acids; Indicators and Reagents; Mice; Mice, Nude; Molecular Conformation; Neoplasm Transplantation; Saccharomyces cerevisiae Proteins | 2003 |
Antiproliferative and phenotype-transforming antitumor agents derived from cysteine.
Topics: Acetylation; Animals; Antineoplastic Agents; Benzylamines; Carboxylic Acids; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine; Drug Screening Assays, Antitumor; Histones; Humans; Models, Molecular; Phenotype; Rats; Structure-Activity Relationship | 2004 |
Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides.
Topics: Amides; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Differentiation; Drug Screening Assays, Antitumor; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Propane; Pyrroles; Repressor Proteins; Structure-Activity Relationship; U937 Cells; Zea mays | 2005 |