transkarbam-12 has been researched along with carbamic-acid* in 2 studies
2 other study(ies) available for transkarbam-12 and carbamic-acid
| Article | Year |
|---|---|
Transkarbams as transdermal permeation enhancers: effects of ester position and ammonium carbamate formation.
Transkarbam 12, an ammonium carbamate formed by the reaction of dodecyl 6-aminohexanoate with carbon dioxide, is a highly active, broad-spectrum, nontoxic, and nonirritant transdermal permeation enhancer. It probably acts by a dual mechanism: a part of its activity is associated with the carbamic acid salt and/or its decomposition in the acidic stratum corneum. The ammonium ester thereby released is an active enhancer species as well, and its activity highly depends on the position of the ester group. Topics: Administration, Cutaneous; Animals; Carbamates; Drug Delivery Systems; Esters; Permeability; Skin; Structure-Activity Relationship; Swine | 2010 |
Synthesis and transdermal penetration-enhancing activity of carbonic and carbamic acid esters--comparison with transkarbam 12.
Transkarbam 12 (T12) is a novel transdermal penetration enhancer with high activity. Its polar head group is formed by carbamic acid salt that is unstable in acidic environment and releases CO(2). To find out whether this property influences its high activity, two series of compounds with CO(2) stronger bound in the polar head have been prepared-carbonic and carbamic acid esters. The carbamate salt in the polar head was found to be essential for the enhancing activity and its decomposition in an acidic environment suggested relating to the mode of action of T12. Topics: Administration, Cutaneous; Animals; Carbamates; Carbonic Acid; Chromatography, High Pressure Liquid; Esters; Permeability; Rats; Swine | 2006 |